BRPI0416593A - moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmas - Google Patents
moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmasInfo
- Publication number
- BRPI0416593A BRPI0416593A BRPI0416593-4A BRPI0416593A BRPI0416593A BR PI0416593 A BRPI0416593 A BR PI0416593A BR PI0416593 A BRPI0416593 A BR PI0416593A BR PI0416593 A BRPI0416593 A BR PI0416593A
- Authority
- BR
- Brazil
- Prior art keywords
- sulfonyl
- peroxic
- derivative
- applications
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"MOLéCULAS DUAIS CONTENDO UM DERIVADO PEROXìDICO, SìNTESE E APLICAçõES DAS MESMAS". A presente invenção refere-se às moléculas duais, correspondentes à fórmula (I), na qual - A representa um resíduo de molécula com atividade antipalúdica e/ou um resíduo que facilita a biodisponibilidade, - p, p<39>, p<39><39> representam independentemente uns dos outros 0 ou 1, pelo menos um de p ou de p<39><39>sendo igual a 1, - Y~ 1~ e Y~ 2~, idênticos ou diferentes, representam uma cadeia alquileno, comportando eventualmente um ou vários radicais amina, amida, tioamida, sulfonila, sulfonato, sulfonamida, carbonila, tiocarbonila, carboxila, tiocarboxila, éter ou tioéter, - U representa um radical amina, amida, tioamida, sulfonila, sulfonato, sulfonamida, carbonila, tiocarbonila, carboxila, tiocarboxila, éter ou tioéter, - Z~ 1~ e Z~ 2~ representam um radical alquileno ou o conjunto Z~ 1~ + Z~ 2~ representa uma estrutura policíclica, - R~ x~ e R~ y~ formam juntos um peróxido cíclico, compreendendo de 4 a 8 cadeias e comportando 1 ou 2 átomos de oxigênio suplementares na estrutura cíclica. Processo de preparo e aplicação como medicamentos com atividade antipalúdica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313371A FR2862304A1 (fr) | 2003-11-14 | 2003-11-14 | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| PCT/FR2004/002874 WO2005049619A1 (fr) | 2003-11-14 | 2004-11-09 | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416593A true BRPI0416593A (pt) | 2007-01-30 |
Family
ID=34508480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416593-4A BRPI0416593A (pt) | 2003-11-14 | 2004-11-09 | moléculas duais contendo um derivado peroxìdico, sìntese e aplicações das mesmas |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7947701B2 (pt) |
| EP (1) | EP1687312B1 (pt) |
| JP (1) | JP2007511489A (pt) |
| CN (1) | CN100448878C (pt) |
| AP (1) | AP2006003626A0 (pt) |
| AR (1) | AR046449A1 (pt) |
| AT (1) | ATE473983T1 (pt) |
| AU (1) | AU2004291374A1 (pt) |
| BR (1) | BRPI0416593A (pt) |
| CA (1) | CA2545491A1 (pt) |
| DE (1) | DE602004028149D1 (pt) |
| DK (1) | DK1687312T3 (pt) |
| ES (1) | ES2348624T3 (pt) |
| FR (1) | FR2862304A1 (pt) |
| HR (1) | HRP20100557T1 (pt) |
| IL (1) | IL175589A0 (pt) |
| MX (1) | MXPA06005409A (pt) |
| NO (1) | NO20062740L (pt) |
| NZ (1) | NZ547805A (pt) |
| PL (1) | PL1687312T3 (pt) |
| PT (1) | PT1687312E (pt) |
| SI (1) | SI1687312T1 (pt) |
| TW (1) | TW200530249A (pt) |
| WO (1) | WO2005049619A1 (pt) |
| ZA (1) | ZA200604247B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| US20170000784A1 (en) * | 2013-12-08 | 2017-01-05 | Van Andel Research Institute | Autophagy Inhibitors |
| JP6889433B2 (ja) * | 2014-02-14 | 2021-06-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
