DE60203142D1 - Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure - Google Patents
Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäureInfo
- Publication number
- DE60203142D1 DE60203142D1 DE60203142T DE60203142T DE60203142D1 DE 60203142 D1 DE60203142 D1 DE 60203142D1 DE 60203142 T DE60203142 T DE 60203142T DE 60203142 T DE60203142 T DE 60203142T DE 60203142 D1 DE60203142 D1 DE 60203142D1
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- hydroxydiphenylmethyl
- hydroxy
- preparation
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003592 fexofenadine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000260A ITRM20010260A1 (it) | 2001-05-17 | 2001-05-17 | Processo per la preparazione della fexofenadina o acido 4 1-idrossi-4-4- (idrossidifenilmetil)-1-piperidinil|-butil|-alfa,alfa-dimetilbenz |
| ITRM20010260 | 2001-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60203142D1 true DE60203142D1 (de) | 2005-04-14 |
| DE60203142T2 DE60203142T2 (de) | 2006-04-13 |
Family
ID=11455529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60203142T Expired - Fee Related DE60203142T2 (de) | 2001-05-17 | 2002-05-16 | Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6815549B2 (de) |
| EP (1) | EP1260505B1 (de) |
| JP (1) | JP2003026658A (de) |
| AT (1) | ATE290528T1 (de) |
| CA (1) | CA2386452A1 (de) |
| CZ (1) | CZ295949B6 (de) |
| DE (1) | DE60203142T2 (de) |
| ES (1) | ES2237631T3 (de) |
| HU (1) | HUP0201673A3 (de) |
| IT (1) | ITRM20010260A1 (de) |
| PL (1) | PL353977A1 (de) |
| PT (1) | PT1260505E (de) |
| SI (1) | SI1260505T1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE03757471T1 (de) * | 2002-06-10 | 2005-09-01 | Teva Pharmaceutical Industries Ltd. | Polymorphe form xvi von fexofenadin-hydrochlorid |
| EP1616861A3 (de) * | 2004-06-15 | 2006-02-08 | Dipharma S.p.A. | Verfahren zur Herstellung von Keto-Verbindungen |
| ITMI20041568A1 (it) * | 2004-07-30 | 2004-10-30 | Dipharma Spa | "polimorfi di fexofenadina base" |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20070987A1 (it) * | 2007-05-16 | 2008-11-17 | Dipharma Francis Srl | Procedimento per la preparazione di composti chetonici |
| IT1395337B1 (it) * | 2009-03-04 | 2012-09-14 | Dipharma Francis Srl | Procedimento per la preparazione di intermedi chetonici |
| WO2011158262A1 (en) * | 2010-06-15 | 2011-12-22 | Chemelectiva S.R.L. | Polymorphic form of fexofenadine hydrochloride, intermediates and process for its preparation |
| CN102079708B (zh) * | 2011-02-11 | 2013-10-02 | 浙江启明药业有限公司 | 4-(4-卤丁酰基)-α,α-二甲基苯乙酸酯的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU671822B2 (en) | 1992-04-10 | 1996-09-12 | Aventisub Ii Inc. | 4-diphenylmethyl piperidine derivatives and process for their preparation |
| US6147216A (en) * | 1993-06-25 | 2000-11-14 | Merrell Pharmaceuticals Inc. | Intermediates useful for the preparation of antihistaminic piperidine derivatives |
| US6153754A (en) | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
-
2001
- 2001-05-17 IT IT2001RM000260A patent/ITRM20010260A1/it unknown
-
2002
- 2002-05-15 CA CA002386452A patent/CA2386452A1/en not_active Abandoned
- 2002-05-16 PT PT02010234T patent/PT1260505E/pt unknown
- 2002-05-16 SI SI200230095T patent/SI1260505T1/xx unknown
- 2002-05-16 ES ES02010234T patent/ES2237631T3/es not_active Expired - Lifetime
- 2002-05-16 HU HU0201673A patent/HUP0201673A3/hu unknown
- 2002-05-16 EP EP02010234A patent/EP1260505B1/de not_active Expired - Lifetime
- 2002-05-16 DE DE60203142T patent/DE60203142T2/de not_active Expired - Fee Related
- 2002-05-16 AT AT02010234T patent/ATE290528T1/de not_active IP Right Cessation
- 2002-05-16 US US10/145,765 patent/US6815549B2/en not_active Expired - Fee Related
- 2002-05-17 PL PL02353977A patent/PL353977A1/xx not_active Application Discontinuation
- 2002-05-17 CZ CZ20021726A patent/CZ295949B6/cs not_active IP Right Cessation
- 2002-05-17 JP JP2002143142A patent/JP2003026658A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0201673A2 (hu) | 2003-02-28 |
| HU0201673D0 (de) | 2002-07-29 |
| HUP0201673A3 (en) | 2004-07-28 |
| CA2386452A1 (en) | 2002-11-17 |
| EP1260505A1 (de) | 2002-11-27 |
| CZ295949B6 (cs) | 2005-12-14 |
| ITRM20010260A0 (it) | 2001-05-17 |
| JP2003026658A (ja) | 2003-01-29 |
| US20020198233A1 (en) | 2002-12-26 |
| EP1260505B1 (de) | 2005-03-09 |
| ATE290528T1 (de) | 2005-03-15 |
| PT1260505E (pt) | 2005-05-31 |
| US6815549B2 (en) | 2004-11-09 |
| PL353977A1 (en) | 2002-11-18 |
| DE60203142T2 (de) | 2006-04-13 |
| ES2237631T3 (es) | 2005-08-01 |
| CZ20021726A3 (cs) | 2003-01-15 |
| ITRM20010260A1 (it) | 2002-11-18 |
| SI1260505T1 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |