NO20062740L - Duale molekyler inneholdende peroksyderivat, syntese derav og terapeutiske anvendelser derav - Google Patents
Duale molekyler inneholdende peroksyderivat, syntese derav og terapeutiske anvendelser deravInfo
- Publication number
- NO20062740L NO20062740L NO20062740A NO20062740A NO20062740L NO 20062740 L NO20062740 L NO 20062740L NO 20062740 A NO20062740 A NO 20062740A NO 20062740 A NO20062740 A NO 20062740A NO 20062740 L NO20062740 L NO 20062740L
- Authority
- NO
- Norway
- Prior art keywords
- residue
- synthesis
- dual molecules
- therapeutic applications
- molecules containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det er beskrevet duale molekyler av formel (I), hvori A er en antimalariamolekylrest og/eller en biotilgjengelighetsfremmende rest, p, p', p" er 0 eller 1 uavhengig av hverandre, ved minst en av p eller p" er lik 1, Y1og Y2 er like eller forskjellige og er en alkylenkjede, eventuelt inneholdende en eller flere amin-, amid-, tioamid-, sulfonyl-, sulfonat-, sulfonamid-, karbonyl-, tiokarbonyl-, karboksyl-, tiokarboksyl-, eter- eller tioeterrester, U er en amin-, amid-, tioamid-, sulfonyl-, sulfonat-, sulfonamid-, karbonyl-, tiokarbonyl-, karboksyl-, tiokarboksyl-, eter- eller tioeterrest, Z1 og Z2 betyr en alkylenrest eller Z1+Z2 betyr en polysyklisk struktur, Rx og Ry danner sammen et syklisk peroksid omfattende fra 4 til 8 kjedeledd og inneholder 1 eller 2 ytterligere oksygenatomer i den sykliske strukturen. Det er ogsa beskrevet en fremgangsmåte for fremstilling og anvendelse av de nevnte duale molekylene i form av antimalarialegemidler.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313371A FR2862304A1 (fr) | 2003-11-14 | 2003-11-14 | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| PCT/FR2004/002874 WO2005049619A1 (fr) | 2003-11-14 | 2004-11-09 | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062740L true NO20062740L (no) | 2006-08-11 |
Family
ID=34508480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062740A NO20062740L (no) | 2003-11-14 | 2006-06-13 | Duale molekyler inneholdende peroksyderivat, syntese derav og terapeutiske anvendelser derav |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7947701B2 (no) |
| EP (1) | EP1687312B1 (no) |
| JP (1) | JP2007511489A (no) |
| CN (1) | CN100448878C (no) |
| AP (1) | AP2006003626A0 (no) |
| AR (1) | AR046449A1 (no) |
| AT (1) | ATE473983T1 (no) |
| AU (1) | AU2004291374A1 (no) |
| BR (1) | BRPI0416593A (no) |
| CA (1) | CA2545491A1 (no) |
| DE (1) | DE602004028149D1 (no) |
| DK (1) | DK1687312T3 (no) |
| ES (1) | ES2348624T3 (no) |
| FR (1) | FR2862304A1 (no) |
| HR (1) | HRP20100557T1 (no) |
| IL (1) | IL175589A0 (no) |
| MX (1) | MXPA06005409A (no) |
| NO (1) | NO20062740L (no) |
| NZ (1) | NZ547805A (no) |
| PL (1) | PL1687312T3 (no) |
| PT (1) | PT1687312E (no) |
| SI (1) | SI1687312T1 (no) |
| TW (1) | TW200530249A (no) |
| WO (1) | WO2005049619A1 (no) |
| ZA (1) | ZA200604247B (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| US20170000784A1 (en) * | 2013-12-08 | 2017-01-05 | Van Andel Research Institute | Autophagy Inhibitors |
| WO2015123595A1 (en) | 2014-02-14 | 2015-08-20 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | Aminopyrizine diol compounds as PI3K–y inhibitors |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2807433B1 (fr) * | 2000-04-06 | 2002-09-20 | Centre Nat Rech Scient | Molecules duales contenant un derives peroxydique, leur synthese et leurs applications therapeutiques |
| US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
-
2003
- 2003-11-14 FR FR0313371A patent/FR2862304A1/fr not_active Withdrawn
-
2004
- 2004-11-09 SI SI200431519T patent/SI1687312T1/sl unknown
- 2004-11-09 JP JP2006538893A patent/JP2007511489A/ja active Pending
- 2004-11-09 BR BRPI0416593-4A patent/BRPI0416593A/pt not_active IP Right Cessation
- 2004-11-09 AP AP2006003626A patent/AP2006003626A0/xx unknown
- 2004-11-09 AU AU2004291374A patent/AU2004291374A1/en not_active Abandoned
- 2004-11-09 CA CA002545491A patent/CA2545491A1/fr not_active Abandoned
- 2004-11-09 MX MXPA06005409A patent/MXPA06005409A/es not_active Application Discontinuation
- 2004-11-09 ZA ZA200604247A patent/ZA200604247B/en unknown
- 2004-11-09 DE DE602004028149T patent/DE602004028149D1/de active Active
- 2004-11-09 PL PL04805417T patent/PL1687312T3/pl unknown
- 2004-11-09 AT AT04805417T patent/ATE473983T1/de active
- 2004-11-09 WO PCT/FR2004/002874 patent/WO2005049619A1/fr active Application Filing
- 2004-11-09 ES ES04805417T patent/ES2348624T3/es active Active
- 2004-11-09 EP EP04805417A patent/EP1687312B1/fr active Active
- 2004-11-09 CN CNB2004800372615A patent/CN100448878C/zh not_active Expired - Fee Related
- 2004-11-09 PT PT04805417T patent/PT1687312E/pt unknown
- 2004-11-09 NZ NZ547805A patent/NZ547805A/en unknown
- 2004-11-09 DK DK04805417.5T patent/DK1687312T3/da active
- 2004-11-12 TW TW093134762A patent/TW200530249A/zh unknown
- 2004-11-12 AR ARP040104170A patent/AR046449A1/es unknown
-
2006
- 2006-05-11 IL IL175589A patent/IL175589A0/en unknown
- 2006-05-12 US US11/433,890 patent/US7947701B2/en not_active Expired - Fee Related
- 2006-06-13 NO NO20062740A patent/NO20062740L/no not_active Application Discontinuation
-
2010
- 2010-10-13 HR HR20100557T patent/HRP20100557T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007511489A (ja) | 2007-05-10 |
| NZ547805A (en) | 2010-05-28 |
| CN100448878C (zh) | 2009-01-07 |
| FR2862304A1 (fr) | 2005-05-20 |
| MXPA06005409A (es) | 2007-11-22 |
| ZA200604247B (en) | 2008-05-28 |
| ES2348624T3 (es) | 2010-12-09 |
| DK1687312T3 (da) | 2010-11-08 |
| PT1687312E (pt) | 2010-10-18 |
| CA2545491A1 (fr) | 2005-06-02 |
| AR046449A1 (es) | 2005-12-07 |
| SI1687312T1 (sl) | 2010-11-30 |
| AP2006003626A0 (en) | 2006-06-30 |
| ATE473983T1 (de) | 2010-07-15 |
| US7947701B2 (en) | 2011-05-24 |
| WO2005049619A1 (fr) | 2005-06-02 |
| HRP20100557T1 (hr) | 2011-03-31 |
| EP1687312A1 (fr) | 2006-08-09 |
| EP1687312B1 (fr) | 2010-07-14 |
| DE602004028149D1 (de) | 2010-08-26 |
| PL1687312T3 (pl) | 2011-07-29 |
| TW200530249A (en) | 2005-09-16 |
| BRPI0416593A (pt) | 2007-01-30 |
| IL175589A0 (en) | 2006-09-05 |
| AU2004291374A1 (en) | 2005-06-02 |
| CN1910189A (zh) | 2007-02-07 |
| US20070021423A1 (en) | 2007-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |