GB1598568A - Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid - Google Patents

Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid Download PDF

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Publication number
GB1598568A
GB1598568A GB16202/77A GB1620277A GB1598568A GB 1598568 A GB1598568 A GB 1598568A GB 16202/77 A GB16202/77 A GB 16202/77A GB 1620277 A GB1620277 A GB 1620277A GB 1598568 A GB1598568 A GB 1598568A
Authority
GB
United Kingdom
Prior art keywords
formula
fur
ceph
carbamoyloxymethyl
methoxyiminoacetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16202/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB16202/77A priority Critical patent/GB1598568A/en
Priority to CA300,315A priority patent/CA1093068A/en
Priority to AT0274878A priority patent/AT363183B/de
Priority to IL54531A priority patent/IL54531A/xx
Priority to IT48941/78A priority patent/IT1104842B/it
Priority to ZA00782211A priority patent/ZA782211B/xx
Priority to SE7804400A priority patent/SE433748B/sv
Priority to JP4643178A priority patent/JPS53132592A/ja
Priority to CH414678A priority patent/CH639096A5/de
Priority to DK168778A priority patent/DK147513C/da
Priority to AU35187/78A priority patent/AU521098B2/en
Priority to NZ186998A priority patent/NZ186998A/xx
Priority to NL7804097A priority patent/NL7804097A/xx
Priority to KR7801139A priority patent/KR840000081B1/ko
Priority to ES468895A priority patent/ES468895A1/es
Priority to IE760/78A priority patent/IE46726B1/en
Priority to BE186875A priority patent/BE866093A/xx
Priority to YU00909/78A priority patent/YU90978A/xx
Priority to DE19782816873 priority patent/DE2816873A1/de
Priority to FR7811514A priority patent/FR2387988A1/fr
Publication of GB1598568A publication Critical patent/GB1598568A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB16202/77A 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid Expired GB1598568A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB16202/77A GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
CA300,315A CA1093068A (en) 1977-04-19 1978-04-03 Cephalosporin antibiotics
AT0274878A AT363183B (de) 1977-04-19 1978-04-18 Verfahren zur herstellung von neuen cephalosporinderivaten
IL54531A IL54531A (en) 1977-04-19 1978-04-18 Carbonic acis esters of cefuroxime, their preparation and pharmaceutical compsitions containing them
IT48941/78A IT1104842B (it) 1977-04-19 1978-04-18 Composti di cefalosporina composizioni antibiotiche che li contengono e procedimento per prepararli
ZA00782211A ZA782211B (en) 1977-04-19 1978-04-18 Improvements in or relating to cephalosporin antibiotics
SE7804400A SE433748B (sv) 1977-04-19 1978-04-18 Forfarande for framstellning av estrar av (6r, 7r-3-karbamoyloximetyl-7-((z)-2-(fur-2-yl)-2-metoxiimionacetamido)-cef-3-em-4-karbonsyra
JP4643178A JPS53132592A (en) 1977-04-19 1978-04-18 Cephalospoline compound and process for preparing same
CH414678A CH639096A5 (en) 1977-04-19 1978-04-18 Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
DK168778A DK147513C (da) 1977-04-19 1978-04-18 Analogifremgangsmaade til fremstilling af cefuroximestere
AU35187/78A AU521098B2 (en) 1977-04-19 1978-04-18 Gephalosporin antibiotics
NZ186998A NZ186998A (en) 1977-04-19 1978-04-18 Esters of cefuroxime ((6r,7r)-3-carbamoyloxy-methyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido) ceph-3-em-carboxylic acid syn isomer) and pharmaceutical compositions
NL7804097A NL7804097A (nl) 1977-04-19 1978-04-18 Verbeteringen betreffende antibiotica van het cefalo- sporinetype. 180478 verbeteringen betreffende antibiotica van het cefalo- sporinetype.
KR7801139A KR840000081B1 (ko) 1977-04-19 1978-04-18 세푸록심 에스테르의 제조방법
ES468895A ES468895A1 (es) 1977-04-19 1978-04-18 Un procedimiento para la preparacion de antibioticos de ce- falosporina.
IE760/78A IE46726B1 (en) 1977-04-19 1978-04-18 Esters of (6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
BE186875A BE866093A (fr) 1977-04-19 1978-04-18 Esters de cefuroxime, leur preparation et leur emploi
YU00909/78A YU90978A (en) 1977-04-19 1978-04-18 Process for obtaining cephalosporin compounds
DE19782816873 DE2816873A1 (de) 1977-04-19 1978-04-18 Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
FR7811514A FR2387988A1 (fr) 1977-04-19 1978-04-19 Esters de cefuroxime, leur preparation et leur application therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB16202/77A GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Publications (1)

Publication Number Publication Date
GB1598568A true GB1598568A (en) 1981-09-23

Family

ID=10073017

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16202/77A Expired GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Country Status (20)

Country Link
JP (1) JPS53132592A (da)
KR (1) KR840000081B1 (da)
AT (1) AT363183B (da)
AU (1) AU521098B2 (da)
BE (1) BE866093A (da)
CA (1) CA1093068A (da)
CH (1) CH639096A5 (da)
DE (1) DE2816873A1 (da)
DK (1) DK147513C (da)
ES (1) ES468895A1 (da)
FR (1) FR2387988A1 (da)
GB (1) GB1598568A (da)
IE (1) IE46726B1 (da)
IL (1) IL54531A (da)
IT (1) IT1104842B (da)
NL (1) NL7804097A (da)
NZ (1) NZ186998A (da)
SE (1) SE433748B (da)
YU (1) YU90978A (da)
ZA (1) ZA782211B (da)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123821A (en) * 1982-06-29 1984-02-08 Astra Laekemedel Ab ???-Halogeno diethyl carbonates and their use in the preparation of antibiotics
US4562181A (en) * 1982-07-30 1985-12-31 Glaxo Group Limited Amorphous form of cefuroxime ester
US4592872A (en) * 1980-05-14 1986-06-03 Societe Nationale Des Poudres Et Explosifs Process for the synthesis of α-chlorinated chloroformates
GB2168050A (en) * 1982-06-29 1986-06-11 Astra Laekemedel Ab Intermediates useful in the preparation of antibiotics
US4614829A (en) * 1983-08-26 1986-09-30 Societe Nationale Des Poudres Et Explosifs Process for the preparation of α-chlorinated chloroformates
EP1228074A1 (en) * 1999-11-08 2002-08-07 Hanmi Pharm. Co., Ltd. Method of preparing highly pure cefpodoxime proxetil
WO2004067536A2 (en) * 2003-01-28 2004-08-12 Sandoz Ag Carboxylic acid esters to improve bioavailability of pharmaceutical compounds

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8166182A (en) * 1981-03-23 1982-09-30 Kyoto Yakuhin Kogyo K.K. Cephalosporin derivatives
FR2532933B1 (fr) * 1982-06-29 1987-11-13 Astra Laekemedel Ab Perfectionnements apportes a la preparation d'antibiotiques
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
US4612143A (en) * 1984-09-17 1986-09-16 Societe Nationale Des Poudres Et Explosifs Process for the preparation of fluoroformates
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592872A (en) * 1980-05-14 1986-06-03 Societe Nationale Des Poudres Et Explosifs Process for the synthesis of α-chlorinated chloroformates
GB2123821A (en) * 1982-06-29 1984-02-08 Astra Laekemedel Ab ???-Halogeno diethyl carbonates and their use in the preparation of antibiotics
GB2168050A (en) * 1982-06-29 1986-06-11 Astra Laekemedel Ab Intermediates useful in the preparation of antibiotics
GB2168699A (en) * 1982-06-29 1986-06-25 Astra Laekemedel Ab alpha -Bromodiethyl carbonate and its use in the preparation of antibiotics
US4562181A (en) * 1982-07-30 1985-12-31 Glaxo Group Limited Amorphous form of cefuroxime ester
US4614829A (en) * 1983-08-26 1986-09-30 Societe Nationale Des Poudres Et Explosifs Process for the preparation of α-chlorinated chloroformates
EP1228074A1 (en) * 1999-11-08 2002-08-07 Hanmi Pharm. Co., Ltd. Method of preparing highly pure cefpodoxime proxetil
EP1228074A4 (en) * 1999-11-08 2003-02-26 Hanmi Pharm Ind Co Ltd A METHOD FOR THE PRODUCTION OF HIGH PURITY CEFPODOXIM PROXETILE
US6639068B1 (en) 1999-11-08 2003-10-28 Hanmi Pharm. Co., Ltd. Method of preparing highly pure cefpodoxime proxetil
WO2004067536A2 (en) * 2003-01-28 2004-08-12 Sandoz Ag Carboxylic acid esters to improve bioavailability of pharmaceutical compounds
WO2004067536A3 (en) * 2003-01-28 2004-12-23 Sandoz Ag Carboxylic acid esters to improve bioavailability of pharmaceutical compounds

Also Published As

Publication number Publication date
DK147513C (da) 1985-03-18
IT7848941A0 (it) 1978-04-18
SE7804400L (sv) 1978-10-20
DK168778A (da) 1978-10-20
KR840000081B1 (ko) 1984-02-08
IL54531A (en) 1981-07-31
IT1104842B (it) 1985-10-28
CA1093068A (en) 1981-01-06
AU521098B2 (en) 1982-03-18
ES468895A1 (es) 1978-12-01
IE780760L (en) 1978-10-19
DK147513B (da) 1984-09-10
NZ186998A (en) 1981-05-01
DE2816873A1 (de) 1978-11-02
BE866093A (fr) 1978-10-18
FR2387988B1 (da) 1982-06-11
ATA274878A (de) 1980-12-15
SE433748B (sv) 1984-06-12
IL54531A0 (en) 1978-07-31
FR2387988A1 (fr) 1978-11-17
IE46726B1 (en) 1983-09-07
NL7804097A (nl) 1978-10-23
YU90978A (en) 1983-01-21
AT363183B (de) 1981-07-10
KR830000246A (ko) 1983-03-30
ZA782211B (en) 1979-04-25
AU3518778A (en) 1979-10-25
JPS53132592A (en) 1978-11-18
CH639096A5 (en) 1983-10-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee