DK2201020T3 - Fremgangsmåde til fremstilling af 2' -deoxy-5-azacytidin (decitabin) - Google Patents

Fremgangsmåde til fremstilling af 2' -deoxy-5-azacytidin (decitabin)

Info

Publication number
DK2201020T3
DK2201020T3 DK08805203.0T DK08805203T DK2201020T3 DK 2201020 T3 DK2201020 T3 DK 2201020T3 DK 08805203 T DK08805203 T DK 08805203T DK 2201020 T3 DK2201020 T3 DK 2201020T3
Authority
DK
Denmark
Prior art keywords
decitabin
azacytidine
deoxy
preparing
procedure
Prior art date
Application number
DK08805203.0T
Other languages
English (en)
Inventor
Oliver Jungmann
Norbert Kraut
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39496166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2201020(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cilag Ag filed Critical Cilag Ag
Application granted granted Critical
Publication of DK2201020T3 publication Critical patent/DK2201020T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK08805203.0T 2007-10-10 2008-10-10 Fremgangsmåde til fremstilling af 2' -deoxy-5-azacytidin (decitabin) DK2201020T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07019826A EP2050757A1 (en) 2007-10-10 2007-10-10 Method of producing 2' -deoxy-5-azacytidine (Decitabine)
PCT/EP2008/063581 WO2009047313A2 (en) 2007-10-10 2008-10-10 Method of producing 2' -deoxy-5-azacytidine (decitabine)

Publications (1)

Publication Number Publication Date
DK2201020T3 true DK2201020T3 (da) 2014-10-13

Family

ID=39496166

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08805203.0T DK2201020T3 (da) 2007-10-10 2008-10-10 Fremgangsmåde til fremstilling af 2' -deoxy-5-azacytidin (decitabin)

Country Status (32)

Country Link
US (1) US20100222565A1 (da)
EP (2) EP2050757A1 (da)
JP (1) JP5453279B2 (da)
KR (1) KR101551779B1 (da)
CN (1) CN102037003B (da)
AP (1) AP2719A (da)
AU (1) AU2008309552B2 (da)
BR (1) BRPI0818595B1 (da)
CA (1) CA2703560C (da)
CO (1) CO6270260A2 (da)
CY (1) CY1116540T1 (da)
DK (1) DK2201020T3 (da)
EA (1) EA018924B1 (da)
EC (1) ECSP10010091A (da)
ES (1) ES2512591T3 (da)
GT (1) GT201000076A (da)
HK (1) HK1152312A1 (da)
HN (1) HN2010000654A (da)
HR (1) HRP20140856T1 (da)
IL (1) IL204918A0 (da)
MX (1) MX2010003887A (da)
MY (1) MY150047A (da)
NI (1) NI201000049A (da)
NZ (1) NZ584373A (da)
PL (1) PL2201020T3 (da)
PT (1) PT2201020E (da)
SI (1) SI2201020T1 (da)
SV (1) SV2010003523A (da)
UA (1) UA101482C2 (da)
UY (1) UY31388A1 (da)
WO (1) WO2009047313A2 (da)
ZA (1) ZA201002517B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
US8586729B2 (en) * 2008-10-03 2013-11-19 Scinopharm Taiwan Ltd. Synthesis of decitabine
WO2010129211A2 (en) * 2009-04-27 2010-11-11 Dr. Reddy's Laboratories Ltd. Preparation of decitabine
IT1399195B1 (it) * 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
CN101948493A (zh) * 2010-06-28 2011-01-19 江苏奥赛康药业有限公司 一种高纯度地西他滨的工业化生产方法
KR101241321B1 (ko) * 2010-08-05 2013-03-11 케이피엑스 라이프사이언스 주식회사 수율 및 순도가 개선된 데시타빈의 제조방법
CN102391338A (zh) * 2011-09-30 2012-03-28 重庆泰濠制药有限公司 一种地西他滨中间体粗品的纯化方法
CN104211743A (zh) * 2013-05-29 2014-12-17 南京工业大学 一种地西他宾的合成
CN103601768B (zh) * 2013-11-13 2015-09-30 齐鲁天和惠世制药有限公司 一种阿米卡星的制备方法
WO2017096357A1 (en) * 2015-12-03 2017-06-08 Epidestiny, Inc. Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof
CN109912672B (zh) * 2019-04-02 2021-07-27 江西师范大学 一种以邻炔基苯酚醚作为离去基的碱基糖苷化的方法
CN112209977B (zh) * 2019-07-10 2023-05-26 鲁南制药集团股份有限公司 一种地西他滨中间体化合物ⅵ
CN112209976B (zh) * 2019-07-10 2023-05-26 鲁南制药集团股份有限公司 一种地西他滨中间体化合物ⅴ

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5811540A (en) * 1993-11-05 1998-09-22 The Noguchi Institute 5-O-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, and production method and use thereof
US6072051A (en) * 1995-11-02 2000-06-06 Chong Kun Dang Corp. Nucleoside derivatives and process for preparing the same
PT1104415E (pt) * 1998-08-12 2005-03-31 Univ Emory Metodo de preparacao de nucleosidos de 1,3-oxatiolano

Also Published As

Publication number Publication date
EP2201020B1 (en) 2014-07-16
JP5453279B2 (ja) 2014-03-26
HK1152312A1 (en) 2012-02-24
AU2008309552A1 (en) 2009-04-16
KR101551779B1 (ko) 2015-09-09
CY1116540T1 (el) 2017-03-15
PT2201020E (pt) 2014-09-23
ECSP10010091A (es) 2010-06-29
AU2008309552B2 (en) 2013-01-17
BRPI0818595A2 (pt) 2015-04-22
WO2009047313A3 (en) 2012-03-01
MY150047A (en) 2013-11-29
EP2050757A1 (en) 2009-04-22
MX2010003887A (es) 2010-04-30
PL2201020T3 (pl) 2014-12-31
EA201070437A2 (ru) 2010-08-30
EA201070437A3 (ru) 2011-02-28
UA101482C2 (ru) 2013-04-10
ES2512591T3 (es) 2014-10-24
NZ584373A (en) 2011-08-26
SI2201020T1 (sl) 2014-11-28
WO2009047313A2 (en) 2009-04-16
SV2010003523A (es) 2011-01-25
IL204918A0 (en) 2010-11-30
CA2703560A1 (en) 2009-04-16
CN102037003A (zh) 2011-04-27
ZA201002517B (en) 2012-07-25
NI201000049A (es) 2010-11-10
EP2201020A2 (en) 2010-06-30
JP2011518759A (ja) 2011-06-30
EA018924B1 (ru) 2013-11-29
CN102037003B (zh) 2014-05-07
CA2703560C (en) 2016-09-13
UY31388A1 (es) 2009-04-30
HN2010000654A (es) 2012-12-03
AP2010005226A0 (en) 2010-04-30
AP2719A (en) 2013-07-31
US20100222565A1 (en) 2010-09-02
CO6270260A2 (es) 2011-04-20
HRP20140856T1 (hr) 2014-10-24
GT201000076A (es) 2012-03-12
BRPI0818595B1 (pt) 2022-02-15
KR20100064387A (ko) 2010-06-14

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