BRPI0417072A - agente preventivo para a vasculite - Google Patents
agente preventivo para a vasculiteInfo
- Publication number
- BRPI0417072A BRPI0417072A BRPI0417072-5A BRPI0417072A BRPI0417072A BR PI0417072 A BRPI0417072 A BR PI0417072A BR PI0417072 A BRPI0417072 A BR PI0417072A BR PI0417072 A BRPI0417072 A BR PI0417072A
- Authority
- BR
- Brazil
- Prior art keywords
- vasculitis
- preventive agent
- agent
- preventive
- vasculite
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
"AGENTE PREVENTIVO PARA A VASCULITE". Para fornecer um agente preventivo e/ou terapêutico para a vasculite tal como poliarterite nodosa, a sindrome de aortite e uma vasculite que é associada com anormalidades imunológicas, dito agente compreendendo um antagonistas da interleucina-6 (IL-6) como um ingrediente ativo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003423517 | 2003-12-19 | ||
JP2003-423517 | 2003-12-19 | ||
PCT/JP2004/019463 WO2005061000A1 (ja) | 2003-12-19 | 2004-12-17 | 血管炎治療剤 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0417072A true BRPI0417072A (pt) | 2007-03-13 |
BRPI0417072B1 BRPI0417072B1 (pt) | 2017-10-24 |
BRPI0417072B8 BRPI0417072B8 (pt) | 2021-05-25 |
Family
ID=34708761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417072A BRPI0417072B8 (pt) | 2003-12-19 | 2004-12-17 | "uso de antagonista de interleucina-6 (il-6)". |
Country Status (22)
Country | Link |
---|---|
US (1) | US20140079695A1 (pt) |
EP (1) | EP1707215B1 (pt) |
JP (1) | JP4785534B2 (pt) |
KR (1) | KR101218532B1 (pt) |
CN (1) | CN1893979B (pt) |
AR (1) | AR048210A1 (pt) |
AT (1) | ATE549034T1 (pt) |
AU (1) | AU2004305379B2 (pt) |
BR (1) | BRPI0417072B8 (pt) |
CA (1) | CA2549467C (pt) |
CO (1) | CO5700792A2 (pt) |
DK (1) | DK1707215T3 (pt) |
ES (1) | ES2382809T3 (pt) |
HK (1) | HK1095751A1 (pt) |
IL (1) | IL176122A (pt) |
MY (1) | MY142986A (pt) |
NO (1) | NO20062718L (pt) |
NZ (1) | NZ547645A (pt) |
RU (1) | RU2379054C2 (pt) |
TW (1) | TWI351967B (pt) |
WO (1) | WO2005061000A1 (pt) |
ZA (1) | ZA200604655B (pt) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2011514B1 (en) | 1997-03-21 | 2012-02-29 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
US8470316B2 (en) | 2005-10-14 | 2013-06-25 | Chugai Seiyaku Kabushiki Kaisha | Agents for suppressing damage to transplanted islets after islet transplantation |
CN101330930B (zh) * | 2005-10-21 | 2011-11-23 | 中外制药株式会社 | 心脏病治疗剂 |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
AU2007208678B2 (en) | 2006-01-27 | 2013-01-10 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for diseases involving choroidal neovascularization |
CN101479381B (zh) | 2006-03-31 | 2015-04-29 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
JP5144499B2 (ja) | 2006-03-31 | 2013-02-13 | 中外製薬株式会社 | 二重特異性抗体を精製するための抗体改変方法 |
JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
JP2010095445A (ja) * | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
US9725514B2 (en) | 2007-01-23 | 2017-08-08 | Shinshu University | Chronic rejection inhibitor |
US9096651B2 (en) | 2007-09-26 | 2015-08-04 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
TWI563002B (en) | 2007-09-26 | 2016-12-21 | Chugai Pharmaceutical Co Ltd | Antibody constant region mutant |
ES2834741T3 (es) | 2007-12-05 | 2021-06-18 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-NR10 y uso del mismo |
PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
CN103251948A (zh) | 2008-04-11 | 2013-08-21 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
US10717781B2 (en) | 2008-06-05 | 2020-07-21 | National Cancer Center | Neuroinvasion inhibitor |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
EP3674317A1 (en) | 2009-03-19 | 2020-07-01 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2010131733A1 (ja) | 2009-05-15 | 2010-11-18 | 中外製薬株式会社 | 抗axl抗体 |
EP2481752B1 (en) | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
CN102596995B (zh) | 2009-10-26 | 2015-08-12 | 弗·哈夫曼-拉罗切有限公司 | 用于生产糖基化免疫球蛋白的方法 |
JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
