ATE146480T1 - Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate - Google Patents

Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate

Info

Publication number
ATE146480T1
ATE146480T1 AT91117889T AT91117889T ATE146480T1 AT E146480 T1 ATE146480 T1 AT E146480T1 AT 91117889 T AT91117889 T AT 91117889T AT 91117889 T AT91117889 T AT 91117889T AT E146480 T1 ATE146480 T1 AT E146480T1
Authority
AT
Austria
Prior art keywords
suitable substituent
alkyl
production
pharmaceutical preparations
preparations containing
Prior art date
Application number
AT91117889T
Other languages
English (en)
Inventor
Masaaki Matsuo
Daijiro Hagiwara
Hiroshi Miyake
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of ATE146480T1 publication Critical patent/ATE146480T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT91117889T 1990-10-24 1991-10-20 Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate ATE146480T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909023116A GB9023116D0 (en) 1990-10-24 1990-10-24 Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
ATE146480T1 true ATE146480T1 (de) 1997-01-15

Family

ID=10684270

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91117889T ATE146480T1 (de) 1990-10-24 1991-10-20 Peptidverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate

Country Status (19)

Country Link
EP (1) EP0482539B1 (de)
JP (1) JP3206764B2 (de)
KR (1) KR920008065A (de)
CN (2) CN1038939C (de)
AT (1) ATE146480T1 (de)
AU (1) AU647534B2 (de)
CA (1) CA2054097A1 (de)
DE (1) DE69123697T2 (de)
DK (1) DK0482539T3 (de)
ES (1) ES2095283T3 (de)
FI (1) FI914961A (de)
GB (1) GB9023116D0 (de)
GR (1) GR3022137T3 (de)
HU (2) HUT59163A (de)
IE (1) IE913599A1 (de)
NO (1) NO914171L (de)
PT (1) PT99317B (de)
RU (1) RU2073683C1 (de)
ZA (1) ZA918011B (de)

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US5328927A (en) * 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
CZ127694A3 (en) * 1992-09-03 1994-11-16 Boehringer Ingelheim Kg Novel derivatives of amino acids, process of their preparation and pharmaceutical preparations in which they are comprised
DE4243496A1 (de) * 1992-09-03 1994-03-10 Boehringer Ingelheim Kg Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
IT1256623B (it) * 1992-12-04 1995-12-12 Federico Arcamone Antagonisti delle tachichinine, procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche
FR2700472B1 (fr) 1993-01-19 1995-02-17 Rhone Poulenc Rorer Sa Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
AU6140694A (en) * 1993-02-22 1994-09-14 Merck Sharp & Dohme Limited Aromatic compounds, compositions containing them and their use in therapy
WO1994020126A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Use of peptides for the manufacture of a medicament
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
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US5455262A (en) * 1993-10-06 1995-10-03 Florida State University Mercaptosulfide metalloproteinase inhibitors
EP0804463A1 (de) * 1994-05-07 1997-11-05 Boehringer Ingelheim Kg Neurokinin (tachykinin)-antagonisten
MX9701305A (es) 1994-08-25 1998-05-31 Merrell Pharma Inc Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas.
US5830868A (en) * 1994-09-13 1998-11-03 Warner-Lambert Company Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
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US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
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US6423689B1 (en) 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
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ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
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US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2109608B1 (de) 2007-01-10 2011-03-23 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer
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US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
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US9446029B2 (en) 2010-07-27 2016-09-20 Colorado State University Research Foundation Use of NK-1 receptor antagonists in management of visceral pain
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
KR102072631B1 (ko) 2010-08-17 2020-02-03 시르나 쎄러퓨틱스 인코퍼레이티드 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제
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US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
AU647534B2 (en) 1994-03-24
CN1038939C (zh) 1998-07-01
CN1148503A (zh) 1997-04-30
KR920008065A (ko) 1992-05-27
DK0482539T3 (da) 1997-01-06
HUT59163A (en) 1992-04-28
JPH04297492A (ja) 1992-10-21
EP0482539A3 (en) 1992-08-26
CN1060848A (zh) 1992-05-06
NO914171D0 (no) 1991-10-23
ES2095283T3 (es) 1997-02-16
IE913599A1 (en) 1992-05-22
DE69123697D1 (de) 1997-01-30
JP3206764B2 (ja) 2001-09-10
ZA918011B (en) 1992-07-29
AU8592591A (en) 1992-04-30
RU2073683C1 (ru) 1997-02-20
FI914961A (fi) 1992-04-25
DE69123697T2 (de) 1997-04-17
HU913331D0 (en) 1992-01-28
CA2054097A1 (en) 1992-04-25
HU211611A9 (en) 1995-12-28
EP0482539A2 (de) 1992-04-29
GR3022137T3 (en) 1997-03-31
PT99317A (pt) 1992-09-30
GB9023116D0 (en) 1990-12-05
FI914961A0 (fi) 1991-10-22
EP0482539B1 (de) 1996-12-18
PT99317B (pt) 1999-04-30
NO914171L (no) 1992-04-27

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee