HK1035001A1 - Method for enzymatic enantiomer-separation of 3(R)-and 3(s)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphe nyl)-1,2,3,6-tetrahydro-pyridine or its carboxylicacid esters - Google Patents

Method for enzymatic enantiomer-separation of 3(R)-and 3(s)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphe nyl)-1,2,3,6-tetrahydro-pyridine or its carboxylicacid esters

Info

Publication number
HK1035001A1
HK1035001A1 HK01105718A HK01105718A HK1035001A1 HK 1035001 A1 HK1035001 A1 HK 1035001A1 HK 01105718 A HK01105718 A HK 01105718A HK 01105718 A HK01105718 A HK 01105718A HK 1035001 A1 HK1035001 A1 HK 1035001A1
Authority
HK
Hong Kong
Prior art keywords
tetrahydro
pyridine
hydroxy
methyl
separation
Prior art date
Application number
HK01105718A
Other languages
English (en)
Inventor
Wolfgang Holla
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1035001A1 publication Critical patent/HK1035001A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
HK01105718A 1998-03-06 2001-08-15 Method for enzymatic enantiomer-separation of 3(R)-and 3(s)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphe nyl)-1,2,3,6-tetrahydro-pyridine or its carboxylicacid esters HK1035001A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19809649A DE19809649A1 (de) 1998-03-06 1998-03-06 Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester
PCT/EP1999/001113 WO1999045133A1 (de) 1998-03-06 1999-02-20 Verfarhen zur enzymatischen enantiomeren-trennung von 3(r)- und 3(s)-hydroxy-1- methyl-4-(2,4, 6-trimethoxyphenyl)-1, 2,3,6- tetrahydro-pyridin bzw. der carbonsäureester

Publications (1)

Publication Number Publication Date
HK1035001A1 true HK1035001A1 (en) 2001-11-09

Family

ID=7859957

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01105718A HK1035001A1 (en) 1998-03-06 2001-08-15 Method for enzymatic enantiomer-separation of 3(R)-and 3(s)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphe nyl)-1,2,3,6-tetrahydro-pyridine or its carboxylicacid esters

Country Status (23)

Country Link
US (1) US6406912B1 (xx)
EP (1) EP1071807B1 (xx)
JP (1) JP4344089B2 (xx)
KR (1) KR100779864B1 (xx)
CN (1) CN1230554C (xx)
AR (1) AR018574A1 (xx)
AT (1) ATE474061T1 (xx)
AU (1) AU758106B2 (xx)
BR (2) BR9908557A (xx)
CA (1) CA2322842C (xx)
CY (1) CY1110919T1 (xx)
CZ (1) CZ301944B6 (xx)
DE (2) DE19809649A1 (xx)
DK (1) DK1071807T3 (xx)
ES (1) ES2348394T3 (xx)
HK (1) HK1035001A1 (xx)
HU (1) HU227994B1 (xx)
ID (1) ID27000A (xx)
PL (1) PL195006B1 (xx)
PT (1) PT1071807E (xx)
RU (1) RU2241040C2 (xx)
TR (1) TR200002576T2 (xx)
WO (1) WO1999045133A1 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60001504T2 (de) 1999-05-13 2004-02-19 Shell Internationale Research Maatschappij B.V. Kohlenwasserstoff umwandlungsverfahren
ATE458066T1 (de) 2001-05-15 2010-03-15 Novartis Ag Verfahren zur herstellung von substituierten carbonsäureestern mittels enzymatischer hydrolyse
CN104278061A (zh) * 2014-10-01 2015-01-14 青岛科技大学 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法
CN104232700A (zh) * 2014-10-01 2014-12-24 青岛科技大学 一种生物法生产(2r,3s)羟基丙酸甲酯的方法
RU2717829C2 (ru) 2015-04-20 2020-03-26 Толеро Фармасьютикалз, Инк. Прогнозирование ответа на альвоцидиб с помощью анализа профиля митохондрий
ES2739749T3 (es) 2015-05-18 2020-02-03 Tolero Pharmaceuticals Inc Profármacos de alvocidib que tienen biodisponibilidad aumentada
WO2017024073A1 (en) 2015-08-03 2017-02-09 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
MX2019007332A (es) 2016-12-19 2019-11-18 Tolero Pharmaceuticals Inc Péptidos indicadores y métodos para caracterizar sensibilidad.
JP7196160B2 (ja) 2017-09-12 2022-12-26 スミトモ ファーマ オンコロジー， インコーポレイテッド Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン
EP3890749A4 (en) 2018-12-04 2022-08-03 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 INHIBITORS AND POLYMORPHS THEREOF FOR USE AS CANCER TREATMENT AGENT
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
CN110577974B (zh) * 2019-09-10 2021-07-20 杭州澳赛诺生物科技有限公司 手性3-羟基-1,2,3,6-四氢吡啶的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法
CA2064676A1 (en) * 1991-04-02 1992-10-03 Manfred Schneider Immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor
JPH0690790A (ja) * 1992-09-08 1994-04-05 Mercian Corp 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin

Also Published As

Publication number Publication date
EP1071807A1 (de) 2001-01-31
ES2348394T3 (es) 2010-12-03
HU227994B1 (en) 2012-08-28
JP4344089B2 (ja) 2009-10-14
TR200002576T2 (tr) 2000-11-21
CA2322842C (en) 2011-04-05
CA2322842A1 (en) 1999-09-10
BR9908557A (pt) 2000-11-21
KR20010041643A (ko) 2001-05-25
AU2927599A (en) 1999-09-20
KR100779864B1 (ko) 2007-11-27
BRPI9908557B8 (pt) 2021-05-25
BRPI9908557B1 (pt) 2018-09-18
DE19809649A1 (de) 1999-09-09
PL195006B1 (pl) 2007-07-31
PL342877A1 (en) 2001-07-16
AU758106B2 (en) 2003-03-13
CN1230554C (zh) 2005-12-07
RU2241040C2 (ru) 2004-11-27
CZ20003223A3 (cs) 2000-11-15
CY1110919T1 (el) 2015-06-10
AR018574A1 (es) 2001-11-28
DK1071807T3 (da) 2010-11-08
CN1292034A (zh) 2001-04-18
US6406912B1 (en) 2002-06-18
HUP0101795A3 (en) 2004-03-01
ATE474061T1 (de) 2010-07-15
DE59915183D1 (de) 2010-08-26
ID27000A (id) 2001-02-22
WO1999045133A1 (de) 1999-09-10
EP1071807B1 (de) 2010-07-14
PT1071807E (pt) 2010-09-29
HUP0101795A2 (hu) 2001-09-28
CZ301944B6 (cs) 2010-08-11
JP2002505112A (ja) 2002-02-19

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Effective date: 20190219