| PL3762368T3 (pl) | 2018-03-08 | 2022-06-06 | Incyte Corporation | ZWIĄZKI AMINOPIRAZYNODIOLOWE JAKO INHIBITORY PI3K-γ |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2807433B1 (fr) * | 2000-04-06 | 2002-09-20 | Centre Nat Rech Scient | Molecules duales contenant un derives peroxydique, leur synthese et leurs applications therapeutiques |
| US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
-
2003
- 2003-11-14 FR FR0313371A patent/FR2862304A1/fr not_active Withdrawn
-
2004
- 2004-11-09 MX MXPA06005409A patent/MXPA06005409A/es not_active Application Discontinuation
- 2004-11-09 AP AP2006003626A patent/AP2006003626A0/xx unknown
- 2004-11-09 AU AU2004291374A patent/AU2004291374A1/en not_active Abandoned
- 2004-11-09 PL PL04805417T patent/PL1687312T3/pl unknown
- 2004-11-09 CA CA002545491A patent/CA2545491A1/fr not_active Abandoned
- 2004-11-09 ES ES04805417T patent/ES2348624T3/es active Active
- 2004-11-09 SI SI200431519T patent/SI1687312T1/sl unknown
- 2004-11-09 PT PT04805417T patent/PT1687312E/pt unknown
- 2004-11-09 WO PCT/FR2004/002874 patent/WO2005049619A1/fr active Application Filing
- 2004-11-09 CN CNB2004800372615A patent/CN100448878C/zh not_active Expired - Fee Related
- 2004-11-09 JP JP2006538893A patent/JP2007511489A/ja active Pending
- 2004-11-09 NZ NZ547805A patent/NZ547805A/en unknown
- 2004-11-09 ZA ZA200604247A patent/ZA200604247B/en unknown
- 2004-11-09 DK DK04805417.5T patent/DK1687312T3/da active
- 2004-11-09 DE DE602004028149T patent/DE602004028149D1/de active Active
- 2004-11-09 BR BRPI0416593-4A patent/BRPI0416593A/pt not_active IP Right Cessation
- 2004-11-09 EP EP04805417A patent/EP1687312B1/fr active Active
- 2004-11-09 AT AT04805417T patent/ATE473983T1/de active
- 2004-11-12 AR ARP040104170A patent/AR046449A1/es unknown
- 2004-11-12 TW TW093134762A patent/TW200530249A/zh unknown
-
2006
- 2006-05-11 IL IL175589A patent/IL175589A0/en unknown
- 2006-05-12 US US11/433,890 patent/US7947701B2/en not_active Expired - Fee Related
- 2006-06-13 NO NO20062740A patent/NO20062740L/no not_active Application Discontinuation
-
2010
- 2010-10-13 HR HR20100557T patent/HRP20100557T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1687312A1 (fr) | 2006-08-09 |
| PT1687312E (pt) | 2010-10-18 |
| IL175589A0 (en) | 2006-09-05 |
| ATE473983T1 (de) | 2010-07-15 |
| DK1687312T3 (da) | 2010-11-08 |
| JP2007511489A (ja) | 2007-05-10 |
| ZA200604247B (en) | 2008-05-28 |
| CN100448878C (zh) | 2009-01-07 |
| AP2006003626A0 (en) | 2006-06-30 |
| DE602004028149D1 (de) | 2010-08-26 |
| EP1687312B1 (fr) | 2010-07-14 |
| HRP20100557T1 (hr) | 2011-03-31 |
| CN1910189A (zh) | 2007-02-07 |
| SI1687312T1 (sl) | 2010-11-30 |
| NZ547805A (en) | 2010-05-28 |
| AU2004291374A1 (en) | 2005-06-02 |
| MXPA06005409A (es) | 2007-11-22 |
| AR046449A1 (es) | 2005-12-07 |
| CA2545491A1 (fr) | 2005-06-02 |
| US20070021423A1 (en) | 2007-01-25 |
| FR2862304A1 (fr) | 2005-05-20 |
| TW200530249A (en) | 2005-09-16 |
| US7947701B2 (en) | 2011-05-24 |
| WO2005049619A1 (fr) | 2005-06-02 |
| NO20062740L (no) | 2006-08-11 |
| PL1687312T3 (pl) | 2011-07-29 |
| ES2348624T3 (es) | 2010-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 8A E 9A ANUIDADES. |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A, 10A, 11A, 12A, 13A, 14A E 15A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |