BRPI0618850A2 - formulações de estabilização para vìrus recombinantes - Google Patents
formulações de estabilização para vìrus recombinantes Download PDFInfo
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- BRPI0618850A2 BRPI0618850A2 BRPI0618850-8A BRPI0618850A BRPI0618850A2 BR PI0618850 A2 BRPI0618850 A2 BR PI0618850A2 BR PI0618850 A BRPI0618850 A BR PI0618850A BR PI0618850 A2 BRPI0618850 A2 BR PI0618850A2
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24051—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59728005P | 2005-11-21 | 2005-11-21 | |
| US60/597,280 | 2005-11-21 | ||
| PCT/CA2006/001855 WO2007056847A1 (en) | 2005-11-21 | 2006-11-15 | Stabilizing formulations for recombinant viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0618850A2 true BRPI0618850A2 (pt) | 2011-09-13 |
Family
ID=38048241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0618850-8A BRPI0618850A2 (pt) | 2005-11-21 | 2006-11-15 | formulações de estabilização para vìrus recombinantes |
Country Status (11)
| Country | Link |
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| US (2) | US20090169581A1 (OSRAM) |
| EP (1) | EP1951865A4 (OSRAM) |
| JP (1) | JP5138601B2 (OSRAM) |
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| CN (2) | CN101360821A (OSRAM) |
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| CA (1) | CA2630349A1 (OSRAM) |
| IL (1) | IL191595A (OSRAM) |
| WO (1) | WO2007056847A1 (OSRAM) |
| ZA (1) | ZA200804356B (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2615390T3 (es) | 2008-03-05 | 2017-06-06 | Sanofi Pasteur | Proceso para estabilizar una composición de vacuna que contiene adyuvante |
| EP2143440A1 (fr) * | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| CN101407788B (zh) * | 2008-11-26 | 2012-01-11 | 中国兽医药品监察所 | 一种促进狂犬病病毒增殖的方法 |
| CA2785926A1 (en) * | 2009-12-31 | 2011-07-07 | Mannkind Corporation | Injectable formulations for parenteral administration |
| EP3409289B1 (en) | 2010-02-26 | 2020-09-30 | Novo Nordisk A/S | Stable antibody containing compositions |
| RS59830B1 (sr) | 2010-03-01 | 2020-02-28 | Bayer Healthcare Llc | Optimizovana monoklonska antitela protiv inhibitora puta faktora tkiva (tfpi) |
| GB2499480A (en) | 2010-03-31 | 2013-08-21 | Stabilitech Ltd | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| JP5960120B2 (ja) | 2010-03-31 | 2016-08-02 | スタビリテック リミテッド | ウイルス粒子の安定化 |
| JP5869553B2 (ja) | 2010-03-31 | 2016-02-24 | スタビリテック リミテッド | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
| RU2012153786A (ru) | 2010-05-28 | 2014-07-10 | Ново Нордиск А/С | Стабильные многодозовые композиции, содержащие антитело и консервант |
| FR2960781B1 (fr) * | 2010-06-07 | 2013-11-22 | Sanofi Pasteur | Preparation d'un vaccin oral sec stabilise, compose d'un virus vivant attenue |
| GB201016471D0 (en) * | 2010-09-30 | 2010-11-17 | Isis Innovation | Viral vector immunogenic compositions |
| MX346784B (es) | 2010-11-12 | 2017-03-31 | Inovio Pharmaceuticals Inc | Antigenos prostaticos de consenso, molecula de acido nucleico que los codifica y vacuna y usos que los comprenden. |
| CN103619349A (zh) * | 2011-05-26 | 2014-03-05 | 葛兰素史密丝克莱恩生物有限公司 | 灭活登革热病毒疫苗 |
| US11060068B2 (en) | 2011-06-28 | 2021-07-13 | Leukocare Ag | Stabilisation method for viruses or bacteria |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| MY168959A (en) * | 2012-07-24 | 2019-01-28 | Sanofi Pasteur | Vaccine compositions for the prevention of dengue virus infection |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| TWI690322B (zh) * | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| US9480739B2 (en) * | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
