ES2074142T3 - Compuestos heterociclicos. - Google Patents
Compuestos heterociclicos.Info
- Publication number
- ES2074142T3 ES2074142T3 ES90313079T ES90313079T ES2074142T3 ES 2074142 T3 ES2074142 T3 ES 2074142T3 ES 90313079 T ES90313079 T ES 90313079T ES 90313079 T ES90313079 T ES 90313079T ES 2074142 T3 ES2074142 T3 ES 2074142T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- phenyl
- group
- formula
- phenylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Detergent Compositions (AREA)
- Air Bags (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE LA FORMULA (I): EN LA QUE P ES UN GRUPO DE FORMULA II O UN GRUPO DE FORMULA III; R ELEVADO A 1 ES ALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, FENILO O FENILALQUILO; R (AL CUADRADO) ES HIDROGENO, ALQUILO, AMINO O ALQUILAMINO; R ELEVADO A 3 Y R ELEVADO A 4 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO, FENILO O BENZILO, R ELEVADO A 6 ES ALQUILO, AMINO O ALQUILAMINO; C Y D SON INDEPENDIENTEMENTE ETILENO O TRIMETILENO; Z ES UN ENLACE DIRECTO ENTRE C Y D, O UN ENLACE OXI, TIO, CARBONILO, METILENO, ETILENODIOXIMETILENO, ETILIDENO, O ISOPROPILIDENO, O Z ES UN GRUPO DE LA FORMULA = N.R ELEVADO A 5 EN LA QUE R ELEVADO A 5 ES ALQUILO, FENILO O BENZILO; R ELEVADO A 8 ES HIDROGENO, CICLOALQUILALQUILO, ALQUILO, ALQUENILO, ALQUINILO O FENILALQUILO; O R ELEVADO A 8 ALQUILENO O UN ALQUENILENO ENLAZADO A UN ATOMO DE NITROGENO DEL GRUPO Q.A.N-, CUALQUIERA DE ESTOS GRUPOS DE ENLACE PUEDE OPCIONALMENTE SOPORTAR UN SUSTITUTO DE ALQUILO, FENILO O FENILALQUILO Y CUALQUIERA DE ESTOS GRUPOS DE ENLACE COMPLETA UN ANILLO QUE INCLUYE DOS ATOMOS DE CARBONO ADYACENTE DEL ANILLO Q, CUALQUIER ATOMO DE CARBONO EN A Y EL ATOMO DE NITROGENO DEL GRUPO -A.N-; A ES UN ENLACE DIRECTO AL GRUPO -N(R ELEVADO A 8)ALQUILENO; Q ES UNA MITAD DE FENILO O DE PIRIDILO; Y ES UN ANION FISIOLOGICAMENTE ACEPTABLE; Y EN LA QUE NINGUNA O MAS DE LAS MITADES DE FENILO, BENZENO O PIRIDILO PUEDEN OPCIONALMENTE SER NO SUSTITUIDAS O PUEDEN SOPORTAR UNO O MAS SUSTITUTOS ELEGIDOS. LA INVENCION TAMBIEN INCLUYE ALGUNOS DERIVADOS DE ANHIDROBASE ESTRECHAMENTE RELACIONADOS QUE, COMO EL COMPUESTO DE FORMULA I, POSEE EFECTOS BENEFICIOSOS PARA EL SISTEMA CARDIOVASCULAR (Y EN PARTICULAR EFECTOS BENEFICIOSOS MODULADOS A TRAVES DEL MODO SINO-ATRIAL). TAMBIEN SE INCLUYEN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN COMPUESTOS DE LA FORMULA I (O ANHIDROBASE RELACIONADO) COMO INGREDIENTE ACTIVO, Y PROCESOS PARA LA REALIZACION DE VARIOS NUEVOS COMPUESTOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898927462A GB8927462D0 (en) | 1989-12-05 | 1989-12-05 | Heterocyclic compounds |
| GB898929020A GB8929020D0 (en) | 1989-12-22 | 1989-12-22 | Aminoheterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2074142T3 true ES2074142T3 (es) | 1995-09-01 |
Family
ID=26296312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90313079T Expired - Lifetime ES2074142T3 (es) | 1989-12-05 | 1990-11-30 | Compuestos heterociclicos. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5332737A (es) |
| EP (1) | EP0431856B1 (es) |
| JP (1) | JPH03181473A (es) |
| KR (1) | KR910011836A (es) |
| AT (1) | ATE124937T1 (es) |
| AU (1) | AU640709B2 (es) |
| CA (1) | CA2031259A1 (es) |
| DE (1) | DE69020868T2 (es) |
| DK (1) | DK0431856T3 (es) |
| ES (1) | ES2074142T3 (es) |
| FI (1) | FI905918A (es) |
| GB (1) | GB9024617D0 (es) |
| HU (1) | HU206097B (es) |
| IE (1) | IE904116A1 (es) |
| IL (1) | IL96383A0 (es) |
| MY (1) | MY106091A (es) |
| NO (1) | NO905245L (es) |
| NZ (1) | NZ236147A (es) |
| PT (1) | PT96075A (es) |
| ZW (1) | ZW18290A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003009815A2 (en) | 2001-07-25 | 2003-02-06 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US7250416B2 (en) * | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| US20090040326A1 (en) * | 2007-08-09 | 2009-02-12 | Micron Technology, Inc | Methods and apparatuses for supplying current using a digital sequence |
| AU2010216512B2 (en) | 2009-02-20 | 2016-06-30 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
| EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB814947A (en) | 1954-08-16 | 1959-06-17 | Geigy Ag J R | Improvements in and relating to plant growth influencing compositions |
| NL131196C (es) | 1966-07-16 | |||
| US3729468A (en) * | 1967-07-20 | 1973-04-24 | Kowa Co | Triazine derivatives and process for their preparation |
| BE726947A (es) * | 1968-04-10 | 1969-07-01 | ||
| US4312988A (en) * | 1980-11-10 | 1982-01-26 | American Cyanamid Company | Synthesis of hydroxy functional melamine derivatives |
| FR2524467A1 (fr) * | 1982-03-30 | 1983-10-07 | Adir | Polymethylene-imines disubstituees, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
| FR2544315B1 (fr) * | 1983-04-12 | 1985-07-05 | Adir | Polymethylene imines disubstituees, leurs procedes de preparation, et les compositions pharmaceutiques les renfermant |
| DE3611427A1 (de) * | 1986-04-05 | 1987-10-08 | Hoechst Ag | Bis-tertiaerbutylamino-substituierte 1,3,5-triazinderivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DE3639563A1 (de) * | 1986-11-20 | 1988-06-01 | Basf Ag | N-arylsulfonyl-n'-pyrimidyl(triazinyl) -harnstoffe |
| AU621082B2 (en) * | 1988-02-08 | 1992-03-05 | Ciba-Geigy Ag | Tetramethylpiperidino-s-triazines |
| GB8808071D0 (en) | 1988-04-07 | 1988-05-11 | Shell Int Research | Triazine herbicides |
| GB8819494D0 (en) * | 1988-08-16 | 1988-09-21 | Ucb Sa | Use of 2-amino-4-morpholino-6-propyl-1 3 5-triazines for preparation of psychotropic medicaments |
| GB8819493D0 (en) * | 1988-08-16 | 1988-09-21 | Ucb Sa | 2-amino-4-morpholino-6-propyl-1 3 5-triazines |
-
1990
- 1990-11-13 GB GB909024617A patent/GB9024617D0/en active Pending
- 1990-11-14 IE IE411690A patent/IE904116A1/en unknown
- 1990-11-18 IL IL96383A patent/IL96383A0/xx unknown
- 1990-11-19 AU AU66713/90A patent/AU640709B2/en not_active Ceased
- 1990-11-20 NZ NZ236147A patent/NZ236147A/en unknown
- 1990-11-21 HU HU907224A patent/HU206097B/hu not_active IP Right Cessation
- 1990-11-26 ZW ZW182/90A patent/ZW18290A1/xx unknown
- 1990-11-30 CA CA002031259A patent/CA2031259A1/en not_active Abandoned
- 1990-11-30 EP EP90313079A patent/EP0431856B1/en not_active Expired - Lifetime
- 1990-11-30 DK DK90313079.7T patent/DK0431856T3/da active
- 1990-11-30 JP JP2336882A patent/JPH03181473A/ja active Pending
- 1990-11-30 FI FI905918A patent/FI905918A/fi not_active Application Discontinuation
- 1990-11-30 AT AT90313079T patent/ATE124937T1/de not_active IP Right Cessation
- 1990-11-30 ES ES90313079T patent/ES2074142T3/es not_active Expired - Lifetime
- 1990-11-30 DE DE69020868T patent/DE69020868T2/de not_active Expired - Fee Related
- 1990-12-03 US US07/621,677 patent/US5332737A/en not_active Expired - Fee Related
- 1990-12-04 PT PT96075A patent/PT96075A/pt not_active Application Discontinuation
- 1990-12-04 MY MYPI90002134A patent/MY106091A/en unknown
- 1990-12-04 NO NO90905245A patent/NO905245L/no unknown
- 1990-12-05 KR KR1019900020008A patent/KR910011836A/ko not_active Application Discontinuation
-
1995
- 1995-06-07 US US08/488,458 patent/US5574037A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO905245L (no) | 1991-06-06 |
| US5574037A (en) | 1996-11-12 |
| HU206097B (en) | 1992-08-28 |
| EP0431856A3 (en) | 1992-01-15 |
| IE904116A1 (en) | 1991-06-05 |
| MY106091A (en) | 1995-03-31 |
| ATE124937T1 (de) | 1995-07-15 |
| FI905918A (fi) | 1991-06-06 |
| FI905918A0 (fi) | 1990-11-30 |
| NZ236147A (en) | 1993-12-23 |
| EP0431856A2 (en) | 1991-06-12 |
| JPH03181473A (ja) | 1991-08-07 |
| ZW18290A1 (en) | 1991-10-02 |
| PT96075A (pt) | 1991-09-30 |
| EP0431856B1 (en) | 1995-07-12 |
| AU6671390A (en) | 1991-06-13 |
| HUT58305A (en) | 1992-02-28 |
| CA2031259A1 (en) | 1991-06-06 |
| GB9024617D0 (en) | 1991-01-02 |
| DK0431856T3 (da) | 1995-12-11 |
| AU640709B2 (en) | 1993-09-02 |
| KR910011836A (ko) | 1991-08-07 |
| US5332737A (en) | 1994-07-26 |
| DE69020868D1 (de) | 1995-08-17 |
| HU907224D0 (en) | 1991-05-28 |
| IL96383A0 (en) | 1991-08-16 |
| NO905245D0 (no) | 1990-12-04 |
| DE69020868T2 (de) | 1995-11-30 |
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|---|---|---|
| NO905519D0 (no) | Pyrimidinderivater. | |
| ES2074142T3 (es) | Compuestos heterociclicos. | |
| NO905378D0 (no) | Fremgangsmaate for fremstilling av terapeutisk aktive diazinderivater. | |
| FI903511A0 (fi) | Pyrrolo (2,1-b) tiazolderivat. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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