CA1104133A - Nitroimidazoles and process for the preparation thereof - Google Patents

Nitroimidazoles and process for the preparation thereof

Info

Publication number
CA1104133A
CA1104133A CA309,523A CA309523A CA1104133A CA 1104133 A CA1104133 A CA 1104133A CA 309523 A CA309523 A CA 309523A CA 1104133 A CA1104133 A CA 1104133A
Authority
CA
Canada
Prior art keywords
lower alkyl
formula
group
hydroxy
nitrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA309,523A
Other languages
English (en)
French (fr)
Inventor
Carey E. Smithen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1104133A publication Critical patent/CA1104133A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA309,523A 1977-08-19 1978-08-17 Nitroimidazoles and process for the preparation thereof Expired CA1104133A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB34908/77 1977-08-19
GB3490877 1977-08-19
GB1953478 1978-05-15
GB19534/78 1978-05-15

Publications (1)

Publication Number Publication Date
CA1104133A true CA1104133A (en) 1981-06-30

Family

ID=26254111

Family Applications (1)

Application Number Title Priority Date Filing Date
CA309,523A Expired CA1104133A (en) 1977-08-19 1978-08-17 Nitroimidazoles and process for the preparation thereof

Country Status (26)

Country Link
US (1) US4241060A (enExample)
EP (1) EP0000928B1 (enExample)
JP (1) JPS5444671A (enExample)
AR (3) AR218325A1 (enExample)
AT (1) AT364829B (enExample)
AU (1) AU516443B2 (enExample)
CA (1) CA1104133A (enExample)
DE (2) DE2860546D1 (enExample)
DK (1) DK155367C (enExample)
ES (3) ES472661A1 (enExample)
FI (1) FI70576C (enExample)
FR (1) FR2400512A1 (enExample)
GB (1) GB2003154A (enExample)
GR (1) GR73055B (enExample)
HU (1) HU179983B (enExample)
IE (1) IE47132B1 (enExample)
IL (1) IL55351A (enExample)
IT (1) IT1098042B (enExample)
MC (1) MC1210A1 (enExample)
NL (1) NL7808597A (enExample)
NO (1) NO151240C (enExample)
NZ (1) NZ188140A (enExample)
PH (1) PH16364A (enExample)
PT (1) PT68441A (enExample)
SE (1) SE7808773L (enExample)
YU (1) YU41317B (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2948884A1 (de) * 1979-12-05 1981-06-11 Basf Ag, 6700 Ludwigshafen 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4494547A (en) * 1981-03-30 1985-01-22 North Carolina Central University 2H-isoindolediones, their synthesis and use as radiosensitizers
US4605744A (en) * 1982-03-18 1986-08-12 Hoffmann-La Roche Inc. Imidazole derivatives
US4537969A (en) * 1982-03-18 1985-08-27 Hoffmann-La Roche Inc. Imidazole derivatives
CA1227211A (en) * 1982-05-27 1987-09-22 Israr Ahmed Nitro imidazolyl aziridino propanols
JPH0649697B2 (ja) * 1982-05-27 1994-06-29 ブリティッシュ・テクノロジー・グループ・リミテッド 放射線治療または化学療法に有用な化合物
US4742050B1 (en) * 1982-08-17 1994-06-28 Alpha Therapeutic Corp Sensitization of hypoxic tumor cells and control of growth thereof
US4889525A (en) * 1982-08-17 1989-12-26 Adamantech, Inc. Sensitization of hypoxic tumor cells and control of growth thereof
AU559559B2 (en) * 1982-08-17 1987-03-12 Suntech, Inc. Perfluorocarbon emulsions and their preparation and use in therapy
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
JP2848602B2 (ja) * 1987-06-24 1999-01-20 京都大学長 新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
DE3854645T2 (de) * 1987-12-04 1996-05-02 British Tech Group Nitro substituierte aromatische und heteroaromatische Verbindungen für Krebsbehandlungen.
GB8728418D0 (en) * 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
US5086068A (en) * 1988-02-26 1992-02-04 Alberta Cancer Board Immunochemical detection of hypoxia in normal and tumor tissue
US5194624A (en) * 1988-05-23 1993-03-16 Fujisawa Pharmaceutical Co., Ltd. Intermediates for the preparation of compounds of antimicrobial activity
JPH02146288A (ja) * 1988-11-25 1990-06-05 Ebara Corp 内部圧縮を持つ容積型圧縮機
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
US5036089A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
US5073639A (en) * 1988-11-25 1991-12-17 Warner-Lambert Company Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents
JP2799368B2 (ja) * 1990-01-10 1998-09-17 ポーラ化成工業株式会社 抗原虫剤
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
MX9304399A (es) * 1992-07-31 1994-02-28 Warner Lambert Co Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US6252087B1 (en) 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
EP0669913B1 (en) * 1992-11-19 2003-03-05 The Trustees Of The University Of Pennsylvania Detection of hypoxia
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
US5741800A (en) * 1993-06-22 1998-04-21 Knoll Aktiengesellachaft Azolyl-cyclic amine derivates with immunomodulatory activity
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US7608612B2 (en) * 2005-01-21 2009-10-27 Richard H. Matthews Radiosensitizer formulations and methods for use
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
MD4150C1 (ro) * 2011-10-11 2012-09-30 Институт Химии Академии Наук Молдовы Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) * 2012-02-27 2013-02-28 Институт Химии Академии Наук Молдовы Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
JP2016525059A (ja) * 2013-07-16 2016-08-22 コーニング インコーポレイテッド 薄ガラスを曲げるための装置及び方法
CN108203411A (zh) * 2016-12-19 2018-06-26 曾舟华 一种高压合成甲硝唑的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA746007A (en) * 1966-11-08 W. Henry David 1-substituted-2-sulfonyl-5-nitroimidazoles
US3255201A (en) * 1965-04-09 1966-06-07 Hoffmann La Roche 2-nitroimidazoles
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
CH513879A (de) * 1966-06-10 1971-10-15 Hoffmann La Roche Verfahren zur Herstellung von Imidazolderivaten
US3646057A (en) * 1969-04-06 1972-02-29 Hoffmann La Roche 2-nitroimidazoles
FR2260996A1 (en) * 1974-02-15 1975-09-12 Hoffmann La Roche (2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents
DE2410749A1 (de) * 1974-03-06 1975-09-11 Hoffmann La Roche 2-nitroimidazole
US4038410A (en) * 1974-03-14 1977-07-26 Schering Aktiengesellschaft Nitroimidazole derivatives and process for the preparation thereof

