BR9913846A - Antagonista receptor de quemocina e ciclosporina em terapia combinada - Google Patents
Antagonista receptor de quemocina e ciclosporina em terapia combinadaInfo
- Publication number
- BR9913846A BR9913846A BR9913846-8A BR9913846A BR9913846A BR 9913846 A BR9913846 A BR 9913846A BR 9913846 A BR9913846 A BR 9913846A BR 9913846 A BR9913846 A BR 9913846A
- Authority
- BR
- Brazil
- Prior art keywords
- cyclosporine
- receptor antagonist
- chemokine
- application
- combination therapy
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 102000019034 Chemokines Human genes 0.000 title 1
- 108010012236 Chemokines Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 229940122444 Chemokine receptor antagonist Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002559 chemokine receptor antagonist Substances 0.000 abstract 1
- 108010054843 cyclosporin receptor Proteins 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98117697A EP1000626A1 (en) | 1998-09-18 | 1998-09-18 | Chemokine receptor antagonist and cyclosporin in combined therapy |
| PCT/EP1999/006844 WO2000016796A1 (en) | 1998-09-18 | 1999-09-16 | Chemokine receptor antagonist and cyclosporin in combined therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9913846A true BR9913846A (pt) | 2001-06-05 |
Family
ID=8232654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9913846-8A BR9913846A (pt) | 1998-09-18 | 1999-09-16 | Antagonista receptor de quemocina e ciclosporina em terapia combinada |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6902728B1 (enExample) |
| EP (2) | EP1000626A1 (enExample) |
| JP (1) | JP2003519082A (enExample) |
| KR (1) | KR100613950B1 (enExample) |
| CN (1) | CN1177613C (enExample) |
| AR (1) | AR021810A1 (enExample) |
| AT (1) | ATE227582T1 (enExample) |
| AU (1) | AU766595B2 (enExample) |
| BR (1) | BR9913846A (enExample) |
| CA (1) | CA2344370A1 (enExample) |
| DE (1) | DE69903964T2 (enExample) |
| DK (1) | DK1113811T3 (enExample) |
| EA (1) | EA003181B1 (enExample) |
| EE (1) | EE04705B1 (enExample) |
| ES (1) | ES2186411T3 (enExample) |
| HK (1) | HK1041225B (enExample) |
| IL (2) | IL141899A0 (enExample) |
| NO (1) | NO20011371D0 (enExample) |
| PT (1) | PT1113811E (enExample) |
| SI (1) | SI1113811T1 (enExample) |
| UA (1) | UA60379C2 (enExample) |
| WO (1) | WO2000016796A1 (enExample) |
| ZA (1) | ZA200101909B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259136B2 (en) | 1999-04-30 | 2007-08-21 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating peripheral vascular disease |
| US6740636B2 (en) | 2000-07-31 | 2004-05-25 | Schering Aktiengesellschaft | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
| LT5132B (lt) | 2000-07-31 | 2004-05-25 | Schering Aktiengesellschaft | Nepeptidiniai ccr1 receptorių antagonistai derinyje su ciklosporinu a širdies transplanto atmetimui gydyti |
| MX2010001307A (es) | 2007-08-02 | 2010-07-30 | Novimmune Sa | Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos. |
| JP6733968B2 (ja) * | 2015-08-31 | 2020-08-05 | 日立化成株式会社 | 腎移植後合併症を評価するための分子法 |
| JP6624704B2 (ja) | 2015-08-31 | 2019-12-25 | 日立化成株式会社 | 尿路上皮疾患の評価のための分子法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2207036A1 (en) * | 1994-12-08 | 1996-06-13 | Glaxo Group Limited | Rantes peptide and fragments and compositions comprising it for treatment of inflammation |
| AU712606B2 (en) * | 1995-08-09 | 1999-11-11 | Schering Corporation | Combined use of interleukin-10 and cyclosporin for immunosuppression therapy |
