CA1063908A - Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes - Google Patents
Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantesInfo
- Publication number
- CA1063908A CA1063908A CA255,929A CA255929A CA1063908A CA 1063908 A CA1063908 A CA 1063908A CA 255929 A CA255929 A CA 255929A CA 1063908 A CA1063908 A CA 1063908A
- Authority
- CA
- Canada
- Prior art keywords
- phase
- dispersion
- fact
- spherules
- encapsulated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000006185 dispersion Substances 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 230000008569 process Effects 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title abstract description 28
- 238000004519 manufacturing process Methods 0.000 title description 4
- 150000002632 lipids Chemical class 0.000 claims abstract description 57
- 239000012071 phase Substances 0.000 claims abstract description 49
- 239000008346 aqueous phase Substances 0.000 claims abstract description 34
- -1 lipid compounds Chemical class 0.000 claims abstract description 24
- 239000013543 active substance Substances 0.000 claims abstract description 10
- 239000002537 cosmetic Substances 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 235000013305 food Nutrition 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 35
- 150000002500 ions Chemical class 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 238000002604 ultrasonography Methods 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000975 dye Substances 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 229930186217 Glycolipid Natural products 0.000 claims description 5
- 150000001412 amines Chemical class 0.000 claims description 5
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims description 4
- 229920000223 polyglycerol Polymers 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 239000004166 Lanolin Substances 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 239000003638 chemical reducing agent Substances 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 125000003010 ionic group Chemical group 0.000 claims description 3
- 229940039717 lanolin Drugs 0.000 claims description 3
- 235000019388 lanolin Nutrition 0.000 claims description 3
- 239000007800 oxidant agent Substances 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 229940124091 Keratolytic Drugs 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000001166 anti-perspirative effect Effects 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000003213 antiperspirant Substances 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 235000012000 cholesterol Nutrition 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- 229940120503 dihydroxyacetone Drugs 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 229930195733 hydrocarbon Natural products 0.000 claims description 2
- 230000001530 keratinolytic effect Effects 0.000 claims description 2
- 239000003410 keratolytic agent Substances 0.000 claims description 2
- 229940099367 lanolin alcohols Drugs 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 239000003605 opacifier Substances 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- 229930182558 Sterol Natural products 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 150000008051 alkyl sulfates Chemical class 0.000 claims 2
- 229930183167 cerebroside Natural products 0.000 claims 2
- 150000001784 cerebrosides Chemical class 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003432 sterols Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 claims 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000003212 astringent agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 230000002951 depilatory effect Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- 239000002608 ionic liquid Substances 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 229940080236 sodium cetyl sulfate Drugs 0.000 claims 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical group [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000003643 water by type Substances 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 abstract description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 26
