BRPI0608340A2 - método, dispositivo e sistema para a enumeração volumétrica de células sangüìneas brancas - Google Patents

método, dispositivo e sistema para a enumeração volumétrica de células sangüìneas brancas

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Publication number
BRPI0608340A2
BRPI0608340A2 BRPI0608340-4A BRPI0608340A BRPI0608340A2 BR PI0608340 A2 BRPI0608340 A2 BR PI0608340A2 BR PI0608340 A BRPI0608340 A BR PI0608340A BR PI0608340 A2 BRPI0608340 A2 BR PI0608340A2
Authority
BR
Brazil
Prior art keywords
blood cells
white blood
sampling device
blood sample
volumetric
Prior art date
Application number
BRPI0608340-4A
Other languages
English (en)
Inventor
Stellan Lindberg
Johnny Svensson
Original Assignee
Hemocue Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemocue Ab filed Critical Hemocue Ab
Publication of BRPI0608340A2 publication Critical patent/BRPI0608340A2/pt
Publication of BRPI0608340B1 publication Critical patent/BRPI0608340B1/pt
Publication of BRPI0608340B8 publication Critical patent/BRPI0608340B8/pt

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04Investigating sedimentation of particle suspensions
    • G01N15/05Investigating sedimentation of particle suspensions in blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/150007Details
    • A61B5/150015Source of blood
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    • AHUMAN NECESSITIES
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    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
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    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
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    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150099Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229Pumps for assisting the blood sampling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/150007Details
    • A61B5/150343Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • GPHYSICS
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
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    • A61B5/157Devices characterised by integrated means for measuring characteristics of blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0325Cells for testing reactions, e.g. containing reagents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/11Filling or emptying of cuvettes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666Particle count or volume standard or control [e.g., platelet count standards, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497Preparation composition [e.g., lysing or precipitation, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

MéTODO, DISPOSITIVO E SISTEMA PARA A ENUMERAçãO VOLUMéTRICA DE CéLULAS SANGUìNEAS BRANCAS. A presente invenção refere-se a um dispositivo de obtenção de amostras para enumeração volumétrica de células sangúíneas brancas em uma amostra de sangue que compreende uma cavidade de medição para receber uma amostra de sangue. A cavidade de medição tem uma espessura fixa predeterminada. O dispositivo de obtenção de amostras compreende, ainda, um reagente, que está disposto em uma forma seca sobre uma superfície que define a cavidade de medição. O reagente compreende um agente de hemólise para lisar células sangúíneas vermelhas na amostra de sangue. Um sistema compreende o dispositivo de obtenção de amostras e um aparelho de medição. O aparelho de medição compreende um suporte de dispositivo de obtenção de amostras, uma fonte de luz e um sistema de formação de imagens para obter uma imagem digital de uma ampliação da amostra. O aparelho de medição compreende, ainda, um analisador de imagens, previsto para analisar a imagem digital obtida para determinar o número de células sangúineas brancas na amostra de sangue.
BRPI0608340A 2005-03-11 2006-03-10 dispositvo de obtenção de amostras, método e sistema para a enumeração volumétrica de células sanguíneas brancas BRPI0608340B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0500549A SE528697C2 (sv) 2005-03-11 2005-03-11 Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov
SE05005491 2005-03-11
PCT/SE2006/000311 WO2006096126A1 (en) 2005-03-11 2006-03-10 A method, device and system for volumetric enumeration of white blood cells.

