BRPI0810530A2 - Selante tecidual polimérico - Google Patents
Selante tecidual poliméricoInfo
- Publication number
- BRPI0810530A2 BRPI0810530A2 BRPI0810530-8A2A BRPI0810530A BRPI0810530A2 BR PI0810530 A2 BRPI0810530 A2 BR PI0810530A2 BR PI0810530 A BRPI0810530 A BR PI0810530A BR PI0810530 A2 BRPI0810530 A2 BR PI0810530A2
- Authority
- BR
- Brazil
- Prior art keywords
- biomaterials
- precursor molecule
- tissue sealant
- polymeric tissue
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
- C08G65/33306—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3342—Polymers modified by chemical after-treatment with organic compounds containing sulfur having sulfur bound to carbon and hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials For Medical Uses (AREA)
- Polyethers (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Surgical Instruments (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Details Of Garments (AREA)
- Laminated Bodies (AREA)
- Sealing Material Composition (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91173707P | 2007-04-13 | 2007-04-13 | |
PCT/EP2008/054487 WO2008125655A1 (en) | 2007-04-13 | 2008-04-14 | Polymeric tissue sealant |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0810530A2 true BRPI0810530A2 (pt) | 2014-10-07 |
BRPI0810530B1 BRPI0810530B1 (pt) | 2018-07-17 |
BRPI0810530B8 BRPI0810530B8 (pt) | 2021-06-22 |
Family
ID=39671705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0810530A BRPI0810530B8 (pt) | 2007-04-13 | 2008-04-14 | composição, uso da mesma, biomaterial sintético, seu método de fabricação e kit para formar o mesmo |
Country Status (14)
Country | Link |
---|---|
US (2) | US8961947B2 (pt) |
EP (2) | EP2136850B1 (pt) |
JP (2) | JP2010523243A (pt) |
CN (1) | CN101711168B (pt) |
AT (1) | ATE543520T1 (pt) |
BR (1) | BRPI0810530B8 (pt) |
CA (1) | CA2685807C (pt) |
DK (1) | DK2136850T3 (pt) |
ES (2) | ES2381639T3 (pt) |
MX (1) | MX2009011005A (pt) |
PL (1) | PL2136850T3 (pt) |
PT (1) | PT2136850E (pt) |
RU (1) | RU2453340C2 (pt) |
WO (1) | WO2008125655A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9211358B2 (en) * | 2007-04-24 | 2015-12-15 | Rutgers, The State University Of New Jersey | Dressing compositions and methods |
WO2011017123A2 (en) | 2009-07-27 | 2011-02-10 | Endologix, Inc. | Stent graft |
DK2459171T3 (en) | 2009-07-31 | 2017-09-25 | Sanofi Aventis Deutschland | Long-acting insulin composition |
RU2554854C9 (ru) | 2009-07-31 | 2017-02-03 | Асцендис Фарма Ас | Биоразлагаемые нерастворимые в воде гидрогели на основе полиэтиленгликоля |
EP2459228B1 (en) | 2009-07-31 | 2020-03-04 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an insulin linker conjugate |
EP2545100A2 (en) | 2010-03-09 | 2013-01-16 | Council of Scientific & Industrial Research | A biodegradable polymeric hydrogel composition |
CA2730598C (en) * | 2010-03-16 | 2018-03-13 | Confluent Surgical, Inc. | Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels |
US9119605B2 (en) | 2010-05-06 | 2015-09-01 | Zimmer, Inc. | Synthetic polymer adhesives and methods for making, using and delivering the same |
WO2011142821A1 (en) | 2010-05-12 | 2011-11-17 | St. Jude Medical, Inc. | Bioadhesive applicator and methods of sealing tissue punctures using same |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
US20140067082A1 (en) | 2012-09-06 | 2014-03-06 | Xinyin Liu | Bioresorbable ceramic composition for forming a three dimensional scaffold |
JP6271566B2 (ja) | 2012-10-11 | 2018-01-31 | アセンディス ファーマ エー/エス | ヒドロゲルプロドラッグ |
US10792044B2 (en) | 2013-03-13 | 2020-10-06 | Applied Cardiovascular Solutions, LLC | Methods, compositions, and devices for the occlusion of cavities and passageways |
JP6325821B2 (ja) * | 2014-01-08 | 2018-05-16 | 株式会社日本触媒 | 硫黄原子含有多分岐ポリアルキレングリコール系ブロック共重合体 |
EP3248622B1 (en) * | 2015-01-20 | 2020-08-19 | National Institute for Materials Science | Surgical sealant |
WO2017103914A1 (en) * | 2015-12-17 | 2017-06-22 | Regentis Biomaterials Ltd. | Ready for use organic solvent free compositions comprising protein-polymer conjugates and uses thereof |
WO2019099935A1 (en) * | 2017-11-16 | 2019-05-23 | Maculus Therapeutix Llc | Materials and methods for administration to nasal cavity |
US20210316046A1 (en) * | 2018-09-05 | 2021-10-14 | National Institute For Materials Science | Adhesion prevention material |
GB2579707A (en) | 2018-10-15 | 2020-07-01 | Avent Inc | Compositions, systems, kits, and methods for neural ablation |
Family Cites Families (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4008341A (en) | 1968-10-11 | 1977-02-15 | W. R. Grace & Co. | Curable liquid polymer compositions |
US3908039A (en) | 1973-10-25 | 1975-09-23 | Grace W R & Co | Photocurable polyene-polythiol lacquer composition |
US4086196A (en) | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
DE3433210C1 (de) | 1984-09-10 | 1986-06-05 | Hans Dr.med. Dr.med.dent. 8000 München Scheicher | Mittel zur Fuellung von Knochen- und Zahndefekten,zum Knochenaufbau,fuer Knochenkontaktschichten und fuer Knochen- und Zahnwurzelersatz und Verwendung von Carbonatapatit fuer diesen Zweck |
DE3543567A1 (de) | 1985-12-10 | 1987-06-11 | Degussa | Verfahren zur herstellung von sulfensaeurechloriden und sulfensaeureestern |
US4711903A (en) | 1986-01-31 | 1987-12-08 | G. D. Searle & Co. | Phenolic thioethers as inhibitors of 5-lipoxygenase |
JPH02500803A (ja) | 1987-07-07 | 1990-03-22 | サイトアールエックス バイオプール リミテッド | フィブリンに結合する化合物および方法 |
US5504001A (en) | 1987-11-25 | 1996-04-02 | Zymogenetics, Inc. | Hybrid plasminogen activator |
US4847325A (en) | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US5582862A (en) | 1988-04-04 | 1996-12-10 | General Hospital Corporation | Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin |
US5100668A (en) | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
US5137819A (en) | 1988-07-08 | 1992-08-11 | University Of British Columbia | Cellulose binding fusion proteins for immobilization and purification of polypeptides |
JP3338441B2 (ja) | 1988-11-09 | 2002-10-28 | プロテイン ポリマー テクノロジーズ,インコーポレイティド | 組換え的に調製された官能的な合成タンパク質ポリマー |
US5527856A (en) | 1988-11-21 | 1996-06-18 | Collagen Corporation | Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5550187A (en) | 1988-11-21 | 1996-08-27 | Collagen Corporation | Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
US5475052A (en) | 1988-11-21 | 1995-12-12 | Collagen Corporation | Collagen-synthetic polymer matrices prepared using a multiple step reaction |
US5247041A (en) | 1989-02-22 | 1993-09-21 | Toray Industries, Inc. | Thiol methacrylate or acrylate resin obtained by polymerizing a thiol methacrylate or acrylate compound |
US5171670A (en) | 1989-05-12 | 1992-12-15 | The General Hospital Corporation | Recombinant dna method for production of parathyroid hormone |
US5268305A (en) | 1989-06-15 | 1993-12-07 | Biocircuits Corporation | Multi-optical detection system |
US5330911A (en) | 1989-09-28 | 1994-07-19 | Board Of Regents, The University Of Texas System | Surfaces having desirable cell adhesive effects |
