BRPI0813729A2 - Método para construção de massas de células miocárdicas e uso da massa de célula miocárdica - Google Patents
Método para construção de massas de células miocárdicas e uso da massa de célula miocárdicaInfo
- Publication number
- BRPI0813729A2 BRPI0813729A2 BRPI0813729-3A2A BRPI0813729A BRPI0813729A2 BR PI0813729 A2 BRPI0813729 A2 BR PI0813729A2 BR PI0813729 A BRPI0813729 A BR PI0813729A BR PI0813729 A2 BRPI0813729 A2 BR PI0813729A2
- Authority
- BR
- Brazil
- Prior art keywords
- myocardic
- cell
- construction
- masses
- cell mass
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3826—Muscle cells, e.g. smooth muscle cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/99—Serum-free medium
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/04—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from germ cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007200246 | 2007-07-31 | ||
JP2007-200246 | 2007-07-31 | ||
JP2008-046772 | 2008-02-27 | ||
JP2008046772 | 2008-02-27 | ||
PCT/JP2008/064168 WO2009017254A1 (ja) | 2007-07-31 | 2008-07-31 | 心筋細胞の細胞塊作製方法及び当該心筋細胞塊の用途 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0813729A2 true BRPI0813729A2 (pt) | 2014-12-30 |
BRPI0813729B1 BRPI0813729B1 (pt) | 2019-04-02 |
BRPI0813729B8 BRPI0813729B8 (pt) | 2022-09-27 |
Family
ID=40304474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0813729A BRPI0813729B8 (pt) | 2007-07-31 | 2008-07-31 | métodos de preparação de massas celulares de cardiomiócitos purificados derivados de células-tronco pluripotentes e de uma película de massas celulares de cardiomiócitos, bem como dispositivo médico e uso das referidas massas celulares |
Country Status (11)
Country | Link |
---|---|
US (2) | US9109205B2 (pt) |
EP (1) | EP2172542B1 (pt) |
JP (1) | JP5523830B2 (pt) |
KR (2) | KR101582483B1 (pt) |
CN (1) | CN101711277B (pt) |
AU (1) | AU2008283255B2 (pt) |
BR (1) | BRPI0813729B8 (pt) |
CA (1) | CA2690610C (pt) |
IL (1) | IL203404A (pt) |
RU (1) | RU2467066C2 (pt) |
WO (1) | WO2009017254A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5674046B2 (ja) * | 2009-09-30 | 2015-02-18 | 国立大学法人鳥取大学 | 新規ペースメーカ細胞 |
EP4364797A3 (en) | 2009-10-19 | 2024-07-10 | FUJIFILM Cellular Dynamics, Inc. | Cardiomyocyte production |
JPWO2011071118A1 (ja) * | 2009-12-09 | 2013-04-22 | 国立大学法人京都大学 | ニトロビンを含む多能性幹細胞の心筋細胞への分化促進剤 |
EP2582792B1 (en) * | 2010-06-18 | 2018-10-31 | FUJIFILM Cellular Dynamics, Inc. | Cardiomyocyte medium with dialyzed serum |
JP5854999B2 (ja) * | 2010-07-29 | 2016-02-09 | テルモ株式会社 | シート状細胞培養物解離システム |
EP3143132A4 (en) * | 2014-05-13 | 2017-11-15 | The Regents Of The University Of Michigan | Compositions and methods employing stem cell-derived cardiomyocytes |
CA2954242C (en) | 2014-07-16 | 2024-02-13 | Heartseed Inc. | Undifferentiated stem cell removal and myocardial purification and refinement culture medium |
WO2016052657A1 (ja) * | 2014-09-30 | 2016-04-07 | 国立研究開発法人産業技術総合研究所 | 万能性幹細胞の培養方法 |
WO2016076368A1 (ja) * | 2014-11-12 | 2016-05-19 | テルモ株式会社 | 心筋細胞シート |
CN104830761A (zh) * | 2015-06-04 | 2015-08-12 | 黑龙江省瑞生会生物技术开发有限公司 | 一种培养心肌细胞的无血清培养基 |
