RU2530642C2 - Стабилизированная липидная препаративная форма промотора апоптоза - Google Patents

Стабилизированная липидная препаративная форма промотора апоптоза Download PDF

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RU2530642C2
RU2530642C2 RU2011148516/15A RU2011148516A RU2530642C2 RU 2530642 C2 RU2530642 C2 RU 2530642C2 RU 2011148516/15 A RU2011148516/15 A RU 2011148516/15A RU 2011148516 A RU2011148516 A RU 2011148516A RU 2530642 C2 RU2530642 C2 RU 2530642C2
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cancer
abt
antioxidant
carrier
composition
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RU2011148516/15A
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Russian (ru)
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RU2011148516A (ru
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Натаниэль КЭТРОН
Майкл ФИКС
Кристина ФИШЕР
Энтони Р. Хэйт
Кэтрин ХИМСТРА
Ешвант САНЗГИРИ
Эрик ШМИТТ
Пин ТУН
Джефф ЧЖАН
Дэлян ЧЖОУ
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Эббви Инк
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2011148516/15A 2009-04-30 2010-04-30 Стабилизированная липидная препаративная форма промотора апоптоза RU2530642C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17429909P 2009-04-30 2009-04-30
US61/174,299 2009-04-30
US28925409P 2009-12-22 2009-12-22
US61/289,254 2009-12-22
PCT/US2010/033075 WO2010127193A1 (en) 2009-04-30 2010-04-30 Stabilized lipid formulation of apoptosis promoter

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RU2011148516A RU2011148516A (ru) 2013-06-10
RU2530642C2 true RU2530642C2 (ru) 2014-10-10

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RU2011148516/15A RU2530642C2 (ru) 2009-04-30 2010-04-30 Стабилизированная липидная препаративная форма промотора апоптоза

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Country Link
US (1) US8728516B2 (es)
EP (1) EP2424499A1 (es)
JP (1) JP5788869B2 (es)
KR (1) KR20120027283A (es)
CN (1) CN102802605B (es)
AR (1) AR076511A1 (es)
AU (1) AU2010242926B2 (es)
BR (1) BRPI1014492A8 (es)
CA (1) CA2758596A1 (es)
CL (1) CL2011002652A1 (es)
CO (1) CO6470833A2 (es)
DO (1) DOP2011000325A (es)
EC (1) ECSP11011491A (es)
IL (1) IL215474A (es)
MX (1) MX2011011525A (es)
MY (1) MY160603A (es)
NZ (1) NZ596047A (es)
PE (1) PE20120642A1 (es)
RU (1) RU2530642C2 (es)
SG (1) SG175145A1 (es)
TW (2) TW201100125A (es)
UY (1) UY32601A (es)
WO (1) WO2010127193A1 (es)
ZA (1) ZA201107594B (es)

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UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
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CN112552348B (zh) * 2019-09-26 2023-03-17 北京桦冠生物技术有限公司 含硒化合物及其制备和应用
WO2021092470A1 (en) * 2019-11-08 2021-05-14 Retina Foundation Of The Southwest Compounds and implants for treating ocular disorders
CN110963954A (zh) * 2019-12-16 2020-04-07 武汉轻工大学 一种硒代蛋氨酸衍生物的合成方法及硒代蛋氨酸制品

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RU2011148516A (ru) 2013-06-10
NZ596047A (en) 2013-11-29
PE20120642A1 (es) 2012-06-24
CN102802605B (zh) 2015-08-12
CA2758596A1 (en) 2010-11-04
MY160603A (en) 2017-03-15
AU2010242926B2 (en) 2014-04-24
JP5788869B2 (ja) 2015-10-07
US20100278905A1 (en) 2010-11-04
BRPI1014492A8 (pt) 2017-10-24
EP2424499A1 (en) 2012-03-07
IL215474A (en) 2015-06-30
CL2011002652A1 (es) 2012-04-20
MX2011011525A (es) 2011-11-18
AU2010242926A1 (en) 2011-11-10
UY32601A (es) 2010-12-31
ECSP11011491A (es) 2011-12-30
IL215474A0 (en) 2011-12-29
CO6470833A2 (es) 2012-06-29
KR20120027283A (ko) 2012-03-21
BRPI1014492A2 (pt) 2016-04-05
TW201628601A (zh) 2016-08-16
ZA201107594B (en) 2014-03-26
DOP2011000325A (es) 2011-11-15
JP2012525435A (ja) 2012-10-22
US8728516B2 (en) 2014-05-20
SG175145A1 (en) 2011-11-28
AR076511A1 (es) 2011-06-15
CN102802605A (zh) 2012-11-28
TW201100125A (en) 2011-01-01
WO2010127193A1 (en) 2010-11-04

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