DE69903964T2 - Chemokin rezeptor antagonist und cyclosporin in kombinationstherapie - Google Patents

Chemokin rezeptor antagonist und cyclosporin in kombinationstherapie

Info

Publication number
DE69903964T2
DE69903964T2 DE69903964T DE69903964T DE69903964T2 DE 69903964 T2 DE69903964 T2 DE 69903964T2 DE 69903964 T DE69903964 T DE 69903964T DE 69903964 T DE69903964 T DE 69903964T DE 69903964 T2 DE69903964 T2 DE 69903964T2
Authority
DE
Germany
Prior art keywords
rantes
cyclosporin
receptor antagonist
cells
met
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69903964T
Other languages
German (de)
English (en)
Other versions
DE69903964D1 (en
Inventor
Hermann-Joseph Grone
J. Nelson
Amanda Proudfoot
N. Wells
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of DE69903964D1 publication Critical patent/DE69903964D1/de
Publication of DE69903964T2 publication Critical patent/DE69903964T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69903964T 1998-09-18 1999-09-16 Chemokin rezeptor antagonist und cyclosporin in kombinationstherapie Expired - Lifetime DE69903964T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117697A EP1000626A1 (en) 1998-09-18 1998-09-18 Chemokine receptor antagonist and cyclosporin in combined therapy
PCT/EP1999/006844 WO2000016796A1 (en) 1998-09-18 1999-09-16 Chemokine receptor antagonist and cyclosporin in combined therapy

Publications (2)

Publication Number Publication Date
DE69903964D1 DE69903964D1 (en) 2002-12-19
DE69903964T2 true DE69903964T2 (de) 2003-03-27

Family

ID=8232654

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903964T Expired - Lifetime DE69903964T2 (de) 1998-09-18 1999-09-16 Chemokin rezeptor antagonist und cyclosporin in kombinationstherapie

Country Status (23)

Country Link
US (1) US6902728B1 (enExample)
EP (2) EP1000626A1 (enExample)
JP (1) JP2003519082A (enExample)
KR (1) KR100613950B1 (enExample)
CN (1) CN1177613C (enExample)
AR (1) AR021810A1 (enExample)
AT (1) ATE227582T1 (enExample)
AU (1) AU766595B2 (enExample)
BR (1) BR9913846A (enExample)
CA (1) CA2344370A1 (enExample)
DE (1) DE69903964T2 (enExample)
DK (1) DK1113811T3 (enExample)
EA (1) EA003181B1 (enExample)
EE (1) EE04705B1 (enExample)
ES (1) ES2186411T3 (enExample)
HK (1) HK1041225B (enExample)
IL (2) IL141899A0 (enExample)
NO (1) NO20011371D0 (enExample)
PT (1) PT1113811E (enExample)
SI (1) SI1113811T1 (enExample)
UA (1) UA60379C2 (enExample)
WO (1) WO2000016796A1 (enExample)
ZA (1) ZA200101909B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6740636B2 (en) 2000-07-31 2004-05-25 Schering Aktiengesellschaft Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
LT5132B (lt) 2000-07-31 2004-05-25 Schering Aktiengesellschaft Nepeptidiniai ccr1 receptorių antagonistai derinyje su ciklosporinu a širdies transplanto atmetimui gydyti
MX2010001307A (es) 2007-08-02 2010-07-30 Novimmune Sa Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos.
JP6733968B2 (ja) * 2015-08-31 2020-08-05 日立化成株式会社 腎移植後合併症を評価するための分子法
JP6624704B2 (ja) 2015-08-31 2019-12-25 日立化成株式会社 尿路上皮疾患の評価のための分子法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2207036A1 (en) * 1994-12-08 1996-06-13 Glaxo Group Limited Rantes peptide and fragments and compositions comprising it for treatment of inflammation
AU712606B2 (en) * 1995-08-09 1999-11-11 Schering Corporation Combined use of interleukin-10 and cyclosporin for immunosuppression therapy
EP0927167A1 (en) * 1996-08-14 1999-07-07 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
WO1998006751A1 (en) * 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists

Also Published As

Publication number Publication date
EA003181B1 (ru) 2003-02-27
SI1113811T1 (en) 2003-04-30
CA2344370A1 (en) 2000-03-30
CN1177613C (zh) 2004-12-01
EP1000626A1 (en) 2000-05-17
ZA200101909B (en) 2001-09-11
IL141899A0 (en) 2002-03-10
WO2000016796A1 (en) 2000-03-30
JP2003519082A (ja) 2003-06-17
ES2186411T3 (es) 2003-05-01
HK1041225A1 (en) 2002-07-05
NO20011371L (no) 2001-03-16
UA60379C2 (uk) 2003-10-15
IL141899A (en) 2007-12-03
AU6191499A (en) 2000-04-10
US6902728B1 (en) 2005-06-07
EP1113811B1 (en) 2002-11-13
HK1041225B (zh) 2005-04-22
KR100613950B1 (ko) 2006-08-18
KR20010075060A (ko) 2001-08-09
AR021810A1 (es) 2002-08-07
PT1113811E (pt) 2003-03-31
EE04705B1 (et) 2006-10-16
EA200100366A1 (ru) 2001-08-27
EP1113811A1 (en) 2001-07-11
EE200100159A (et) 2002-08-15
BR9913846A (pt) 2001-06-05
ATE227582T1 (de) 2002-11-15
DK1113811T3 (da) 2003-03-10
CN1319021A (zh) 2001-10-24
AU766595B2 (en) 2003-10-16
DE69903964D1 (en) 2002-12-19
NO20011371D0 (no) 2001-03-16

Similar Documents

Publication Publication Date Title
Gröne et al. Met‐RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment
DE3854351T2 (de) Methode zur verminderung von gewebsschäden an einer entzündeten stelle durch verwendung von monoklonalen antikörpern.
DE69715611T2 (de) Verwendung eines rapamycinderivates zur behandlung von gefäss erkrankungen und xenotransplantationen
Hirano et al. Electron microscopy of the blood‐brain barrier in disease
Goldsmith The omentum: Research and clinical applications
Fanny et al. The IL-33 receptor ST2 regulates pulmonary inflammation and fibrosis to bleomycin
Randolph et al. Mononuclear phagocytes egress from an in vitro model of the vascular wall by migrating across endothelium in the basal to apical direction: role of intercellular adhesion molecule 1 and the CD11/CD18 integrins.
DE69935853T2 (de) Anwendung von alfa1beta1 integrinrezeptorinhibitoren und tgf-beta1-inhibitoren zur behandlung von nierenkrankheiten
Amersi et al. Fibronectin-α4β1 integrin-mediated blockade protects genetically fat zucker rat livers from ischemia/reperfusion injury
DE19708713C2 (de) Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
Nagineni et al. INFLAMMATORY CYTOKINES INDUCE INTERCELLULAR ADHESION MOLECULE-1 (ICAM–1) mRNA SYNTHESIS AND PROTEIN SECRETION BY HUMAN RETINAL PIGMENT EPITHELIAL CELL CULTURES
Okada et al. Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndrome
Cammermeyer Mast cells in the mammalian area postrema
DE69428278T2 (de) Leukozytadhaesiontest
Emanuelli et al. Role of platelet activating factor in acute pancreatitis induced by lipopolysaccharides in rabbits
US6902728B1 (en) Chemokine receptor antagonist and cyclosporin in combined therapy
EP1226433A1 (de) Verfahren zur identifizierung von anti-apoptotisch wirksamen verbindungen
DE102004042894A1 (de) Verwendung von Blockern der NKG2D-Rezeptor-/NKG2D-Liganden-Interaktion bei Autoimmunerkrankungen
DE69824862T2 (de) Zusammenstellungen zur verbesserten wundheilung
DE69934336T2 (de) Verwendung von halofuginone zur behandlung von urethralstriktur
WO2018137701A1 (zh) 靶向cxcr7的药物组合物和方法
DE69814148T2 (de) Zielspezifische abgabe zum nukleus mittels protein h von streptococcus
DE3874142T2 (de) Pharmazeutische zusammensetzung mit antikrebswirkung und methode fuer die behandlung von krebs.
DE69429534T2 (de) Monoklonale antikörper gegen schaumzellen und ihre pharmazeutische und diagnostische anwendung
DE60216788T2 (de) Den calciumeinstrom hemmender faktor und verfahren zu dessen isolierung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH