BR9914527A - Vetores de replicação seletiva viral - Google Patents
Vetores de replicação seletiva viralInfo
- Publication number
- BR9914527A BR9914527A BR9914527-8A BR9914527A BR9914527A BR 9914527 A BR9914527 A BR 9914527A BR 9914527 A BR9914527 A BR 9914527A BR 9914527 A BR9914527 A BR 9914527A
- Authority
- BR
- Brazil
- Prior art keywords
- vectors
- virus
- cell
- target cell
- replication
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4736—Retinoblastoma protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"VETORES DE REPLICAçãO SELETIVA VIRAL'' <D>A presente invenção fornece vírus recombinantes que replicam seletivamente o genoma viral em resposta às condições intracelulares da célula alvo, através do uso de um promotor responsivo de percurso, que substancialmente inibe a replicação viral na célula hospedeira, com base no fenótipo ou genótipo da célula infectada. Na célula alvo, o elemento que promove o promotor responsivo de percurso é <MU>inativo<MV> e, portanto, o vírus é permitido replicar. Isso resulta em: (1) morte das células pela natureza lítica natural do vírus e/ou (2) proporciona uma dose terapêutica de um produto de transgene (amplificado em comparação aos vetores imcompetentes de replicação) para a célula alvo e (3) produz uma concentração localizada do vírus que facilita a infecção das células adjacentes ao vírus recombinante. A invenção ainda fornece métodos terapêuticos e de diagnóstico do uso dos vetores, formulações farmacêuticas compreendendo os vetores, métodos de fabricação dos vetores e células transformadas compreendendo os vetores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17268698A | 1998-10-15 | 1998-10-15 | |
PCT/US1999/021452 WO2000022137A2 (en) | 1998-10-15 | 1999-10-14 | Selectively replicating viral vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914527A true BR9914527A (pt) | 2001-06-26 |
Family
ID=22628758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914527-8A BR9914527A (pt) | 1998-10-15 | 1999-10-14 | Vetores de replicação seletiva viral |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1121441B1 (pt) |
JP (2) | JP4404490B2 (pt) |
KR (1) | KR100841815B1 (pt) |
CN (2) | CN101092636B (pt) |
AR (1) | AR020897A1 (pt) |
AT (1) | ATE348169T1 (pt) |
AU (1) | AU758354B2 (pt) |
BR (1) | BR9914527A (pt) |
CA (1) | CA2345900A1 (pt) |
CZ (1) | CZ301506B6 (pt) |
DE (1) | DE69934421T2 (pt) |
ES (1) | ES2279636T3 (pt) |
HK (1) | HK1040529B (pt) |
HU (1) | HU226602B1 (pt) |
IL (2) | IL142337A0 (pt) |
NO (1) | NO330666B1 (pt) |
NZ (2) | NZ528283A (pt) |
PL (1) | PL347898A1 (pt) |
SK (1) | SK4412001A3 (pt) |
TW (1) | TWI262948B (pt) |
WO (1) | WO2000022137A2 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU758354B2 (en) * | 1998-10-15 | 2003-03-20 | Canji, Inc. | Selectively replicating viral vectors |
KR100492017B1 (ko) * | 2002-06-24 | 2005-05-30 | 학교법인고려중앙학원 | 인간 간엽줄기 세포를 이용한 항암치료방법 |
GB0416487D0 (en) | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
WO2013138650A1 (en) * | 2012-03-14 | 2013-09-19 | Salk Institute For Biological Studies | Adenoviral tumor diagnostics |
WO2014153204A1 (en) | 2013-03-14 | 2014-09-25 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
EP2986306A4 (en) | 2013-04-18 | 2016-12-07 | Armo Biosciences Inc | METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING |
AU2016312510A1 (en) | 2015-08-25 | 2018-03-08 | Armo Biosciences, Inc. | Methods of using Interleukin-10 for treating diseases and disorders |
JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
WO2019020992A1 (en) * | 2017-07-25 | 2019-01-31 | Oxford Genetics Limited | ADENOVIRAL VECTOR |
US11485957B2 (en) * | 2017-10-10 | 2022-11-01 | Nantbio, Inc. | Modified EC7 cells having low toxicity to viral production payloads |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE178490T1 (de) * | 1993-02-16 | 1999-04-15 | Onyx Pharmaceuticals | Cytopathische viren zur therapie und prophylaxe der neoplasie |
WO1998013508A1 (en) * | 1996-09-24 | 1998-04-02 | Dana-Farber Cancer Institute | Method of targeting malignant cells using an e2f responsive promoter |
IL129922A0 (en) * | 1996-11-15 | 2000-02-29 | Canji Inc | Tissue specific expression of retinoblastoma protein |
AU744725B2 (en) * | 1997-03-03 | 2002-02-28 | Cold Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
AU758354B2 (en) * | 1998-10-15 | 2003-03-20 | Canji, Inc. | Selectively replicating viral vectors |
-
1999
- 1999-10-14 AU AU63915/99A patent/AU758354B2/en not_active Ceased
- 1999-10-14 CA CA002345900A patent/CA2345900A1/en not_active Abandoned
- 1999-10-14 KR KR1020017004690A patent/KR100841815B1/ko not_active IP Right Cessation
- 1999-10-14 TW TW088117803A patent/TWI262948B/zh not_active IP Right Cessation
- 1999-10-14 EP EP99951481A patent/EP1121441B1/en not_active Expired - Lifetime
- 1999-10-14 CN CN2007101040311A patent/CN101092636B/zh not_active Expired - Fee Related
- 1999-10-14 NZ NZ528283A patent/NZ528283A/en unknown
- 1999-10-14 HU HU0104107A patent/HU226602B1/hu unknown
- 1999-10-14 ES ES99951481T patent/ES2279636T3/es not_active Expired - Lifetime
- 1999-10-14 CZ CZ20011129A patent/CZ301506B6/cs not_active IP Right Cessation
- 1999-10-14 SK SK441-2001A patent/SK4412001A3/sk unknown
- 1999-10-14 PL PL99347898A patent/PL347898A1/xx not_active Application Discontinuation
- 1999-10-14 JP JP2000576027A patent/JP4404490B2/ja not_active Expired - Fee Related
- 1999-10-14 IL IL14233799A patent/IL142337A0/xx unknown
- 1999-10-14 AT AT99951481T patent/ATE348169T1/de not_active IP Right Cessation
- 1999-10-14 DE DE69934421T patent/DE69934421T2/de not_active Expired - Lifetime
- 1999-10-14 WO PCT/US1999/021452 patent/WO2000022137A2/en active IP Right Grant
- 1999-10-14 BR BR9914527-8A patent/BR9914527A/pt not_active IP Right Cessation
- 1999-10-14 CN CNB998143618A patent/CN1325647C/zh not_active Expired - Fee Related
- 1999-10-14 NZ NZ510805A patent/NZ510805A/en not_active IP Right Cessation
- 1999-10-15 AR ARP990105247A patent/AR020897A1/es active IP Right Grant
-
2001
- 2001-04-01 IL IL142337A patent/IL142337A/en not_active IP Right Cessation
- 2001-04-10 NO NO20011843A patent/NO330666B1/no not_active IP Right Cessation
-
2002
- 2002-02-08 HK HK02101003.1A patent/HK1040529B/zh not_active IP Right Cessation
-
2009
- 2009-08-04 JP JP2009181782A patent/JP2009254385A/ja not_active Withdrawn
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |