BRPI0513143A - antagonistas de vla-4 multivalentes compreendendo porções poliméricas - Google Patents
antagonistas de vla-4 multivalentes compreendendo porções poliméricasInfo
- Publication number
- BRPI0513143A BRPI0513143A BRPI0513143-0A BRPI0513143A BRPI0513143A BR PI0513143 A BRPI0513143 A BR PI0513143A BR PI0513143 A BRPI0513143 A BR PI0513143A BR PI0513143 A BRPI0513143 A BR PI0513143A
- Authority
- BR
- Brazil
- Prior art keywords
- vla
- conjugates
- multivalent
- antagonists
- inflammatory
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58697504P | 2004-07-08 | 2004-07-08 | |
PCT/US2005/024369 WO2006010054A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0513143A true BRPI0513143A (pt) | 2008-04-29 |
Family
ID=35501261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0513143-0A BRPI0513143A (pt) | 2004-07-08 | 2005-07-08 | antagonistas de vla-4 multivalentes compreendendo porções poliméricas |
Country Status (20)
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4754693B2 (ja) * | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4関連障害を処置するアシル誘導体 |
CA2554188A1 (en) * | 2004-01-23 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
EP2258400A3 (en) | 2004-07-08 | 2011-08-10 | Elan Pharmaceuticals, Inc. | Multivalent VLA-4 antagonists comprising polymer moieties |
AU2006251620B8 (en) * | 2005-05-20 | 2013-07-18 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as VLA-4 antagonists |
EP1901778A2 (en) * | 2005-07-08 | 2008-03-26 | Elan Pharmaceuticals Inc. | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
DK1940826T3 (da) * | 2005-09-29 | 2011-04-18 | Elan Pharm Inc | Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4 |
AU2006297180A1 (en) * | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US20090111828A1 (en) * | 2005-11-23 | 2009-04-30 | Astrazeneca Ab | L-alanine derivatives |
EA017110B1 (ru) * | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
HUE047230T2 (hu) * | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
EP1991267B1 (en) | 2006-03-03 | 2017-12-20 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
BRPI0712013A2 (pt) * | 2006-05-22 | 2011-12-27 | Elan Pharm Inc | preparaÇço de conjugados polimÉricos de compostos terapÊuticos, agrÍcolas e aditivos alimentares |
JP2009539815A (ja) * | 2006-06-09 | 2009-11-19 | アストラゼネカ アクチボラグ | 固形腫瘍の治療用のa5b1アンタゴニストとしてのN−(ベンゾイル)−O−[2−(ピリジン−2−イルアミノ)エチル]−L−チロシン誘導体と関連化合物 |
WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
WO2008153967A1 (en) * | 2007-06-08 | 2008-12-18 | Contec Therapeutics, Inc. | Bk1 antagonist conjugates |
US8269009B2 (en) * | 2007-12-07 | 2012-09-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
US8367836B2 (en) * | 2009-04-27 | 2013-02-05 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
US20120258093A1 (en) * | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
EP4152004A1 (en) | 2010-01-11 | 2023-03-22 | Biogen MA Inc. | Assay for jc virus antibodies |
US9561285B2 (en) * | 2010-01-22 | 2017-02-07 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
CN102883750A (zh) * | 2010-04-30 | 2013-01-16 | 伊兰药品公司 | 选择性整联蛋白抑制剂 |
WO2013019326A2 (en) | 2011-08-03 | 2013-02-07 | Henkel Corporation | Electrically conductive structural adhesive |
CA2902624C (en) | 2013-02-28 | 2021-05-18 | Takeda Pharmaceutical Company Limited | Method for producing sulfonyl chloride compound |
EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
WO2015003156A1 (en) * | 2013-07-05 | 2015-01-08 | Biogen Idec Ma Inc. | Compositions and methods for treatment of stroke |
CA2939512C (en) * | 2014-02-12 | 2023-02-28 | 7 Hills Interests, Llc | Compositions and methods to improve the homing and grafting of hematopoetic stem cells |
WO2017015544A1 (en) * | 2015-07-23 | 2017-01-26 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
CR20210213A (es) | 2018-10-30 | 2021-06-24 | Gilead Sciences Inc | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
WO2024054632A2 (en) * | 2022-09-08 | 2024-03-14 | Roswell ME Inc. | N-terminal multifunctional conjugation of proteins and peptides for biosensing |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5177059A (en) | 1989-11-15 | 1993-01-05 | Sandoz Ltd. | Polymyxin B conjugates |
DE4107857A1 (de) | 1991-03-12 | 1992-09-17 | Thomae Gmbh Dr K | Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
CA2101918A1 (en) | 1991-03-18 | 1992-09-19 | Samuel Zalipsky | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
JP2002512625A (ja) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
CA2291762A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
US6939855B2 (en) | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
AR016133A1 (es) * | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
US6489300B1 (en) | 1997-07-31 | 2002-12-03 | Eugene D. Thorsett | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 |
ATE399809T1 (de) | 1998-03-12 | 2008-07-15 | Nektar Therapeutics Al Corp | Verfahren zur herstellung von polymerkonjugaten |
GB9821061D0 (en) * | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
AU2623900A (en) | 1999-01-22 | 2000-08-07 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
JP4754693B2 (ja) | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4関連障害を処置するアシル誘導体 |
US6436904B1 (en) | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
CZ2002518A3 (cs) * | 1999-08-13 | 2002-05-15 | Biogen, Inc. | Inhibitory buněčné adheze a farmaceutické prostředky, které je obsahují |
EP1253923A1 (en) | 2000-01-28 | 2002-11-06 | Biogen, Inc. | Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses |
WO2002008202A2 (en) | 2000-07-21 | 2002-01-31 | Elan Pharmaceuticals, Inc. | Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by vla-4 |
US20040043030A1 (en) | 2001-07-31 | 2004-03-04 | Immunomedics, Inc. | Polymeric delivery systems |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
ES2197003B1 (es) | 2002-04-08 | 2005-03-16 | J. URIACH & CIA S.A. | Nuevos compuestos antagonistas de integrinas alfa. |
TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
TW200307671A (en) * | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
SK50642005A3 (sk) | 2003-01-24 | 2006-02-02 | Elan Pharmaceuticals, Inc. | Kompozícia na liečenie demyelizačných ochorení a paralýzy podávaním remyelizačných látok |
JP2007526230A (ja) | 2003-06-25 | 2007-09-13 | エラン ファーマシューティカルズ,インコーポレイテッド | 関節リウマチを治療する方法および組成物 |
CA2554188A1 (en) * | 2004-01-23 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
WO2005097162A2 (en) | 2004-04-01 | 2005-10-20 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and their use |
WO2005111020A2 (en) * | 2004-04-30 | 2005-11-24 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by vla-4 |
EP2258400A3 (en) | 2004-07-08 | 2011-08-10 | Elan Pharmaceuticals, Inc. | Multivalent VLA-4 antagonists comprising polymer moieties |
AU2006251620B8 (en) | 2005-05-20 | 2013-07-18 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as VLA-4 antagonists |
EP1901778A2 (en) | 2005-07-08 | 2008-03-26 | Elan Pharmaceuticals Inc. | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
US8269009B2 (en) | 2007-12-07 | 2012-09-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
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2005
- 2005-07-08 EP EP10180274A patent/EP2258400A3/en not_active Withdrawn
- 2005-07-08 BR BRPI0513143-0A patent/BRPI0513143A/pt not_active IP Right Cessation
- 2005-07-08 AU AU2005265316A patent/AU2005265316B2/en not_active Ceased
- 2005-07-08 NZ NZ588839A patent/NZ588839A/xx not_active IP Right Cessation
- 2005-07-08 US US11/177,748 patent/US7794700B2/en not_active Expired - Fee Related
- 2005-07-08 EP EP10179709A patent/EP2258399A3/en not_active Withdrawn
- 2005-07-08 TW TW094123303A patent/TWI418346B/zh not_active IP Right Cessation
- 2005-07-08 MX MX2007000228A patent/MX2007000228A/es active IP Right Grant
- 2005-07-08 AR ARP050102848A patent/AR050425A1/es not_active Application Discontinuation
- 2005-07-08 KR KR1020077003108A patent/KR101273614B1/ko not_active IP Right Cessation
- 2005-07-08 EP EP05770402A patent/EP1765412A2/en not_active Withdrawn
- 2005-07-08 EA EA200700212A patent/EA012433B1/ru not_active IP Right Cessation
- 2005-07-08 JP JP2007520561A patent/JP2008505927A/ja active Pending
- 2005-07-08 CN CN2005800298537A patent/CN101035563B/zh not_active Expired - Fee Related
- 2005-07-08 EP EP10179711A patent/EP2298356A3/en not_active Withdrawn
- 2005-07-08 CA CA2573245A patent/CA2573245C/en not_active Expired - Fee Related
- 2005-07-08 WO PCT/US2005/024369 patent/WO2006010054A2/en active Application Filing
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2007
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- 2007-01-09 ZA ZA200700238A patent/ZA200700238B/en unknown
- 2007-01-12 NO NO20070216A patent/NO20070216L/no not_active Application Discontinuation
- 2007-02-05 MA MA29658A patent/MA28786B1/fr unknown
- 2007-02-08 EC EC2007007231A patent/ECSP077231A/es unknown
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2008
- 2008-02-29 HK HK08102319.2A patent/HK1111674A1/xx not_active IP Right Cessation
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2010
- 2010-09-08 US US12/877,496 patent/US8263063B2/en not_active Expired - Fee Related
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2012
- 2012-09-07 US US13/606,783 patent/US20120329807A1/en not_active Abandoned
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2013
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