| EP0927167A1 (en) * | 1996-08-14 | 1999-07-07 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| WO1998006751A1 (en) * | 1996-08-16 | 1998-02-19 | Research Corporation Technologies, Inc. | Mcp-3, rantes and mip-1alpha receptor antagonists |
-
1998
- 1998-09-18 EP EP98117697A patent/EP1000626A1/en not_active Withdrawn
-
1999
- 1999-09-16 CN CNB998111252A patent/CN1177613C/zh not_active Expired - Fee Related
- 1999-09-16 AT AT99948760T patent/ATE227582T1/de active
- 1999-09-16 SI SI9930157T patent/SI1113811T1/xx unknown
- 1999-09-16 DK DK99948760T patent/DK1113811T3/da active
- 1999-09-16 AR ARP990104655A patent/AR021810A1/es unknown
- 1999-09-16 ZA ZA200101909A patent/ZA200101909B/xx unknown
- 1999-09-16 ES ES99948760T patent/ES2186411T3/es not_active Expired - Lifetime
- 1999-09-16 DE DE69903964T patent/DE69903964T2/de not_active Expired - Lifetime
- 1999-09-16 EE EEP200100159A patent/EE04705B1/xx not_active IP Right Cessation
- 1999-09-16 EA EA200100366A patent/EA003181B1/ru not_active IP Right Cessation
- 1999-09-16 KR KR1020017003199A patent/KR100613950B1/ko not_active Expired - Fee Related
- 1999-09-16 PT PT99948760T patent/PT1113811E/pt unknown
- 1999-09-16 HK HK02103034.0A patent/HK1041225B/zh not_active IP Right Cessation
- 1999-09-16 EP EP99948760A patent/EP1113811B1/en not_active Expired - Lifetime
- 1999-09-16 IL IL141899??A patent/IL141899A0/xx active IP Right Grant
- 1999-09-16 BR BR9913846-8A patent/BR9913846A/pt not_active Application Discontinuation
- 1999-09-16 US US09/787,335 patent/US6902728B1/en not_active Expired - Fee Related
- 1999-09-16 AU AU61914/99A patent/AU766595B2/en not_active Ceased
- 1999-09-16 JP JP2000573757A patent/JP2003519082A/ja not_active Withdrawn
- 1999-09-16 UA UA2001042570A patent/UA60379C2/uk unknown
- 1999-09-16 CA CA002344370A patent/CA2344370A1/en not_active Abandoned
- 1999-09-16 WO PCT/EP1999/006844 patent/WO2000016796A1/en not_active Ceased
-
2001
- 2001-03-08 IL IL141899A patent/IL141899A/en not_active IP Right Cessation
- 2001-03-16 NO NO20011371A patent/NO20011371D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA003181B1 (ru) | 2003-02-27 |
| DE69903964T2 (de) | 2003-03-27 |
| SI1113811T1 (en) | 2003-04-30 |
| CA2344370A1 (en) | 2000-03-30 |
| CN1177613C (zh) | 2004-12-01 |
| EP1000626A1 (en) | 2000-05-17 |
| ZA200101909B (en) | 2001-09-11 |
| IL141899A0 (en) | 2002-03-10 |
| WO2000016796A1 (en) | 2000-03-30 |
| JP2003519082A (ja) | 2003-06-17 |
| ES2186411T3 (es) | 2003-05-01 |
| HK1041225A1 (en) | 2002-07-05 |
| NO20011371L (no) | 2001-03-16 |
| UA60379C2 (uk) | 2003-10-15 |
| IL141899A (en) | 2007-12-03 |
| AU6191499A (en) | 2000-04-10 |
| US6902728B1 (en) | 2005-06-07 |
| EP1113811B1 (en) | 2002-11-13 |
| HK1041225B (zh) | 2005-04-22 |
| KR100613950B1 (ko) | 2006-08-18 |
| KR20010075060A (ko) | 2001-08-09 |
| AR021810A1 (es) | 2002-08-07 |
| PT1113811E (pt) | 2003-03-31 |
| EE04705B1 (et) | 2006-10-16 |
| EA200100366A1 (ru) | 2001-08-27 |
| EP1113811A1 (en) | 2001-07-11 |
| EE200100159A (et) | 2002-08-15 |
| ATE227582T1 (de) | 2002-11-15 |
| DK1113811T3 (da) | 2003-03-10 |
| CN1319021A (zh) | 2001-10-24 |
| AU766595B2 (en) | 2003-10-16 |
| DE69903964D1 (en) | 2002-12-19 |
| NO20011371D0 (no) | 2001-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: LABORATOIRES SERONO S.A. (CH) Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 10 (VIII) DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |