CA1092100A - Ergoline i derivatives - Google Patents

Ergoline i derivatives

Info

Publication number
CA1092100A
CA1092100A CA268,415A CA268415A CA1092100A CA 1092100 A CA1092100 A CA 1092100A CA 268415 A CA268415 A CA 268415A CA 1092100 A CA1092100 A CA 1092100A
Authority
CA
Canada
Prior art keywords
carbon atoms
formula
compound
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA268,415A
Other languages
English (en)
French (fr)
Inventor
Peter Stutz
Paul Stadler
Theodor Fehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1668075A external-priority patent/CH620441A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1092100A publication Critical patent/CA1092100A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA268,415A 1975-12-23 1976-12-21 Ergoline i derivatives Expired CA1092100A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1668075A CH620441A5 (en) 1975-12-23 1975-12-23 Process for the preparation of novel ergoline compounds
CH16680/75 1975-12-23
CH6188/76 1976-05-18
CH618876 1976-05-18

Publications (1)

Publication Number Publication Date
CA1092100A true CA1092100A (en) 1980-12-23

Family

ID=25699142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA268,415A Expired CA1092100A (en) 1975-12-23 1976-12-21 Ergoline i derivatives

Country Status (20)

Country Link
US (1) US4348391A (en, 2012)
JP (1) JPS5278900A (en, 2012)
AU (1) AU514288B2 (en, 2012)
CA (1) CA1092100A (en, 2012)
DE (1) DE2656344A1 (en, 2012)
DK (2) DK146205C (en, 2012)
ES (1) ES454442A1 (en, 2012)
FI (1) FI763587A7 (en, 2012)
FR (1) FR2336135A1 (en, 2012)
GB (1) GB1567484A (en, 2012)
HK (1) HK3483A (en, 2012)
IE (1) IE44242B1 (en, 2012)
IL (1) IL51133A (en, 2012)
MY (1) MY8400060A (en, 2012)
NL (1) NL7614018A (en, 2012)
NZ (1) NZ182934A (en, 2012)
PH (1) PH14035A (en, 2012)
PT (1) PT66006B (en, 2012)
SE (1) SE432253B (en, 2012)
SG (1) SG63382G (en, 2012)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3127845A1 (de) * 1980-07-25 1982-04-22 Sandoz-Patent-GmbH, 7850 Lörrach Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen und ihre anwendung bei der therapeutischen behandlung
BE889713A (fr) * 1980-07-25 1982-01-25 Sandoz Sa Nouveaux derives de l'ergoline, leur preparation et leur application comme medicaments
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
CH652719A5 (en) * 1983-02-16 1985-11-29 Sandoz Ag Ergoline derivatives, their preparation and use
NL8400333A (nl) * 1983-02-16 1984-09-17 Sandoz Ag Moederkoornalkaloiden, hun bereiding en hun toepassing.
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
HU195810B (en) * 1984-12-24 1988-07-28 Sandoz Ag Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
GB8615471D0 (en) * 1986-06-25 1986-07-30 Erba Farmitalia T-butyl ergoline derivatives
US4798834A (en) * 1987-08-31 1989-01-17 Eli Lilly And Company Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement
AT392945B (de) * 1988-06-27 1991-07-10 Gerhard Mader Ges M B H Ing Lager- und transportbehaelter fuer schuettgueter und lose materialien
IT1232692B (it) * 1989-08-04 1992-03-04 Poli Ind Chimica Spa Derivati ergolinici con attivita' dopaminergica
WO2000054776A1 (en) * 1999-03-17 2000-09-21 Eugen Eigenmann Use of prolactin inhibitors for the treatment of fertility problems in animal species
EP4126857A1 (en) 2021-01-15 2023-02-08 Beckley Psytech Limited Ergoline analogues
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2533698A (en) * 1950-12-12 Urethanes containing the lysergic
US3185695A (en) * 1965-05-25 Dbwethyl-ergoline ii derivatives
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US3232943A (en) * 1966-02-01 Cyanoethyl ergolene and ergoline derivatives
US3245996A (en) * 1966-04-12 Cyanoethyl lysergol
US3270020A (en) * 1966-08-30 Dihydro ergocornine
CH415658A (de) * 1962-06-18 1966-06-30 Sandoz Ag Verfahren zur Herstellung von neuen Urethanen
BE712054A (en, 2012) * 1967-03-16 1968-07-15
US3920664A (en) * 1972-07-21 1975-11-18 Lilly Co Eli D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US3880856A (en) * 1973-06-29 1975-04-29 Lilly Co Eli Ergoline dimers
CS171480B1 (en, 2012) * 1974-03-19 1976-10-29
CH605936A5 (en) * 1974-07-19 1978-10-13 Sandoz Ag 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
GB1517971A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 8alpha-substituted ergoline i derivatives
US3904757A (en) * 1974-08-08 1975-09-09 Lilly Co Eli Treatment of parkinsonism
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes

Also Published As

Publication number Publication date
ES454442A1 (es) 1978-03-01
JPS5278900A (en) 1977-07-02
IL51133A0 (en) 1977-02-28
US4348391A (en) 1982-09-07
MY8400060A (en) 1984-12-31
NL7614018A (nl) 1977-06-27
DE2656344A1 (de) 1977-07-07
SE7614085L (sv) 1977-06-24
JPS6133031B2 (en, 2012) 1986-07-31
IL51133A (en) 1981-11-30
DK146205B (da) 1983-07-25
NZ182934A (en) 1978-12-18
AU514288B2 (en) 1981-02-05
PH14035A (en) 1980-12-12
FI763587A7 (en, 2012) 1977-06-24
SG63382G (en) 1983-09-09
PT66006A (fr) 1977-01-01
DK146205C (da) 1983-12-27
IE44242B1 (en) 1981-09-23
DE2656344C2 (en, 2012) 1990-11-08
SE432253B (sv) 1984-03-26
HK3483A (en) 1983-01-20
DK554179A (da) 1979-12-21
FR2336135A1 (fr) 1977-07-22
AU2079376A (en) 1978-06-29
FR2336135B1 (en, 2012) 1980-03-07
DK562376A (da) 1977-06-24
PT66006B (fr) 1978-07-06
GB1567484A (en) 1980-05-14

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Legal Events

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