Publications (3)

Publication Number Publication Date
BRPI0608340A2 true BRPI0608340A2 (pt) 2009-12-01
BRPI0608340B1 BRPI0608340B1 (pt) 2019-04-02
BRPI0608340B8 BRPI0608340B8 (pt) 2021-07-27

Family

ID=36538562

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Application Number Title Priority Date Filing Date
BRPI0608340A BRPI0608340B8 (pt) 2005-03-11 2006-03-10 dispositvo de obtenção de amostras, método e sistema para a enumeração volumétrica de células sanguíneas brancas

Country Status (19)

Country Link
US (2) US7521243B2 (pt)
EP (1) EP1701150B1 (pt)
JP (1) JP4642893B2 (pt)
KR (1) KR101244234B1 (pt)
CN (1) CN101137904B (pt)
AU (1) AU2006221130B2 (pt)
BR (1) BRPI0608340B8 (pt)
CA (1) CA2599747C (pt)
DK (1) DK1701150T3 (pt)
LT (1) LT1701150T (pt)
MX (1) MX2007011104A (pt)
MY (1) MY143768A (pt)
NO (1) NO340137B1 (pt)
PL (1) PL1701150T3 (pt)
PT (1) PT1701150T (pt)
RU (1) RU2365919C2 (pt)
SE (1) SE528697C2 (pt)
WO (1) WO2006096126A1 (pt)
ZA (1) ZA200707425B (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3270156A1 (en) 2004-04-07 2018-01-17 Abbott Laboratories Disposable chamber for analyzing biologic fluids
SE528697C2 (sv) * 2005-03-11 2007-01-30 Hemocue Ab Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov
US7796797B2 (en) * 2005-09-28 2010-09-14 Sysmex Corporation Apparatus for obtaining an image of a blood cell and method for obtaining an image of a blood cell
US7731901B2 (en) 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
SE531041C2 (sv) * 2006-07-17 2008-11-25 Hemocue Ab Räkning av trombocyter
SE530192C2 (sv) 2006-07-19 2008-03-25 Hemocue Ab Apparat för avbildning av prov där provhållaren är flyttbar medelst magnetisk växelverkan
SE530750C2 (sv) * 2006-07-19 2008-09-02 Hemocue Ab En mätapparat, en metod och ett datorprogram
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
AP2937A (en) 2007-04-20 2014-07-31 Gen Hospital Corp Method for counting cells
SE532499C2 (sv) * 2008-01-18 2010-02-09 Hemocue Ab Metod och apparat för analys av partiklar i ett vätskeformigt prov
US8114580B2 (en) * 2009-01-13 2012-02-14 Bio-Rad Laboratories, Inc. Simulation of normal fresh blood platelets for reference control
WO2011075667A2 (en) 2009-12-18 2011-06-23 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
SE535918C2 (sv) * 2010-06-10 2013-02-19 Hemocue Ab Detektion av magnetiskt inmärkta biologiska komponenter
JP5058320B2 (ja) * 2010-09-16 2012-10-24 シスメックス株式会社 血液撮像装置および血液撮像方法
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
US9873118B2 (en) 2010-12-30 2018-01-23 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
CN103890590B (zh) 2011-08-24 2016-03-09 艾博特健康公司 生物流体样品分析盒
WO2013041951A1 (en) * 2011-09-22 2013-03-28 Foce Technology International Bv Optical platelet counter method
EP3441142A1 (en) 2011-11-16 2019-02-13 Becton, Dickinson and Company Methods and systems for detecting an analyte in a sample
JP5918988B2 (ja) * 2011-12-14 2016-05-18 公益財団法人ヒューマンサイエンス振興財団 染色キット及び染色方法
EP2911791A4 (en) 2012-10-29 2016-11-02 Mbio Diagnostics Inc SYSTEM FOR IDENTIFYING BIOLOGICAL PARTICLES, CARTRIDGE AND ASSOCIATED METHODS
EP2917719B1 (en) * 2012-11-09 2024-04-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Receptacle and system for optically analyzing a sample without optical lenses
CN104755925B (zh) 2013-01-11 2017-06-23 贝克顿·迪金森公司 低成本的定点照护测定装置
IL227276A0 (en) * 2013-07-01 2014-03-06 Parasight Ltd A method and system for obtaining a monolayer of cells, for use specifically for diagnosis
