CA1040630A - 9-alkoxy-5-methyl-6,7-benzomorphans - Google Patents

9-alkoxy-5-methyl-6,7-benzomorphans

Info

Publication number
CA1040630A
CA1040630A CA224,879A CA224879A CA1040630A CA 1040630 A CA1040630 A CA 1040630A CA 224879 A CA224879 A CA 224879A CA 1040630 A CA1040630 A CA 1040630A
Authority
CA
Canada
Prior art keywords
methyl
compound
hydroxy
benzomorphan
allyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA224,879A
Other languages
English (en)
French (fr)
Inventor
Thomas A. Montzka
John D. Matiskella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of CA1040630A publication Critical patent/CA1040630A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA224,879A 1974-04-18 1975-04-17 9-alkoxy-5-methyl-6,7-benzomorphans Expired CA1040630A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46200774A 1974-04-18 1974-04-18

Publications (1)

Publication Number Publication Date
CA1040630A true CA1040630A (en) 1978-10-17

Family

ID=23834846

Family Applications (1)

Application Number Title Priority Date Filing Date
CA224,879A Expired CA1040630A (en) 1974-04-18 1975-04-17 9-alkoxy-5-methyl-6,7-benzomorphans

Country Status (23)

Country Link
JP (3) JPS6218552B2 (de)
BE (1) BE828054A (de)
CA (1) CA1040630A (de)
CH (1) CH623812A5 (de)
CS (1) CS199586B2 (de)
DD (1) DD119787A5 (de)
DE (1) DE2517220A1 (de)
DK (2) DK155999C (de)
FI (1) FI60564C (de)
FR (1) FR2267774B1 (de)
GB (1) GB1493420A (de)
HU (1) HU173039B (de)
IE (1) IE41003B1 (de)
IL (1) IL47114A (de)
LU (1) LU72315A1 (de)
NL (1) NL159971C (de)
NO (1) NO143155C (de)
OA (1) OA04983A (de)
PH (1) PH12067A (de)
SE (1) SE427181B (de)
SU (1) SU721002A3 (de)
YU (1) YU93275A (de)
ZA (1) ZA752471B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01179624A (ja) * 1988-01-12 1989-07-17 Matsushita Refrig Co Ltd 生鮮物貯蔵装置
GB2442535B (en) 2006-10-05 2011-07-13 Ngf Europ Ltd Method and articles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation

Also Published As

Publication number Publication date
JPS6127390B2 (de) 1986-06-25
HU173039B (hu) 1979-02-28
FR2267774B1 (de) 1978-08-04
IL47114A (en) 1979-01-31
FR2267774A1 (de) 1975-11-14
DK155999B (da) 1989-06-12
FI60564C (fi) 1982-02-10
ZA752471B (en) 1976-03-31
JPS50142568A (de) 1975-11-17
NO143155B (no) 1980-09-15
PH12067A (en) 1978-10-30
IE41003L (en) 1975-10-18
SE427181B (sv) 1983-03-14
OA04983A (fr) 1980-11-30
DE2517220A1 (de) 1975-11-06
CS199586B2 (en) 1980-07-31
JPS6218552B2 (de) 1987-04-23
JPS60120868A (ja) 1985-06-28
JPH0119387B2 (de) 1989-04-11
SE7504469L (sv) 1975-10-20
IE41003B1 (en) 1979-09-26
NL7504648A (nl) 1975-10-21
NO143155C (no) 1980-12-29
AU8025875A (en) 1976-10-21
IL47114A0 (en) 1975-06-25
DK166375A (da) 1975-10-19
FI60564B (fi) 1981-10-30
DD119787A5 (de) 1976-05-12
NL159971C (nl) 1979-09-17
NO751371L (de) 1975-10-21
SU721002A3 (ru) 1980-03-05
DK155999C (da) 1989-11-06
DE2517220C2 (de) 1990-04-19
GB1493420A (en) 1977-11-30
DK194088D0 (da) 1988-04-08
FI751106A (de) 1975-10-19
LU72315A1 (de) 1976-03-17
BE828054A (fr) 1975-10-17
YU93275A (en) 1982-02-28
DK194088A (da) 1988-04-08
JPS60142964A (ja) 1985-07-29
CH623812A5 (en) 1981-06-30

Similar Documents

Publication Publication Date Title
CA2109613C (en) Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
DE69616817T2 (de) Substituierte benzylaminopiperloin verbindungen
CA2106200C (en) Stereoselective preparation of substituted piperidines
CA1049511A (en) 2-tetrahydrofurfuryl-6,7-benzomorphanes, their acid addition salts, their use as pharmaceuticals and processes for their production
MAY et al. Structures related to morphine. III. Synthesis of an analog of N-methylmorphinan
US4272540A (en) 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
CA1204745A (en) Hexahydronaphth (1,2-b) -1,4 -oxazines
CA1040630A (en) 9-alkoxy-5-methyl-6,7-benzomorphans
US4001331A (en) Benzobicycloalkane
CA2009992A1 (en) 2-amino-7-hydroxytetralin carboxyalkyl ethers
CA1049019A (en) Benzo(b)bicyclo(3,31)nona-3,6a(10a)diene compounds
JPH0260653B2 (de)
GB1575009A (en) 6,7-benzomorphan derivatives
CA1092113A (en) Benzylamines
US3810899A (en) 2-hydroxy-n-substituted-morphinan derivatives
GB1559980A (en) 11-hydroxy - 6 - hydroxymethyl - 1,2,3,4,5,6-hexahydro - 2,6 - methano - 3 - benzazocines
US3914232A (en) 2-And 4-acryloxy-N-substituted-morphinan derivatives
US4265889A (en) 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
JPS6137768A (ja) １，３‐二置換ピペリジン化合物
EP0002327B1 (de) Pharmakologisch aktive 6-nieder-Alkyl-7,8-dihydroxy-1-phenyl -2,3,4,5- tetrahydro-1H-3- benzazepine, Verfahren zu ihrer Herstellung und Zwischenprodukte
Sugasawa et al. Extension of Bischler-Napieralski reaction—I: Synthesis of isoquinoline derivatives: A synthesis of rac.-apomorphine dimethyl ether
US3914234A (en) 2-Lower alkoxy-N-substituted-morphinan derivatives
Siddiqi et al. A new pyrrolizidine alkaloid from Caccinia glauca
CA1118775A (en) 6-azido-decohydro-4a phenyl-cis-isoquinoline compounds
US3956336A (en) 9-Alkoxy-5-methyl-6,7-benzomorphans