BRPI0818595A2 - Método de produção de 2'-desóxi-5-azacitina (decitabina) - Google Patents

Método de produção de 2'-desóxi-5-azacitina (decitabina)

Info

Publication number
BRPI0818595A2
BRPI0818595A2 BRPI0818595A BRPI0818595A2 BR PI0818595 A2 BRPI0818595 A2 BR PI0818595A2 BR PI0818595 A BRPI0818595 A BR PI0818595A BR PI0818595 A2 BRPI0818595 A2 BR PI0818595A2
Authority
BR
Brazil
Prior art keywords
azacytine
decitabine
deoxy
production method
production
Prior art date
Application number
Other languages
English (en)
Inventor
Oliver Jungmann
Norbert Kraut
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39496166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0818595(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of BRPI0818595A2 publication Critical patent/BRPI0818595A2/pt
Publication of BRPI0818595B1 publication Critical patent/BRPI0818595B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
BRPI0818595-6A 2007-10-10 2008-10-10 Método de produção de 2'-desóxi-5-azacitina (decitabina) BRPI0818595B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07019826.2 2007-10-10
EP07019826A EP2050757A1 (en) 2007-10-10 2007-10-10 Method of producing 2' -deoxy-5-azacytidine (Decitabine)
PCT/EP2008/063581 WO2009047313A2 (en) 2007-10-10 2008-10-10 Method of producing 2' -deoxy-5-azacytidine (decitabine)

Publications (2)

Publication Number Publication Date
BRPI0818595A2 true BRPI0818595A2 (pt) 2015-04-22
BRPI0818595B1 BRPI0818595B1 (pt) 2022-02-15

Family

ID=39496166

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0818595-6A BRPI0818595B1 (pt) 2007-10-10 2008-10-10 Método de produção de 2'-desóxi-5-azacitina (decitabina)

Country Status (32)

Country Link
US (1) US20100222565A1 (pt)
EP (2) EP2050757A1 (pt)
JP (1) JP5453279B2 (pt)
KR (1) KR101551779B1 (pt)
CN (1) CN102037003B (pt)
AP (1) AP2719A (pt)
AU (1) AU2008309552B2 (pt)
BR (1) BRPI0818595B1 (pt)
CA (1) CA2703560C (pt)
CO (1) CO6270260A2 (pt)
CY (1) CY1116540T1 (pt)
DK (1) DK2201020T3 (pt)
EA (1) EA018924B1 (pt)
EC (1) ECSP10010091A (pt)
ES (1) ES2512591T3 (pt)
GT (1) GT201000076A (pt)
HK (1) HK1152312A1 (pt)
HN (1) HN2010000654A (pt)
HR (1) HRP20140856T1 (pt)
IL (1) IL204918A0 (pt)
MX (1) MX2010003887A (pt)
MY (1) MY150047A (pt)
NI (1) NI201000049A (pt)
NZ (1) NZ584373A (pt)
PL (1) PL2201020T3 (pt)
PT (1) PT2201020E (pt)
SI (1) SI2201020T1 (pt)
SV (1) SV2010003523A (pt)
UA (1) UA101482C2 (pt)
UY (1) UY31388A1 (pt)
WO (1) WO2009047313A2 (pt)
ZA (1) ZA201002517B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
US8586729B2 (en) * 2008-10-03 2013-11-19 Scinopharm Taiwan Ltd. Synthesis of decitabine
AR076418A1 (es) * 2009-04-27 2011-06-08 Reddys Lab Inc Dr Preparacion de decitabina
IT1399195B1 (it) * 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
CN101948493A (zh) * 2010-06-28 2011-01-19 江苏奥赛康药业有限公司 一种高纯度地西他滨的工业化生产方法
KR101241321B1 (ko) * 2010-08-05 2013-03-11 케이피엑스 라이프사이언스 주식회사 수율 및 순도가 개선된 데시타빈의 제조방법
CN102391338A (zh) * 2011-09-30 2012-03-28 重庆泰濠制药有限公司 一种地西他滨中间体粗品的纯化方法
CN104211743A (zh) * 2013-05-29 2014-12-17 南京工业大学 一种地西他宾的合成
CN103601768B (zh) * 2013-11-13 2015-09-30 齐鲁天和惠世制药有限公司 一种阿米卡星的制备方法
WO2017096357A1 (en) 2015-12-03 2017-06-08 Epidestiny, Inc. Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof
CN109912672B (zh) * 2019-04-02 2021-07-27 江西师范大学 一种以邻炔基苯酚醚作为离去基的碱基糖苷化的方法
CN112209976B (zh) * 2019-07-10 2023-05-26 鲁南制药集团股份有限公司 一种地西他滨中间体化合物ⅴ
CN112209977B (zh) * 2019-07-10 2023-05-26 鲁南制药集团股份有限公司 一种地西他滨中间体化合物ⅵ

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5811540A (en) * 1993-11-05 1998-09-22 The Noguchi Institute 5-O-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, and production method and use thereof
JPH11514642A (ja) * 1995-11-02 1999-12-14 チョング クン ダング シーオーアールピー． 新規なヌクレオシド誘導体及びその製造方法
CN1141305C (zh) * 1998-08-12 2004-03-10 三角药物公司 生产1,3-氧硫戊环核苷的方法

Also Published As

Publication number Publication date
CN102037003A (zh) 2011-04-27
HRP20140856T1 (hr) 2014-10-24
JP2011518759A (ja) 2011-06-30
BRPI0818595B1 (pt) 2022-02-15
JP5453279B2 (ja) 2014-03-26
US20100222565A1 (en) 2010-09-02
KR101551779B1 (ko) 2015-09-09
AP2010005226A0 (en) 2010-04-30
AP2719A (en) 2013-07-31
CA2703560C (en) 2016-09-13
DK2201020T3 (da) 2014-10-13
AU2008309552B2 (en) 2013-01-17
EA018924B1 (ru) 2013-11-29
ECSP10010091A (es) 2010-06-29
CY1116540T1 (el) 2017-03-15
EA201070437A3 (ru) 2011-02-28
WO2009047313A2 (en) 2009-04-16
IL204918A0 (en) 2010-11-30
EP2201020B1 (en) 2014-07-16
MY150047A (en) 2013-11-29
PL2201020T3 (pl) 2014-12-31
CN102037003B (zh) 2014-05-07
ZA201002517B (en) 2012-07-25
CA2703560A1 (en) 2009-04-16
HK1152312A1 (en) 2012-02-24
SI2201020T1 (sl) 2014-11-28
GT201000076A (es) 2012-03-12
WO2009047313A3 (en) 2012-03-01
UA101482C2 (ru) 2013-04-10
AU2008309552A1 (en) 2009-04-16
MX2010003887A (es) 2010-04-30
EP2201020A2 (en) 2010-06-30
UY31388A1 (es) 2009-04-30
NI201000049A (es) 2010-11-10
SV2010003523A (es) 2011-01-25
EP2050757A1 (en) 2009-04-22
KR20100064387A (ko) 2010-06-14
ES2512591T3 (es) 2014-10-24
NZ584373A (en) 2011-08-26
CO6270260A2 (es) 2011-04-20
HN2010000654A (es) 2012-12-03
PT2201020E (pt) 2014-09-23
EA201070437A2 (ru) 2010-08-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07H 19/12

Ipc: C07H 19/12 (2006.01), A61P 35/00 (2006.01), A61P 3

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/10/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.