Also Published As

Publication number Publication date
AU3891578A (en) 1980-02-21
ES478052A1 (es) 1979-10-16
YU195378A (en) 1983-01-21
YU41317B (en) 1987-02-28
IE47132B1 (en) 1983-12-28
IT7826792A0 (it) 1978-08-16
US4241060A (en) 1980-12-23
MC1210A1 (fr) 1979-05-18
NL7808597A (nl) 1979-02-21
AU516443B2 (en) 1981-06-04
NZ188140A (en) 1981-01-23
FI70576C (fi) 1986-09-24
DK366678A (da) 1979-02-20
FR2400512B1 (enExample) 1980-07-04
PH16364A (en) 1983-09-08
FR2400512A1 (fr) 1979-03-16
SE7808773L (sv) 1979-02-20
AR218553A1 (es) 1980-06-13
HU179983B (en) 1983-01-28
ES478051A1 (es) 1979-10-16
EP0000928A1 (de) 1979-03-07
AR218325A1 (es) 1980-05-30
PT68441A (enExample) 1978-09-01
ATA601078A (de) 1981-04-15
EP0000928B1 (de) 1981-03-18
AR220216A1 (es) 1980-10-15
NO151240B (no) 1984-11-26
DE2860546D1 (en) 1981-04-16
FI70576B (fi) 1986-06-06
JPS6220187B2 (enExample) 1987-05-06
NO782813L (no) 1979-02-20
DK155367B (da) 1989-04-03
AT364829B (de) 1981-11-25
DK155367C (da) 1989-08-14
FI782530A7 (fi) 1979-02-20
GR73055B (enExample) 1984-01-26
NO151240C (no) 1985-03-06
IL55351A (en) 1982-07-30
IL55351A0 (en) 1978-10-31
GB2003154A (en) 1979-03-07
DE2836073A1 (de) 1979-03-01
IE781453L (en) 1979-02-19
ES472661A1 (es) 1979-02-16
IT1098042B (it) 1985-08-31
JPS5444671A (en) 1979-04-09

Similar Documents

Publication Publication Date Title
CA1104133A (en) Nitroimidazoles and process for the preparation thereof
US3505350A (en) Certain substituted 2-mercaptoimidazole derivatives
US5073671A (en) 1-(benzyl or pyridylmethyl)-4 or 5-aminomethyl-pyrrolidin-2-ones
EP0479546B1 (en) Piperazine derivatives
GB1573809A (en) Basically substituted indole derivative and process for their manufacture
EP0079545A1 (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
GB1566307A (en) Indole derivatives of amides and amino esters and process for their manufacture
US4322418A (en) Substituted 1-(α-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines, compositions and use
GB1569251A (en) Pyridobenzodiazepines
NZ210722A (en) Imidazoles and pharmaceutical compositions
US3299090A (en) Nitroimidazoles
EP0361577B1 (en) Tetrahydronaphthalene and indane derivatives
US3971814A (en) Benzo(b)thiophene derivatives
US4479948A (en) Triazino(2,1-a)isoquinoline derivatives, compositions and their use as medicaments
IE840682L (en) Bis(piperazinyl or homopiperazinyl) alkanes
US4118494A (en) Substituted 3,4-dihydro-2H-isoquinolin-1-thiones
US3930008A (en) 4-Aryl-5-aminoalkyl-4-oxazolin-2-ones
CA1117526A (en) Substituted 0-(2-hydroxypropyl)-aldoximes
US4018793A (en) Benzo (b) thiophene derivatives
KR810002122B1 (ko) 니트로 이미다졸류의 제조방법
US3728389A (en) Biologically active amidines and their preparation
KR810002123B1 (ko) 니트로 이미다졸류의 제조방법
US4056526A (en) Benzo(b)thiophene derivatives
US4082770A (en) Benzo(b)thiophene derivatives
KR810002124B1 (ko) 니트로 이미다졸류의 제조방법

Legal Events

Date Code Title Description
MKEX Expiry