HRP20100557T1 - Dvojne molekule koje sadrže peroksi derivat, njihova sinteza i terapijske primjene - Google Patents
Dvojne molekule koje sadrže peroksi derivat, njihova sinteza i terapijske primjene Download PDFInfo
- Publication number
- HRP20100557T1 HRP20100557T1 HR20100557T HRP20100557T HRP20100557T1 HR P20100557 T1 HRP20100557 T1 HR P20100557T1 HR 20100557 T HR20100557 T HR 20100557T HR P20100557 T HRP20100557 T HR P20100557T HR P20100557 T1 HRP20100557 T1 HR P20100557T1
- Authority
- HR
- Croatia
- Prior art keywords
- ring
- formula
- groups
- compound
- branched
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 37
- -1 and -OH Chemical group 0.000 claims abstract 24
- 150000002978 peroxides Chemical class 0.000 claims abstract 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 16
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 15
- 150000003254 radicals Chemical class 0.000 claims abstract 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 12
- 125000000217 alkyl group Chemical group 0.000 claims abstract 12
- 125000005843 halogen group Chemical group 0.000 claims abstract 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 10
- 125000002947 alkylene group Chemical group 0.000 claims abstract 9
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 9
- 150000001408 amides Chemical class 0.000 claims abstract 8
- 150000001412 amines Chemical class 0.000 claims abstract 8
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 8
- 229910052799 carbon Inorganic materials 0.000 claims abstract 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 7
- 125000004036 acetal group Chemical group 0.000 claims abstract 6
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract 5
- 150000002367 halogens Chemical class 0.000 claims abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 4
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000000524 functional group Chemical group 0.000 claims abstract 4
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 4
- 229940124530 sulfonamide Drugs 0.000 claims abstract 4
- 150000003456 sulfonamides Chemical class 0.000 claims abstract 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims abstract 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract 4
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 3
- 230000000078 anti-malarial effect Effects 0.000 claims abstract 2
- 150000005840 aryl radicals Chemical class 0.000 claims abstract 2
- 125000003367 polycyclic group Chemical group 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 18
- 239000002253 acid Substances 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000005010 aminoquinolines Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- VMLKTERJLVWEJJ-UHFFFAOYSA-N 1,5-naphthyridine Chemical compound C1=CC=NC2=CC=CN=C21 VMLKTERJLVWEJJ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000004901 trioxanes Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0313371A FR2862304A1 (fr) | 2003-11-14 | 2003-11-14 | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
PCT/FR2004/002874 WO2005049619A1 (fr) | 2003-11-14 | 2004-11-09 | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100557T1 true HRP20100557T1 (hr) | 2011-03-31 |
Family
ID=34508480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100557T HRP20100557T1 (hr) | 2003-11-14 | 2010-10-13 | Dvojne molekule koje sadrže peroksi derivat, njihova sinteza i terapijske primjene |
Country Status (25)
Country | Link |
---|---|
US (1) | US7947701B2 (pt) |
EP (1) | EP1687312B1 (pt) |
JP (1) | JP2007511489A (pt) |
CN (1) | CN100448878C (pt) |
AP (1) | AP2006003626A0 (pt) |
AR (1) | AR046449A1 (pt) |
AT (1) | ATE473983T1 (pt) |
AU (1) | AU2004291374A1 (pt) |
BR (1) | BRPI0416593A (pt) |
CA (1) | CA2545491A1 (pt) |
DE (1) | DE602004028149D1 (pt) |
DK (1) | DK1687312T3 (pt) |
ES (1) | ES2348624T3 (pt) |
FR (1) | FR2862304A1 (pt) |
HR (1) | HRP20100557T1 (pt) |
IL (1) | IL175589A0 (pt) |
MX (1) | MXPA06005409A (pt) |
NO (1) | NO20062740L (pt) |
NZ (1) | NZ547805A (pt) |
PL (1) | PL1687312T3 (pt) |
PT (1) | PT1687312E (pt) |
SI (1) | SI1687312T1 (pt) |
TW (1) | TW200530249A (pt) |
WO (1) | WO2005049619A1 (pt) |
ZA (1) | ZA200604247B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
US20170000784A1 (en) * | 2013-12-08 | 2017-01-05 | Van Andel Research Institute | Autophagy Inhibitors |
JP6889433B2 (ja) * | 2014-02-14 | 2021-06-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド |
PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2807433B1 (fr) * | 2000-04-06 | 2002-09-20 | Centre Nat Rech Scient | Molecules duales contenant un derives peroxydique, leur synthese et leurs applications therapeutiques |
US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
-
2003
- 2003-11-14 FR FR0313371A patent/FR2862304A1/fr not_active Withdrawn
-
2004
- 2004-11-09 MX MXPA06005409A patent/MXPA06005409A/es not_active Application Discontinuation
- 2004-11-09 AT AT04805417T patent/ATE473983T1/de active
- 2004-11-09 CA CA002545491A patent/CA2545491A1/fr not_active Abandoned
- 2004-11-09 PT PT04805417T patent/PT1687312E/pt unknown
- 2004-11-09 AU AU2004291374A patent/AU2004291374A1/en not_active Abandoned
- 2004-11-09 EP EP04805417A patent/EP1687312B1/fr active Active
- 2004-11-09 DK DK04805417.5T patent/DK1687312T3/da active
- 2004-11-09 PL PL04805417T patent/PL1687312T3/pl unknown
- 2004-11-09 ES ES04805417T patent/ES2348624T3/es active Active
- 2004-11-09 NZ NZ547805A patent/NZ547805A/en unknown
- 2004-11-09 AP AP2006003626A patent/AP2006003626A0/xx unknown
- 2004-11-09 DE DE602004028149T patent/DE602004028149D1/de active Active
- 2004-11-09 WO PCT/FR2004/002874 patent/WO2005049619A1/fr active Application Filing
- 2004-11-09 SI SI200431519T patent/SI1687312T1/sl unknown
- 2004-11-09 CN CNB2004800372615A patent/CN100448878C/zh not_active Expired - Fee Related
- 2004-11-09 JP JP2006538893A patent/JP2007511489A/ja active Pending
- 2004-11-09 BR BRPI0416593-4A patent/BRPI0416593A/pt not_active IP Right Cessation
- 2004-11-09 ZA ZA200604247A patent/ZA200604247B/en unknown
- 2004-11-12 TW TW093134762A patent/TW200530249A/zh unknown
- 2004-11-12 AR ARP040104170A patent/AR046449A1/es unknown
-
2006
- 2006-05-11 IL IL175589A patent/IL175589A0/en unknown
- 2006-05-12 US US11/433,890 patent/US7947701B2/en not_active Expired - Fee Related
- 2006-06-13 NO NO20062740A patent/NO20062740L/no not_active Application Discontinuation
-
2010
- 2010-10-13 HR HR20100557T patent/HRP20100557T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
PT1687312E (pt) | 2010-10-18 |
US20070021423A1 (en) | 2007-01-25 |
TW200530249A (en) | 2005-09-16 |
CN100448878C (zh) | 2009-01-07 |
BRPI0416593A (pt) | 2007-01-30 |
ZA200604247B (en) | 2008-05-28 |
AP2006003626A0 (en) | 2006-06-30 |
ES2348624T3 (es) | 2010-12-09 |
US7947701B2 (en) | 2011-05-24 |
WO2005049619A1 (fr) | 2005-06-02 |
PL1687312T3 (pl) | 2011-07-29 |
FR2862304A1 (fr) | 2005-05-20 |
NO20062740L (no) | 2006-08-11 |
NZ547805A (en) | 2010-05-28 |
SI1687312T1 (sl) | 2010-11-30 |
EP1687312B1 (fr) | 2010-07-14 |
MXPA06005409A (es) | 2007-11-22 |
EP1687312A1 (fr) | 2006-08-09 |
ATE473983T1 (de) | 2010-07-15 |
IL175589A0 (en) | 2006-09-05 |
DE602004028149D1 (de) | 2010-08-26 |
DK1687312T3 (da) | 2010-11-08 |
JP2007511489A (ja) | 2007-05-10 |
AR046449A1 (es) | 2005-12-07 |
CA2545491A1 (fr) | 2005-06-02 |
AU2004291374A1 (en) | 2005-06-02 |
CN1910189A (zh) | 2007-02-07 |
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