DE69432304D1 - Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure - Google Patents

Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure

Info

Publication number
DE69432304D1
DE69432304D1 DE69432304T DE69432304T DE69432304D1 DE 69432304 D1 DE69432304 D1 DE 69432304D1 DE 69432304 T DE69432304 T DE 69432304T DE 69432304 T DE69432304 T DE 69432304T DE 69432304 D1 DE69432304 D1 DE 69432304D1
Authority
DE
Germany
Prior art keywords
clavulic
production
acid
dehydrogenase
acid dehydrogenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432304T
Other languages
English (en)
Other versions
DE69432304T2 (de
Inventor
Stephen William Elson
Neville Hubert Nicholson
Stefan Roland Woroniecki
Janice Arnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69432304D1 publication Critical patent/DE69432304D1/de
Publication of DE69432304T2 publication Critical patent/DE69432304T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DE69432304T 1993-07-24 1994-07-15 Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure Expired - Lifetime DE69432304T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939315393A GB9315393D0 (en) 1993-07-24 1993-07-24 Novel product
PCT/EP1994/002346 WO1995003416A1 (en) 1993-07-24 1994-07-15 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid

Publications (2)

Publication Number Publication Date
DE69432304D1 true DE69432304D1 (de) 2003-04-24
DE69432304T2 DE69432304T2 (de) 2003-12-11

Family

ID=10739405

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432304T Expired - Lifetime DE69432304T2 (de) 1993-07-24 1994-07-15 Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure

Country Status (10)

Country Link
US (1) US6692950B1 (de)
EP (2) EP1236729A1 (de)
JP (1) JPH09502085A (de)
AT (1) ATE234927T1 (de)
AU (1) AU7494294A (de)
DE (1) DE69432304T2 (de)
DK (1) DK0711350T3 (de)
ES (1) ES2194871T3 (de)
GB (1) GB9315393D0 (de)
WO (1) WO1995003416A1 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
GB1504425A (en) 1975-08-20 1978-03-22 Beecham Group Ltd Salts of clavulanic acid
GB1504426A (en) 1975-10-13 1978-03-22 Beecham Group Ltd Clavulanic acid derivatives
GB1573153A (en) * 1977-02-26 1980-08-13 Beecham Group Ltd 2-hydroxy - 4 - oxa - 1 - azobicyclo(3,2,0)-heptan-7-one derivatives
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance

Also Published As

Publication number Publication date
AU7494294A (en) 1995-02-20
DE69432304T2 (de) 2003-12-11
ES2194871T3 (es) 2003-12-01
US6692950B1 (en) 2004-02-17
ATE234927T1 (de) 2003-04-15
JPH09502085A (ja) 1997-03-04
EP0711350A1 (de) 1996-05-15
EP1236729A1 (de) 2002-09-04
GB9315393D0 (en) 1993-09-08
WO1995003416A1 (en) 1995-02-02
EP0711350B1 (de) 2003-03-19
DK0711350T3 (da) 2003-07-07

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