- 239000011780 sodium chloride Substances 0.000 description 13
- 239000000126 substance Substances 0.000 description 6
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 229920005654 Sephadex Polymers 0.000 description 5
- 239000012507 Sephadex™ Substances 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000002353 niosome Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
- PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical compound [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000532370 Atla Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000208202 Linaceae Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000655872 Puia Species 0.000 description 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000008040 ionic compounds Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000199 molecular distillation Methods 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/34—Higher-molecular-weight carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K19/54—Additives having no specific mesophase characterised by their chemical composition
- C09K19/542—Macromolecular compounds
- C09K19/544—Macromolecular compounds as dispersing or encapsulating medium around the liquid crystal
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K2019/523—Organic solid particles
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K2019/528—Surfactants
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Cosmetics (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Colloid Chemistry (AREA)
- Liquid Crystal Substances (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7520456A FR2315991A1 (fr) | 1975-06-30 | 1975-06-30 | Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1063908A true CA1063908A (fr) | 1979-10-09 |
Family
ID=9157266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA255,929A Expired CA1063908A (fr) | 1975-06-30 | 1976-06-29 | Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes |
Country Status (14)
| Country | Link |
|---|---|
| JP (2) | JPS588287B2 (de) |
| AT (1) | AT361893B (de) |
| AU (1) | AU505843B2 (de) |
| BE (1) | BE843300A (de) |
| BR (1) | BR7604270A (de) |
| CA (1) | CA1063908A (de) |
| CH (2) | CH616087A5 (de) |
| DE (3) | DE2661108C2 (de) |
| DK (1) | DK150967C (de) |
| ES (1) | ES449312A1 (de) |
| FR (1) | FR2315991A1 (de) |
| GB (1) | GB1539625A (de) |
| IT (1) | IT1062389B (de) |
| NL (1) | NL168715C (de) |
Cited By (1)
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|---|---|---|---|---|
| US4456586A (en) * | 1980-10-24 | 1984-06-26 | L'oreal | Non-ionic surface-active agents derived from glucose, process for their preparation and compositions containing them |
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| CH624011A5 (de) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| BE871908R (fr) * | 1977-11-15 | 1979-05-10 | Oreal | Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes |
| FI790164A (fi) * | 1978-01-27 | 1979-07-28 | Sandoz Ag | Liposomfrigoerelsesystem |
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| JPS5916534A (ja) * | 1982-07-19 | 1984-01-27 | Lion Corp | 非イオン性界面活性剤系ベシクル分散液 |
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| FR2597345B1 (fr) * | 1986-04-22 | 1990-08-03 | Oreal | Composition cosmetique ou pharmaceutique a base d'une dispersion aqueuse de spherules lipidiques. |
| JPS63182029A (ja) * | 1987-01-22 | 1988-07-27 | Agency Of Ind Science & Technol | リポソ−ム |
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| FR2679446B1 (fr) * | 1991-07-24 | 1993-10-29 | Oreal | Procede de fabrication d'une composition cosmetique pour application sur les cheveux, composition obtenue par ce procede et procede de traitement cosmetique a l'aide de ladite composition. |
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| FR2971706B1 (fr) | 2011-02-18 | 2013-02-15 | Oreal | Composition contenant des particules composites filtrantes et des particules de filtres inorganiques modifiees hydrophobes par une huile ou cire d'origine naturelle |
| FR2972348B1 (fr) | 2011-03-09 | 2013-03-08 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un compose monoester monoamide d'acide methyl succinique ; procede de photostabilisation |
| FR2972346B1 (fr) | 2011-03-09 | 2013-11-08 | Oreal | Utilisation d'un derive diester d'acide 2-methyl succinique comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant |
| FR2977490B1 (fr) | 2011-07-07 | 2014-03-21 | Oreal | Composition photoprotectrice |
| WO2013010590A1 (en) | 2011-07-21 | 2013-01-24 | L'oreal | Cosmetic and/or dermatological composition containing a merocyanine derivative comprising specific polar groups consisting of hydroxyl- and ether-functionalities |
| FR2982770B1 (fr) | 2011-11-18 | 2014-09-26 | Oreal | Utilisation cosmetique de composes catalytiques d'oxydation choisis parmi les porphyrines, les phthalocyanines et/ou les porphyrazines comme agent deodorant |
| FR2986422B1 (fr) | 2012-02-06 | 2014-02-21 | Oreal | Composition solaire non pulverulente comprenant une phase huileuse polaire et des particules d'aerogel de silice hydrophobes |
| FR2992858B1 (fr) | 2012-07-04 | 2015-10-30 | Oreal | Composition cosmetique photoprotectrice. |
| FR2993176B1 (fr) | 2012-07-13 | 2014-06-27 | Oreal | Composition cosmetique contenant des particules composites filtrantes de taille moyenne superieure a 0,1 micron et des particules de filtre inorganique et une phase aqueuse |
| WO2014010100A1 (en) | 2012-07-13 | 2014-01-16 | L'oreal | Cosmetic composition comprising composite sunscreen particles |
| EP2872106B2 (de) | 2012-07-13 | 2023-08-02 | L'oreal | Verbundpigment und verfahren zur herstellung davon |
| WO2014111563A2 (en) | 2013-01-21 | 2014-07-24 | L'oreal | Cosmetic or dermatological composition comprising a merocyanine and a lipophilic benzotriazole uv-screening agent and/or a bis-resorcinyl triazine compound |
| FR3001216B1 (fr) | 2013-01-21 | 2015-02-27 | Oreal | Composition cosmetique ou dermatologique comprenant une merocyanine, une phase huileuse et un mono-alcanol en c1-c4 |
| FR3001131B1 (fr) | 2013-01-21 | 2015-06-19 | Oreal | Emulsion cosmetique ou dermatologique comprenant une merocyanine et un systeme emulsionnant contenant un tensioactif gemine. |
| EP2945602B1 (de) | 2013-01-21 | 2018-01-10 | L'Oréal | Kosmetische oder dermatologische zusammensetzung mit einem merocyanin und einem unlöslichen organischen uv-abschirmenden und/oder einem unlöslichen anorganischen uv-abschirmendem mittel |
| BR112015017297B1 (pt) | 2013-01-21 | 2020-03-10 | L'oreal | Composição cosmética ou dermatológica e processos cosméticos não terapêuticos |
| EP2945605B1 (de) | 2013-01-21 | 2018-08-29 | L'Oréal | Kosmetische oder dermatologische zusammensetzung mit einem merocyanin, einem organischen uvb-screeningmittel und einem zusätzlichen organischen uva-screeningmittel |
| FR3001136B1 (fr) | 2013-01-21 | 2015-06-19 | Oreal | Emulsion cosmetique ou dermatologique comprenant une merocyanine et un systeme emulsionnant contenant un polymere amphiphile comportant au moins un motif acide acrylamido 2-methylpropane sulfonique |
| FR3001133B1 (fr) | 2013-01-21 | 2015-03-20 | Oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un compose amide particulier |
| FR3001128B1 (fr) | 2013-01-21 | 2015-06-19 | Oreal | Emulsion cosmetique ou dermatologique comprenant une merocyanine et un systeme emulsionnant contenant un sel de metal alcalin d'ester d'acide phosphorique et d'alcool gras |
| FR3006176B1 (fr) | 2013-05-29 | 2015-06-19 | Oreal | Particules composites a base de filtre uv inorganique et de perlite ; compositions cosmetiques ou dermatologiques les contenant |
| EP3016631B1 (de) | 2013-05-30 | 2019-10-02 | L'oreal | Kosmetische zusammensetzung |
| WO2014203913A1 (en) | 2013-06-18 | 2014-12-24 | L'oreal | Cosmetic composition |
| FR3046930B1 (fr) | 2016-01-26 | 2018-03-02 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un polyalkyleneglycol |
| FR3046928B1 (fr) | 2016-01-26 | 2019-08-09 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un amide n-substitue |
| FR3046927B1 (fr) | 2016-01-26 | 2018-03-02 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un ether d'isosorbide |
| FR3046929B1 (fr) | 2016-01-26 | 2018-03-02 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un ester d'acide di ou tricarboxylique |
| FR3068354B1 (fr) | 2017-06-29 | 2020-07-31 | Oreal | Compositions photoprotectrices comprenant un derive dibenzoylmethane, un compose merocyanine et un compose susceptible d'accepter l'energie de niveau excite triplet du compose dibenzoylmethane |
| FR3073409B1 (fr) | 2017-11-15 | 2019-10-11 | L'oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et un polymere acrylique. |
| FR3073408B1 (fr) | 2017-11-15 | 2019-10-11 | L'oreal | Compositions comprenant au moins un polymere acrylique et au moins un filtre organique insoluble |
| FR3083097B1 (fr) | 2018-06-28 | 2020-11-27 | Oreal | Composition cosmetique ou dermatologique comprenant une merocyanine et une phase huileuse comprenant au moins un carbonate d’alkyle ou d’alkylene |
| EP3854377A1 (de) | 2020-01-22 | 2021-07-28 | Laboratoires Genevrier Sas | Zusammensetzung, die eine hyaluronsäure und ein polyol oder carboxymethylcellulose umfasst |
| CN115485048A (zh) * | 2020-04-14 | 2022-12-16 | 陶氏环球技术有限责任公司 | 基于聚甘油醚的泡沫控制剂及其在生物乙醇处理中的用途 |
| FR3117824A1 (fr) | 2020-12-18 | 2022-06-24 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et une phase huileuse comprenant au moins un ester d’acide citrique |
| FR3117825A1 (fr) | 2020-12-18 | 2022-06-24 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine, un filtre UV triazine, et un polysaccharide modifié par des chaînes hydrophobes |
| FR3119988B1 (fr) | 2021-02-25 | 2023-12-29 | Oreal | Composition aqueuse comprenant un filtre UV organique, un polymère superabsorbant, de la perlite et un alcool gras |
| FR3124698A1 (fr) | 2021-06-30 | 2023-01-06 | L'oreal | Composition comprenant au moins un filtre UV, du nitrure de bore, et un tensioactif non ionique de type ester |
| FR3128118A1 (fr) | 2021-10-14 | 2023-04-21 | L'oreal | ProceDE de traitement des cheveux comprenant l’application d’une émulsion huile-dans-eau comprenant une phase aqueuse, une phase grasse et un polymère |
| FR3141059A1 (fr) | 2022-10-20 | 2024-04-26 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et une gamma-butyrolactone et/ou un gamma-butyrolactame |
| FR3130598A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et du tétra hydroxycinnamate de di-t-butyle pentaérythrityle |
| WO2023110767A1 (en) | 2021-12-17 | 2023-06-22 | L'oreal | Cosmetic or dermatological composition comprising a merocyanine and a gamma-butyrolactone and/or a gamma-butyrolactam |
| FR3130593A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et le dipropylène glycol |
| FR3130599A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et une gamma-butyrolactone et/ou un gamma-butyrolactame |
| FR3130594A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et du resvératrol et/ou un dérivé de resvératrol |
| FR3130597A1 (fr) | 2021-12-17 | 2023-06-23 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et au moins un diol comportant de 4 à 7 atomes de carbone |
| FR3132637A1 (fr) | 2022-02-15 | 2023-08-18 | L'oreal | Composition cosmétique ou dermatologique comprenant une mérocyanine et un complexe polyionique |
| FR3141062A1 (fr) | 2022-10-21 | 2024-04-26 | L'oreal | Composition comprenant un filtre organique lipophile, un filtre organique hydrophile, avec une quantité en poids de phase grasse entre 20 et 70 % et un ratio massique filtres organiques hydrophiles / filtres organiques lipophiles supérieur à 0,3 |
| FR3141061A1 (fr) | 2022-10-21 | 2024-04-26 | L'oreal | Composition comprenant un filtre organique lipophile, un filtre organique hydrophile, des particules sphériques de silice poreuse, des particules sphériques de cellulose, et une poudre d’acide aminé N-acylé |
| FR3141060A1 (fr) | 2022-10-21 | 2024-04-26 | L'oreal | Composition comprenant un filtre UV organique lipophile, un filtre UV organique hydrophile et un polymère gélifiant hydrophile spécifique |
| WO2024083567A1 (en) | 2022-10-21 | 2024-04-25 | L'oreal | Composition comprising a lipophilic organic screening agent, a hydrophilic organic screening agent, with an amount by weight of fatty phase between 20 and 70% |
| FR3142897A1 (fr) | 2022-12-09 | 2024-06-14 | L'oreal | Composition comprenant un filtre organique hydrodispersible et au moins un complexe polyionique contenant un polysaccharide cationique et un acide non polymérique ayant au moins 3 valeurs de pKa et/ou l’un de ses sels |
| FR3143344A1 (fr) | 2022-12-16 | 2024-06-21 | L'oreal | Composition comprenant un filtre UV, un polymère lipophile convenablement sélectionné, et un carraghénane |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2249552A1 (de) * | 1971-10-12 | 1973-05-30 | Inchema S A | Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen |
-
1975
- 1975-06-30 FR FR7520456A patent/FR2315991A1/fr active Granted
-
1976
- 1976-06-23 BE BE168219A patent/BE843300A/xx not_active IP Right Cessation
- 1976-06-28 AT AT470376A patent/AT361893B/de not_active IP Right Cessation
- 1976-06-28 ES ES449312A patent/ES449312A1/es not_active Expired
- 1976-06-29 DE DE2661108A patent/DE2661108C2/de not_active Expired - Lifetime
- 1976-06-29 DE DE2660069A patent/DE2660069C2/de not_active Expired - Lifetime
- 1976-06-29 CA CA255,929A patent/CA1063908A/fr not_active Expired
- 1976-06-29 GB GB27094/76A patent/GB1539625A/en not_active Expired
- 1976-06-29 CH CH830776A patent/CH616087A5/fr not_active IP Right Cessation
- 1976-06-29 DE DE2629100A patent/DE2629100C3/de not_active Expired
- 1976-06-29 DK DK291376A patent/DK150967C/da not_active IP Right Cessation
- 1976-06-29 AU AU15393/76A patent/AU505843B2/en not_active Expired
- 1976-06-30 NL NLAANVRAGE7607210,A patent/NL168715C/xx not_active IP Right Cessation
- 1976-06-30 JP JP51076601A patent/JPS588287B2/ja not_active Expired
- 1976-06-30 IT IT68608/76A patent/IT1062389B/it active
- 1976-06-30 BR BR7604270A patent/BR7604270A/pt unknown
-
1980
- 1980-01-18 CH CH42980A patent/CH623236A5/fr not_active IP Right Cessation
-
1981
- 1981-01-07 JP JP51981A patent/JPS56108528A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456586A (en) * | 1980-10-24 | 1984-06-26 | L'oreal | Non-ionic surface-active agents derived from glucose, process for their preparation and compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS588287B2 (ja) | 1983-02-15 |
| DK150967C (da) | 1988-02-15 |
| IT1062389B (it) | 1984-10-10 |
| NL7607210A (nl) | 1977-01-03 |
| JPS6156016B2 (de) | 1986-12-01 |
| ATA470376A (de) | 1980-09-15 |
| DE2629100A1 (de) | 1977-01-20 |
| CH623236A5 (en) | 1981-05-29 |
| DK291376A (da) | 1976-12-31 |
| DE2661108C2 (de) | 1993-12-16 |
| DE2629100C3 (de) | 1980-08-14 |
| NL168715C (nl) | 1982-05-17 |
| BR7604270A (pt) | 1977-04-05 |
| DE2629100B2 (de) | 1979-11-29 |
| JPS56108528A (en) | 1981-08-28 |
| ES449312A1 (es) | 1977-08-16 |
| AU505843B2 (en) | 1979-12-06 |
| AT361893B (de) | 1981-04-10 |
| AU1539376A (en) | 1978-01-05 |
| DE2660069C2 (de) | 1990-09-13 |
| BE843300A (fr) | 1976-12-23 |
| GB1539625A (en) | 1979-01-31 |
| JPS526375A (en) | 1977-01-18 |
| FR2315991A1 (fr) | 1977-01-28 |
| DK150967B (da) | 1987-10-05 |
| CH616087A5 (en) | 1980-03-14 |
| FR2315991B1 (de) | 1977-12-02 |
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