BRPI0607671A2 - anticorpo monoclonal dirigido contra o peptìdeo beta-amilóide, cadeia pesada, cadeia leve e fragmento de anticorpo, composição farmacêutica e uso da mesma, bem como polinucleotédeios, vetor e célula hospedeira compreendendo estes - Google Patents

anticorpo monoclonal dirigido contra o peptìdeo beta-amilóide, cadeia pesada, cadeia leve e fragmento de anticorpo, composição farmacêutica e uso da mesma, bem como polinucleotédeios, vetor e célula hospedeira compreendendo estes

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Publication number
BRPI0607671A2
BRPI0607671A2 BRPI0607671-8A BRPI0607671A BRPI0607671A2 BR PI0607671 A2 BRPI0607671 A2 BR PI0607671A2 BR PI0607671 A BRPI0607671 A BR PI0607671A BR PI0607671 A2 BRPI0607671 A2 BR PI0607671A2
Authority
BR
Brazil
Prior art keywords
beta
pharmaceutical composition
well
directed against
polynucleotides
Prior art date
Application number
BRPI0607671-8A
Other languages
English (en)
Inventor
Arnon Rosenthal
Jaume Pons
Wei-Hsien Ho
Original Assignee
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37308500&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0607671(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rinat Neuroscience Corp filed Critical Rinat Neuroscience Corp
Publication of BRPI0607671A2 publication Critical patent/BRPI0607671A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ANTICORPO MONOCLONAL DIRIGIDO CONTRA O PEPTIDEO BETA-AMILóIDE, CADEIA PESADA, CADEIA LEVE E FRAGMENTO DE ANTICORPO, COMPOSIçãO FARMACêUTICA E USO DA MESMA, BEM COMO POLINUCLEOTéDEOS, VETOR E CéLULA HOSPEDEIRA COMPREENDENDO ESTES. A presente invenção refere-se a anticorpos dirigidos ao lado C-terminal do peptídeo <225>-amiíoide e métodos de uso desses anticorpos para diagnóstico e tratamento de mal de Alzheimer e doenças associadas ao peptídeo A<225>.
BRPI0607671-8A 2005-04-29 2006-04-28 anticorpo monoclonal dirigido contra o peptìdeo beta-amilóide, cadeia pesada, cadeia leve e fragmento de anticorpo, composição farmacêutica e uso da mesma, bem como polinucleotédeios, vetor e célula hospedeira compreendendo estes BRPI0607671A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67609305P 2005-04-29 2005-04-29
US70481805P 2005-08-01 2005-08-01
PCT/US2006/016071 WO2006118959A2 (en) 2005-04-29 2006-04-28 Antibodies directed against amyloid-beta peptide and methods using same

Publications (1)

Publication Number Publication Date
BRPI0607671A2 true BRPI0607671A2 (pt) 2009-09-22

Family

ID=37308500

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607671-8A BRPI0607671A2 (pt) 2005-04-29 2006-04-28 anticorpo monoclonal dirigido contra o peptìdeo beta-amilóide, cadeia pesada, cadeia leve e fragmento de anticorpo, composição farmacêutica e uso da mesma, bem como polinucleotédeios, vetor e célula hospedeira compreendendo estes

Country Status (30)

Country Link
US (4) US7763250B2 (pt)
EP (1) EP1877442B1 (pt)
JP (1) JP4280300B2 (pt)
KR (2) KR101130874B1 (pt)
CN (1) CN102617733B (pt)
AP (1) AP2007004217A0 (pt)
AR (1) AR053252A1 (pt)
AU (1) AU2006242546B2 (pt)
BR (1) BRPI0607671A2 (pt)
CA (1) CA2605759C (pt)
CR (1) CR9478A (pt)
DK (1) DK1877442T3 (pt)
DO (1) DOP2006000099A (pt)
EA (1) EA016193B9 (pt)
ES (1) ES2597403T3 (pt)
GE (1) GEP20125385B (pt)
GT (1) GT200600182A (pt)
HK (1) HK1117543A1 (pt)
IL (1) IL186671A (pt)
MA (1) MA29409B1 (pt)
MX (1) MX2007013626A (pt)
MY (1) MY148086A (pt)
NO (1) NO20076021L (pt)
NZ (1) NZ562589A (pt)
PE (1) PE20061323A1 (pt)
SV (1) SV2008002511A (pt)
TN (1) TNSN07401A1 (pt)
TW (1) TWI501975B (pt)
UY (1) UY29504A1 (pt)
WO (1) WO2006118959A2 (pt)

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KR20100120242A (ko) 2010-11-12
TWI501975B (zh) 2015-10-01
US8398978B2 (en) 2013-03-19
UY29504A1 (es) 2006-10-31
GEP20125385B (en) 2012-01-25
AR053252A1 (es) 2007-04-25
CN102617733B (zh) 2016-01-20
MX2007013626A (es) 2008-01-24
JP2008538925A (ja) 2008-11-13
AP2007004217A0 (en) 2007-10-31
CA2605759A1 (en) 2006-11-09
AU2006242546B2 (en) 2011-04-21
US20160096884A1 (en) 2016-04-07
US20130236451A1 (en) 2013-09-12
DOP2006000099A (es) 2006-10-31
NZ562589A (en) 2009-07-31
SV2008002511A (es) 2008-04-11
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MA29409B1 (fr) 2008-04-01
MY148086A (en) 2013-02-28
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US7763250B2 (en) 2010-07-27
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US20060292152A1 (en) 2006-12-28
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IL186671A (en) 2014-01-30
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