| WO2015038755A1 (en) * | 2013-09-13 | 2015-03-19 | Wake Forest University Health Sciences | Methods and compositions for treatment of chlamydial infection and related diseases and disorders |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
| EP3087188A1 (en) | 2013-12-23 | 2016-11-02 | Theravectys | Lyophilized lentiviral vector particles, compositions and methods |
| AR099470A1 (es) * | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| TWI670085B (zh) | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| US10183068B2 (en) | 2014-05-16 | 2019-01-22 | Stc.Unm | Vaccination compositions, methods of making, and methods of use |
| EP3552615B8 (en) | 2014-07-16 | 2022-03-02 | Transgene | Oncolytic virus for expression of immune checkpoint modulators |
| TWI852899B (zh) | 2014-09-02 | 2024-08-21 | 法商賽諾菲巴斯德公司 | 疫苗組合物 |
| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| MX2017012389A (es) * | 2015-03-27 | 2018-09-19 | Cadila Healthcare Ltd | Vacuna del virus de la parotiditis recombinante jeryl lynn2. |
| US10857222B2 (en) | 2015-07-03 | 2020-12-08 | Sanofi Pasteur | Concomitant dengue and yellow fever vaccination |
| EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
| TW201825674A (zh) | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | 表現雙特異性接合分子的溶瘤病毒 |
| US11166915B2 (en) | 2016-09-16 | 2021-11-09 | Leukocare Ag | Method for obtaining efficient viral vector-based compositions for vaccination or gene therapy |
| EP3512496B1 (en) * | 2016-09-16 | 2025-07-30 | Leukocare Ag | A novel method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| EP3562946B1 (en) | 2016-12-28 | 2021-11-24 | Transgene SA | Oncolytic viruses and therapeutic molecules |
| WO2018152237A1 (en) | 2017-02-14 | 2018-08-23 | Inventprise, Llc | Heat stable liquid rotavirus vaccine |
| US11110163B2 (en) | 2017-02-14 | 2021-09-07 | Inventprise, Llc | Heat stable vaccines |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| JP7334124B2 (ja) | 2017-06-21 | 2023-08-28 | トランジェーヌ | 個別化ワクチン |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| AU2018346724B2 (en) | 2017-10-05 | 2025-01-09 | Sanofi Pasteur | Compositions for booster vaccination against dengue |
| WO2019170820A1 (en) | 2018-03-07 | 2019-09-12 | Transgene | Parapoxvirus vectors |
| CN112041434A (zh) | 2018-04-27 | 2020-12-04 | 克里斯托生物技术股份有限公司 | 用于美容性应用的编码一种或多种美容蛋白的重组核酸 |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| EP3847246A1 (en) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| EP3875119A4 (en) | 2018-10-30 | 2022-08-31 | The University of Tokyo | ONCOLYTIC VIRUS FOR CANCER THERAPY |
| AU2019393877A1 (en) * | 2018-12-05 | 2021-06-17 | Seres Therapeutics, Inc. | Compositions for stabilizing bacteria and uses thereof |
| CN113453712A (zh) | 2018-12-28 | 2021-09-28 | 特兰斯吉恩股份有限公司 | M2缺陷型痘病毒 |
| WO2020136232A1 (en) | 2018-12-28 | 2020-07-02 | Transgene Sa | Immunosuppressive m2 protein |
| JP7810554B2 (ja) | 2019-03-01 | 2026-02-03 | アケロイス バイオファーマ， インコーポレイテッド | 抗原特異的免疫細胞におけるｃｄ１６０機能をモジュレートする方法およびその使用 |
| WO2021180943A1 (en) | 2020-03-12 | 2021-09-16 | Bavarian Nordic A/S | Compositions improving poxvirus stability |
| CN117664682A (zh) * | 2020-06-15 | 2024-03-08 | 深圳市瑞赛生物技术有限公司 | 即用型维生素标准品及其制备方法、使用方法和贮存稳定剂 |
| CN116322740A (zh) | 2020-07-13 | 2023-06-23 | 特兰斯吉恩股份有限公司 | 免疫抑制的治疗 |
| CN114617972B (zh) * | 2020-12-11 | 2023-12-01 | 康希诺生物股份公司 | 一种药物组合物及其应用 |
