BR9812272A - Respostas imunológicas contra antìgenos de hpv, eliciadas por composições que compreendem um antìgeno de hpv e uma proteìna de tensão ou um vetor de expressão capaz de expressar essas proteìnas - Google Patents

Respostas imunológicas contra antìgenos de hpv, eliciadas por composições que compreendem um antìgeno de hpv e uma proteìna de tensão ou um vetor de expressão capaz de expressar essas proteìnas

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Publication number
BR9812272A
BR9812272A BR9812272A BR9812272A BR9812272A BR 9812272 A BR9812272 A BR 9812272A BR 9812272 A BR9812272 A BR 9812272A BR 9812272 A BR9812272 A BR 9812272A BR 9812272 A BR9812272 A BR 9812272A
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Prior art keywords
hpv
protein
antigen
response
compositions
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BR9812272A
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English (en)
Inventor
Lee Mizzen
Randall Chu
Huacheng Bill Wu
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Stressgen Biotechnologies Corp
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21993829&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9812272(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stressgen Biotechnologies Corp filed Critical Stressgen Biotechnologies Corp
Publication of BR9812272A publication Critical patent/BR9812272A/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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Abstract

"RESPOSTAS IMUNOLóGICAS CONTRA ANTìGENOS DE HPV, ELICIADAS POR COMPOSIçõES QUE COMPREENDEM UM ANTìGENO DE HPV E UMA PROTEìNA DE TENSãO OU UM VETOR DE EXPRESSãO CAPAZ DE EXPRESSAR ESSAS PROTEìNAS" A presente invenção refere-se a composições para induzir uma resposta imunológica, de preferência uma resposta imunológica celular, particularmente uma resposta imunológica citolítica mediada por células, aos antígenos das proteínas do vírus do papiloma humano (HPV) manifestados pelo HPV ou apresentados por células infectadas que incluem células de tumores cervicais e de outros tumores. Em uma modalidade, as composições compreendem um antígeno de proteínas de HPV unido a uma proteína de tensão (ou proteína de choque térmico (Hsp)). O antígeno de proteínas de HPV pode ser unido à proteína de tensão por conjugação química ou de modo não covalente, usandogrupamentos ligantes, ou o antígeno de proteínas de HPV e a proteína de tensão podem ser unidos em uma proteína de fusão que contém as seq³ências do antígeno de proteínas de HPV e da proteía de tensão. Em outra modalidade, as composições compreendem um vetor de expressão que inclui, de forma expressável, seq³ências que codificam o antígeno de proteínas de HPV e seq³ências que codificam a proteína de tensão. O vetor de expressão pode ser introduzido nas células de um indivíduo, ou ele pode ser usado para transduzir células do indivíduo ex vivo, resultando na expressão de uma proteína de fusão "antígeno de proteínas de HPV/proteína de tensão" que estimulará a resposta imunológica do indivíduo ao antígeno de proteínas de HPV. A presente invenção refere-se também a composições que compreendem uma proteína de tensão ligada a um antígeno de HPV e outro componente de uso farmacológico, a fusões e conjugados de proteína de tensão-antígeno de proteínas de HPV, e a vetores de expressão que codificam e são capazes de direcionar a expressão, em células de um indivíduo, de uma proteína de fusão que compreende uma seq³ência de proteína de tensão e de antígeno de proteínas de HPV. A presente invenção refere-se também aos usos dessas composições para induzir respostas imunológicas contra HPV e células que apresentam antígeno de proteína de HPV, inclusive tumores associados a HPV.
BR9812272A 1997-08-05 1998-03-20 Respostas imunológicas contra antìgenos de hpv, eliciadas por composições que compreendem um antìgeno de hpv e uma proteìna de tensão ou um vetor de expressão capaz de expressar essas proteìnas BR9812272A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5483597P 1997-08-05 1997-08-05
PCT/CA1998/000246 WO1999007860A1 (en) 1997-08-05 1998-03-20 Immune responses against hpv antigens elicited by compositions comprising an hpv antigen and a stress protein or an expression vector capable of expression of these proteins

Publications (1)

Publication Number Publication Date
BR9812272A true BR9812272A (pt) 2000-07-18

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BR9812272A BR9812272A (pt) 1997-08-05 1998-03-20 Respostas imunológicas contra antìgenos de hpv, eliciadas por composições que compreendem um antìgeno de hpv e uma proteìna de tensão ou um vetor de expressão capaz de expressar essas proteìnas

Country Status (19)

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US (4) US6524825B1 (pt)
EP (1) EP1002110B2 (pt)
JP (2) JP4198315B2 (pt)
KR (2) KR100843109B1 (pt)
CN (3) CN1915425A (pt)
AT (2) ATE231917T1 (pt)
AU (1) AU6492498A (pt)
BR (1) BR9812272A (pt)
CA (1) CA2298840A1 (pt)
DE (2) DE69811087T2 (pt)
DK (1) DK1002110T3 (pt)
ES (2) ES2266652T3 (pt)
HK (2) HK1028981A1 (pt)
HU (1) HUP0003601A3 (pt)
IL (1) IL134341A0 (pt)
NZ (3) NZ522653A (pt)
PL (1) PL196805B1 (pt)
PT (2) PT1002110E (pt)
WO (1) WO1999007860A1 (pt)

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