BR9908256A - Uso de extratos obtidos de iridáceas e cimicifuga racemosa e de tectorigenin como medicamento organoseletivo do tipo estrogênio não possuindo efeito uterotrópico - Google Patents
Uso de extratos obtidos de iridáceas e cimicifuga racemosa e de tectorigenin como medicamento organoseletivo do tipo estrogênio não possuindo efeito uterotrópicoInfo
- Publication number
- BR9908256A BR9908256A BR9908256-0A BR9908256A BR9908256A BR 9908256 A BR9908256 A BR 9908256A BR 9908256 A BR9908256 A BR 9908256A BR 9908256 A BR9908256 A BR 9908256A
- Authority
- BR
- Brazil
- Prior art keywords
- organoselective
- iridaceae
- tectorigenin
- extracts obtained
- estrogen
- Prior art date
Links
- OBBCRPUNCUPUOS-UHFFFAOYSA-N tectorigenin Chemical compound O=C1C2=C(O)C(OC)=C(O)C=C2OC=C1C1=CC=C(O)C=C1 OBBCRPUNCUPUOS-UHFFFAOYSA-N 0.000 title abstract 5
- 241001113425 Iridaceae Species 0.000 title abstract 3
- 239000000284 extract Substances 0.000 title abstract 3
- UYLQOGTYNFVQQX-UHFFFAOYSA-N psi-tectorigenin Natural products COC1=C(O)C=C(O)C(C2=O)=C1OC=C2C1=CC=C(O)C=C1 UYLQOGTYNFVQQX-UHFFFAOYSA-N 0.000 title abstract 3
- OYUJPVCKGSEYDD-UHFFFAOYSA-N tectorigenin Natural products COc1c(O)cc2OCC(C(=O)c2c1O)c1ccc(O)cc1 OYUJPVCKGSEYDD-UHFFFAOYSA-N 0.000 title abstract 3
- 230000001836 utereotrophic effect Effects 0.000 title abstract 3
- 241000206501 Actaea <angiosperm> Species 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 229940011871 estrogen Drugs 0.000 abstract 2
- 239000000262 estrogen Substances 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- -1 tectorigenin glycosides Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<B>USO DE EXTRATOS OBTIDOS DE IRIDáCEAS E CIMICIFUGA RACEMOSA E DE TECTORIGENIN COMO MEDICAMENTO ORGANOSELETIVO DO TIPO ESTROGêNIO NãO POSSUINDO EFEITO UTEROTRóPICO<D> A presente invenção se refere ao uso de extratos obtidos a partir de Iridáceas e da Cimicifuga racemosa, e de tectorigenin e/ou glicosídeos de tectorigenin como um medicamento organoseletivo do tipo estrogênio, para o tratamento seletivo e/ou profilaxia de doenças cardiovasculares, em particular arteriosclerose, osteoporose, e desordens climatéricas, e.g., para prevenir ou aliviar calores quentes. Praticamente, não são observados efeitos uterotrópicos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19812204A DE19812204A1 (de) | 1998-03-19 | 1998-03-19 | Verwendung von Extrakten aus Cimicifuga racemosa und Belamcanda sinensis als estrogenartiges organselektives Arzneimittel ohne uterotrope Wirkung |
| PCT/EP1999/001860 WO1999047149A1 (de) | 1998-03-19 | 1999-03-19 | Verwendung von extrakten aus irisgewächsen und cimicifuga racemosa und tectorigenin als estrogenartiges organselektives arzneimittel ohne uterotrope wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908256A true BR9908256A (pt) | 2000-12-12 |
Family
ID=7861630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908256-0A BR9908256A (pt) | 1998-03-19 | 1999-03-19 | Uso de extratos obtidos de iridáceas e cimicifuga racemosa e de tectorigenin como medicamento organoseletivo do tipo estrogênio não possuindo efeito uterotrópico |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1064009B2 (pt) |
| JP (2) | JP2002506827A (pt) |
| KR (1) | KR100623333B1 (pt) |
| CN (2) | CN100581541C (pt) |
| AT (1) | ATE225182T1 (pt) |
| AU (1) | AU755900C (pt) |
| BR (1) | BR9908256A (pt) |
| CA (1) | CA2321444C (pt) |
| CZ (1) | CZ292684B6 (pt) |
| DE (2) | DE19812204A1 (pt) |
| DK (1) | DK1064009T4 (pt) |
| ES (1) | ES2184427T5 (pt) |
| HK (1) | HK1035660A1 (pt) |
| HU (1) | HU227694B1 (pt) |
| MX (1) | MXPA00007986A (pt) |
| PL (1) | PL194096B1 (pt) |
| PT (1) | PT1064009E (pt) |
| RU (2) | RU2228188C2 (pt) |
| SE (1) | SE1064009T4 (pt) |
| TR (1) | TR200002686T2 (pt) |
