ATE234927T1 - Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure - Google Patents
Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäureInfo
- Publication number
- ATE234927T1 ATE234927T1 AT94924775T AT94924775T ATE234927T1 AT E234927 T1 ATE234927 T1 AT E234927T1 AT 94924775 T AT94924775 T AT 94924775T AT 94924775 T AT94924775 T AT 94924775T AT E234927 T1 ATE234927 T1 AT E234927T1
- Authority
- AT
- Austria
- Prior art keywords
- clavulanic acid
- production
- dehydrogenase
- acid dehydrogenase
- clavulanic
- Prior art date
Links
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 2
- 108010012258 clavulanate-9-aldehyde reductase Proteins 0.000 title abstract 2
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 2
- 229960003324 clavulanic acid Drugs 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939315393A GB9315393D0 (en) | 1993-07-24 | 1993-07-24 | Novel product |
| PCT/EP1994/002346 WO1995003416A1 (en) | 1993-07-24 | 1994-07-15 | Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234927T1 true ATE234927T1 (de) | 2003-04-15 |
Family
ID=10739405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94924775T ATE234927T1 (de) | 1993-07-24 | 1994-07-15 | Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6692950B1 (de) |
| EP (2) | EP1236729A1 (de) |
| JP (1) | JPH09502085A (de) |
| AT (1) | ATE234927T1 (de) |
| AU (1) | AU7494294A (de) |
| DE (1) | DE69432304T2 (de) |
| DK (1) | DK0711350T3 (de) |
| ES (1) | ES2194871T3 (de) |
| GB (1) | GB9315393D0 (de) |
| WO (1) | WO1995003416A1 (de) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ177159A (en) * | 1974-04-20 | 1978-03-06 | Beecham Group Ltd | Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions |
| GB1504425A (en) * | 1975-08-20 | 1978-03-22 | Beecham Group Ltd | Salts of clavulanic acid |
| GB1504426A (en) * | 1975-10-13 | 1978-03-22 | Beecham Group Ltd | Clavulanic acid derivatives |
| GB1573153A (en) * | 1977-02-26 | 1980-08-13 | Beecham Group Ltd | 2-hydroxy - 4 - oxa - 1 - azobicyclo(3,2,0)-heptan-7-one derivatives |
| NZ213963A (en) | 1984-10-27 | 1989-01-06 | Antibioticos Sa | Production of clavulanic acid |
| GB8813055D0 (en) * | 1988-06-02 | 1988-07-06 | Beecham Group Plc | Novel substance |
-
1993
- 1993-07-24 GB GB939315393A patent/GB9315393D0/en active Pending
-
1994
- 1994-07-15 EP EP02077067A patent/EP1236729A1/de not_active Withdrawn
- 1994-07-15 JP JP7504921A patent/JPH09502085A/ja not_active Ceased
- 1994-07-15 EP EP94924775A patent/EP0711350B1/de not_active Expired - Lifetime
- 1994-07-15 US US08/586,664 patent/US6692950B1/en not_active Expired - Fee Related
- 1994-07-15 AT AT94924775T patent/ATE234927T1/de not_active IP Right Cessation
- 1994-07-15 AU AU74942/94A patent/AU7494294A/en not_active Abandoned
- 1994-07-15 DK DK94924775T patent/DK0711350T3/da active
- 1994-07-15 DE DE69432304T patent/DE69432304T2/de not_active Expired - Lifetime
- 1994-07-15 ES ES94924775T patent/ES2194871T3/es not_active Expired - Lifetime
- 1994-07-15 WO PCT/EP1994/002346 patent/WO1995003416A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1236729A1 (de) | 2002-09-04 |
| DK0711350T3 (da) | 2003-07-07 |
| JPH09502085A (ja) | 1997-03-04 |
| DE69432304T2 (de) | 2003-12-11 |
| AU7494294A (en) | 1995-02-20 |
| WO1995003416A1 (en) | 1995-02-02 |
| EP0711350B1 (de) | 2003-03-19 |
| EP0711350A1 (de) | 1996-05-15 |
| GB9315393D0 (en) | 1993-09-08 |
| US6692950B1 (en) | 2004-02-17 |
| ES2194871T3 (es) | 2003-12-01 |
| DE69432304D1 (de) | 2003-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |