HUP0100075A2 - Kristályos teriparatid - Google Patents

Kristályos teriparatid

Info

Publication number
HUP0100075A2
HUP0100075A2 HU0100075A HUP0100075A HUP0100075A2 HU P0100075 A2 HUP0100075 A2 HU P0100075A2 HU 0100075 A HU0100075 A HU 0100075A HU P0100075 A HUP0100075 A HU P0100075A HU P0100075 A2 HUP0100075 A2 HU P0100075A2
Authority
HU
Hungary
Prior art keywords
teriparatide
crystalline
pth
subject
production
Prior art date
Application number
HU0100075A
Other languages
English (en)
Inventor
Faming Zhang
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0100075A2 publication Critical patent/HUP0100075A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Abstract

A találmány tárgyát a paratiroid hormon tisztakristályos formája képezi, pontosabban a teriparatid, PTH (1-34),valamint ennek előállítási és tisztítási módszerei. Ó
HU0100075A 1997-12-18 1998-12-08 Kristályos teriparatid HUP0100075A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6987597P 1997-12-18 1997-12-18
PCT/US1998/026044 WO1999031137A1 (en) 1997-12-18 1998-12-08 Crystalline teriparatide

Publications (1)

Publication Number Publication Date
HUP0100075A2 true HUP0100075A2 (hu) 2001-05-28

Family

ID=22091750

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100075A HUP0100075A2 (hu) 1997-12-18 1998-12-08 Kristályos teriparatid

Country Status (24)

Country Link
US (1) US6590081B1 (hu)
EP (1) EP0926158B1 (hu)
JP (1) JP2002508395A (hu)
KR (1) KR20010033268A (hu)
CN (1) CN1281467A (hu)
AR (1) AR038648A1 (hu)
AT (1) ATE245165T1 (hu)
AU (1) AU748271B2 (hu)
BR (1) BR9813740A (hu)
CA (1) CA2315103A1 (hu)
DE (1) DE69816409T2 (hu)
DK (1) DK0926158T3 (hu)
EA (1) EA200000672A1 (hu)
ES (1) ES2202729T3 (hu)
HU (1) HUP0100075A2 (hu)
ID (1) ID25660A (hu)
IL (1) IL136824A0 (hu)
NO (1) NO20003131L (hu)
PE (1) PE20000056A1 (hu)
PL (1) PL341209A1 (hu)
PT (1) PT926158E (hu)
TR (1) TR200002179T2 (hu)
WO (1) WO1999031137A1 (hu)
ZA (1) ZA9811407B (hu)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
JP4560291B2 (ja) * 2001-12-18 2010-10-13 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 組織操作のための成長因子改変タンパク質マトリクス
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
EP1864681A1 (en) 2001-12-18 2007-12-12 Eidgenössische Technische Hochschule Zürich Growth factor modified protein matrices for tissue engineering
US7497855B2 (en) * 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
CA2512052C (en) 2002-12-31 2016-06-21 Altus Pharmaceuticals Inc. Human growth hormone crystals and methods for preparing them
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7429378B2 (en) * 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en) * 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
EP1750756A2 (en) * 2004-05-10 2007-02-14 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
US7691105B2 (en) 2005-09-26 2010-04-06 Depuy Spine, Inc. Tissue augmentation, stabilization and regeneration technique
US20070088436A1 (en) * 2005-09-29 2007-04-19 Matthew Parsons Methods and devices for stenting or tamping a fractured vertebral body
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
CA2628945A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20070168041A1 (en) * 2006-01-17 2007-07-19 Sudhakar Kadiyala Method and instruments for intervertebral disc augmentation through a pedicular approach
PL2136850T3 (pl) 2007-04-13 2012-07-31 Kuros Biosurgery Ag Polimeryczny uszczelniacz tkankowy
EP2173768B1 (en) * 2007-08-09 2014-03-05 USV Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
AR066166A1 (es) * 2007-09-21 2009-07-29 Organon Nv Sistema de suministro de droga
US8241363B2 (en) 2007-12-19 2012-08-14 Depuy Spine, Inc. Expandable corpectomy spinal fusion cage
US8241294B2 (en) 2007-12-19 2012-08-14 Depuy Spine, Inc. Instruments for expandable corpectomy spinal fusion cage
US8986696B2 (en) * 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
JP2012512812A (ja) 2007-12-28 2012-06-07 クロス・バイオサージェリー・アクチェンゲゼルシャフト フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質
US8876905B2 (en) 2009-04-29 2014-11-04 DePuy Synthes Products, LLC Minimally invasive corpectomy cage and instrument
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8865220B2 (en) 2010-06-14 2014-10-21 Kaohsiung Medical University Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
EP2686027B1 (en) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmaceutical formulation for use in spinal fusion
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
US10413504B2 (en) 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
US10596103B2 (en) 2013-12-11 2020-03-24 Merek Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
CN104910269B (zh) * 2015-06-02 2018-08-17 成都圣诺生物科技股份有限公司 一种合成特立帕肽的方法
JP6577683B2 (ja) * 2017-09-22 2019-09-18 旭化成ファーマ株式会社 安定性に優れるテリパラチド含有液状医薬組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62106000A (ja) 1985-10-30 1987-05-16 Fujitsu Ltd 生体高分子結晶自動作製装置
WO1989003873A1 (en) * 1987-10-20 1989-05-05 Holick Michael F Regulation of cell proliferation and differentiation using peptides
AU2764492A (en) 1991-10-09 1993-05-03 Schering Corporation Crystal forming device and automated crystallization system
US5400741A (en) * 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US5419278A (en) * 1994-05-25 1995-05-30 Carter; Daniel C. Vapor equilibration tray for growing protein crystals
CA2178894A1 (en) 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use

Also Published As

Publication number Publication date
ID25660A (id) 2000-10-19
DE69816409D1 (de) 2003-08-21
ATE245165T1 (de) 2003-08-15
KR20010033268A (ko) 2001-04-25
BR9813740A (pt) 2000-10-10
ZA9811407B (en) 2000-07-13
PE20000056A1 (es) 2000-02-08
ES2202729T3 (es) 2004-04-01
PL341209A1 (en) 2001-03-26
US6590081B1 (en) 2003-07-08
PT926158E (pt) 2003-11-28
AR038648A1 (es) 2005-01-26
AU1632699A (en) 1999-07-05
NO20003131D0 (no) 2000-06-16
EP0926158B1 (en) 2003-07-16
CA2315103A1 (en) 1999-06-24
WO1999031137A1 (en) 1999-06-24
DE69816409T2 (de) 2004-06-09
EP0926158A1 (en) 1999-06-30
EA200000672A1 (ru) 2000-12-25
JP2002508395A (ja) 2002-03-19
IL136824A0 (en) 2001-06-14
DK0926158T3 (da) 2003-11-10
AU748271B2 (en) 2002-05-30
CN1281467A (zh) 2001-01-24
NO20003131L (no) 2000-06-16
TR200002179T2 (tr) 2001-07-23

Similar Documents

Publication Publication Date Title
HUP0100075A2 (hu) Kristályos teriparatid
MXPA02004666A (es) Gelatinas recombinantes.
IL154122A0 (en) Crystalline and pure modafinil, and process of preparing the same
CY1112833T1 (el) Καινοφανης προσδετης της κυτοκινης ζcυτοr17
HUP0000527A2 (hu) Eljárás tolterodin előállítására és az intermedier
ATE244249T1 (de) Kristallinisches aminsalz von cefdinir
HUP9904596A1 (hu) Mellékpajzsmirigy-hormon analógok
ATE450619T1 (de) Defructosylierungsverfahren
HK1078588A1 (en) Process to prepare eplerenone
MY128843A (en) Transport stream to program stream conversion
EP0911856A3 (en) Getter system for plasma flat panels used as screens
WO2003102572A3 (en) Mass spectrometry
HUP0003399A2 (hu) Javított eljárás parazitaellenes anyag előállítására
PL339296A1 (en) Novel stereoselective methods of obtaining gabapwenting analoques
HRP20050415B1 (en) A process for the purification of 1,4-butanediol mononitrate
DK0975601T3 (da) Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor
DE69737457D1 (de) O-fukosyltransferase
DE59813625D1 (de) Metallhaltige ribonukleotidpolypeptide
WO2001019989A3 (en) Method of producing and purifying endostatintm protein
ATE179167T1 (de) Antivirale analoge von difluorostaton
EA200000705A1 (ru) Промежуточные соединения и способ синтеза 17-замещенных 16.бета.-арилокси 4-азастероидов
ATE81508T1 (de) Herstellung von corticoiden aus steroidischen 17- cyanohydrinen.
ATE295746T1 (de) Radioaktiv beschichtete stents
PL355009A1 (en) Novel benzenesulphonamide compounds, method of obtaining them and pharmacological compoistions containing such compounds
DK0925290T3 (da) Fremgangsmåde til selektiv alkylering af epoxy-alkoholer