SI2578231T1 (sl) | 2010-05-28 | 2023-01-31 | Chugai Seiyaku Kabushiki Kaisha | Okrepljen protitumorski T celični odzivnik |
KR20190120439A (ko) | 2010-11-08 | 2019-10-23 | 제넨테크, 인크. | 피하 투여용 항―il―6 수용체 항체 |
CN107973851A (zh) | 2010-11-30 | 2018-05-01 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
ES2690557T3 (es) | 2011-06-02 | 2018-11-21 | University Of Louisville Research Foundation, Inc. | Nanopartículas conjugadas a un agente antinucleolina |
US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
KR102248581B1 (ko) | 2013-07-04 | 2021-05-06 | 에프. 호프만-라 로슈 아게 | 혈청 샘플 중 항-약물 항체를 검출하기 위한 간섭-억제된 면역분석 |
PT3050896T (pt) | 2013-09-27 | 2021-08-24 | Chugai Pharmaceutical Co Ltd | Processo para a produção de heteromultímeros de polipéptidos |
CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
US10857237B2 (en) | 2015-05-05 | 2020-12-08 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and MRI and/or X-ray contrast agents |
EP3299810B1 (en) | 2015-05-19 | 2021-07-07 | National Center of Neurology and Psychiatry | Method for determining application of novel therapy to multiple sclerosis (ms) patient |
CA3004288A1 (en) | 2015-12-28 | 2017-07-06 | Nobuyuki Tanaka | Method for promoting efficiency of purification of fc region-containing polypeptide |
SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
AU2018331725A1 (en) | 2017-09-13 | 2020-04-23 | Jiangsu Hengrui Medicine Co., Ltd. | IL-6R antibody and antigen binding fragment thereof and medical use |
KR20200074160A (ko) | 2017-10-20 | 2020-06-24 | 가꼬우호우징 효고 이카다이가쿠 | 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물 |
KR20200132938A (ko) | 2018-03-15 | 2020-11-25 | 추가이 세이야쿠 가부시키가이샤 | 지카 바이러스에 대해 교차-반응성을 갖는 항-뎅기 바이러스 항체 및 사용 방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5216128A (en) | 1989-06-01 | 1993-06-01 | Yeda Research And Development Co., Ltd. | IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it |
ES2134212T3 (es) * | 1991-04-25 | 1999-10-01 | Chugai Pharmaceutical Co Ltd | Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano. |
FR2694767B1 (fr) | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
AU7967294A (en) | 1993-10-06 | 1995-05-01 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
IT1274350B (it) | 1994-12-06 | 1997-07-17 | Angeletti P Ist Richerche Bio | Antagonisti di interleuchina-6(il-6) che consistono di forme solubili del ricettore alfa di il-6, mutate nell'interfaccia che si lega a gp 130 |
IT1274782B (it) | 1994-12-14 | 1997-07-24 | Angeletti P Ist Richerche Bio | Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130 |
JPH08311098A (ja) * | 1995-05-22 | 1996-11-26 | Daicel Chem Ind Ltd | 新規ペプチド類およびそれを含有するインターロイキン6拮抗剤 |
EP2011514B1 (en) * | 1997-03-21 | 2012-02-29 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient |
DE19923961A1 (de) * | 1999-05-25 | 2000-11-30 | Euro Nippon Kayaku Gmbh | Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen |
JP2003026699A (ja) * | 2001-07-13 | 2003-01-29 | Inter Cyto Nano Science Co Ltd | Il−6シグナル伝達拮抗ペプチド |
DK1562968T3 (da) * | 2001-11-14 | 2013-10-28 | Janssen Biotech Inc | Anti-il-6-antistoffer, sammensætninger, fremgangsmåder og anvendelser |
FR2833011B1 (fr) * | 2001-12-04 | 2004-10-29 | Univ Claude Bernard Lyon | Nouvelle proteine a activite inhibitrice de l'il-6 |
GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
-
2004
- 2004-12-13 AR ARP040104641A patent/AR048210A1/es unknown
- 2004-12-16 TW TW093139137A patent/TWI351967B/zh active
- 2004-12-17 CA CA2549467A patent/CA2549467C/en active Active
- 2004-12-17 NZ NZ547645A patent/NZ547645A/en unknown
- 2004-12-17 JP JP2005516531A patent/JP4785534B2/ja active Active
- 2004-12-17 RU RU2006126092/15A patent/RU2379054C2/ru active
- 2004-12-17 AU AU2004305379A patent/AU2004305379B2/en active Active
- 2004-12-17 ES ES04807818T patent/ES2382809T3/es active Active
- 2004-12-17 EP EP04807818A patent/EP1707215B1/en not_active Revoked
- 2004-12-17 CN CN2004800378876A patent/CN1893979B/zh active Active
- 2004-12-17 MY MYPI20045223A patent/MY142986A/en unknown
- 2004-12-17 WO PCT/JP2004/019463 patent/WO2005061000A1/ja active Application Filing
