CN1177613C - 联合治疗中的趋化因子受体拮抗剂和环孢菌素 - Google Patents

联合治疗中的趋化因子受体拮抗剂和环孢菌素 Download PDF

Info

Publication number
CN1177613C
CN1177613C CNB998111252A CN99811125A CN1177613C CN 1177613 C CN1177613 C CN 1177613C CN B998111252 A CNB998111252 A CN B998111252A CN 99811125 A CN99811125 A CN 99811125A CN 1177613 C CN1177613 C CN 1177613C
Authority
CN
China
Prior art keywords
rantes
cyclosporine
met
cells
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB998111252A
Other languages
English (en)
Chinese (zh)
Other versions
CN1319021A (zh
Inventor
H-J
H·－J·格罗纳
�ɶ�ѷ
P·J·纳尔逊
�͵¸�
A·普劳德富特
��C����
T·N·C·韦尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serono Laboratories UK Ltd
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Publication of CN1319021A publication Critical patent/CN1319021A/zh
Application granted granted Critical
Publication of CN1177613C publication Critical patent/CN1177613C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNB998111252A 1998-09-18 1999-09-16 联合治疗中的趋化因子受体拮抗剂和环孢菌素 Expired - Fee Related CN1177613C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117697.7 1998-09-18
EP98117697A EP1000626A1 (en) 1998-09-18 1998-09-18 Chemokine receptor antagonist and cyclosporin in combined therapy

Publications (2)

Publication Number Publication Date
CN1319021A CN1319021A (zh) 2001-10-24
CN1177613C true CN1177613C (zh) 2004-12-01

Family

ID=8232654

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998111252A Expired - Fee Related CN1177613C (zh) 1998-09-18 1999-09-16 联合治疗中的趋化因子受体拮抗剂和环孢菌素

Country Status (23)

Country Link
US (1) US6902728B1 (enExample)
EP (2) EP1000626A1 (enExample)
JP (1) JP2003519082A (enExample)
KR (1) KR100613950B1 (enExample)
CN (1) CN1177613C (enExample)
AR (1) AR021810A1 (enExample)
AT (1) ATE227582T1 (enExample)
AU (1) AU766595B2 (enExample)
BR (1) BR9913846A (enExample)
CA (1) CA2344370A1 (enExample)
DE (1) DE69903964T2 (enExample)
DK (1) DK1113811T3 (enExample)
EA (1) EA003181B1 (enExample)
EE (1) EE04705B1 (enExample)
ES (1) ES2186411T3 (enExample)
HK (1) HK1041225B (enExample)
IL (2) IL141899A0 (enExample)
NO (1) NO20011371D0 (enExample)
PT (1) PT1113811E (enExample)
SI (1) SI1113811T1 (enExample)
UA (1) UA60379C2 (enExample)
WO (1) WO2000016796A1 (enExample)
ZA (1) ZA200101909B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6740636B2 (en) 2000-07-31 2004-05-25 Schering Aktiengesellschaft Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
LT5132B (lt) 2000-07-31 2004-05-25 Schering Aktiengesellschaft Nepeptidiniai ccr1 receptorių antagonistai derinyje su ciklosporinu a širdies transplanto atmetimui gydyti
MX2010001307A (es) 2007-08-02 2010-07-30 Novimmune Sa Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos.
JP6733968B2 (ja) * 2015-08-31 2020-08-05 日立化成株式会社 腎移植後合併症を評価するための分子法
JP6624704B2 (ja) 2015-08-31 2019-12-25 日立化成株式会社 尿路上皮疾患の評価のための分子法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2207036A1 (en) * 1994-12-08 1996-06-13 Glaxo Group Limited Rantes peptide and fragments and compositions comprising it for treatment of inflammation
AU712606B2 (en) * 1995-08-09 1999-11-11 Schering Corporation Combined use of interleukin-10 and cyclosporin for immunosuppression therapy
EP0927167A1 (en) * 1996-08-14 1999-07-07 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
WO1998006751A1 (en) * 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists

Also Published As

Publication number Publication date
EA003181B1 (ru) 2003-02-27
DE69903964T2 (de) 2003-03-27
SI1113811T1 (en) 2003-04-30
CA2344370A1 (en) 2000-03-30
EP1000626A1 (en) 2000-05-17
ZA200101909B (en) 2001-09-11
IL141899A0 (en) 2002-03-10
WO2000016796A1 (en) 2000-03-30
JP2003519082A (ja) 2003-06-17
ES2186411T3 (es) 2003-05-01
HK1041225A1 (en) 2002-07-05
NO20011371L (no) 2001-03-16
UA60379C2 (uk) 2003-10-15
IL141899A (en) 2007-12-03
AU6191499A (en) 2000-04-10
US6902728B1 (en) 2005-06-07
EP1113811B1 (en) 2002-11-13
HK1041225B (zh) 2005-04-22
KR100613950B1 (ko) 2006-08-18
KR20010075060A (ko) 2001-08-09
AR021810A1 (es) 2002-08-07
PT1113811E (pt) 2003-03-31
EE04705B1 (et) 2006-10-16
EA200100366A1 (ru) 2001-08-27
EP1113811A1 (en) 2001-07-11
EE200100159A (et) 2002-08-15
BR9913846A (pt) 2001-06-05
ATE227582T1 (de) 2002-11-15
DK1113811T3 (da) 2003-03-10
CN1319021A (zh) 2001-10-24
AU766595B2 (en) 2003-10-16
DE69903964D1 (en) 2002-12-19
NO20011371D0 (no) 2001-03-16

Similar Documents

Publication Publication Date Title
Kurihara et al. Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment
Vieira et al. A crucial role for TNF‐α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5
Nishida et al. Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
TAYLOR et al. Induction of vascular adhesion molecules during rejection of human cardiac allografts
Reinders et al. Proinflammatory functions of vascular endothelial growth factor in alloimmunity
Castaño et al. Serum amyloid P inhibits fibrosis through FcγR-dependent monocyte-macrophage regulation in vivo
Duffield et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
US20020018776A1 (en) Method of treating graft rejection using inhibitors of CXCR3 function
Murphy et al. Role of mast cells in early epithelial target cell injury in experimental acute graft-versus-host disease
Strawn et al. Novel mechanisms linking angiotensin II and early atherogenesis
US20140088006A1 (en) Stem Cell Mobilization and Tissue Repair and Regeneration
Ruers et al. Immunohistological observations in rat kidney allografts after local steroid administration.
US5675062A (en) Cellular basis of transplant arteriosclerosis in mice
HK1041225A1 (en) Chemokine receptor antagonist and cyclosporin in combined therapy
JP7787381B2 (ja) 医薬組成物、及び粒子
Li et al. Retracted: CCR5 blockade in combination with rapamycin prolongs cardiac allograft survival in mice
CN108355133A (zh) 靶向cxcr7的药物组合物和方法
AU2862300A (en) Methods for preventing graft rejection and ischemia-reperfusion injury
MXPA01002838A (en) Chemokine receptor antagonist and cyclosporin in combined therapy
WO2025101966A1 (en) Hif-2alpha targeting for enhanced transplant tolerance
US20210113524A1 (en) Methods of treating myeloproliferative disorders
JP2025508550A (ja) Ｐｅｇ－リン脂質分子の新規使用
Okahara et al. P1270 Nanoparticle-mediated simultaneous targeting of mitochondria and inflammatory monocytes protects the brain from ischemia-reperfusion injury in mice
CN118900913A (zh) Peg-磷脂分子的新用途
EP2552463A1 (fr) Compositions proangiogeniques, leur procede de preparation et leurs utilisations

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1041225

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: SERONO LABORATORY CO., LTD.

Free format text: FORMER OWNER: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

Effective date: 20080516

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20080516

Address after: Swiss Coyne Hince

Patentee after: Serono Lab

Address before: Curacao, Netherlands Antilles

Patentee before: Applied Research Systems ARS Holding N. V.

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041201

Termination date: 20091016