CA1104124A - Derivatives of 9-fluoroprednisolone - Google Patents

Derivatives of 9-fluoroprednisolone

Info

Publication number
CA1104124A
CA1104124A CA299,299A CA299299A CA1104124A CA 1104124 A CA1104124 A CA 1104124A CA 299299 A CA299299 A CA 299299A CA 1104124 A CA1104124 A CA 1104124A
Authority
CA
Canada
Prior art keywords
alpha
pregnadiene
dione
fluoro
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA299,299A
Other languages
English (en)
French (fr)
Inventor
Klaus Annen
Henry Laurent
Helmut Hofmeister
Rudolf Wiechert
Hans Wendt
Joachim-Friedrich Kapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2712862A external-priority patent/DE2712862C2/de
Priority claimed from DE19782809732 external-priority patent/DE2809732C2/de
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of CA1104124A publication Critical patent/CA1104124A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA299,299A 1977-03-21 1978-03-20 Derivatives of 9-fluoroprednisolone Expired CA1104124A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP2712862.7 1977-03-21
DE2712862A DE2712862C2 (de) 1977-03-21 1977-03-21 Derivate des 9-Fluorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DEP2809732.7 1978-03-03
DE19782809732 DE2809732C2 (de) 1978-03-03 1978-03-03 Derivate des 9-Fluorprednisolons, Verfahren zu ihrer Herstellung, und pharmazeutische Präparate, die diese Wirkstoffe enthalten

Publications (1)

Publication Number Publication Date
CA1104124A true CA1104124A (en) 1981-06-30

Family

ID=25771793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA299,299A Expired CA1104124A (en) 1977-03-21 1978-03-20 Derivatives of 9-fluoroprednisolone

Country Status (20)

Country Link
JP (1) JPS53130651A (nl)
AT (1) AT365203B (nl)
AU (1) AU525614B2 (nl)
CA (1) CA1104124A (nl)
CH (1) CH638226A5 (nl)
CS (1) CS202591B2 (nl)
DD (1) DD134955A5 (nl)
DK (1) DK126378A (nl)
ES (1) ES468107A1 (nl)
FR (1) FR2384792A1 (nl)
GB (1) GB1603281A (nl)
GR (1) GR70385B (nl)
IE (1) IE46584B1 (nl)
IL (1) IL54308A (nl)
IT (1) IT1095477B (nl)
LU (1) LU79271A1 (nl)
NO (1) NO151043C (nl)
NZ (1) NZ186735A (nl)
RO (1) RO81525B (nl)
SE (1) SE431656B (nl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853785A1 (de) * 1978-12-11 1980-06-19 Schering Ag Neue prednison-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische praeparate und deren verwendung
JPH07116215B2 (ja) * 1989-04-19 1995-12-13 エスエス製薬株式会社 新規なステロイド化合物
JPH07213320A (ja) * 1994-02-04 1995-08-15 Daiwa:Kk 長尺物用バック

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055221A1 (en) * 1970-11-10 1972-05-18 Laboratorio Chimico Farmaceutico Dr. P. Blasina S.R.L., Mailand (Italien) 17-acyloxy-3-keto-pregn-4-enes prepn - by acylating 17-hydroxy steroids in presence ofstannic chloride
CH529739A (fr) * 1972-02-28 1972-10-31 Sdc Steroidi Dev Co Procédé pour la préparation d'un stéroïde de la série des prégnadiènes
US3832366A (en) * 1973-07-30 1974-08-27 Squibb & Sons Inc Process for preparing 21-chloro-17-acyloxy-20-ketosteroids

Also Published As

Publication number Publication date
IE780545L (en) 1978-09-21
NO151043B (no) 1984-10-22
IL54308A0 (en) 1978-06-15
JPS6131116B2 (nl) 1986-07-17
LU79271A1 (de) 1978-06-29
NZ186735A (en) 1980-10-24
NO780984L (no) 1978-09-22
SE431656B (sv) 1984-02-20
GB1603281A (en) 1981-11-25
ATA195978A (de) 1981-05-15
DD134955A5 (de) 1979-04-04
DK126378A (da) 1978-09-22
IL54308A (en) 1984-03-30
SE7803168L (sv) 1978-09-22
IE46584B1 (en) 1983-07-27
ES468107A1 (es) 1979-07-01
AU3434678A (en) 1979-09-27
AU525614B2 (en) 1982-11-18
CH638226A5 (en) 1983-09-15
RO81525B (ro) 1983-04-30
FR2384792A1 (fr) 1978-10-20
IT7821364A0 (it) 1978-03-20
JPS53130651A (en) 1978-11-14
NO151043C (no) 1985-01-30
AT365203B (de) 1981-12-28
GR70385B (nl) 1982-10-05
RO81525A (ro) 1983-04-29
CS202591B2 (en) 1981-01-30
FR2384792B1 (nl) 1980-04-04
IT1095477B (it) 1985-08-10

Similar Documents

Publication Publication Date Title
US4587236A (en) Novel 6α-methylprednisolone derivatives, their preparation, and their use
NO157020B (no) AnalogifremgangsmŸte ved fremstilling av terapeutisk aktive 3,20-dioxo-1,4-pregnadien-17alfa-ol-17-aromatiske heterocykliske carboxylater.
US4555507A (en) Novel 6, 16-dimethylcorticoids, their preparation and use
CA1104124A (en) Derivatives of 9-fluoroprednisolone
EP0072546B1 (de) Neue Hydrocortison-Derivate, ihre Herstellung und Verwendung
IE56281B1 (en) Novel 6alpha-methylcorticoins and their manufacture and use
US4777165A (en) 6α, 16β-dimethyl corticoids and their anti-inflammatory use
CA1251784A (en) Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
US4243664A (en) Novel corticoids
US4432976A (en) Cyclocarbonate esters of 16α,17α, dihydroxy anti-inflammatory steroids
US4619922A (en) 6α, 16α-dimethyl corticoids
JPH0257559B2 (nl)
IE45877B1 (en) New derivatives of 9-chloroprednisolone
CA1100943A (en) Derivatives of 9-chloroprednisolone
IE45305B1 (en) New corticoids
CA1250571A (en) 6 -methylprednisolone derivatives and their manufacture and use
JPS6361000B2 (nl)
CS199512B2 (cs) Způsob výroby kortikoidfi
PL114012B1 (en) Process for preparing novel derivatives of 9-fluoroprednisolone
CS244662B2 (cs) Způsob výroby nových derivátů 9-chlorprednisolonu
CS207758B2 (cs) Způsob výroby v poloze pregnanové řady 17 substituovaných 11/3-hydroxysteroidů
CS244663B2 (cs) Způsob výroby nových derivátů 9-chlorprednisolonu
CS202593B2 (cs) Způsob výroby derivátů 9-fluorprednisolonu
DE2809732A1 (de) Neue derivate des 9-fluorprednisolons

Legal Events

Date Code Title Description
MKEX Expiry