AT363183B - Verfahren zur herstellung von neuen cephalosporinderivaten - Google Patents

Verfahren zur herstellung von neuen cephalosporinderivaten

Info

Publication number
AT363183B
AT363183B AT0274878A AT274878A AT363183B AT 363183 B AT363183 B AT 363183B AT 0274878 A AT0274878 A AT 0274878A AT 274878 A AT274878 A AT 274878A AT 363183 B AT363183 B AT 363183B
Authority
AT
Austria
Prior art keywords
producing new
cephalosporine derivatives
new cephalosporine
derivatives
producing
Prior art date
Application number
AT0274878A
Other languages
English (en)
Other versions
ATA274878A (de
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of ATA274878A publication Critical patent/ATA274878A/de
Application granted granted Critical
Publication of AT363183B publication Critical patent/AT363183B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0274878A 1977-04-19 1978-04-18 Verfahren zur herstellung von neuen cephalosporinderivaten AT363183B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB16202/77A GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Publications (2)

Publication Number Publication Date
ATA274878A ATA274878A (de) 1980-12-15
AT363183B true AT363183B (de) 1981-07-10

Family

ID=10073017

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0274878A AT363183B (de) 1977-04-19 1978-04-18 Verfahren zur herstellung von neuen cephalosporinderivaten

Country Status (20)

Country Link
JP (1) JPS53132592A (de)
KR (1) KR840000081B1 (de)
AT (1) AT363183B (de)
AU (1) AU521098B2 (de)
BE (1) BE866093A (de)
CA (1) CA1093068A (de)
CH (1) CH639096A5 (de)
DE (1) DE2816873A1 (de)
DK (1) DK147513C (de)
ES (1) ES468895A1 (de)
FR (1) FR2387988A1 (de)
GB (1) GB1598568A (de)
IE (1) IE46726B1 (de)
IL (1) IL54531A (de)
IT (1) IT1104842B (de)
NL (1) NL7804097A (de)
NZ (1) NZ186998A (de)
SE (1) SE433748B (de)
YU (1) YU90978A (de)
ZA (1) ZA782211B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT392470B (de) * 1983-07-29 1991-04-10 Glaxo Group Ltd Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482587A1 (fr) * 1980-05-14 1981-11-20 Poudres & Explosifs Ste Nale Procede de synthese de chloroformiates a-chlores et nouveaux chloroformiates a-chlores
AU8166182A (en) * 1981-03-23 1982-09-30 Kyoto Yakuhin Kogyo K.K. Cephalosporin derivatives
SE454879B (sv) * 1982-06-29 1988-06-06 Astra Laekemedel Ab Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g
GB2123821B (en) * 1982-06-29 1987-04-23 Astra Laekemedel Ab At-halogeno diethyl carbonates and their use in the preparation of antibiotics
FR2532933B1 (fr) * 1982-06-29 1987-11-13 Astra Laekemedel Ab Perfectionnements apportes a la preparation d'antibiotiques
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
FR2551058B1 (fr) * 1983-08-26 1986-09-26 Poudres & Explosifs Ste Nale Procede de preparation de chloroformiates a-chlores
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
US4612143A (en) * 1984-09-17 1986-09-16 Societe Nationale Des Poudres Et Explosifs Process for the preparation of fluoroformates
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
KR100342944B1 (ko) 1999-11-08 2002-07-02 민경윤 고순도 세프포독심 프록세틸의 제조방법
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT392470B (de) * 1983-07-29 1991-04-10 Glaxo Group Ltd Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester

Also Published As

Publication number Publication date
CA1093068A (en) 1981-01-06
SE7804400L (sv) 1978-10-20
JPS53132592A (en) 1978-11-18
IL54531A (en) 1981-07-31
KR830000246A (ko) 1983-03-30
GB1598568A (en) 1981-09-23
AU3518778A (en) 1979-10-25
AU521098B2 (en) 1982-03-18
DK168778A (da) 1978-10-20
DE2816873A1 (de) 1978-11-02
FR2387988B1 (de) 1982-06-11
IE780760L (en) 1978-10-19
IE46726B1 (en) 1983-09-07
IT7848941A0 (it) 1978-04-18
IL54531A0 (en) 1978-07-31
SE433748B (sv) 1984-06-12
BE866093A (fr) 1978-10-18
YU90978A (en) 1983-01-21
NL7804097A (nl) 1978-10-23
DK147513B (da) 1984-09-10
KR840000081B1 (ko) 1984-02-08
ATA274878A (de) 1980-12-15
ZA782211B (en) 1979-04-25
CH639096A5 (en) 1983-10-31
NZ186998A (en) 1981-05-01
FR2387988A1 (fr) 1978-11-17
IT1104842B (it) 1985-10-28
ES468895A1 (es) 1978-12-01
DK147513C (da) 1985-03-18

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee