BR9916102A - Desenvolvimentos em ou relacionados com pós - Google Patents
Desenvolvimentos em ou relacionados com pósInfo
- Publication number
- BR9916102A BR9916102A BR9916102-8A BR9916102A BR9916102A BR 9916102 A BR9916102 A BR 9916102A BR 9916102 A BR9916102 A BR 9916102A BR 9916102 A BR9916102 A BR 9916102A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- particles
- developments
- powders
- gcm
- Prior art date
Links
- 239000000843 powder Substances 0.000 title abstract 3
- 238000011161 development Methods 0.000 title 1
- 230000018109 developmental process Effects 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 239000002245 particle Substances 0.000 abstract 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glanulating (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Carbon And Carbon Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
Abstract
Patente de Invenção: <B>"DESENVOLVIMENTOS EM OU RELACIONADOS COM PóS"<D>. Partículas de um aminoácido tal como leucina podem ser formadas de um vapor de aminoácido, por exemplo por condensação de aerossol, ou por secagem por spray. As partículas de aminoácido têm uma densidade de carga de não mais do que 0,1 gcm^ -3^ ou têm um diâmetro aerodinâmico médio de massa de não mais do que 10<109>m ou são na forma de flocos tendo uma espessura de não mais do que 100 <109>m. Constatou-se que a inclusão das partículas de aminoácido em pó para uso em inaladores de pó seco melhora a fração respirável do material ativo no pó.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9827145.5A GB9827145D0 (en) | 1998-12-09 | 1998-12-09 | Improvements in or relating to powders |
PCT/GB1999/004156 WO2000033811A2 (en) | 1998-12-09 | 1999-12-09 | Improvements in or relating to powders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916102A true BR9916102A (pt) | 2001-09-04 |
Family
ID=10843948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916102-8A BR9916102A (pt) | 1998-12-09 | 1999-12-09 | Desenvolvimentos em ou relacionados com pós |
Country Status (24)
Country | Link |
---|---|
US (1) | US6989155B1 (pt) |
EP (1) | EP1137399B1 (pt) |
JP (1) | JP4410942B2 (pt) |
KR (1) | KR20010101138A (pt) |
CN (1) | CN1334723A (pt) |
AT (1) | ATE240093T1 (pt) |
AU (1) | AU770461B2 (pt) |
BR (1) | BR9916102A (pt) |
CA (1) | CA2353448C (pt) |
CZ (1) | CZ20012043A3 (pt) |
DE (1) | DE69907951T2 (pt) |
DK (1) | DK1137399T3 (pt) |
EA (1) | EA004045B1 (pt) |
ES (1) | ES2198973T3 (pt) |
GB (1) | GB9827145D0 (pt) |
HU (1) | HUP0104513A3 (pt) |
MX (1) | MXPA01005584A (pt) |
NO (1) | NO20012825D0 (pt) |
NZ (1) | NZ511965A (pt) |
PL (1) | PL348831A1 (pt) |
PT (1) | PT1137399E (pt) |
SK (1) | SK284775B6 (pt) |
TR (1) | TR200101591T2 (pt) |
WO (1) | WO2000033811A2 (pt) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
DK2280021T3 (en) | 1999-06-29 | 2016-05-02 | Mannkind Corp | Pharmaceutical formulations comprising insulin complexed to a diketopiperazine |
US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6586008B1 (en) | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
JP2001151673A (ja) * | 1999-09-06 | 2001-06-05 | Nikken Chem Co Ltd | 吸入用粉末製剤の製造方法 |
US7744855B2 (en) * | 2000-06-27 | 2010-06-29 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
JP5698423B2 (ja) * | 2000-06-27 | 2015-04-08 | ベクトゥラ・リミテッド | 医薬組成物で使用するための粒子の製造法 |
EP1337240B2 (en) † | 2000-11-30 | 2014-09-24 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
ES2334642T5 (es) * | 2000-11-30 | 2016-03-07 | Vectura Limited | Partículas para usar en una composición farmacéutica |
PT1920763E (pt) | 2000-11-30 | 2014-06-25 | Vectura Ltd | Composições farmacêuticas para inalação |
US20110123574A1 (en) * | 2002-03-20 | 2011-05-26 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
US7754242B2 (en) | 2002-03-20 | 2010-07-13 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
JP2005520847A (ja) * | 2002-03-20 | 2005-07-14 | アドバンスト インハレーション リサーチ,インコーポレイテッド | 肺投与用hGH(ヒト成長ホルモン)製剤 |
CA2478974C (en) * | 2002-03-20 | 2014-12-16 | Advanced Inhalation Research, Inc. | Inhalable sustained therapeutic formulations |
CA2479751C (en) | 2002-03-20 | 2008-06-03 | Trent Poole | Inhalation apparatus |