- 2004-12-17 DK DK04807818.2T patent/DK1707215T3/da active
- 2004-12-17 AT AT04807818T patent/ATE549034T1/de active
- 2004-12-17 BR BRPI0417072A patent/BRPI0417072B8/pt active IP Right Grant
-
2006
- 2006-06-05 IL IL176122A patent/IL176122A/en active IP Right Grant
- 2006-06-07 ZA ZA200604655A patent/ZA200604655B/en unknown
- 2006-06-12 NO NO20062718A patent/NO20062718L/no not_active Application Discontinuation
- 2006-06-15 KR KR1020067011829A patent/KR101218532B1/ko active IP Right Grant
- 2006-07-14 CO CO06069184A patent/CO5700792A2/es not_active Application Discontinuation
-
2007
- 2007-03-20 HK HK07102960.5A patent/HK1095751A1/xx unknown
-
2013
- 2013-11-22 US US14/087,168 patent/US20140079695A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1893979B (zh) | 2011-06-08 |
JPWO2005061000A1 (ja) | 2007-07-12 |
ATE549034T1 (de) | 2012-03-15 |
IL176122A (en) | 2011-07-31 |
RU2006126092A (ru) | 2008-01-27 |
EP1707215A4 (en) | 2009-07-15 |
TW200524630A (en) | 2005-08-01 |
AU2004305379B2 (en) | 2011-04-07 |
ES2382809T3 (es) | 2012-06-13 |
US20140079695A1 (en) | 2014-03-20 |
CA2549467A1 (en) | 2005-07-07 |
NO20062718L (no) | 2006-09-18 |
DK1707215T3 (da) | 2012-04-16 |
MY142986A (en) | 2011-02-14 |
AR048210A1 (es) | 2006-04-12 |
EP1707215A1 (en) | 2006-10-04 |
BRPI0417072B1 (pt) | 2017-10-24 |
BRPI0417072B8 (pt) | 2021-05-25 |
EP1707215B1 (en) | 2012-03-14 |
JP4785534B2 (ja) | 2011-10-05 |
HK1095751A1 (en) | 2007-05-18 |
WO2005061000A1 (ja) | 2005-07-07 |
CO5700792A2 (es) | 2006-11-30 |
CN1893979A (zh) | 2007-01-10 |
KR20060132616A (ko) | 2006-12-21 |
TWI351967B (en) | 2011-11-11 |
NZ547645A (en) | 2009-05-31 |
AU2004305379A1 (en) | 2005-07-07 |
IL176122A0 (en) | 2006-10-05 |
ZA200604655B (en) | 2007-11-28 |
KR101218532B1 (ko) | 2013-01-03 |
CA2549467C (en) | 2012-12-11 |
RU2379054C2 (ru) | 2010-01-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0417072A (pt) | agente preventivo para a vasculite | |
ECSP045474A (es) | 1-(aminoalquil)-3-sulfonilazaindoles como ligandos de 5-hidroxitriptamina-6 | |
CL2008002207A1 (es) | Composicion farmaceutica que comprende inmunosupresores para la mejora del efecto en el uso de un antagonista de interleucina-6 (il-6) para el tratamiento de enfermedades relacionadas con il-6 (div. sol. 896-04). | |
BRPI0415505A (pt) | agente terapêutico para mesotelioma | |
PL402389A1 (pl) | Sposób hamowania aktywnosci kinazy Raf u ludzi lub zwierzat | |
BR0313371A (pt) | Composto, uso de um composto e método de tratamento de doença | |
UY27939A1 (es) | Compuestos | |
TR200101859T2 (tr) | Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler | |
BRPI0517015A (pt) | compostos e composições como inibidores de atividade de receptor 1 de canabinóide | |
BR0214343A (pt) | Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1 | |
PT1379520E (pt) | Antagonistas (nao-aril)-heterociclicos n-substituidos de nmda/nr2b | |
NO20043411L (no) | Substituerte quinazolin-4-ylamin analoger | |
NO20064365L (no) | Terapeutisk forbindelse | |
HK1132175A1 (en) | Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity | |
MY154869A (en) | Composition for treating metabolic syndrome | |
IS2533B (is) | (S)-2-N-própýlamínó-5-hýdroxýetralín sem D3-gerandefni | |
PT1506185E (pt) | Compostos novos e sua utilizacao | |
NO20043013L (no) | Tetrahydrokinolin analoger som muskarine agonister | |
ECSP045156A (es) | Derivados de indolilalquilamina como ligandos 5-hidroxitriptamina-6 | |
PA8575601A1 (es) | Procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso | |
PA8532001A1 (es) | Bifenilcarboxamidas utiles como agentes reductores de lipidos | |
DK1246808T3 (da) | 1,2-diarylbenzimidazoler til behandling af sygdomme, som er associeret med en mikroglia-aktivering | |
BR9916575A (pt) | Composição farmacêutica de liberação controlada com mesilato de tilidina como substância-ativa | |
BR0314058A (pt) | Composições para cuidados pessoais a base de álcool ramificado | |
PA8542601A1 (es) | Bifenilcarboxamidas reductoras de lipidos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |