BRPI9604907B8 - derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral e composição contendo derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral com princípios ativos. - Google Patents

derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral e composição contendo derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral com princípios ativos.

Info

Publication number
BRPI9604907B8
BRPI9604907B8 BRPI9604907A BR9604907A BRPI9604907B8 BR PI9604907 B8 BRPI9604907 B8 BR PI9604907B8 BR PI9604907 A BRPI9604907 A BR PI9604907A BR 9604907 A BR9604907 A BR 9604907A BR PI9604907 B8 BRPI9604907 B8 BR PI9604907B8
Authority
BR
Brazil
Prior art keywords
substituted
homocarbocyclic
pyrimidinodione
atom
nucleoside derivatives
Prior art date
Application number
BRPI9604907A
Other languages
English (en)
Other versions
BR9604907B1 (pt
BR9604907A (pt
Inventor
Byung-Chul Kim
Dong-Wook Kang
Eui-Hwan Cho
Ho-Seok Kwon
Jae-Eung Lee
Jeong-Ho Joo
Joong-Young Kim
Sun-Gan Chung
Sun-Hwan Lee
Original Assignee
Samjin Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960047458A external-priority patent/KR100197791B1/ko
Priority claimed from KR1019960047459A external-priority patent/KR100197792B1/ko
Application filed by Samjin Pharm Co Ltd filed Critical Samjin Pharm Co Ltd
Publication of BR9604907A publication Critical patent/BR9604907A/pt
Publication of BR9604907B1 publication Critical patent/BR9604907B1/pt
Publication of BRPI9604907B8 publication Critical patent/BRPI9604907B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Abstract

"derivados de nucleosídios homocarbocíclico de perimidinodiona substituída antiviral e método de preparo dos mesmos e composições contendo tais derivados como princípios ativos", a presente invenção refere-se ao composto inédito da fórmula geral (i) e sais farmaceuticamente aceitos do mesmo e processo de preparo de tais derivados e compostos farmacêuticos contendo os mesmos como princípio ativo. fórmula gera (i) em que r~ 1~, r~ 2~ e r~ 3~ representam independentemente átomo de hidrogênio, átomo halogênio, alcil c~ 1~-c~ 10~, tioalcil c~ 1~-c~ 10~, alcil cíclico c~ 3~-c~8~ de substituição opcional, alcil insaturado, hidroxila de alcil substituído, ou hidroxila aril, alcilamina c~ 1~-c~ 10~, nitro, éster inferior c~ 1~-c~ 4~, alcoxi, tioalcoxi inferior c~ 1~-c~ 4~; z representa o átomo de oxigênio, átomo de enxofre, átomo de carbono e grupo carbonil; x representa o átomo de oxigênio, átomo de enxofre; n representa um inteiro de 1-3; e (sub) cicloalc(en)il representa em que representa em que r~ 4~ e r~ 5~ representam independentemente átomo de hidrogênio, hidroximetil, hidroximetil protegido, benzila, carbonila substituída, alcilsulfonil substituída, arilsulfonil, silil substituída ou outro semelhante.
BRPI9604907A 1996-02-22 1996-12-30 derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral e composição contendo derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral com princípios ativos. BRPI9604907B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR19960004189 1996-02-22
KR19960025441 1996-06-28
KR1019960047458A KR100197791B1 (ko) 1996-02-22 1996-10-22 신규 항바이러스성 6위치에 치환된 피리미딘디온호모 카보사이 클릭 뉴클레오시드 유도체 및 그의 제조방법
KR1019960047459A KR100197792B1 (ko) 1996-06-28 1996-10-22 신규 항바이러스성 2-비스 (하이드록시메틸) 사이클로프로판-1- 메틸 피리미딘디온 유도체 및 그의 제조방법
PCT/KR1996/000265 WO1997030979A1 (en) 1996-02-22 1996-12-30 New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients

Publications (3)

Publication Number Publication Date
BR9604907A BR9604907A (pt) 1998-07-21
BR9604907B1 BR9604907B1 (pt) 2011-10-18
BRPI9604907B8 true BRPI9604907B8 (pt) 2016-11-08

Family

ID=27483113

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9604907A BRPI9604907B8 (pt) 1996-02-22 1996-12-30 derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral e composição contendo derivados de nucleosidios homocarbociclico de pirimidinodiona substituída antiviral com princípios ativos.