US5292362A (en) | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5169764A (en) | 1990-08-08 | 1992-12-08 | Regeneron Pharmaceuticals, Inc. | Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras |
US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
US5626863A (en) | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
DK0564502T3 (da) | 1990-11-27 | 2002-05-13 | Univ Loyola Chicago | Vævsforseglingsmiddel og vækstfaktorholdige præparater, der fremmer accelereret sårheling |
US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
SE9101853D0 (sv) | 1991-06-17 | 1991-06-17 | Jonas Wadstroem | Improved tissue ashesive |
SE470006B (sv) | 1991-09-26 | 1993-10-25 | Corline Systems Ab | Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet |
US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
AU673160B2 (en) | 1992-02-28 | 1996-10-31 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
US5292514A (en) | 1992-06-24 | 1994-03-08 | Minnesota Mining And Manufacturing Company | Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof |
US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
CA2103400C (en) | 1992-11-19 | 1998-08-25 | Andrew T. C. Liu | Abrasion resistant dental composition product and process |
AU675252B2 (en) | 1992-12-18 | 1997-01-30 | Tremco, Inc. | Fast-curing, high strength, two-part sealants using acetoacetate-amine cure chemistry |
US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
ES2219646T5 (es) | 1993-02-22 | 2008-11-01 | Abraxis Bioscience, Inc. | Metodos para la administracion in vivo de compuestos biologicos y composiciones utiles para los mismos. |
EP0696201B2 (en) | 1993-03-12 | 2012-09-19 | The American National Red Cross | Supplemented tissue sealants, methods of their production and use |
TW303299B (pt) | 1993-07-22 | 1997-04-21 | Lilly Co Eli | |
US5428014A (en) | 1993-08-13 | 1995-06-27 | Zymogenetics, Inc. | Transglutaminase cross-linkable polypeptides and methods relating thereto |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5773577A (en) | 1994-03-03 | 1998-06-30 | Protein Polymer Technologies | Products comprising substrates capable of enzymatic cross-linking |
US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
CA2155762C (en) | 1994-08-23 | 2000-04-25 | Haruya Sato | Protein modification method |
JP4223548B2 (ja) | 1994-12-07 | 2009-02-12 | ジ・アメリカン・ナショナル・レッド・クロス | 補足または非補足組織シーラント、それらの製法および使用 |
US5747456A (en) | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5693341A (en) | 1995-03-16 | 1997-12-02 | Collagen Corporation | Affinity bound collagen matrices for the delivery of biologically active agents |
US5561982A (en) | 1995-05-02 | 1996-10-08 | Universal Vortex, Inc. | Method for energy separation and utilization in a vortex tube which operates with pressure not exceeding atmospheric pressure |
DE19624148A1 (de) * | 1995-06-22 | 1997-01-02 | Henkel Kgaa | Masse zum Kleben, Dichten und Beschichten |
JP2000500019A (ja) | 1995-11-16 | 2000-01-11 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | ストレプトアビジン融合タンパク質経由でのペプチドの生産方法 |
US7026292B1 (en) | 1995-12-12 | 2006-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
PT876165E (pt) | 1995-12-18 | 2006-10-31 | Angiotech Biomaterials Corp | Composicoes de polimeros reticulados e processos para a sua utilizacao |
US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
US5874308A (en) | 1996-01-16 | 1999-02-23 | University Of British Columbia | Compositions and methods for modulating cell proliferation using growth factor-polysaccharide binding fusion proteins |
CN1215421A (zh) | 1996-04-05 | 1999-04-28 | 美国3M公司 | 可见光可聚合的组合物 |
US5914182A (en) | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
US5877153A (en) | 1996-06-11 | 1999-03-02 | Commonwealth Biotechnologies Inc. | Heparin-binding peptides |
AU4648697A (en) | 1996-09-23 | 1998-04-14 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
US7009034B2 (en) | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
EP0950665A4 (en) | 1996-09-26 | 2004-05-06 | Ajinomoto Kk | PHYSIOLOGICALLY ACTIVE MODIFIED PROTEINS AND DRUG COMPOSITIONS CONTAINING THEM |
US6258351B1 (en) | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
DE59807348D1 (de) | 1997-02-05 | 2003-04-10 | Rolic Ag Zug | Photovernetzbare Silanderivate |
DE19705963A1 (de) | 1997-02-17 | 1998-08-20 | Hoechst Ag | Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung |
WO1998043686A1 (en) | 1997-04-03 | 1998-10-08 | California Institute Of Technology | Enzyme-mediated modification of fibrin for tissue engineering |
HUP0100075A2 (hu) | 1997-12-18 | 2001-05-28 | Eli Lilly And Co. | Kristályos teriparatid |
US5958874A (en) | 1998-02-18 | 1999-09-28 | The Research Foundation Of State University Of New York | Recombinant fibronectin-based extracellular matrix for wound healing |
US6818018B1 (en) | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
AR033639A1 (es) | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
US6894022B1 (en) | 1998-08-27 | 2005-05-17 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
US7601685B2 (en) | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
US7241730B2 (en) | 1998-08-27 | 2007-07-10 | Universitat Zurich | Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides |
US6165486A (en) | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
AU2707500A (en) | 1998-12-04 | 2000-06-26 | Incept Llc | Biocompatible crosslinked polymers |
US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
MXPA01007777A (es) | 1999-02-01 | 2003-10-06 | Eidgenoess Tech Hochschule | Bio-materiales formadas por reaccion de adicion nucleofila a grupos insaturados conjugados. |
US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
EP1178834B1 (en) | 1999-04-22 | 2006-01-04 | Eidgenössische Technische Hochschule (ETH) | Controlled release of growth factors from heparin containing matrices |
US6639046B1 (en) | 1999-04-26 | 2003-10-28 | Akzo Nobel N.V. | Composition comprising mercapto-functional compounds |
KR100345214B1 (ko) | 1999-08-17 | 2002-07-25 | 이강춘 | 생체적합성 고분자가 수식된 펩타이드의 비점막 전달 |
EP2093245B1 (en) | 1999-08-27 | 2012-02-22 | AngioDevice International GmbH | Biocompatible polymer device |
CA2394653A1 (en) | 2000-01-05 | 2001-07-12 | Novartis Ag | Hydrogels |
US7758882B2 (en) | 2000-01-31 | 2010-07-20 | Indiana University Research And Technology Corporation | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
US7291673B2 (en) | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
WO2002055185A2 (en) | 2000-10-19 | 2002-07-18 | Eidgenoess Tech Hochschule | Block copolymers for multifunctional self-assembled systems |
DE60218814T2 (de) | 2001-01-03 | 2007-12-06 | Santa Fe Science and Technology, Inc., Santa Fe | Stabile, konjugiertes polymer enthaltende elektrochrome vorrichtungen mit ionischen flüssigkeiten |
WO2002074158A2 (en) * | 2001-03-20 | 2002-09-26 | Eidgenossische Technische Hochschule Zurich | Two-phase processing of thermosensitive polymers for use as biomaterials |
CA2367636C (en) | 2001-04-12 | 2010-05-04 | Lisa Mckerracher | Fusion proteins |
ATE420670T1 (de) | 2001-04-25 | 2009-01-15 | Eidgenoess Tech Hochschule | Arzneimittel freisetzende matrizen zur förderung der wundheilung |
CN1328319C (zh) | 2001-11-07 | 2007-07-25 | 苏黎世大学 | 用于控制细胞向内生长和组织再生的合成基质 |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
CA2470419A1 (en) | 2001-12-18 | 2003-06-26 | Eidgenossisch Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
EP1494730B1 (en) | 2002-03-22 | 2012-01-18 | Kuros Biosurgery AG | Composition for hard tissue augmentation |
US20040002770A1 (en) | 2002-06-28 | 2004-01-01 | King Richard S. | Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof |
US7208171B2 (en) | 2002-10-31 | 2007-04-24 | Northwestern University | Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation |
DE60331367D1 (de) * | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
US8013068B2 (en) | 2003-01-02 | 2011-09-06 | Rohm And Haas Company | Michael addition compositions |
ATE336270T1 (de) | 2003-02-13 | 2006-09-15 | Synthes Ag | Injizierbare knochenersatzmischung |
US7273896B2 (en) | 2003-04-10 | 2007-09-25 | Angiotech Pharmaceuticals (Us), Inc. | Compositions and methods of using a transient colorant |
CN1626549A (zh) * | 2003-12-11 | 2005-06-15 | 中国人民解放军军事医学科学院基础医学研究所 | 胸腺五肽的聚乙二醇化衍生物,含有它们的药物组合物及用途 |
EP1593728B1 (en) | 2004-05-03 | 2012-05-09 | Rohm And Haas Company | Michael addition compositions |
EP1593727B1 (en) | 2004-05-03 | 2008-08-06 | Rohm And Haas Company | Michael addition compositions |
WO2006067221A2 (en) | 2004-12-22 | 2006-06-29 | Kuros Biosurgery Ag | Michael-type addition reaction functionalised peg hydrogels with factor xiiia incorporated biofactors |
WO2006073711A2 (en) | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
WO2007019461A2 (en) | 2005-08-08 | 2007-02-15 | Angstrom Medica, Inc. | Cement products and methods of making and using the same |
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- 2008-04-14 JP JP2010502533A patent/JP2010523243A/ja active Pending
- 2008-04-14 WO PCT/EP2008/054487 patent/WO2008125655A1/en active Search and Examination
- 2008-04-14 EP EP12153260.0A patent/EP2537539B1/en active Active
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- 2008-04-14 RU RU2009141875/15A patent/RU2453340C2/ru active
- 2008-04-14 ES ES12153260T patent/ES2733276T3/es active Active
- 2008-04-14 PT PT08749553T patent/PT2136850E/pt unknown
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Also Published As
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BRPI0810530B8 (pt) | 2021-06-22 |
EP2537539B1 (en) | 2019-04-03 |
US8961947B2 (en) | 2015-02-24 |
JP2014176736A (ja) | 2014-09-25 |
RU2453340C2 (ru) | 2012-06-20 |
MX2009011005A (es) | 2009-11-02 |
US20080253987A1 (en) | 2008-10-16 |
JP5930336B2 (ja) | 2016-06-08 |
JP2010523243A (ja) | 2010-07-15 |
CA2685807C (en) | 2016-04-12 |
CA2685807A1 (en) | 2008-10-23 |
ATE543520T1 (de) | 2012-02-15 |
PL2136850T3 (pl) | 2012-07-31 |
PT2136850E (pt) | 2012-04-27 |
RU2009141875A (ru) | 2011-05-20 |
EP2136850B1 (en) | 2012-02-01 |
EP2136850A1 (en) | 2009-12-30 |
EP2537539A1 (en) | 2012-12-26 |
DK2136850T3 (da) | 2012-04-10 |
ES2381639T3 (es) | 2012-05-30 |
WO2008125655A1 (en) | 2008-10-23 |
US20150133579A1 (en) | 2015-05-14 |
CN101711168A (zh) | 2010-05-19 |
BRPI0810530B1 (pt) | 2018-07-17 |
CN101711168B (zh) | 2013-05-01 |
ES2733276T3 (es) | 2019-11-28 |
US9180222B2 (en) | 2015-11-10 |
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