| WO (1) | WO1999047149A1 (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000302667A (ja) * | 1999-04-23 | 2000-10-31 | Kobe Tennenbutsu Kagaku Kk | 豊胸促進剤 |
| JP5106739B2 (ja) * | 2000-06-29 | 2012-12-26 | クイック−メッド テクノロジーズ、インク． | 化粧品組成物および方法 |
| TWI303990B (en) | 2000-10-17 | 2008-12-11 | Pfizer Prod Inc | New use of estrogen agonists/antagonists for improving vascular health |
| DE10054641A1 (de) | 2000-11-03 | 2002-05-16 | Schaper & Bruemmer Gmbh | Verwendung einer Zubereitung von Cimicifuga racemosa |
| DE10123503A1 (de) * | 2001-05-15 | 2002-11-21 | Bionorica Ag | Verwendung von Extrakten und Zubereitungen aus Irisgewächsen und Tectorigenin als organselektives Arzneimittel zur Behandlung von sexualhormon-abhängigen Erkrankungen des Urogenitaltraktes |
| DE10127897B4 (de) * | 2001-06-08 | 2006-04-20 | Bionorica Ag | Manteltablette mit Pflanzentrockenextrakten |
| DE10146159A1 (de) * | 2001-09-19 | 2003-04-10 | Bionorica Ag | Verwendung von Extrakten aus Cimicifuga-Arten als organselektives Arzneimittel zur Behandlung von sexualhormonabhängigen Erkrankungen des Urogenitaltraktes |
| EP1325681A1 (en) * | 2001-12-11 | 2003-07-09 | Société des Produits Nestlé S.A. | Composition for promotion of bone growth and maintenance of bone health |
| DE10206390A1 (de) * | 2002-02-15 | 2003-08-28 | Bionorica Ag | Verwendung von selektiv den Estrogenrezeptor beta modulierenden phytoestrogenhaltigen Extrakten |
| JP4605984B2 (ja) * | 2002-12-20 | 2011-01-05 | アサヒビール株式会社 | ストレス緩和剤 |
| EP1630160B1 (en) * | 2003-05-15 | 2009-04-08 | Chengdu Dikang Pharmaceutical Institute | The isoflavone derivatives of tectoridin, the preparation thereof and the anti-virus medicines containing the same as the effective constituents |
| EP1591143A1 (en) * | 2004-04-26 | 2005-11-02 | Schaper & Brümmer Gmbh & Co. Kg | Composition comprising a combination of Calcium, Cimicifugae racemosae rhizoma and vitamin D and its use as a pharmaceutical in conditions or disorders associated with or resulting from calcium deficiency or as a nutritional supplement |
| EP1588739A1 (en) * | 2004-04-23 | 2005-10-26 | Schaper & Brümmer Gmbh & Co. Kg | Composition comprising a combination of calcium, Cimicifugae racemosae rhizoma and vitamin D and its use as a pharmaceutical in conditions or disorders associated with or resulting from calcium deficiency or as a nutritional supplement |
| US7887851B2 (en) | 2004-06-07 | 2011-02-15 | Kao Corporation | Aromatase activator |
| CN100381435C (zh) * | 2005-03-24 | 2008-04-16 | 深圳海王药业有限公司 | 射干总黄酮提取物及其制备方法和其在药物制备中的应用 |
| EP1745796A1 (de) | 2005-07-19 | 2007-01-24 | Bionorica Research GmbH | Kombinationspräparat insbesondere zur Therapie des Prostatakarzinoms |
| CN101057854B (zh) * | 2006-05-31 | 2010-05-12 | 南京大学 | 升麻环菠萝蜜烷型三萜类化合物在抗骨质疏松及更年期综合症的用途 |
| DE102007044916A1 (de) | 2007-09-19 | 2009-04-23 | Bionorica Ag | Kosmetische oder dermatologische Zusammensetzung zur topischen Verwendung |
| KR100928013B1 (ko) * | 2008-01-25 | 2009-11-24 | 이화여자대학교 산학협력단 | 범부채 추출물을 이용한 돌피의 생장 촉진방법 및 이방법을 적용한 중금속 오염 토양의 정화방법 |
| CN101797265A (zh) * | 2010-04-09 | 2010-08-11 | 中国人民解放军第二军医大学 | 射干总异黄酮或异黄酮类化合物在制备防治妇女病的药物或食品中的应用 |
| WO2013007807A1 (de) | 2011-07-12 | 2013-01-17 | Bionorica Se | Ausgewählte cimicifuga-fraktionen zur behandlung von osteoporose |
| EP2545932A1 (de) | 2011-07-12 | 2013-01-16 | Bionorica Se | Ausgewählte Cimicifuga-Fraktionen zur Behandlung von Osteoporose |
| EP2620155A1 (de) | 2012-01-30 | 2013-07-31 | Bionorica SE | Arzneimittel enthaltend Cimicifuga zur Anwendung bei der Behandlung von Sarkopenie und Herzmuskelschwäche |
| CN102525907B (zh) * | 2012-02-22 | 2013-06-05 | 四川省中医药科学院 | 鸢尾苷元磺酸钠注射液 |
| CN102631363A (zh) * | 2012-04-11 | 2012-08-15 | 李超生 | 鸢尾苷在制备防治骨质疏松症的药物中的应用 |
| WO2013192114A1 (en) * | 2012-06-22 | 2013-12-27 | Golden Biotechnology Corporation | Methods and compositions for treating arteriosclerotic vascular diseases |
| US11541093B2 (en) | 2012-07-03 | 2023-01-03 | Max Zeller Soehne Ag | Pharmacological use of Cimicifuga extract |
| JP2014091706A (ja) * | 2012-11-02 | 2014-05-19 | Kao Corp | Ｇｌｐ−１分泌促進剤 |
| KR101964841B1 (ko) * | 2017-03-07 | 2019-08-07 | 주식회사 엘지생활건강 | 여성 갱년기 증상 개선용 조성물 |
| KR101965849B1 (ko) * | 2017-03-07 | 2019-04-04 | 주식회사 엘지생활건강 | 텍토리게닌 7-0-자일로실글루코시드를 포함하는 여성 갱년기 증상 완화용 조성물 |
| TWI761372B (zh) * | 2017-09-22 | 2022-04-21 | 日商東洋新藥股份有限公司 | 組合物 |
| EP3906040A1 (en) | 2018-12-31 | 2021-11-10 | Max Zeller Söhne AG | Combination of cimicifuga and petasites extracts for anticancer therapy and prophylaxis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6330417A (ja) * | 1986-07-23 | 1988-02-09 | Tsumura Juntendo Inc | 抗アレルギ−剤 |
| PL186769B1 (pl) * | 1995-09-07 | 2004-02-27 | Oreal | Zastosowanie wyciągu z Iridaceae i kompozycja zawierająca taki wyciąg |
| AU706262B2 (en) * | 1995-10-23 | 1999-06-10 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
| JPH09301884A (ja) * | 1996-05-15 | 1997-11-25 | Ichimaru Pharcos Co Ltd | ヒオウギ抽出物及びα−ヒドロキシ酸を含有するテストステロン５α−リダクターゼ阻害剤とその応用 |
| JPH107580A (ja) * | 1996-06-15 | 1998-01-13 | Michio Yoshida | コラゲナ−ゼ阻害剤 |
| JP3665848B2 (ja) * | 1996-09-18 | 2005-06-29 | 木村 幸代 | ヒメヒオウギズイセン球根抽出液の発酵飲料及びその製造方法 |
| DE19652183C1 (de) * | 1996-12-14 | 1998-02-12 | Schaper & Bruemmer Gmbh | Verwendung eines Extraktes aus Cimicifuga racemosa |
-
1998
- 1998-03-19 DE DE19812204A patent/DE19812204A1/de not_active Withdrawn
-
1999
- 1999-03-19 JP JP2000536389A patent/JP2002506827A/ja not_active Withdrawn
- 1999-03-19 MX MXPA00007986A patent/MXPA00007986A/es active IP Right Grant
- 1999-03-19 RU RU2000126476/15A patent/RU2228188C2/ru not_active IP Right Cessation
- 1999-03-19 PT PT99913282T patent/PT1064009E/pt unknown
- 1999-03-19 KR KR1020007008724A patent/KR100623333B1/ko not_active IP Right Cessation
- 1999-03-19 PL PL99342486A patent/PL194096B1/pl not_active IP Right Cessation
- 1999-03-19 CA CA2321444A patent/CA2321444C/en not_active Expired - Fee Related
- 1999-03-19 RU RU2003137324/15A patent/RU2263505C2/ru not_active IP Right Cessation
- 1999-03-19 EP EP99913282A patent/EP1064009B2/de not_active Expired - Lifetime
- 1999-03-19 CN CN03145494A patent/CN100581541C/zh not_active Expired - Fee Related
- 1999-03-19 HU HU0200921A patent/HU227694B1/hu not_active IP Right Cessation
- 1999-03-19 ES ES99913282T patent/ES2184427T5/es not_active Expired - Lifetime
- 1999-03-19 AU AU31466/99A patent/AU755900C/en not_active Ceased
- 1999-03-19 DE DE59902932T patent/DE59902932D1/de not_active Expired - Lifetime
- 1999-03-19 SE SE99913282T patent/SE1064009T4/xx unknown
- 1999-03-19 TR TR2000/02686T patent/TR200002686T2/xx unknown
- 1999-03-19 CN CNB998041238A patent/CN100444867C/zh not_active Expired - Fee Related
- 1999-03-19 CZ CZ20002810A patent/CZ292684B6/cs not_active IP Right Cessation
- 1999-03-19 WO PCT/EP1999/001860 patent/WO1999047149A1/de not_active Application Discontinuation
- 1999-03-19 DK DK99913282T patent/DK1064009T4/da active
- 1999-03-19 BR BR9908256-0A patent/BR9908256A/pt not_active IP Right Cessation
- 1999-03-19 AT AT99913282T patent/ATE225182T1/de active
-
2001
- 2001-07-03 HK HK01104552A patent/HK1035660A1/xx not_active IP Right Cessation
-
2010
- 2010-03-01 JP JP2010044419A patent/JP2010132699A/ja active Pending
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| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time | ||
| B11N | Dismissal: publication cancelled [chapter 11.14 patent gazette] |
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| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/352 (2006.01), A61K 36/71 (2006.0 |