EP3066190B1 (en) 2013-11-06 2020-12-30 Becton, Dickinson and Company Microfluidic devices, and methods of using the same
CN105899936B (zh) 2013-11-13 2019-12-24 贝克顿·迪金森公司 光学成像系统及使用其的方法
US10706260B2 (en) 2014-06-16 2020-07-07 Siemens Healthcare Diagnostics Inc. Analyzing digital holographic microscopy data for hematology applications
US10614287B2 (en) 2014-06-16 2020-04-07 Siemens Healthcare Diagnostics Inc. Virtual staining of cells in digital holographic microscopy images using general adversarial networks
CA3044748C (en) 2014-10-14 2021-10-26 Becton, Dickinson And Company Blood sample management using open cell foam
EP3094252B1 (en) 2014-10-14 2021-08-25 Becton, Dickinson and Company Blood sample management using open cell foam
MX2017002125A (es) 2015-03-10 2017-05-12 Becton Dickinson Co Dispositivo de gestion de micromuestras de fluido biologico.
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
WO2016200922A1 (en) 2015-06-12 2016-12-15 Cytochip Inc. Fluidic units and cartridges for multi-analyte analysis
EP3322968B1 (en) 2015-07-14 2024-02-21 Cytochip Inc. Volume sensing in a fluidic cartridge
CA3109854C (en) 2015-09-01 2023-07-25 Becton, Dickinson And Company Depth filtration device for separating specimen phases
CN105728069B (zh) * 2016-01-30 2021-01-19 深圳市安测健康信息技术有限公司 用于快速自检血液的多通道微流控芯片
CN107058455B (zh) * 2016-08-10 2021-09-17 黑龙江省农业科学院畜牧研究所 猪2细胞胚胎体积的测量方法
FR3060746B1 (fr) * 2016-12-21 2019-05-24 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede de numeration de particules dans un echantillon par imagerie sans lentille
WO2019035079A1 (en) 2017-08-17 2019-02-21 Abbott Point Of Care Inc. DEVICES, SYSTEMS AND METHODS FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS
CN111164412A (zh) * 2017-08-17 2020-05-15 雅培医护站股份有限公司 对血细胞成像的方法
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
CN107817259B (zh) * 2017-10-30 2020-05-08 中国水产科学研究院黄海水产研究所 一种海水蚶科贝类血细胞采集和超微结构观察的方法
US11327084B2 (en) 2019-09-19 2022-05-10 Invidx Corp. Joint hematology and biochemistry point-of-care testing system
US11161109B2 (en) 2019-09-19 2021-11-02 Invidx Corp. Point-of-care testing cartridge with sliding cap
EP3842782B1 (en) * 2019-12-27 2024-06-26 Beckman Coulter, Inc. Sample preparation instrument
GB2616840A (en) * 2022-03-18 2023-09-27 Entia Ltd A cuvette for analysing biological samples
CN114813522B (zh) * 2022-06-29 2022-10-21 深圳安侣医学科技有限公司 基于显微放大数字图像的血液细胞分析方法及系统
CN116046647B (zh) * 2023-01-28 2023-06-09 深圳安侣医学科技有限公司 血液成像分析系统和方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906120A (en) * 1970-10-30 1975-09-16 Gen Electric Method for preparing slides for blood evaluation
US3824393A (en) * 1971-08-25 1974-07-16 American Express Invest System for differential particle counting
SE399768B (sv) * 1975-09-29 1978-02-27 Lilja Jan E Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet
US4156570A (en) * 1977-04-18 1979-05-29 Robert A. Levine Apparatus and method for measuring white blood cell and platelet concentrations in blood
US4581223A (en) * 1980-03-12 1986-04-08 Lawrence Kass Individual leukocyte determination by means of differential metachromatic dye sorption
US4420558A (en) * 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
FR2555754A1 (fr) 1983-11-28 1985-05-31 Inter Inf Procede et dispositif d'analyse automatique d'echantillons biologiques