EP3150696A1 (en) | 2015-09-30 | 2017-04-05 | Shibuya Corporation | Apparatus for producing cell mass sheet and method for producing cell mass sheet |
JP6593589B2 (ja) * | 2015-09-30 | 2019-10-23 | 澁谷工業株式会社 | 細胞塊シートの作製方法および細胞塊シート |
EP3162890A1 (en) | 2015-10-29 | 2017-05-03 | Shibuya Corporation | Method and apparatus for producing cell mass structure |
EP3431584B1 (en) * | 2016-03-18 | 2023-06-28 | Kyoto University | Methods for freezing an aggregate of pluripotent stem cell-derived cardiomyocytes |
SG11201903254PA (en) | 2016-10-17 | 2019-05-30 | Univ Keio | Undifferentiated stem cell-removing agent, and method for removing undifferentiated stem cells |
EP3406704B1 (en) * | 2016-11-01 | 2021-10-20 | Terumo Kabushiki Kaisha | Modification method for adhesion-state cell culture |
JP2018093823A (ja) | 2016-12-15 | 2018-06-21 | Heartseed株式会社 | 未分化幹細胞除去剤及び未分化幹細胞除去方法 |
WO2018164098A1 (ja) * | 2017-03-06 | 2018-09-13 | 国立大学法人大阪大学 | 心臓線維化モデルとして用いられる細胞集団、その製造方法、それを利用したスクリーニング方法及び心臓線維化モデルの評価方法、並びに心臓線維化モデルの評価システム |
CN106957815B (zh) | 2017-03-16 | 2021-05-07 | 杨涛 | 一种用于人类多潜能干细胞的无血清培养基的配方 |
JPWO2018164098A1 (ja) * | 2017-03-16 | 2020-01-16 | 国立大学法人大阪大学 | 心臓線維化モデルとして用いられる細胞集団、その製造方法、それを利用したスクリーニング方法及び心臓線維化モデルの評価方法、並びに心臓線維化モデルの評価システム |
CN110506109B (zh) * | 2017-06-05 | 2024-03-12 | 泰尔茂株式会社 | 细胞培养物的制造方法 |
WO2020009188A1 (ja) * | 2018-07-06 | 2020-01-09 | 株式会社マイオリッジ | 細胞シートの製造方法、心筋細胞シート、および心筋細胞シート製造用キット |
US20220389355A1 (en) * | 2019-11-21 | 2022-12-08 | The Japan Wool Textile Co., Ltd. | Cell aggregate, producing method for manufacturing cell aggregate, producing kit for cell aggregate, and chemical compound evaluating method using cell aggregate |
KR102188256B1 (ko) * | 2019-12-02 | 2020-12-08 | 주식회사 티앤알바이오팹 | 동결보관 및 저산소 조건에서의 생존율을 향상시키는 심근세포 응집체 제작 기술 |
EP4183867A1 (en) | 2020-07-14 | 2023-05-24 | Kaneka Corporation | Method for producing cardiomyocyte cell mass |
CN112657051B (zh) * | 2020-12-25 | 2023-08-04 | 上海交通大学医学院附属上海儿童医学中心 | 一种基于共轭同轴静电纺丝技术的生物型心室辅助泵及其制备方法 |
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US20050214938A1 (en) | 2004-03-26 | 2005-09-29 | Gold Joseph D | Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function |
US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
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CN101711277B (zh) | 2018-06-19 |
EP2172542B1 (en) | 2017-03-22 |
RU2467066C2 (ru) | 2012-11-20 |
US9109205B2 (en) | 2015-08-18 |
CA2690610A1 (en) | 2009-02-05 |
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WO2009017254A1 (ja) | 2009-02-05 |
KR20100040276A (ko) | 2010-04-19 |
CA2690610C (en) | 2023-03-28 |
IL203404A (en) | 2014-08-31 |
CN101711277A (zh) | 2010-05-19 |
AU2008283255A1 (en) | 2009-02-05 |
JP5523830B2 (ja) | 2014-06-18 |
KR101582483B1 (ko) | 2016-01-06 |
US10918671B2 (en) | 2021-02-16 |
RU2010101091A (ru) | 2011-07-20 |
AU2008283255B2 (en) | 2013-07-04 |
BRPI0813729B8 (pt) | 2022-09-27 |
EP2172542A4 (en) | 2011-12-21 |
EP2172542A1 (en) | 2010-04-07 |
BRPI0813729B1 (pt) | 2019-04-02 |
US20150366918A1 (en) | 2015-12-24 |
US20100189699A1 (en) | 2010-07-29 |
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