CA1093068A - Cephalosporin antibiotics - Google Patents

Cephalosporin antibiotics

Info

Publication number
CA1093068A
CA1093068A CA300,315A CA300315A CA1093068A CA 1093068 A CA1093068 A CA 1093068A CA 300315 A CA300315 A CA 300315A CA 1093068 A CA1093068 A CA 1093068A
Authority
CA
Canada
Prior art keywords
formula
cefuroxime
fur
ceph
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA300,315A
Other languages
English (en)
French (fr)
Inventor
Michael Gregson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Application granted granted Critical
Publication of CA1093068A publication Critical patent/CA1093068A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA300,315A 1977-04-19 1978-04-03 Cephalosporin antibiotics Expired CA1093068A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB16202/77A GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
GB16202/77 1977-04-19

Publications (1)

Publication Number Publication Date
CA1093068A true CA1093068A (en) 1981-01-06

Family

ID=10073017

Family Applications (1)

Application Number Title Priority Date Filing Date
CA300,315A Expired CA1093068A (en) 1977-04-19 1978-04-03 Cephalosporin antibiotics

Country Status (20)

Country Link
JP (1) JPS53132592A (da)
KR (1) KR840000081B1 (da)
AT (1) AT363183B (da)
AU (1) AU521098B2 (da)
BE (1) BE866093A (da)
CA (1) CA1093068A (da)
CH (1) CH639096A5 (da)
DE (1) DE2816873A1 (da)
DK (1) DK147513C (da)
ES (1) ES468895A1 (da)
FR (1) FR2387988A1 (da)
GB (1) GB1598568A (da)
IE (1) IE46726B1 (da)
IL (1) IL54531A (da)
IT (1) IT1104842B (da)
NL (1) NL7804097A (da)
NZ (1) NZ186998A (da)
SE (1) SE433748B (da)
YU (1) YU90978A (da)
ZA (1) ZA782211B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595695A (en) * 1983-01-05 1986-06-17 Teva Pharmaceutical Industries Ltd. 1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and pharmaceutical compositions containing it

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482587A1 (fr) * 1980-05-14 1981-11-20 Poudres & Explosifs Ste Nale Procede de synthese de chloroformiates a-chlores et nouveaux chloroformiates a-chlores
AU8166182A (en) * 1981-03-23 1982-09-30 Kyoto Yakuhin Kogyo K.K. Cephalosporin derivatives
FR2532933B1 (fr) * 1982-06-29 1987-11-13 Astra Laekemedel Ab Perfectionnements apportes a la preparation d'antibiotiques
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
IL68992A (en) * 1982-06-29 1991-06-10 Astra Laekemedel Ab Alpha-bromo diethyl carbonate and process for the preparation of ethoxycarbonyloxy esters of penicillanic acids
GB2123821B (en) * 1982-06-29 1987-04-23 Astra Laekemedel Ab At-halogeno diethyl carbonates and their use in the preparation of antibiotics
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
FR2551058B1 (fr) * 1983-08-26 1986-09-26 Poudres & Explosifs Ste Nale Procede de preparation de chloroformiates a-chlores
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
US4612143A (en) * 1984-09-17 1986-09-16 Societe Nationale Des Poudres Et Explosifs Process for the preparation of fluoroformates
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
KR100342944B1 (ko) 1999-11-08 2002-07-02 민경윤 고순도 세프포독심 프록세틸의 제조방법
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595695A (en) * 1983-01-05 1986-06-17 Teva Pharmaceutical Industries Ltd. 1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and pharmaceutical compositions containing it

Also Published As

Publication number Publication date
DK147513B (da) 1984-09-10
DE2816873A1 (de) 1978-11-02
ES468895A1 (es) 1978-12-01
FR2387988A1 (fr) 1978-11-17
JPS53132592A (en) 1978-11-18
IT1104842B (it) 1985-10-28
ZA782211B (en) 1979-04-25
BE866093A (fr) 1978-10-18
SE7804400L (sv) 1978-10-20
NZ186998A (en) 1981-05-01
ATA274878A (de) 1980-12-15
IL54531A (en) 1981-07-31
YU90978A (en) 1983-01-21
CH639096A5 (en) 1983-10-31
AU521098B2 (en) 1982-03-18
DK147513C (da) 1985-03-18
FR2387988B1 (da) 1982-06-11
IE780760L (en) 1978-10-19
KR830000246A (ko) 1983-03-30
AT363183B (de) 1981-07-10
IE46726B1 (en) 1983-09-07
IL54531A0 (en) 1978-07-31
AU3518778A (en) 1979-10-25
DK168778A (da) 1978-10-20
SE433748B (sv) 1984-06-12
IT7848941A0 (it) 1978-04-18
KR840000081B1 (ko) 1984-02-08
NL7804097A (nl) 1978-10-23
GB1598568A (en) 1981-09-23

Similar Documents

Publication Publication Date Title
CA1094545A (en) Cephalosporin antibiotics
CA1093068A (en) Cephalosporin antibiotics
CH634578A5 (de) Verfahren zur herstellung von neuen cephalosporinderivaten.
GB1571683A (en) Ester derivatives of cefuroxime
CA1060432A (en) 7 .alpha. METHOXYCEPHALOSPORIN DERIVATIVES
JPS63146863A (ja) カルボン酸類
SU1487814A3 (ru) СПОСОБ ПОЛУЧЕНИЯ 7-АМИНО-З-[3(4-КАРБАМОИЛ-1-ПИРИДИНИО)-1-ПРОПЕН1-ИЛ]-3-ЦЕФЕМ-4-КАРБОКСИЛАТА ч.
EP0134420A1 (en) Cephalosporin derivatives, a process for their preparation and compositions containing them
NO173736B (no) Analogifremgangsmaate for fremstilling av en terapeutisk aktiv forbindelse bestaaende hovedsaklig av diastereomer (i)av cefalosporinderivater
DD282691A5 (de) Verfahren zur herstellung von cephalosporin
GB2092575A (en) 7-acylaminocephalosporanic acid derivatives
US4446317A (en) Cephalosporin antibiotics
FI69468C (fi) Foerfarande foer framstaellning av nya farmakologiskt vaerdefulla oximderivat av 3-tiadiazolyl-tiometyl-7-amino-tiazolylacetamido-cefalosporansyra
PT92890A (pt) Processo para a preparacao de derivados de cefalosporina e de composicoes farmaceuticas que os contem
US4200746A (en) Cephalosporins
GB1572993A (en) Ester derivatives of cefuroxime
JPS6019317B2 (ja) チエノチアジン誘導体及びその製造方法
US4385054A (en) 1-Acetoxyethyl-3-(2-chloroethylcarbamoyloxymethyl)-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylate
KR830001543B1 (ko) 세파로스포린 항생물질의 제조방법
JPH021835B2 (da)
CH615186A5 (en) Process for the preparation of cephem compounds
KR830001521B1 (ko) 세팔로스포린 항생물질의 제조 방법
GB2153818A (en) Pyrazolopyridine derivatives
US2784194A (en) Phenacylsulfonyl pyridine compounds
JPS58183695A (ja) 経口投与用活性セフロキシム誘導体、その製造方法およびその医薬組成物

Legal Events

Date Code Title Description
MKEX Expiry