ECSP10010091A - Proceso para producir 2-desoxi-5-azacitidina (decitabina) - Google Patents

Proceso para producir 2-desoxi-5-azacitidina (decitabina)

Info

Publication number
ECSP10010091A
ECSP10010091A EC2010010091A ECSP10010091A ECSP10010091A EC SP10010091 A ECSP10010091 A EC SP10010091A EC 2010010091 A EC2010010091 A EC 2010010091A EC SP10010091 A ECSP10010091 A EC SP10010091A EC SP10010091 A ECSP10010091 A EC SP10010091A
Authority
EC
Ecuador
Prior art keywords
azacitidine
desoxi
decitabin
produce
derivative
Prior art date
Application number
EC2010010091A
Other languages
English (en)
Inventor
Oliver Jungmann
Norbert Kraut
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39496166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP10010091(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of ECSP10010091A publication Critical patent/ECSP10010091A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un proceso para producir 2´-desoxi-azacitidina (Decitabina) haciendo reaccionar un dador de glicósidos, preferiblemente un derivado 1-halogenado, o un imidato, preferiblemente un derivado de triclorometilo, o un derivado de tio-alquilo de un monosacárido bloqueado con una base sililada seleccionada en presencia de un catalizador seleccionado.
EC2010010091A 2007-10-10 2010-04-09 Proceso para producir 2-desoxi-5-azacitidina (decitabina) ECSP10010091A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07019826A EP2050757A1 (en) 2007-10-10 2007-10-10 Method of producing 2' -deoxy-5-azacytidine (Decitabine)

Publications (1)

Publication Number Publication Date
ECSP10010091A true ECSP10010091A (es) 2010-06-29

Family

ID=39496166

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010091A ECSP10010091A (es) 2007-10-10 2010-04-09 Proceso para producir 2-desoxi-5-azacitidina (decitabina)

Country Status (32)

Country Link
US (1) US20100222565A1 (es)
EP (2) EP2050757A1 (es)
JP (1) JP5453279B2 (es)
KR (1) KR101551779B1 (es)
CN (1) CN102037003B (es)
AP (1) AP2719A (es)
AU (1) AU2008309552B2 (es)
BR (1) BRPI0818595B1 (es)
CA (1) CA2703560C (es)
CO (1) CO6270260A2 (es)
CY (1) CY1116540T1 (es)
DK (1) DK2201020T3 (es)
EA (1) EA018924B1 (es)
EC (1) ECSP10010091A (es)
ES (1) ES2512591T3 (es)
GT (1) GT201000076A (es)
HK (1) HK1152312A1 (es)
HN (1) HN2010000654A (es)
HR (1) HRP20140856T1 (es)
IL (1) IL204918A0 (es)
MX (1) MX2010003887A (es)
MY (1) MY150047A (es)
NI (1) NI201000049A (es)
NZ (1) NZ584373A (es)
PL (1) PL2201020T3 (es)
PT (1) PT2201020E (es)
SI (1) SI2201020T1 (es)
SV (1) SV2010003523A (es)
UA (1) UA101482C2 (es)
UY (1) UY31388A1 (es)
WO (1) WO2009047313A2 (es)
ZA (1) ZA201002517B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
US8586729B2 (en) * 2008-10-03 2013-11-19 Scinopharm Taiwan Ltd. Synthesis of decitabine
EP2424845A4 (en) * 2009-04-27 2014-03-05 Reddys Lab Ltd Dr PREPARATION OF DECITABIN
IT1399195B1 (it) * 2010-03-30 2013-04-11 Chemi Spa Processo per la sintesi di azacitidina e decitabina
CN101948493A (zh) * 2010-06-28 2011-01-19 江苏奥赛康药业有限公司 一种高纯度地西他滨的工业化生产方法
KR101241321B1 (ko) * 2010-08-05 2013-03-11 케이피엑스 라이프사이언스 주식회사 수율 및 순도가 개선된 데시타빈의 제조방법
CN102391338A (zh) * 2011-09-30 2012-03-28 重庆泰濠制药有限公司 一种地西他滨中间体粗品的纯化方法
CN104211743A (zh) * 2013-05-29 2014-12-17 南京工业大学 一种地西他宾的合成
CN103601768B (zh) * 2013-11-13 2015-09-30 齐鲁天和惠世制药有限公司 一种阿米卡星的制备方法
US11376270B2 (en) 2015-12-03 2022-07-05 Epidestiny, Inc. Compositions containing decitabine, 5Azacytidine and tetrahydrouridine and uses thereof
CN109912672B (zh) * 2019-04-02 2021-07-27 江西师范大学 一种以邻炔基苯酚醚作为离去基的碱基糖苷化的方法
CN112209976B (zh) * 2019-07-10 2023-05-26 鲁南制药集团股份有限公司 一种地西他滨中间体化合物ⅴ
CN112209977B (zh) * 2019-07-10 2023-05-26 鲁南制药集团股份有限公司 一种地西他滨中间体化合物ⅵ

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5606048A (en) 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
WO1995012593A1 (fr) * 1993-11-05 1995-05-11 The Noguchi Institute Derive de 5-0-pyrimidyle-2,3-didesoxy-1-thiofuranoside, procede de production et utilisation
AU7341896A (en) * 1995-11-02 1997-05-22 Chong Kun Dang Corporation Novel nucleoside derivatives and process for preparing the same
RU2439069C2 (ru) * 1998-08-12 2012-01-10 Гайлид Сайенсиз, Инк. Способ получения 1,3-оксатиолановых нуклеозидов

Also Published As

Publication number Publication date
KR101551779B1 (ko) 2015-09-09
JP2011518759A (ja) 2011-06-30
CY1116540T1 (el) 2017-03-15
PL2201020T3 (pl) 2014-12-31
IL204918A0 (en) 2010-11-30
ES2512591T3 (es) 2014-10-24
CO6270260A2 (es) 2011-04-20
EP2201020A2 (en) 2010-06-30
DK2201020T3 (da) 2014-10-13
HK1152312A1 (en) 2012-02-24
EA201070437A3 (ru) 2011-02-28
MX2010003887A (es) 2010-04-30
AU2008309552B2 (en) 2013-01-17
EP2201020B1 (en) 2014-07-16
NI201000049A (es) 2010-11-10
UA101482C2 (ru) 2013-04-10
CA2703560A1 (en) 2009-04-16
AP2010005226A0 (en) 2010-04-30
AP2719A (en) 2013-07-31
WO2009047313A3 (en) 2012-03-01
BRPI0818595B1 (pt) 2022-02-15
CN102037003A (zh) 2011-04-27
CN102037003B (zh) 2014-05-07
PT2201020E (pt) 2014-09-23
MY150047A (en) 2013-11-29
EA018924B1 (ru) 2013-11-29
KR20100064387A (ko) 2010-06-14
UY31388A1 (es) 2009-04-30
EP2050757A1 (en) 2009-04-22
AU2008309552A1 (en) 2009-04-16
CA2703560C (en) 2016-09-13
NZ584373A (en) 2011-08-26
EA201070437A2 (ru) 2010-08-30
HN2010000654A (es) 2012-12-03
GT201000076A (es) 2012-03-12
BRPI0818595A2 (pt) 2015-04-22
JP5453279B2 (ja) 2014-03-26
ZA201002517B (en) 2012-07-25
SV2010003523A (es) 2011-01-25
HRP20140856T1 (hr) 2014-10-24
WO2009047313A2 (en) 2009-04-16
US20100222565A1 (en) 2010-09-02
SI2201020T1 (sl) 2014-11-28

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