PE20120642A1 - Formulacion en lipidos estabilizada de un promotor de la apoptosis - Google Patents

Formulacion en lipidos estabilizada de un promotor de la apoptosis

Info

Publication number
PE20120642A1
PE20120642A1 PE2011001864A PE2011001864A PE20120642A1 PE 20120642 A1 PE20120642 A1 PE 20120642A1 PE 2011001864 A PE2011001864 A PE 2011001864A PE 2011001864 A PE2011001864 A PE 2011001864A PE 20120642 A1 PE20120642 A1 PE 20120642A1
Authority
PE
Peru
Prior art keywords
methyl
apoptosis
antioxidant
promoter
phospholipid
Prior art date
Application number
PE2011001864A
Other languages
English (en)
Inventor
Nathaniel Catron
Michael Fickes
Cristina Fischer
Anthony R Haight
Yeshwant Sanzgiri
Eric Schmitt
Ping Tong
Geoff Zhang
Deliang Zhou
Katherine Heemstra
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20120642A1 publication Critical patent/PE20120642A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE: A) UN COMPUESTO PROMOTOR DE LA APOPTOSIS QUE INHIBE LAS PROTEINAS DE LA FAMILIA Bcl-2 TAL COMO N-(4-(4-((2-(4-CLOROFENIL)-5,5-DIMETIL-1-CICLOHEX-1-EN-1-IL)METIL)PIPERAZIN-1-IL)BENZOIL)-4-(((1R)-3-(MORFOLIN-4-IL)-1-((FENILSULFANIL)METIL)PROPIL)AMINO-3-((TRIFLUOROMETIL)SULFONIL)BENCENOSULFONAMIDA (ABT-263) O UNA SAL DE LA MISMA; B) UN ANTIOXIDANTE CALCOGENO TAL COMO N-ACETILCISTEINA, N-ACETILMETIONINA, TIODIGLICOLATO DE DIBUTILO, ENTRE OTROS; C) UN VEHICULO LIPIDO QUE COMPRENDE i) UN FOSFOLIPIDO TAL COMO FOSFATIDILCOLINA, Y ii) UN AGENTE SOLUBILIZANTE TAL COMO TRIGLICERIDOS DE CADENA MEDIA; D) UN TENSIOACTIVO NO FOSFOLIPIDO TAL COMO POLISORBATOS; Y E) UN AGENTE QUELANTE TAL COMO EDTA; DONDE DICHO COMPUESTO Y EL ANTIOXIDANTE ESTAN FORMANDO UNA SOLUCION EN EL VEHICULO LIPIDO. DICHA COMPOSICION ES DE ADMINISTRACION ORAL SIENDO UTIL EN EL TRATAMIENTO DE LINFOMA NO DE HODGKIN, LEUCEMIA LINFOCITICA CRONICA Y AGUDA
PE2011001864A 2009-04-30 2010-04-30 Formulacion en lipidos estabilizada de un promotor de la apoptosis PE20120642A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17429909P 2009-04-30 2009-04-30
US28925409P 2009-12-22 2009-12-22

Publications (1)

Publication Number Publication Date
PE20120642A1 true PE20120642A1 (es) 2012-06-24

Family

ID=42732293

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001864A PE20120642A1 (es) 2009-04-30 2010-04-30 Formulacion en lipidos estabilizada de un promotor de la apoptosis

Country Status (24)

Country Link
US (1) US8728516B2 (es)
EP (1) EP2424499A1 (es)
JP (1) JP5788869B2 (es)
KR (1) KR20120027283A (es)
CN (1) CN102802605B (es)
AR (1) AR076511A1 (es)
AU (1) AU2010242926B2 (es)
BR (1) BRPI1014492A8 (es)
CA (1) CA2758596A1 (es)
CL (1) CL2011002652A1 (es)
CO (1) CO6470833A2 (es)
DO (1) DOP2011000325A (es)
EC (1) ECSP11011491A (es)
IL (1) IL215474A (es)
MX (1) MX2011011525A (es)
MY (1) MY160603A (es)
NZ (1) NZ596047A (es)
PE (1) PE20120642A1 (es)
RU (1) RU2530642C2 (es)
SG (1) SG175145A1 (es)
TW (2) TW201100125A (es)
UY (1) UY32601A (es)
WO (1) WO2010127193A1 (es)
ZA (1) ZA201107594B (es)

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Also Published As

Publication number Publication date
MY160603A (en) 2017-03-15
BRPI1014492A8 (pt) 2017-10-24
AU2010242926B2 (en) 2014-04-24
CA2758596A1 (en) 2010-11-04
ZA201107594B (en) 2014-03-26
BRPI1014492A2 (pt) 2016-04-05
CN102802605A (zh) 2012-11-28
JP2012525435A (ja) 2012-10-22
WO2010127193A1 (en) 2010-11-04
JP5788869B2 (ja) 2015-10-07
US20100278905A1 (en) 2010-11-04
MX2011011525A (es) 2011-11-18
UY32601A (es) 2010-12-31
DOP2011000325A (es) 2011-11-15
RU2011148516A (ru) 2013-06-10
AR076511A1 (es) 2011-06-15
EP2424499A1 (en) 2012-03-07
RU2530642C2 (ru) 2014-10-10
IL215474A (en) 2015-06-30
TW201100125A (en) 2011-01-01
CO6470833A2 (es) 2012-06-29
CL2011002652A1 (es) 2012-04-20
AU2010242926A1 (en) 2011-11-10
NZ596047A (en) 2013-11-29
SG175145A1 (en) 2011-11-28
ECSP11011491A (es) 2011-12-30
US8728516B2 (en) 2014-05-20
KR20120027283A (ko) 2012-03-21
CN102802605B (zh) 2015-08-12
TW201628601A (zh) 2016-08-16
IL215474A0 (en) 2011-12-29

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