DE60203142D1 - Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure - Google Patents

Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure

Info

Publication number
DE60203142D1
DE60203142D1 DE60203142T DE60203142T DE60203142D1 DE 60203142 D1 DE60203142 D1 DE 60203142D1 DE 60203142 T DE60203142 T DE 60203142T DE 60203142 T DE60203142 T DE 60203142T DE 60203142 D1 DE60203142 D1 DE 60203142D1
Authority
DE
Germany
Prior art keywords
alpha
hydroxydiphenylmethyl
hydroxy
preparation
piperidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60203142T
Other languages
English (en)
Other versions
DE60203142T2 (de
Inventor
Graziano Castaldi
Giuseppe Barreca
Domenico Magrone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma SpA
Original Assignee
Dipharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dipharma SpA filed Critical Dipharma SpA
Application granted granted Critical
Publication of DE60203142D1 publication Critical patent/DE60203142D1/de
Publication of DE60203142T2 publication Critical patent/DE60203142T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DE60203142T 2001-05-17 2002-05-16 Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure Expired - Fee Related DE60203142T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000260A ITRM20010260A1 (it) 2001-05-17 2001-05-17 Processo per la preparazione della fexofenadina o acido 4 1-idrossi-4-4- (idrossidifenilmetil)-1-piperidinil|-butil|-alfa,alfa-dimetilbenz
ITRM20010260 2001-05-17

Publications (2)

Publication Number Publication Date
DE60203142D1 true DE60203142D1 (de) 2005-04-14
DE60203142T2 DE60203142T2 (de) 2006-04-13

Family

ID=11455529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60203142T Expired - Fee Related DE60203142T2 (de) 2001-05-17 2002-05-16 Verfahren zur Herstellung von 4-[1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl]-alpha, alpha-dimethylphenylessigsäure

Country Status (13)

Country Link
US (1) US6815549B2 (de)
EP (1) EP1260505B1 (de)
JP (1) JP2003026658A (de)
AT (1) ATE290528T1 (de)
CA (1) CA2386452A1 (de)
CZ (1) CZ295949B6 (de)
DE (1) DE60203142T2 (de)
ES (1) ES2237631T3 (de)
HU (1) HUP0201673A3 (de)
IT (1) ITRM20010260A1 (de)
PL (1) PL353977A1 (de)
PT (1) PT1260505E (de)
SI (1) SI1260505T1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005532356A (ja) 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
EP1616861A3 (de) * 2004-06-15 2006-02-08 Dipharma S.p.A. Verfahren zur Herstellung von Keto-Verbindungen
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20070987A1 (it) 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
IT1395337B1 (it) * 2009-03-04 2012-09-14 Dipharma Francis Srl Procedimento per la preparazione di intermedi chetonici
WO2011158262A1 (en) * 2010-06-15 2011-12-22 Chemelectiva S.R.L. Polymorphic form of fexofenadine hydrochloride, intermediates and process for its preparation
CN102079708B (zh) * 2011-02-11 2013-10-02 浙江启明药业有限公司 4-(4-卤丁酰基)-α,α-二甲基苯乙酸酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0635004B1 (de) 1992-04-10 2002-07-17 Merrell Pharmaceuticals Inc. 4-diphenylmethylpiperidine und verfahren zu ihrer herstellung
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives

Also Published As

Publication number Publication date
DE60203142T2 (de) 2006-04-13
CA2386452A1 (en) 2002-11-17
US20020198233A1 (en) 2002-12-26
CZ295949B6 (cs) 2005-12-14
ATE290528T1 (de) 2005-03-15
HUP0201673A2 (hu) 2003-02-28
JP2003026658A (ja) 2003-01-29
US6815549B2 (en) 2004-11-09
ITRM20010260A1 (it) 2002-11-18
HUP0201673A3 (en) 2004-07-28
ITRM20010260A0 (it) 2001-05-17
ES2237631T3 (es) 2005-08-01
HU0201673D0 (de) 2002-07-29
PT1260505E (pt) 2005-05-31
CZ20021726A3 (cs) 2003-01-15
EP1260505A1 (de) 2002-11-27
SI1260505T1 (en) 2005-06-30
PL353977A1 (en) 2002-11-18
EP1260505B1 (de) 2005-03-09

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8339 Ceased/non-payment of the annual fee