BRPI0213936B8 - métodos de ensaio de ciclização enzimática para homocisteína e cistationina e de teste de amostras contendo homocisteína, bem como kit de teste para quantificar homocisteína e ensaios de avaliação da quantidade de homocisteína - Google Patents

métodos de ensaio de ciclização enzimática para homocisteína e cistationina e de teste de amostras contendo homocisteína, bem como kit de teste para quantificar homocisteína e ensaios de avaliação da quantidade de homocisteína

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Publication number
BRPI0213936B8
BRPI0213936B8 BRPI0213936A BR0213936A BRPI0213936B8 BR PI0213936 B8 BRPI0213936 B8 BR PI0213936B8 BR PI0213936 A BRPI0213936 A BR PI0213936A BR 0213936 A BR0213936 A BR 0213936A BR PI0213936 B8 BRPI0213936 B8 BR PI0213936B8
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BR
Brazil
Prior art keywords
homocysteine
cystathionine
amount
assays
evaluating
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BRPI0213936A
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English (en)
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BRPI0213936B1 (pt
BR0213936A (pt
Inventor
Forest Doreen
Kawasaki Glenn
Kay Webb Heather
Owens Jeffrey
Legaz Mark
Liedtke Raymond
Lawson Sobomabo
Original Assignee
Axis Shield Diagnostics Ltd
Catch Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21756556&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0213936(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Axis Shield Diagnostics Ltd, Catch Inc filed Critical Axis Shield Diagnostics Ltd
Publication of BR0213936A publication Critical patent/BR0213936A/pt
Publication of BRPI0213936B1 publication Critical patent/BRPI0213936B1/pt
Publication of BRPI0213936B8 publication Critical patent/BRPI0213936B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"ensaios de ciclização enzimática para homocisteína e cistationina". a presente invenção refere-se a um ensaio de ciclização enzimática para avaliação da quantidade de homocisteína e/ou cistationina em uma solução tal como sangue, derivados de sangue ou urina. o ensaio compreende as etapas de contato da solução contendo homocisteína e/ou cistationina para formar uma mistura de reação, com cbs, ou um seu derivado, l-serina, e cbl, ou um seu derivado, por um período de tempo suficiente para catalisar a conversão clínica da forma homocisteína em cistationina e a reconversão de cistationina em homocisteína com a produção de piruvato e amônia; determinação da quantidade de homocisteína e/ou amônia presente na mistura de reação; e determinação da quantidade de homocisteína e/ou cistationina presente na solução baseada na quantidade de piruvato e/ou amônia formada. vetores de expressão e procedimentos de isolamento para cbs, ou seus derivados, e cbi, ou seus derivados, são também providos, bem como kits de teste para realizar o ensaio. em modalidades preferidas, os ensaios podem ser realizados em 15 minutos ou menos, com um mínimo de uso de enzima.
BRPI0213936A 2001-11-06 2002-11-06 métodos de ensaio de ciclização enzimática para homocisteína e cistationina e de teste de amostras contendo homocisteína, bem como kit de teste para quantificar homocisteína e ensaios de avaliação da quantidade de homocisteína BRPI0213936B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/012,762 US6635438B2 (en) 1999-11-02 2001-11-06 Enzymatic cycling assays for homocysteine and cystathionine
PCT/US2002/035777 WO2003040694A2 (en) 2001-11-06 2002-11-06 Enzymatic cycling assays for homocysteine and cystathionine

Publications (3)

Publication Number Publication Date
BR0213936A BR0213936A (pt) 2004-08-31
BRPI0213936B1 BRPI0213936B1 (pt) 2015-08-25
BRPI0213936B8 true BRPI0213936B8 (pt) 2021-07-27

Family

ID=21756556

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0213936A BRPI0213936B8 (pt) 2001-11-06 2002-11-06 métodos de ensaio de ciclização enzimática para homocisteína e cistationina e de teste de amostras contendo homocisteína, bem como kit de teste para quantificar homocisteína e ensaios de avaliação da quantidade de homocisteína

Country Status (12)

Country Link
US (2) US6635438B2 (pt)
EP (1) EP1470242B1 (pt)
CN (1) CN1612937B (pt)
AU (1) AU2002352538A1 (pt)
BR (1) BRPI0213936B8 (pt)
DK (1) DK1470242T3 (pt)
HU (1) HU228343B1 (pt)
NO (1) NO20042144L (pt)
RU (1) RU2344176C2 (pt)
SK (1) SK288189B6 (pt)
WO (1) WO2003040694A2 (pt)
ZA (1) ZA200403395B (pt)

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US8476034B2 (en) * 2003-07-10 2013-07-02 General Atomics Methods and compositions for assaying homocysteine
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CN104198726B (zh) * 2014-08-14 2016-07-06 上海睿康生物科技有限公司 一种稳定的同型半胱氨酸检测试剂盒
CN105039368A (zh) * 2015-07-08 2015-11-11 北京嘉万生物技术有限公司 一种重组酵母胱硫醚beta合酶催化中心的表达及放大生产
CN105181970B (zh) * 2015-08-28 2017-05-03 宁波瑞源生物科技有限公司 一种稳定的同型半胱氨酸检测试剂盒
CN106970230B (zh) * 2017-03-29 2019-06-11 广州市伊川生物科技有限公司 一种同型半胱氨酸测定试剂盒
CN110346572A (zh) * 2018-04-04 2019-10-18 浙江力耐得传动科技有限公司 偶联丙酮酸氧化酶测定同型半胱氨酸（Hcy）的方法及测定试剂盒
CN108802125B (zh) * 2018-08-28 2023-09-15 长沙理工大学 基于七(6-巯基-6-去氧)-β-环糊精的L-半胱氨酸的检测方法及传感器
CN109975279B (zh) * 2019-03-07 2021-05-28 广州悦蜂生物防治科技有限公司 一种检测脂肪酶活性的方法、试剂盒及速测卡
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CN114689415A (zh) * 2020-12-31 2022-07-01 桂林优利特医疗电子有限公司 一种稳定性好的同型半胱氨酸检测试剂盒及制备方法
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Also Published As

Publication number Publication date
HUP0500095A3 (en) 2010-03-29
AU2002352538A1 (en) 2003-05-19
US6867014B2 (en) 2005-03-15
HU228343B1 (en) 2013-03-28
ZA200403395B (en) 2006-06-28
RU2004117087A (ru) 2005-04-27
HUP0500095A2 (hu) 2005-05-30
WO2003040694A3 (en) 2004-08-19
BRPI0213936B1 (pt) 2015-08-25
CN1612937B (zh) 2010-05-05
RU2344176C2 (ru) 2009-01-20
SK2042004A3 (en) 2004-10-05
US6635438B2 (en) 2003-10-21
WO2003040694A2 (en) 2003-05-15
BR0213936A (pt) 2004-08-31
EP1470242A2 (en) 2004-10-27
US20030138872A1 (en) 2003-07-24
US20040096929A1 (en) 2004-05-20
NO20042144L (no) 2004-08-06
EP1470242B1 (en) 2013-08-14
SK288189B6 (sk) 2014-05-06
CN1612937A (zh) 2005-05-04
DK1470242T3 (da) 2013-11-11
EP1470242A4 (en) 2007-01-03

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