US5188935A (en) * 1984-05-31 1993-02-23 Coulter Electronics, Inc. Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
US5262302A (en) * 1987-03-13 1993-11-16 Coulter Corporation Method for screening white blood cells
US4950455A (en) 1987-12-22 1990-08-21 Board Of Regents, University Of Texas System Apparatus for quantifying components in liquid samples
US5472671A (en) * 1989-04-26 1995-12-05 Nilsson; Sven-Erik Cuvette
US5585246A (en) * 1993-02-17 1996-12-17 Biometric Imaging, Inc. Method for preparing a sample in a scan capillary for immunofluorescent interrogation
AU6235994A (en) * 1993-02-25 1994-09-14 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
SE504193C2 (sv) * 1995-04-21 1996-12-02 Hemocue Ab Kapillär mikrokyvett
AU6542196A (en) 1995-06-30 1997-02-05 Biometric Imaging, Inc. Volumetric cell quantification method and system
ATE514072T1 (de) * 1997-05-05 2011-07-15 Chemometec As Verfahren zur bestimmung von teilchen in einer flüssigen probe
US5874310A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of nucleated red blood cells
SE9800070D0 (sv) * 1998-01-14 1998-01-14 Hemocue Ab Blandningsmetod
US5948686A (en) * 1998-03-07 1999-09-07 Robert A. Leuine Method for performing blood cell counts
US6350613B1 (en) 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts
US6828429B1 (en) * 1999-03-26 2004-12-07 Henry M. Jackson Foundation For The Advancement Of Military Medicine Prostate-specific gene, PCGEM1, and the methods of using PCGEM1 to detect, treat, and prevent prostate cancer
WO2000065329A1 (en) * 1999-04-23 2000-11-02 Surromed, Inc. Disposable optical cuvette cartridge
KR20020021810A (ko) * 1999-08-11 2002-03-22 야마모토 카즈모토 분석용 카트리지 및 송액 제어 장치
JP2001349825A (ja) * 2000-06-06 2001-12-21 Kowa Co キュベット・スタンド及びキュベット付きスタンド
JP2002148261A (ja) 2000-11-09 2002-05-22 Sysmex Corp 異常細胞分類計数方法
WO2002057997A1 (en) 2001-01-18 2002-07-25 Cellavision Ab Method and arrangement for segmenting white blood cells in a digital colour image
US20030133119A1 (en) * 2002-01-17 2003-07-17 Bachur Nicholas R. Rapid imaging of particles in a large fluid volume through flow cell imaging
CA2474509C (en) * 2002-02-14 2012-01-31 Immunivest Corporation Methods and algorithms for cell enumeration in a low-cost cytometer
WO2003104771A1 (en) 2002-06-01 2003-12-18 Chempaq A/S Lysing reagent, cartridge and automatic electronic cell counter for simultaneous enumeration of different types of white blood cells
ATE425456T1 (de) 2002-06-24 2009-03-15 Sysmex Corp Verfahren zur klassifizierung und zählung von leukozyten
EP1651947B1 (en) 2003-07-19 2015-11-04 NanoEnTek, Inc. Device for counting micro particles
US7745219B2 (en) * 2003-07-21 2010-06-29 Siemens Healthcare Diagnostics Inc. Reagent composition for the analysis of residual white blood cells in leuko-reduced blood banking products
SE528697C2 (sv) * 2005-03-11 2007-01-30 Hemocue Ab Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov
US7067365B1 (en) * 2005-05-26 2006-06-27 United Microelectronics Corp. High-voltage metal-oxide-semiconductor devices and method of making the same
SE531233C2 (sv) * 2006-03-28 2009-01-27 Hemocue Ab Anordning och förfarande för detektion av fluorecensmärkta biologiska komponenter
SE530750C2 (sv) * 2006-07-19 2008-09-02 Hemocue Ab En mätapparat, en metod och ett datorprogram

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US8092758B2 (en) 2012-01-10

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