BRPI0415489A - derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica - Google Patents

derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica

Info

Publication number
BRPI0415489A
BRPI0415489A BRPI0415489-4A BRPI0415489A BRPI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A
Authority
BR
Brazil
Prior art keywords
alkoxy
alkyl
nhso
halo
optionally substituted
Prior art date
Application number
BRPI0415489-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Pascale Magat
Benoit Marabout
Pierre Roger
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0415489A publication Critical patent/BRPI0415489A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
BRPI0415489-4A 2003-10-17 2004-10-15 derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica BRPI0415489A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312165A FR2861076B1 (fr) 2003-10-17 2003-10-17 Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
PCT/FR2004/002643 WO2005037783A2 (fr) 2003-10-17 2004-10-15 Composes tricycliques comme inhibiteurs de transport de glycine

Publications (1)

Publication Number Publication Date
BRPI0415489A true BRPI0415489A (pt) 2006-12-26

Family

ID=34385252

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415489-4A BRPI0415489A (pt) 2003-10-17 2004-10-15 derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica

Country Status (32)

Country Link
US (3) US7288656B2 (cg-RX-API-DMAC10.html)
EP (1) EP1680421B1 (cg-RX-API-DMAC10.html)
JP (1) JP4853918B2 (cg-RX-API-DMAC10.html)
KR (1) KR101125305B1 (cg-RX-API-DMAC10.html)
CN (2) CN101684118B (cg-RX-API-DMAC10.html)
AT (1) ATE386036T1 (cg-RX-API-DMAC10.html)
AU (1) AU2004281217B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0415489A (cg-RX-API-DMAC10.html)
CA (1) CA2542647C (cg-RX-API-DMAC10.html)
CR (1) CR8342A (cg-RX-API-DMAC10.html)
CY (1) CY1108925T1 (cg-RX-API-DMAC10.html)
DE (1) DE602004011806T2 (cg-RX-API-DMAC10.html)
DK (1) DK1680421T3 (cg-RX-API-DMAC10.html)
EC (1) ECSP066511A (cg-RX-API-DMAC10.html)
ES (1) ES2300837T3 (cg-RX-API-DMAC10.html)
FR (1) FR2861076B1 (cg-RX-API-DMAC10.html)
HR (1) HRP20080186T3 (cg-RX-API-DMAC10.html)
IL (1) IL174940A (cg-RX-API-DMAC10.html)
MA (1) MA28099A1 (cg-RX-API-DMAC10.html)
ME (1) ME00111B (cg-RX-API-DMAC10.html)
NO (1) NO335462B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ547163A (cg-RX-API-DMAC10.html)
OA (1) OA13317A (cg-RX-API-DMAC10.html)
PL (1) PL1680421T3 (cg-RX-API-DMAC10.html)
PT (1) PT1680421E (cg-RX-API-DMAC10.html)
RS (2) RS51587B (cg-RX-API-DMAC10.html)
RU (1) RU2346945C2 (cg-RX-API-DMAC10.html)
SG (1) SG147435A1 (cg-RX-API-DMAC10.html)
TN (1) TNSN06110A1 (cg-RX-API-DMAC10.html)
UA (1) UA81186C2 (cg-RX-API-DMAC10.html)
WO (1) WO2005037783A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200603861B (cg-RX-API-DMAC10.html)

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FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
JP2007530664A (ja) * 2004-03-30 2007-11-01 ペインセプター ファーマ コーポレーション ゲートイオンチャンネルを調節するための組成物及び方法
FR2906251B1 (fr) 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US11817637B2 (en) 2006-11-18 2023-11-14 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds
CA2691450A1 (en) 2007-08-22 2009-02-26 Abbott Gmbh & Co. Kg 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
MX2010010773A (es) 2008-04-01 2011-04-11 Abbott Gmbh & Co Kg Tetrahidroisoquinolinas, composiciones farmaceuticas que las contienen y su uso en terapia.
JP2012511006A (ja) * 2008-12-04 2012-05-17 サノフイ アザビシクロ−トリフルオロメチルベンズアミド誘導体の新規な結晶多形
WO2010087761A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.2]octane compounds and uses thereof
UY32397A (es) * 2009-01-28 2010-08-31 Astrazeneca Ab Compuestos de 2-aza-biciclo [2,2,1] heptano y sus usos
FR2941954B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
FR2941953B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2943059A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
AU2010224720A1 (en) * 2009-03-16 2011-10-06 Sanofi Derivatives of N-[(2-aza-bicyclo [2.1.1]hex-1-yl)-aryl-methyl]-heterobenzamide, preparation thereof and application of same in therapeutics
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
US8153653B2 (en) * 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) * 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
TW201319049A (zh) 2011-08-05 2013-05-16 Abbott Gmbh & Co Kg 胺基□唍、胺基硫□唍及胺基-1,2,3,4-四氫喹啉衍生物,包含彼等之醫藥組合物及彼等於治療之用途
CN104011028A (zh) 2011-11-18 2014-08-27 艾伯维德国有限责任两合公司 N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途
US9359346B2 (en) 2011-11-29 2016-06-07 Vivozon, Inc. Benzamide derivative and use thereof
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP3057958B1 (en) 2013-10-17 2019-05-01 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
CN105992764A (zh) 2013-10-17 2016-10-05 艾伯维德国有限责任两合公司 氨基色满、氨基硫代色满及氨基-1,2,3,4-四氢喹啉衍生物,包含其的药物组合物及其在治疗中的用途
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016060938A2 (en) 2014-10-08 2016-04-21 RF Micron, Inc. Radio frequency identification (rfid) moisture tag(s) and sensors with extended sensing via capillaries
JP6906227B2 (ja) * 2017-08-18 2021-07-21 国立大学法人千葉大学 ハロゲン結合ドナー/有機塩基複合型化合物及び酸塩基複合触媒

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Also Published As

Publication number Publication date
JP2007508361A (ja) 2007-04-05
RS51587B (sr) 2011-08-31
CA2542647C (fr) 2012-07-10
RU2006116889A (ru) 2007-11-27
DK1680421T3 (da) 2008-06-09
MA28099A1 (fr) 2006-08-01
CY1108925T1 (el) 2014-07-02
WO2005037783A3 (fr) 2005-07-07
NZ547163A (en) 2010-01-29
MEP12208A (en) 2010-06-10
NO335462B1 (no) 2014-12-15
KR20060109432A (ko) 2006-10-20
CN101684118B (zh) 2013-04-10
ZA200603861B (en) 2007-12-27
IL174940A (en) 2010-11-30
DE602004011806D1 (de) 2008-03-27
WO2005037783A2 (fr) 2005-04-28
PL1680421T3 (pl) 2008-07-31
CN1882587A (zh) 2006-12-20
US20060264441A1 (en) 2006-11-23
UA81186C2 (en) 2007-12-10
JP4853918B2 (ja) 2012-01-11
US20080070941A1 (en) 2008-03-20
FR2861076A1 (fr) 2005-04-22
US7288656B2 (en) 2007-10-30
CA2542647A1 (fr) 2005-04-28
ES2300837T3 (es) 2008-06-16
DE602004011806T2 (de) 2009-02-05
ME00111B (me) 2010-10-10
CN101684118A (zh) 2010-03-31
US8513246B2 (en) 2013-08-20
AU2004281217A1 (en) 2005-04-28
SG147435A1 (en) 2008-11-28
ATE386036T1 (de) 2008-03-15
US7619089B2 (en) 2009-11-17
EP1680421A2 (fr) 2006-07-19
OA13317A (fr) 2007-04-13
RU2346945C2 (ru) 2009-02-20
ECSP066511A (es) 2006-10-10
HK1098465A1 (en) 2007-07-20
HRP20080186T3 (en) 2008-05-31
US20100022548A1 (en) 2010-01-28
PT1680421E (pt) 2008-05-13
AU2004281217B2 (en) 2010-07-22
IL174940A0 (en) 2006-08-20
NO20062030L (no) 2006-07-07
HK1142887A1 (en) 2010-12-17
RS20060314A (sr) 2008-08-07
CN1882587B (zh) 2012-06-27
FR2861076B1 (fr) 2006-01-06
CR8342A (es) 2006-10-04
EP1680421B1 (fr) 2008-02-13
KR101125305B1 (ko) 2012-03-27
TNSN06110A1 (fr) 2007-11-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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