BRPI1014492A2 - formação lípida estabilizada de promotor de apoptose - Google Patents

formação lípida estabilizada de promotor de apoptose

Info

Publication number
BRPI1014492A2
BRPI1014492A2 BRPI1014492A BRPI1014492A BRPI1014492A2 BR PI1014492 A2 BRPI1014492 A2 BR PI1014492A2 BR PI1014492 A BRPI1014492 A BR PI1014492A BR PI1014492 A BRPI1014492 A BR PI1014492A BR PI1014492 A2 BRPI1014492 A2 BR PI1014492A2
Authority
BR
Brazil
Prior art keywords
apoptosis promoter
stabilized lipid
lipid formation
formation
stabilized
Prior art date
Application number
BRPI1014492A
Other languages
English (en)
Inventor
Anthony R Haight
Cristina Fischer
Deliang Zhou
Eric Schmitt
Geoff Zhang
Katherine Heemstra
Michael Fickes
Nathaniel Catron
Ping Tong
Yeshwant Sanzgiri
Original Assignee
Abbott Laboraties
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboraties filed Critical Abbott Laboraties
Publication of BRPI1014492A2 publication Critical patent/BRPI1014492A2/pt
Publication of BRPI1014492A8 publication Critical patent/BRPI1014492A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI1014492A 2009-04-30 2010-04-30 Formação lípida estabilizada de promotor de apoptose BRPI1014492A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17429909P 2009-04-30 2009-04-30
US28925409P 2009-12-22 2009-12-22
PCT/US2010/033075 WO2010127193A1 (en) 2009-04-30 2010-04-30 Stabilized lipid formulation of apoptosis promoter

Publications (2)

Publication Number Publication Date
BRPI1014492A2 true BRPI1014492A2 (pt) 2016-04-05
BRPI1014492A8 BRPI1014492A8 (pt) 2017-10-24

Family

ID=42732293

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014492A BRPI1014492A8 (pt) 2009-04-30 2010-04-30 Formação lípida estabilizada de promotor de apoptose

Country Status (24)

Country Link
US (1) US8728516B2 (pt)
EP (1) EP2424499A1 (pt)
JP (1) JP5788869B2 (pt)
KR (1) KR20120027283A (pt)
CN (1) CN102802605B (pt)
AR (1) AR076511A1 (pt)
AU (1) AU2010242926B2 (pt)
BR (1) BRPI1014492A8 (pt)
CA (1) CA2758596A1 (pt)
CL (1) CL2011002652A1 (pt)
CO (1) CO6470833A2 (pt)
DO (1) DOP2011000325A (pt)
EC (1) ECSP11011491A (pt)
IL (1) IL215474A (pt)
MX (1) MX2011011525A (pt)
MY (1) MY160603A (pt)
NZ (1) NZ596047A (pt)
PE (1) PE20120642A1 (pt)
RU (1) RU2530642C2 (pt)
SG (1) SG175145A1 (pt)
TW (2) TW201100125A (pt)
UY (1) UY32601A (pt)
WO (1) WO2010127193A1 (pt)
ZA (1) ZA201107594B (pt)

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TWI471321B (zh) * 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Ｂｃｌ－２族群抑制劑之口服醫藥劑型
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JP6968080B2 (ja) * 2016-03-02 2021-11-17 メディヴィル・アクチエボラーグ ソラフェニブ又はレゴラフェニブとトロキサシタビンのホスホロアミデートプロドラッグを用いた併用療法
CN112552348B (zh) * 2019-09-26 2023-03-17 北京桦冠生物技术有限公司 含硒化合物及其制备和应用
JP2022553868A (ja) * 2019-11-08 2022-12-26 レティナ ファウンデーション オブ ザ サウスウエスト 眼障害を治療するための化合物およびインプラント
CN110963954A (zh) * 2019-12-16 2020-04-07 武汉轻工大学 一种硒代蛋氨酸衍生物的合成方法及硒代蛋氨酸制品

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Also Published As

Publication number Publication date
JP5788869B2 (ja) 2015-10-07
US20100278905A1 (en) 2010-11-04
US8728516B2 (en) 2014-05-20
MX2011011525A (es) 2011-11-18
EP2424499A1 (en) 2012-03-07
SG175145A1 (en) 2011-11-28
CN102802605A (zh) 2012-11-28
ECSP11011491A (es) 2011-12-30
BRPI1014492A8 (pt) 2017-10-24
AU2010242926B2 (en) 2014-04-24
TW201628601A (zh) 2016-08-16
MY160603A (en) 2017-03-15
WO2010127193A1 (en) 2010-11-04
NZ596047A (en) 2013-11-29
KR20120027283A (ko) 2012-03-21
PE20120642A1 (es) 2012-06-24
CA2758596A1 (en) 2010-11-04
DOP2011000325A (es) 2011-11-15
JP2012525435A (ja) 2012-10-22
IL215474A (en) 2015-06-30
CN102802605B (zh) 2015-08-12
UY32601A (es) 2010-12-31
CL2011002652A1 (es) 2012-04-20
CO6470833A2 (es) 2012-06-29
IL215474A0 (en) 2011-12-29
AU2010242926A1 (en) 2011-11-10
AR076511A1 (es) 2011-06-15
RU2011148516A (ru) 2013-06-10
TW201100125A (en) 2011-01-01
RU2530642C2 (ru) 2014-10-10
ZA201107594B (en) 2014-03-26

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