Country Status (14)

Country Link
US (1) US5922727A (pt)
EP (1) EP0827498B1 (pt)
JP (1) JP3049095B2 (pt)
CN (1) CN1092647C (pt)
AT (1) ATE243202T1 (pt)
AU (1) AU710490B2 (pt)
BR (1) BRPI9604907B8 (pt)
CA (1) CA2217026C (pt)
DE (1) DE69628750T2 (pt)
ID (1) ID15963A (pt)
MX (1) MX9708110A (pt)
RU (1) RU2138487C1 (pt)
TW (1) TW494098B (pt)
WO (1) WO1997030979A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826517B4 (de) * 1998-06-15 2006-03-23 Baxter Healthcare S.A. Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette
WO2000051990A1 (en) * 1999-03-04 2000-09-08 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR100311949B1 (ko) 1999-03-10 2001-11-02 최승주 1-[(사이클로펜트-3-엔-1-일)메틸]-5-에틸-6-(3,5-다이메틸벤조일)-2,4-피리미딘다이온의제조방법
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
KR101237312B1 (ko) 2006-02-10 2013-03-04 삼진제약주식회사 피리미딘다이온 유도체를 포함하는 ｃ형 간염의 예방 및치료용 약학 조성물
CN101495461A (zh) * 2006-07-24 2009-07-29 吉里德科学公司 新的hiv逆转录酶抑制剂
TW200918507A (en) * 2007-06-29 2009-05-01 Gilead Sciences Inc Novel HIV reverse transcriptase inhibitors
US8354421B2 (en) * 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
WO2009085797A1 (en) * 2007-12-21 2009-07-09 Gilead Sciences, Inc. Processes for preparing hiv reverse transcriptase inhibitors
CN102603652A (zh) * 2011-12-27 2012-07-25 河南师范大学 5-甲酰基嘧啶碳环核苷及制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730001A (en) * 1986-01-22 1988-03-08 Southern Research Institute Carbocyclic analogues of amino and azido thymidines
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
DE69126469T2 (de) * 1990-03-29 1998-01-29 Mitsubishi Chem Corp Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten
AU1994492A (en) * 1991-07-22 1993-02-23 Baker Cummins Pharmaceuticals, Inc. Acyclic 6-phenylselenenyl pyrimidine nucleosides
KR950011530A (ko) * 1993-10-21 1995-05-15 도바 다다스 사이클로프로판 유도체 및 이를 함유하는 항바이러스제
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
RU2138487C1 (ru) 1999-09-27
TW494098B (en) 2002-07-11
MX9708110A (es) 1998-06-30
WO1997030979A1 (en) 1997-08-28
CN1182420A (zh) 1998-05-20
DE69628750D1 (de) 2003-07-24
JPH10507780A (ja) 1998-07-28
BR9604907B1 (pt) 2011-10-18
CN1092647C (zh) 2002-10-16
ATE243202T1 (de) 2003-07-15
EP0827498B1 (en) 2003-06-18
CA2217026C (en) 2001-11-20
CA2217026A1 (en) 1997-08-28
AU1212497A (en) 1997-09-10
US5922727A (en) 1999-07-13
BR9604907A (pt) 1998-07-21
EP0827498A1 (en) 1998-03-11
DE69628750T2 (de) 2004-04-29
JP3049095B2 (ja) 2000-06-05
ID15963A (id) 1997-08-21
AU710490B2 (en) 1999-09-23

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FD5 Application fees: dismissal - article 86 of industrial property law
B08G Application fees: restoration [chapter 8.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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Free format text: INPI-52400.068486/2013 SECAO JUDICIARIA DE SAO PAULO - 25A VARA FEDERAL CIVEL DE SAO PAULO PROCESSO NO0017574-93.2013.403.6100 AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: BAYER SAS, CENTELION, CENTELION S.A, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MERCK SERONO S.A E SAMJIN PHARMACEUTICAL CO. LTDA DECISAO: JULGO PROCEDENTE O PEDIDO FORMULADO PARA DECLARAR A NULIDADE PARCIAL DAS PATENTES PI 9607583-0, PI 9610511-9, PI 9707889-1 E PI 9604907-3 E DETERMINO A RETIFICACAO DOS RESPECTIVOS PRAZOS DE VIGENCIA DE MODO A OBSERVAR A O DISPOSTO NO PARAGRAFO UNICO DO ARTIGO 229 DA LEI NO 9.279-96, EM INTERPRETACAO CONJUNTA COM O CAPUT DO ARTIGO 40 DO MESMO DIPLOMA.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2128 DE 18/10/2011, QUANTO AO PRAZO DE VALIDADE POR DETERMINACAO DA 25A VARA CIVEL FEDERAL DE SAO PAULO, PROC. 0017574-93.2013.403.6100 - ACAO ORDINARIA - INPI 52400.068486/2013-05.