BR9815613A - Isoindolinas 2-( 2,6-dioxi-3-fluorpiperidina-3-yl ) substituìdas e seu uso para reduzir os nìveis de tnf"alfa", método de redução de nìveis indesejáveis de citoquinas inflamatórias em mamìferos composição farmacêutica - Google Patents

Isoindolinas 2-( 2,6-dioxi-3-fluorpiperidina-3-yl ) substituìdas e seu uso para reduzir os nìveis de tnf"alfa", método de redução de nìveis indesejáveis de citoquinas inflamatórias em mamìferos composição farmacêutica

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Publication number
BR9815613A
BR9815613A BR9815613-6A BR9815613A BR9815613A BR 9815613 A BR9815613 A BR 9815613A BR 9815613 A BR9815613 A BR 9815613A BR 9815613 A BR9815613 A BR 9815613A
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BR
Brazil
Prior art keywords
levels
fluorpiperidine
isoindolines
dioxy
tnf
Prior art date
Application number
BR9815613-6A
Other languages
English (en)
Inventor
George W Muller
David I Stirling
Roger Shen-Chu Chen
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BR9815613A publication Critical patent/BR9815613A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"ISOINDOLINAS 2-( 2,6-DIOXI-3-FLUORPIPERIDINA-3-YL ) SUBSTITUìDAS E SEU USO PARA REDUZIR OS NìVEIS DE TNF<244>, MéTODO DE REDUçãO DE NìVEIS INDESEJáVEIS DE CITOQUINAS INFLAMATóRIAS EM MAMìFEROS E COMPOSIçãO FARMACêUTICA". Sendo 1-oxi-2-( 2,6-dioxi-3-fluorpipeddina-3-yl )-isoindolinas e 1,3-dioxi2-( 2,6-dioxi-3-fluorpiperidina-3-yl )-isoindolinas reduzindo os níveis de citoquinas inflamatórias tais como TNF<244> em um mamífero. Uma configuração típica é 1,3-dioxi-2( 2,6-dioxi-3-fluorpiperidina-3-yl )-isoindolinas.
BR9815613-6A 1998-03-13 1998-11-17 Isoindolinas 2-( 2,6-dioxi-3-fluorpiperidina-3-yl ) substituìdas e seu uso para reduzir os nìveis de tnf"alfa", método de redução de nìveis indesejáveis de citoquinas inflamatórias em mamìferos composição farmacêutica BR9815613A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/042,274 US5955476A (en) 1997-11-18 1998-03-13 Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
PCT/US1998/024453 WO1999046258A1 (en) 1998-03-13 1998-11-17 SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFα LEVELS

Publications (1)

Publication Number Publication Date
BR9815613A true BR9815613A (pt) 2002-05-28

Family

ID=21920983

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815613-6A BR9815613A (pt) 1998-03-13 1998-11-17 Isoindolinas 2-( 2,6-dioxi-3-fluorpiperidina-3-yl ) substituìdas e seu uso para reduzir os nìveis de tnf"alfa", método de redução de nìveis indesejáveis de citoquinas inflamatórias em mamìferos composição farmacêutica

Country Status (12)

Country Link
US (1) US5955476A (pt)
JP (1) JP4819998B2 (pt)
KR (1) KR100685356B1 (pt)
CN (1) CN1271067C (pt)
BR (1) BR9815613A (pt)
CA (1) CA2317834C (pt)
HK (1) HK1035363A1 (pt)
HU (1) HUP0100615A3 (pt)
NZ (1) NZ504650A (pt)
PL (1) PL190857B1 (pt)
TR (1) TR200002627T2 (pt)
WO (1) WO1999046258A1 (pt)

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HUP0100615A3 (en) 2002-12-28
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