CA1085852A - 1,3-dihydro-1- 3-(1-piperidinyl)propyl -2h- benzimidazol-2-ones and related compounds - Google Patents

1,3-dihydro-1- 3-(1-piperidinyl)propyl -2h- benzimidazol-2-ones and related compounds

Info

Publication number
CA1085852A
CA1085852A CA256,450A CA256450A CA1085852A CA 1085852 A CA1085852 A CA 1085852A CA 256450 A CA256450 A CA 256450A CA 1085852 A CA1085852 A CA 1085852A
Authority
CA
Canada
Prior art keywords
dihydro
group
benzimidazol
formula
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA256,450A
Other languages
English (en)
French (fr)
Inventor
Albert H.M.Th. Van Heertum
Marcel J.M.C. Van Der Aa
Ludo E.J. Kennis
Jan Vandenberk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of CA1085852A publication Critical patent/CA1085852A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA256,450A 1975-07-21 1976-07-07 1,3-dihydro-1- 3-(1-piperidinyl)propyl -2h- benzimidazol-2-ones and related compounds Expired CA1085852A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
US687,139 1976-05-17
KR7601697A KR810000334B1 (ko) 1975-07-21 1976-07-12 1-(벤즈 아조릴알킬) 피페리딘 유도체의 제조방법
US597,793 1984-04-06

Publications (1)

Publication Number Publication Date
CA1085852A true CA1085852A (en) 1980-09-16

Family

ID=27348142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA256,450A Expired CA1085852A (en) 1975-07-21 1976-07-07 1,3-dihydro-1- 3-(1-piperidinyl)propyl -2h- benzimidazol-2-ones and related compounds

Country Status (25)

Country Link
JP (1) JPS5217475A (hu)
AT (1) AT364358B (hu)
AU (1) AU511027B2 (hu)
BG (1) BG26526A3 (hu)
CA (1) CA1085852A (hu)
CH (1) CH623820A5 (hu)
CS (1) CS202550B2 (hu)
DE (1) DE2632870A1 (hu)
DK (1) DK154950C (hu)
ES (3) ES449740A1 (hu)
FI (1) FI62667C (hu)
GB (1) GB1542514A (hu)
HK (1) HK14180A (hu)
IE (1) IE43496B1 (hu)
IT (1) IT1062614B (hu)
KE (1) KE3215A (hu)
LU (1) LU75354A1 (hu)
MY (1) MY8100017A (hu)
NL (1) NL187442C (hu)
NZ (1) NZ181256A (hu)
PH (1) PH13710A (hu)
PT (1) PT65387B (hu)
RO (1) RO70566A (hu)
SE (2) SE426490B (hu)
YU (1) YU39969B (hu)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846929B2 (en) 2007-08-31 2014-09-30 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
JPS6248684A (ja) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd 新規なヨ−ドブチロフエノン誘導体およびその製造法
JPS62251313A (ja) * 1986-04-25 1987-11-02 信越ポリマー株式会社 結束装置
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
PA8603801A1 (es) * 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
CA2549869C (en) 2003-12-18 2015-05-05 Janssen Pharmaceutica N.V. Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
AU2007274284B2 (en) 2006-07-13 2012-04-26 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
ES2562218T3 (es) 2007-07-27 2016-03-03 Janssen Pharmaceutica, N.V. Pirrolopirimidinas útiles para el tratamiento de enfermedades proliferativas
CN113995755A (zh) * 2016-02-04 2022-02-01 辛多美制药有限公司 氘代多潘立酮组合物和用于治疗病症的方法
KR20240125702A (ko) 2017-06-30 2024-08-19 신돔 파마, 인크. 중수소화 돔페리돈 조성물, 방법, 및 제조

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (hu) * 1962-06-13
BE633914A (hu) * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846929B2 (en) 2007-08-31 2014-09-30 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9278967B2 (en) 2007-08-31 2016-03-08 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9527840B2 (en) 2007-08-31 2016-12-27 Purdue Pharma L.P. Substituted-quinoxaline-type piperidine compounds and the uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US9598411B2 (en) 2012-12-27 2017-03-21 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof

Also Published As

Publication number Publication date
FI762086A (hu) 1977-01-22
ES449740A1 (es) 1978-02-16
AT364358B (de) 1981-10-12
HK14180A (en) 1980-03-28
ES461631A1 (es) 1978-12-01
PT65387A (en) 1976-08-01
FI62667B (fi) 1982-10-29
IT1062614B (it) 1984-10-20
JPS5217475A (en) 1977-02-09
GB1542514A (en) 1979-03-21
CS202550B2 (en) 1981-01-30
YU179476A (en) 1983-01-21
JPS6131109B2 (hu) 1986-07-17
DK327576A (da) 1977-01-22
DE2632870A1 (de) 1977-02-10
RO70566A (ro) 1982-10-11
AU511027B2 (en) 1980-07-24
CH623820A5 (en) 1981-06-30
DK154950C (da) 1989-05-29
IE43496B1 (en) 1981-03-11
FI62667C (fi) 1983-02-10
DK154950B (da) 1989-01-09
SE435621B (sv) 1984-10-08
IE43496L (en) 1977-01-21
BG26526A3 (bg) 1979-04-12
ATA534776A (de) 1981-03-15
SE7608265L (sv) 1977-01-22
ES461630A1 (es) 1978-06-16
DE2632870C2 (hu) 1989-02-16
SE426490B (sv) 1983-01-24
MY8100017A (en) 1981-12-31
PT65387B (en) 1978-06-09
YU39969B (en) 1985-06-30
LU75354A1 (hu) 1977-02-28
NZ181256A (en) 1978-04-28
NL187442C (nl) 1991-10-01
SE8008713L (sv) 1980-12-11
NL187442B (nl) 1991-05-01
AU1596476A (en) 1978-01-19
NL7608023A (nl) 1977-01-25
KE3215A (en) 1982-07-09
PH13710A (en) 1980-09-09

Similar Documents

Publication Publication Date Title
US4066772A (en) 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
CA1085852A (en) 1,3-dihydro-1- 3-(1-piperidinyl)propyl -2h- benzimidazol-2-ones and related compounds
US4200641A (en) 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
EP0005318B1 (en) N-heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates
US4219559A (en) N-Heterocyclyl-4-piperidinamines
US4031226A (en) N-[(1-piperidinyl)alkyl]arylcarboxamide derivatives
CA1163994A (en) 3-(1-piperidinylalkyl)-4h-pyrido¬1,2-a|-pyrimidin- 4-one derivatives
IE53400B1 (en) Novel bicyclic pyrimidin-5-one derivatives
US4250176A (en) Piperazine derivatives
DK163239B (da) N-(bicykliske heterocyklyl)-4-piperidinaminer, en fremgangsmaade til fremstilling deraf samt antiallergiske praeparater indeholdende dem
US4126687A (en) Antiemetic, 1-(benzimidazolyl-alkyl)-piperidine derivatives
US3989707A (en) Benzimidazolinone derivatives
EP0037713B1 (en) Novel 1,3-dihydro-1-((1-piperidinyl)alkyl)-2h-benzimidazol-2-one derivatives
FI63228B (fi) Foerfarande foer framstaellning av 1-bensazolyl-4-substituerade piperidiner anvaendbara saosom neuroleptiska medel
HU221298B1 (en) Substituted thiazolyl and pyridyl derivatives and pharmaceutical compositions comprising same and process for producing them
US4377578A (en) Piperazine derivatives
US4175129A (en) Antiemetic 1-(benzoxazolylalkyl)-piperidine derivatives
US5378714A (en) Antipsychotic piperidine derivatives
KR800000491B1 (ko) 1-벤즈아조릴알킬-4-치환된 피페리딘의 제조방법
PL102727B1 (pl) Sposob wytwarzania nowych n-/(1-piperydynylo)-alkilo/arylokarbonamidow
PL118633B1 (en) Method of manufacture of novel derivatives of 1-/benzazolyl-alkyl/-piperidineil/-piperidina

Legal Events

Date Code Title Description
MKEX Expiry