AR018574A1 - Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilico - Google Patents

Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilico

Info

Publication number
AR018574A1
AR018574A1 ARP990100907A ARP990100907A AR018574A1 AR 018574 A1 AR018574 A1 AR 018574A1 AR P990100907 A ARP990100907 A AR P990100907A AR P990100907 A ARP990100907 A AR P990100907A AR 018574 A1 AR018574 A1 AR 018574A1
Authority
AR
Argentina
Prior art keywords
enantiomers
tetrahydro
pyridine
methyl
trimetoxifenil
Prior art date
Application number
ARP990100907A
Other languages
English (en)
Original Assignee
Gompel Marie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gompel Marie filed Critical Gompel Marie
Publication of AR018574A1 publication Critical patent/AR018574A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

Abstract

Se describe un procedimiento para la preparacion de compuestos opticamente puros de 3(R)- y 3(S)-hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los ésteres de ácido carboxílico por conversion estereodiferenciadora del a mezcla de enantiomeros por medio de unaenzima.
ARP990100907A 1998-03-06 1999-03-04 Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilico AR018574A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19809649A DE19809649A1 (de) 1998-03-06 1998-03-06 Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester

Publications (1)

Publication Number Publication Date
AR018574A1 true AR018574A1 (es) 2001-11-28

Family

ID=7859957

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100907A AR018574A1 (es) 1998-03-06 1999-03-04 Procedimiento para la separacion enzimatica de enantiomeros de 3 (r)- y 3 (s) - hidroxi-1-metil-4-(2,4,6-trimetoxifenil)-1,2,3,6-tetrahidro-piridina o bien de los esteres de acido carboxilico

Country Status (23)

Country Link
US (1) US6406912B1 (es)
EP (1) EP1071807B1 (es)
JP (1) JP4344089B2 (es)
KR (1) KR100779864B1 (es)
CN (1) CN1230554C (es)
AR (1) AR018574A1 (es)
AT (1) ATE474061T1 (es)
AU (1) AU758106B2 (es)
BR (2) BRPI9908557B8 (es)
CA (1) CA2322842C (es)
CY (1) CY1110919T1 (es)
CZ (1) CZ301944B6 (es)
DE (2) DE19809649A1 (es)
DK (1) DK1071807T3 (es)
ES (1) ES2348394T3 (es)
HK (1) HK1035001A1 (es)
HU (1) HU227994B1 (es)
ID (1) ID27000A (es)
PL (1) PL195006B1 (es)
PT (1) PT1071807E (es)
RU (1) RU2241040C2 (es)
TR (1) TR200002576T2 (es)
WO (1) WO1999045133A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908602B1 (en) 1999-05-13 2005-06-21 Shell Oil Company Hydrocarbon conversion process
IL158586A0 (en) 2001-05-15 2004-05-12 Speedel Pharma Ag Process for the preparation of substituted carboxylic acid esters by enzymatic hydrolysis
CN104232700A (zh) * 2014-10-01 2014-12-24 青岛科技大学 一种生物法生产(2r,3s)羟基丙酸甲酯的方法
CN104278061A (zh) * 2014-10-01 2015-01-14 青岛科技大学 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法
JP6851978B2 (ja) 2015-04-20 2021-03-31 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド ミトコンドリアプロファイリングによるアルボシジブ応答の予測
TR201911032T4 (tr) 2015-05-18 2019-08-21 Tolero Pharmaceuticals Inc Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları.
RU2759963C2 (ru) 2015-08-03 2021-11-19 Сумитомо Даиниппон Фарма Онколоджи, Инк. Комбинированные терапии для лечения рака
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
EP3362471B1 (en) 2016-12-19 2021-11-17 Sumitomo Dainippon Pharma Oncology, Inc. Profiling peptides and methods for sensitivity profiling
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
CN110577974B (zh) * 2019-09-10 2021-07-20 杭州澳赛诺生物科技有限公司 手性3-羟基-1,2,3,6-四氢吡啶的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法
AU647603B2 (en) * 1991-04-02 1994-03-24 Hoechst Aktiengesellschaft An immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor
JPH0690790A (ja) * 1992-09-08 1994-04-05 Mercian Corp 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin

Also Published As

Publication number Publication date
CZ20003223A3 (cs) 2000-11-15
US6406912B1 (en) 2002-06-18
HUP0101795A2 (hu) 2001-09-28
HK1035001A1 (en) 2001-11-09
PT1071807E (pt) 2010-09-29
DE59915183D1 (de) 2010-08-26
EP1071807B1 (de) 2010-07-14
BRPI9908557B1 (pt) 2018-09-18
JP4344089B2 (ja) 2009-10-14
CY1110919T1 (el) 2015-06-10
PL342877A1 (en) 2001-07-16
HUP0101795A3 (en) 2004-03-01
CZ301944B6 (cs) 2010-08-11
PL195006B1 (pl) 2007-07-31
JP2002505112A (ja) 2002-02-19
AU758106B2 (en) 2003-03-13
EP1071807A1 (de) 2001-01-31
RU2241040C2 (ru) 2004-11-27
CA2322842C (en) 2011-04-05
CA2322842A1 (en) 1999-09-10
ES2348394T3 (es) 2010-12-03
BR9908557A (pt) 2000-11-21
CN1230554C (zh) 2005-12-07
ATE474061T1 (de) 2010-07-15
KR20010041643A (ko) 2001-05-25
DK1071807T3 (da) 2010-11-08
CN1292034A (zh) 2001-04-18
DE19809649A1 (de) 1999-09-09
TR200002576T2 (tr) 2000-11-21
AU2927599A (en) 1999-09-20
BRPI9908557B8 (pt) 2021-05-25
ID27000A (id) 2001-02-22
KR100779864B1 (ko) 2007-11-27
WO1999045133A1 (de) 1999-09-10
HU227994B1 (en) 2012-08-28

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