RU2364400C2 (ru) * | 2003-04-14 | 2009-08-20 | Вектура Лтд | Фармацевтические композиции |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
GB0321607D0 (en) * | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
BRPI0514263B8 (pt) | 2004-08-20 | 2021-05-25 | Mannkind Corp | método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida |
DK2314298T3 (en) | 2004-08-23 | 2015-06-15 | Mannkind Corp | Microparticles comprising diketopiperazinsalte for drug delivery |
GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
GB0426301D0 (en) * | 2004-11-30 | 2004-12-29 | Vectura Ltd | Pharmaceutical formulations |
MX2007009656A (es) | 2005-02-10 | 2007-11-07 | Glaxo Group Ltd | Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma. |
WO2007019229A1 (en) * | 2005-08-05 | 2007-02-15 | 3M Innovative Properties Company | Compositions exhibiting improved flowability |
US7803404B2 (en) | 2005-09-14 | 2010-09-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
GB0525254D0 (en) | 2005-12-12 | 2006-01-18 | Jagotec Ag | Powder compositions for inhalation |
BRPI0707991B8 (pt) * | 2006-02-22 | 2021-05-25 | Mannkind Corp | métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco |
DE102006030164A1 (de) * | 2006-06-29 | 2008-01-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Pulver |
DE102006053375A1 (de) * | 2006-11-10 | 2008-05-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mischung von Pulvern |
US20090048155A1 (en) | 2007-08-15 | 2009-02-19 | Endacea, Inc. | Methods for preventing and treating tissue injury and sepsis associated with Yersinia pestis infection |
US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
US9522916B2 (en) | 2007-12-21 | 2016-12-20 | Constance Neely Wilson | A1 adenosine receptor antagonists |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
AU2009257311B2 (en) | 2008-06-13 | 2014-12-04 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
US9358352B2 (en) | 2008-06-13 | 2016-06-07 | Mannkind Corporation | Dry powder drug delivery system and methods |
DK2300083T3 (da) | 2008-06-20 | 2013-07-22 | Mannkind Corp | Interaktivt apparat og fremgangsmåde til realtids-profilering af inhalationsforsøg |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2400950T3 (pl) | 2009-02-26 | 2019-12-31 | Glaxo Group Limited | Preparaty farmaceutyczne zawierające 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzylo)oksy]etoksy}heksylo)amino]-1-hydroksyetylo}-2-(hydroksymetylo)fenol |
US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
GB0908129D0 (en) * | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
WO2011094208A2 (en) | 2010-01-26 | 2011-08-04 | Endacea, Inc. | Methods and pharmaceutical compositions for preventing and treating renal impairment |
WO2012030645A1 (en) * | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
WO2012044736A1 (en) | 2010-09-29 | 2012-04-05 | Pulmatrix, Inc. | Monovalent metal cation dry powders for inhalation |
ES2732818T3 (es) * | 2010-11-09 | 2019-11-26 | Mannkind Corp | Composición que comprende un agonista de receptores de serotonina y una dicetopiperazina para tratar migrañas |
AU2015249177B2 (en) * | 2010-11-09 | 2017-08-03 | Mannkind Corporation | Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines |
ES2625858T3 (es) | 2011-04-01 | 2017-07-20 | Mannkind Corporation | Paquete de tipo blíster para cartuchos farmacéuticos |
RU2448717C1 (ru) * | 2011-04-20 | 2012-04-27 | Закрытое акционерное общество Научно-производственное предприятие "Тринита" | Способ получения антикоагулянтно-фибринолитического средства на основе гепарина |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
JP6018640B2 (ja) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
ES2624294T3 (es) | 2012-07-12 | 2017-07-13 | Mannkind Corporation | Sistemas de suministro de fármacos en polvo seco |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
WO2014106727A1 (en) | 2013-01-03 | 2014-07-10 | Vectura Limited | Inhaler and formulation |
EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
CN105324106A (zh) | 2013-04-01 | 2016-02-10 | 普马特里克斯营业公司 | 噻托铵干粉 |
CN114848614A (zh) | 2013-07-18 | 2022-08-05 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
AU2015338717B2 (en) | 2014-10-31 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
ES2908479T3 (es) | 2015-08-26 | 2022-04-29 | Achillion Pharmaceuticals Inc | Compuestos para el tratamiento de trastornos inmunitarios e inflamatorios |
JP7057290B2 (ja) | 2016-06-27 | 2022-04-19 | アキリオン ファーマシューティカルズ,インコーポレーテッド | 医学的障害を治療するためのキナゾリン及びインドール化合物 |
WO2018163085A1 (en) * | 2017-03-07 | 2018-09-13 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
US20190177588A1 (en) * | 2017-12-12 | 2019-06-13 | Xotramorphic LLC | Compositions, Methods, and Systems For Producing Flocculent Materials for Special Effects |
CN111902141A (zh) | 2018-03-26 | 2020-11-06 | C4医药公司 | 用于ikaros降解的羟脑苷脂结合剂 |
CN110441198A (zh) * | 2018-05-03 | 2019-11-12 | 人福普克药业(武汉)有限公司 | 一种检测尼达尼布软胶囊中尼达尼布粒径的方法 |
EP3841086A4 (en) | 2018-08-20 | 2022-07-27 | Achillion Pharmaceuticals, Inc. | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF MEDICAL DISORDERS RELATED TO COMPLEMENT FACTOR D |
JP2022517466A (ja) | 2018-10-16 | 2022-03-09 | ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド | 医学的障害の治療のための一酸化炭素プロドラッグ |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
US6136346A (en) | 1995-04-14 | 2000-10-24 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
ES2343124T3 (es) * | 1999-10-29 | 2010-07-23 | Novartis Ag | Composiciones de polvo seco con dispersabilidad mejorada. |
-
1998
- 1998-12-09 GB GBGB9827145.5A patent/GB9827145D0/en not_active Ceased
-
1999
- 1999-12-09 CZ CZ20012043A patent/CZ20012043A3/cs unknown
- 1999-12-09 DK DK99958404T patent/DK1137399T3/da active
- 1999-12-09 EP EP99958404A patent/EP1137399B1/en not_active Expired - Lifetime
- 1999-12-09 EA EA200100636A patent/EA004045B1/ru not_active IP Right Cessation
- 1999-12-09 HU HU0104513A patent/HUP0104513A3/hu unknown
- 1999-12-09 US US09/857,392 patent/US6989155B1/en not_active Expired - Fee Related
- 1999-12-09 CN CN99816052A patent/CN1334723A/zh active Pending
- 1999-12-09 CA CA2353448A patent/CA2353448C/en not_active Expired - Fee Related
- 1999-12-09 SK SK777-2001A patent/SK284775B6/sk unknown
- 1999-12-09 ES ES99958404T patent/ES2198973T3/es not_active Expired - Lifetime
- 1999-12-09 TR TR2001/01591T patent/TR200101591T2/xx unknown
- 1999-12-09 AT AT99958404T patent/ATE240093T1/de not_active IP Right Cessation
- 1999-12-09 DE DE69907951T patent/DE69907951T2/de not_active Expired - Lifetime
- 1999-12-09 PT PT99958404T patent/PT1137399E/pt unknown
- 1999-12-09 JP JP2000586305A patent/JP4410942B2/ja not_active Expired - Fee Related
- 1999-12-09 PL PL99348831A patent/PL348831A1/xx not_active IP Right Cessation
- 1999-12-09 WO PCT/GB1999/004156 patent/WO2000033811A2/en active IP Right Grant
- 1999-12-09 BR BR9916102-8A patent/BR9916102A/pt not_active Application Discontinuation
- 1999-12-09 KR KR1020017007067A patent/KR20010101138A/ko not_active Application Discontinuation
- 1999-12-09 AU AU15777/00A patent/AU770461B2/en not_active Ceased
- 1999-12-09 NZ NZ511965A patent/NZ511965A/en not_active IP Right Cessation
- 1999-12-09 MX MXPA01005584A patent/MXPA01005584A/es unknown
-
2001
- 2001-06-08 NO NO20012825A patent/NO20012825D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PT1137399E (pt) | 2003-09-30 |
HUP0104513A2 (hu) | 2002-03-28 |
CA2353448C (en) | 2010-02-23 |
US6989155B1 (en) | 2006-01-24 |
CN1334723A (zh) | 2002-02-06 |
EP1137399B1 (en) | 2003-05-14 |
DK1137399T3 (da) | 2003-08-18 |
NO20012825L (no) | 2001-06-08 |
SK284775B6 (sk) | 2005-11-03 |
JP4410942B2 (ja) | 2010-02-10 |
CZ20012043A3 (cs) | 2001-12-12 |
EA004045B1 (ru) | 2003-12-25 |
DE69907951D1 (de) | 2003-06-18 |
EP1137399A2 (en) | 2001-10-04 |
WO2000033811A3 (en) | 2000-10-12 |
WO2000033811A2 (en) | 2000-06-15 |
TR200101591T2 (tr) | 2001-11-21 |
DE69907951T2 (de) | 2004-03-11 |
SK7772001A3 (en) | 2001-12-03 |
AU770461B2 (en) | 2004-02-19 |
ATE240093T1 (de) | 2003-05-15 |
EA200100636A1 (ru) | 2001-12-24 |
HUP0104513A3 (en) | 2003-12-29 |
CA2353448A1 (en) | 2000-06-15 |
KR20010101138A (ko) | 2001-11-14 |
NZ511965A (en) | 2003-09-26 |
JP2002531487A (ja) | 2002-09-24 |
ES2198973T3 (es) | 2004-02-01 |
MXPA01005584A (es) | 2003-07-14 |
PL348831A1 (en) | 2002-06-17 |
NO20012825D0 (no) | 2001-06-08 |
GB9827145D0 (en) | 1999-02-03 |
AU1577700A (en) | 2000-06-26 |
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