| WO2023025899A2 (en) | 2021-08-26 | 2023-03-02 | Transgene | Delivery system for targeting genes of the interferon pathway |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| AU2023300419A1 (en) | 2022-07-01 | 2025-01-02 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
| WO2024038175A1 (en) | 2022-08-18 | 2024-02-22 | Transgene | Chimeric poxviruses |
| WO2026041811A1 (en) | 2024-08-23 | 2026-02-26 | Transgene | Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3429965A (en) * | 1966-08-01 | 1969-02-25 | Sterling Drug Inc | Avian pox virus vaccine and process of preparing same |
| FR2505657A1 (fr) * | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| JPS60193925A (ja) * | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| FR2633518B1 (fr) * | 1988-06-30 | 1991-03-22 | Merieux Inst | Procede de stabilisation des vaccins et associations de vaccins a virus attenues conserves sous forme lyophilisee, et compositions obtenues |
| EP0872249A4 (en) * | 1995-03-17 | 2001-10-24 | Hisamitsu Pharmaceutical Co | GENE TRANSFER PREPARATION |
| US6616931B1 (en) * | 1996-09-26 | 2003-09-09 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| ES2323991T3 (es) * | 1998-11-16 | 2009-07-28 | Introgen Therapeutics, Inc. | Formulacion de adenovirus para terapia genica. |
| US6689600B1 (en) * | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| US6225289B1 (en) * | 1998-12-10 | 2001-05-01 | Genvec, Inc. | Methods and compositions for preserving adenoviral vectors |
| FR2814957B1 (fr) * | 2000-10-06 | 2002-12-20 | Aventis Pasteur | Composition vaccinale et procede de stabilisation |
| ATE467680T1 (de) * | 2001-10-11 | 2010-05-15 | Merck Sharp & Dohme | Hepatitis-c-virus-impfstoff |
| ATE300954T1 (de) * | 2001-12-10 | 2005-08-15 | Bavarian Nordic As | Poxvirus-enthaltende zusammensetzungen und verfahren zu ihrer herstellung |
| WO2005066333A1 (en) * | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
| US10446282B2 (en) * | 2011-12-23 | 2019-10-15 | Ge-Hitachi Nuclear Energy Americas Llc | Methods, systems, and computer program products for generating fast neutron spectra |
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2006
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- 2006-11-15 BR BRPI0618850-8A patent/BRPI0618850A2/pt active Search and Examination
- 2006-11-15 CN CNA2006800512997A patent/CN101360821A/zh active Pending
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- 2006-11-15 EP EP06804724A patent/EP1951865A4/en not_active Withdrawn
- 2006-11-15 WO PCT/CA2006/001855 patent/WO2007056847A1/en not_active Ceased
- 2006-11-15 CA CA002630349A patent/CA2630349A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2007056847A1 (en) | 2007-05-24 |
| ZA200804356B (en) | 2009-11-25 |
| AU2006315026B2 (en) | 2012-11-22 |
| EP1951865A4 (en) | 2010-06-23 |
| AU2006315026A1 (en) | 2007-05-24 |
| EP1951865A1 (en) | 2008-08-06 |
| JP2009516519A (ja) | 2009-04-23 |
| IL191595A0 (en) | 2008-12-29 |
| IL191595A (en) | 2012-05-31 |
| US20150265688A1 (en) | 2015-09-24 |
| KR101357685B1 (ko) | 2014-02-06 |
| CA2630349A1 (en) | 2007-05-24 |
| JP5138601B2 (ja) | 2013-02-06 |
| US20090169581A1 (en) | 2009-07-02 |
| CN104984352A (zh) | 2015-10-21 |
| KR20080070866A (ko) | 2008-07-31 |
| CN101360821A (zh) | 2009-02-04 |
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Free format text: REF. A RPI NO 2150 DE 20/03/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO. |
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