BRPI0408861A - processo de fabricação de telmisartan - Google Patents

processo de fabricação de telmisartan

Info

Publication number
BRPI0408861A
BRPI0408861A BRPI0408861-1A BRPI0408861A BRPI0408861A BR PI0408861 A BRPI0408861 A BR PI0408861A BR PI0408861 A BRPI0408861 A BR PI0408861A BR PI0408861 A BRPI0408861 A BR PI0408861A
Authority
BR
Brazil
Prior art keywords
manufacturing process
telmisartan
methylbenzimidazole
propyl
methyl
Prior art date
Application number
BRPI0408861-1A
Other languages
English (en)
Inventor
Norbert Hauel
Rolf Dach
Helmut Heitger
Oliver Meyer
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33016100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0408861(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0408861A publication Critical patent/BRPI0408861A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Abstract

"PROCESSO DE FABRICAçãO DE TELMISARTANTI. A presente invenção refere-se a um novo processo de preparação de telmisartan pela reação do 2-n-propil-4-metil-6-(1<39>-metilbenzimidazol-2<39>-il)-benzimidazol com um composto de fórmula geral na qual Z denota um grupo de saída para obter o composto 2-ciano-4<39>-¢2'-n-propil-4'-metil-6'-(1<39><39><39>-metilbenzimid azol-2<39><39><39>-il)benzimidazol-1'-ilmetil!bifenila e subseqüente hidrólise da função nitrila para obter a função ácida.
BRPI0408861-1A 2003-03-31 2004-03-26 processo de fabricação de telmisartan BRPI0408861A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10314702A DE10314702A1 (de) 2003-03-31 2003-03-31 Verfahren zur Herstellung von Telmisartan
PCT/EP2004/003217 WO2004087676A1 (de) 2003-03-31 2004-03-26 Verfahren zur herstellung von telmisartan

Publications (1)

Publication Number Publication Date
BRPI0408861A true BRPI0408861A (pt) 2006-04-11

Family

ID=33016100

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408861-1A BRPI0408861A (pt) 2003-03-31 2004-03-26 processo de fabricação de telmisartan

Country Status (26)

Country Link
US (2) US7193089B2 (pt)
EP (2) EP1611108B1 (pt)
JP (1) JP5160740B2 (pt)
KR (1) KR101096499B1 (pt)
CN (1) CN100418953C (pt)
AR (2) AR043794A1 (pt)
AT (1) ATE515500T1 (pt)
AU (1) AU2004226239B2 (pt)
BR (1) BRPI0408861A (pt)
CA (1) CA2520714C (pt)
CL (1) CL2004000687A1 (pt)
CY (2) CY1112020T1 (pt)
DE (1) DE10314702A1 (pt)
DK (2) DK2322511T3 (pt)
ES (2) ES2369081T3 (pt)
IL (1) IL171145A (pt)
MX (1) MXPA05009529A (pt)
NZ (1) NZ543244A (pt)
PE (1) PE20050390A1 (pt)
PL (2) PL2322511T3 (pt)
PT (2) PT2322511E (pt)
RU (1) RU2430092C2 (pt)
SI (2) SI2322511T1 (pt)
TW (1) TWI335916B (pt)
UY (1) UY28246A1 (pt)
WO (1) WO2004087676A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
US7501448B2 (en) * 2004-10-15 2009-03-10 Teva Pharmaceutical Industries, Ltd. Process for preparing telmisartan
US7943781B2 (en) 2004-10-18 2011-05-17 Dr. Reddy's Laboratories Limited Process for preparing telmisartan
US7968727B2 (en) 2005-04-01 2011-06-28 Lek Pharmaceuticals, D.D. Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists
ITMI20050801A1 (it) * 2005-05-03 2006-11-04 Dipharma Spa Procedimento per la preparazione di telmisartan
WO2006136916A2 (en) * 2005-06-20 2006-12-28 Glenmark Pharmaceuticals Limited Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
US20060264491A1 (en) * 2006-06-08 2006-11-23 Chemagis Ltd. Telmisartan production process
CN101172968B (zh) * 2006-11-01 2010-05-12 浙江天宇药业有限公司 2-正丙基-4甲基-6-(甲基苯并咪唑-2-基)苯并咪唑盐及其制备方法
EP2170835A1 (en) * 2007-07-03 2010-04-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing telmisartan
CZ302272B6 (cs) 2007-07-09 2011-01-19 Zentiva, A. S. Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
WO2009116089A2 (en) * 2008-03-14 2009-09-24 Ipca Laboratories Limited Novel intermediates and method for synthesis of 4'-[(1,4'-dimethyl-2'-propyl-[2,6'- bi-1hbenzimidazol]-l-yl)methyl]-1,1-biphenyl]-2-carboxylic acid.
EP2279185B1 (en) * 2008-03-20 2014-01-15 LEK Pharmaceuticals d.d. Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
EP2103609A1 (en) * 2008-03-20 2009-09-23 Lek Pharmaceuticals D.D. Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
EP2103588A1 (en) * 2008-03-20 2009-09-23 Lek Pharmaceuticals D.D. 2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
EP2123648A1 (en) 2008-05-20 2009-11-25 Chemo Ibérica, S.A. A process for the preparation of Telmisartan.
EP2149566A1 (en) 2008-07-15 2010-02-03 Chemo Ibérica, S.A. A process for the preparation of telmisartan
ES2415357T3 (es) 2009-06-19 2013-07-25 Krka Tovarna Zdravil, D.D., Novo Mesto Procedimiento para la preparación de telmisartán
EP2277866A1 (en) 2009-06-22 2011-01-26 Inke, S.A. Process for preparing telmisartan
EP2305650A1 (en) 2009-09-21 2011-04-06 Chemo Ibérica, S.A. Novel process for the preparation of telmisartan
WO2012055941A1 (en) 2010-10-27 2012-05-03 Krka,Tovarna Zdravil, D. D., Novo Mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
CN102267949A (zh) * 2011-06-14 2011-12-07 张长利 替米沙坦制备新工艺
WO2014027280A1 (en) 2012-08-14 2014-02-20 U Amarnath Amarnath One pot process for the preparation of telmisartan
CN103787982A (zh) * 2012-10-31 2014-05-14 上海特化医药科技有限公司 制备替米沙坦的方法及其中间体
CN104557724B (zh) * 2014-11-17 2017-01-11 江苏中邦制药有限公司 替米沙坦不定形晶型及其制备方法
CN105130905B (zh) * 2015-09-17 2017-09-08 浙江金立源药业有限公司 一种替米沙坦的合成方法
CN109912512B (zh) * 2017-12-13 2023-05-30 上海科胜药物研发有限公司 一种新的替米沙坦杂质化合物及其制备方法和用途
CN112251770B (zh) * 2020-10-14 2021-07-27 湖南大学 一种抗高血压药替米沙坦中间体电化学制备新方法
CN113307775B (zh) * 2021-04-16 2022-04-22 河北戴桥医药科技有限公司 一种替米沙坦的制备方法
WO2023204729A1 (ru) * 2022-04-19 2023-10-26 Общество с ограниченной ответственностью "Гелеспон" Фармацевтические композиции на основе новой субстанции 4-[2-(1н-имидазол-4-ил)-этилкарбамоил]-бутановой кислоты и способ получения субстанции

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
DE4023369A1 (de) * 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
DE4103492A1 (de) * 1991-02-06 1992-10-08 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5614519A (en) 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US6358986B1 (en) 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
DE19901921C2 (de) * 1999-01-19 2001-01-04 Boehringer Ingelheim Pharma Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
US6737432B2 (en) 2001-10-31 2004-05-18 Boehringer Ingelheim Pharma Kg Crystalline form of telmisartan sodium
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan

Also Published As

Publication number Publication date
CN1768044A (zh) 2006-05-03
RU2005133479A (ru) 2006-07-27
PL2322511T3 (pl) 2014-01-31
CA2520714A1 (en) 2004-10-14
US20130137878A1 (en) 2013-05-30
AU2004226239A1 (en) 2004-10-14
PT1611108E (pt) 2011-09-01
EP2322511B1 (de) 2013-07-31
EP1611108A1 (de) 2006-01-04
ES2432647T3 (es) 2013-12-04
SI2322511T1 (sl) 2013-10-30
UY28246A1 (es) 2004-11-08
RU2430092C2 (ru) 2011-09-27
CA2520714C (en) 2012-05-15
AR043794A1 (es) 2005-08-10
DK2322511T3 (da) 2013-10-28
IL171145A (en) 2010-12-30
US7193089B2 (en) 2007-03-20
CL2004000687A1 (es) 2005-02-04
ES2369081T3 (es) 2011-11-25
AR087209A2 (es) 2014-02-26
MXPA05009529A (es) 2005-10-19
DK1611108T3 (da) 2011-10-10
AU2004226239B2 (en) 2011-04-21
CY1115156T1 (el) 2016-12-14
US20040236113A1 (en) 2004-11-25
JP5160740B2 (ja) 2013-03-13
PL1611108T3 (pl) 2011-12-30
KR101096499B1 (ko) 2011-12-20
EP2322511A1 (de) 2011-05-18
CN100418953C (zh) 2008-09-17
PT2322511E (pt) 2013-08-29
JP2006521289A (ja) 2006-09-21
NZ543244A (en) 2010-02-26
CY1112020T1 (el) 2015-11-04
WO2004087676A1 (de) 2004-10-14
TWI335916B (en) 2011-01-11
ATE515500T1 (de) 2011-07-15
EP1611108B1 (de) 2011-07-06
PE20050390A1 (es) 2005-06-23
DE10314702A1 (de) 2004-10-21
SI1611108T1 (sl) 2011-10-28
KR20050118699A (ko) 2005-12-19
TW200504055A (en) 2005-02-01
US8993778B2 (en) 2015-03-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B65X Notification of requirement for priority examination of patent application
B65Y Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117)
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 235/18

Ipc: C07D 235/18 (2006.01), A61K 31/4184 (2006.01), A61

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8 E 13 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]