BR9908557A - Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico - Google Patents

Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico

Info

Publication number
BR9908557A
BR9908557A BR9908557-7A BR9908557A BR9908557A BR 9908557 A BR9908557 A BR 9908557A BR 9908557 A BR9908557 A BR 9908557A BR 9908557 A BR9908557 A BR 9908557A
Authority
BR
Brazil
Prior art keywords
hydroxy
methyl
pyridine
trimethoxyphenyl
carboxylic acid
Prior art date
Application number
BR9908557-7A
Other languages
English (en)
Inventor
Wolfgang Holla
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR9908557A publication Critical patent/BR9908557A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA SEPARAçãO ENANCIOMéRICA ENZIMáTICA DE 3(R)-HIDRóXI-1-METIL-4-(2,4,6-TRIMETOXIFENIL)-1,2,3,6-TETR AHIDRO-PIRIDINA E 3-(S)- HIDRóXI-1-METIL-4-(2,4,6-TRIMETOXIFENIL)-1,2,3,6-TETRAHID RO-PIRIDINA E OS éSTERES DE áCIDO CARBOXìLICO"<D>. é descrito um processo para preparação de compostos oticamente puros de 3(R)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina ou 3(S)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidropiridina e, dos ésteres de ácido carboxílico, por conversão estereodiferenciada das misturas enancioméricas com auxílio de uma enzima.
BR9908557-7A 1998-03-06 1999-02-20 Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico BR9908557A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19809649A DE19809649A1 (de) 1998-03-06 1998-03-06 Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester
PCT/EP1999/001113 WO1999045133A1 (de) 1998-03-06 1999-02-20 Verfarhen zur enzymatischen enantiomeren-trennung von 3(r)- und 3(s)-hydroxy-1- methyl-4-(2,4, 6-trimethoxyphenyl)-1, 2,3,6- tetrahydro-pyridin bzw. der carbonsäureester

Publications (1)

Publication Number Publication Date
BR9908557A true BR9908557A (pt) 2000-11-21

Family

ID=7859957

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9908557A BRPI9908557B8 (pt) 1998-03-06 1999-02-20 processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e os ésteres de ácido carboxílico
BR9908557-7A BR9908557A (pt) 1998-03-06 1999-02-20 Processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetr ahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahid ro-piridina e os ésteres de ácido carboxìlico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9908557A BRPI9908557B8 (pt) 1998-03-06 1999-02-20 processo para separação enanciomérica enzimática de 3(r)-hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e 3-(s)- hidróxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina e os ésteres de ácido carboxílico

Country Status (23)

Country Link
US (1) US6406912B1 (pt)
EP (1) EP1071807B1 (pt)
JP (1) JP4344089B2 (pt)
KR (1) KR100779864B1 (pt)
CN (1) CN1230554C (pt)
AR (1) AR018574A1 (pt)
AT (1) ATE474061T1 (pt)
AU (1) AU758106B2 (pt)
BR (2) BRPI9908557B8 (pt)
CA (1) CA2322842C (pt)
CY (1) CY1110919T1 (pt)
CZ (1) CZ301944B6 (pt)
DE (2) DE19809649A1 (pt)
DK (1) DK1071807T3 (pt)
ES (1) ES2348394T3 (pt)
HK (1) HK1035001A1 (pt)
HU (1) HU227994B1 (pt)
ID (1) ID27000A (pt)
PL (1) PL195006B1 (pt)
PT (1) PT1071807E (pt)
RU (1) RU2241040C2 (pt)
TR (1) TR200002576T2 (pt)
WO (1) WO1999045133A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201160A3 (en) 1999-05-13 2004-03-29 Shell Int Research Hydrocarbon conversion process
US7153675B2 (en) 2001-05-15 2006-12-26 Speedel Pharma Ag Process for the preparation of substituted carboxylic esters
CN104278061A (zh) * 2014-10-01 2015-01-14 青岛科技大学 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法
CN104232700A (zh) * 2014-10-01 2014-12-24 青岛科技大学 一种生物法生产(2r,3s)羟基丙酸甲酯的方法
CA2982928A1 (en) 2015-04-20 2016-10-27 Tolero Pharmaceuticals, Inc. Predicting response to alvocidib by mitochondrial profiling
KR102608921B1 (ko) 2015-05-18 2023-12-01 스미토모 파마 온콜로지, 인크. 생체 이용률이 증가된 알보시딥 프로드러그
CN108289861B (zh) 2015-08-03 2021-11-02 大日本住友制药肿瘤公司 用于治疗癌症的组合疗法
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
WO2018119000A1 (en) 2016-12-19 2018-06-28 Tolero Pharmaceuticals, Inc. Profiling peptides and methods for sensitivity profiling
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
CN110577974B (zh) * 2019-09-10 2021-07-20 杭州澳赛诺生物科技有限公司 手性3-羟基-1,2,3,6-四氢吡啶的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法
JPH05192145A (ja) * 1991-04-02 1993-08-03 Hoechst Ag 固定化生体触媒、その製造およびカラムリアクター中でのエステル合成におけるその使用
JPH0690790A (ja) * 1992-09-08 1994-04-05 Mercian Corp 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin

Also Published As

Publication number Publication date
CN1292034A (zh) 2001-04-18
HUP0101795A3 (en) 2004-03-01
JP2002505112A (ja) 2002-02-19
RU2241040C2 (ru) 2004-11-27
CZ20003223A3 (cs) 2000-11-15
PT1071807E (pt) 2010-09-29
KR100779864B1 (ko) 2007-11-27
AU758106B2 (en) 2003-03-13
AU2927599A (en) 1999-09-20
ATE474061T1 (de) 2010-07-15
HUP0101795A2 (hu) 2001-09-28
ES2348394T3 (es) 2010-12-03
EP1071807B1 (de) 2010-07-14
KR20010041643A (ko) 2001-05-25
EP1071807A1 (de) 2001-01-31
CA2322842C (en) 2011-04-05
WO1999045133A1 (de) 1999-09-10
HU227994B1 (en) 2012-08-28
AR018574A1 (es) 2001-11-28
PL342877A1 (en) 2001-07-16
TR200002576T2 (tr) 2000-11-21
BRPI9908557B8 (pt) 2021-05-25
CY1110919T1 (el) 2015-06-10
CN1230554C (zh) 2005-12-07
US6406912B1 (en) 2002-06-18
HK1035001A1 (en) 2001-11-09
DE59915183D1 (de) 2010-08-26
DE19809649A1 (de) 1999-09-09
BRPI9908557B1 (pt) 2018-09-18
ID27000A (id) 2001-02-22
DK1071807T3 (da) 2010-11-08
CZ301944B6 (cs) 2010-08-11
CA2322842A1 (en) 1999-09-10
PL195006B1 (pl) 2007-07-31
JP4344089B2 (ja) 2009-10-14

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B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 37, OPINO PELO INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O COMBINADO COM O ART. 13 DA LPI 9279/96).

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/09/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

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