BR9808068A - Processo in vitro para eliminar células tumorosas de uma população de células que inclui células não-tumorosas, para enriquecerr o número de células germinativas numa população de células hematopoéticas, para preparar células hematopoéticas isoladas para reintrodução num paciente, para a eliminação de uma primeira população de células de uma segunda população de células, e, processo de eliminação de células tumorosas de uma população de células que inclui células não-tumorosas - Google Patents

Processo in vitro para eliminar células tumorosas de uma população de células que inclui células não-tumorosas, para enriquecerr o número de células germinativas numa população de células hematopoéticas, para preparar células hematopoéticas isoladas para reintrodução num paciente, para a eliminação de uma primeira população de células de uma segunda população de células, e, processo de eliminação de células tumorosas de uma população de células que inclui células não-tumorosas

Info

Publication number
BR9808068A
BR9808068A BR9808068-7A BR9808068A BR9808068A BR 9808068 A BR9808068 A BR 9808068A BR 9808068 A BR9808068 A BR 9808068A BR 9808068 A BR9808068 A BR 9808068A
Authority
BR
Brazil
Prior art keywords
cells
cell population
tumor cells
population
includes non
Prior art date
Application number
BR9808068-7A
Other languages
English (en)
Portuguese (pt)
Inventor
Bernhard O Palsson
Original Assignee
Bernhard O Palsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bernhard O Palsson filed Critical Bernhard O Palsson
Publication of BR9808068A publication Critical patent/BR9808068A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081Purging biological preparations of unwanted cells
    • C12N5/0087Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081Purging biological preparations of unwanted cells
    • C12N5/0093Purging against cancer cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/0088Inverse microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/16Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365Control or image processing arrangements for digital or video microscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
BR9808068-7A 1997-03-27 1998-03-27 Processo in vitro para eliminar células tumorosas de uma população de células que inclui células não-tumorosas, para enriquecerr o número de células germinativas numa população de células hematopoéticas, para preparar células hematopoéticas isoladas para reintrodução num paciente, para a eliminação de uma primeira população de células de uma segunda população de células, e, processo de eliminação de células tumorosas de uma população de células que inclui células não-tumorosas BR9808068A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/824,968 US5874266A (en) 1997-03-27 1997-03-27 Targeted system for removing tumor cells from cell populations
PCT/US1998/006125 WO1998042356A1 (en) 1997-03-27 1998-03-27 Targeted system for removing tumor cells from cell populations

Publications (1)

Publication Number Publication Date
BR9808068A true BR9808068A (pt) 2000-03-08

Family

ID=25242769

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808068-7A BR9808068A (pt) 1997-03-27 1998-03-27 Processo in vitro para eliminar células tumorosas de uma população de células que inclui células não-tumorosas, para enriquecerr o número de células germinativas numa população de células hematopoéticas, para preparar células hematopoéticas isoladas para reintrodução num paciente, para a eliminação de uma primeira população de células de uma segunda população de células, e, processo de eliminação de células tumorosas de uma população de células que inclui células não-tumorosas

Country Status (11)

Country Link
US (3) US5874266A (https=)
EP (1) EP1011697B1 (https=)
JP (2) JP4512206B2 (https=)
KR (1) KR20000075758A (https=)
CN (1) CN1251528A (https=)
AT (1) ATE349220T1 (https=)
AU (1) AU743239B2 (https=)
BR (1) BR9808068A (https=)
CA (1) CA2281112A1 (https=)
DE (1) DE69836747T2 (https=)
WO (1) WO1998042356A1 (https=)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040139A (en) * 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
EP1562035B1 (en) 1997-01-31 2017-01-25 Xy, Llc Optical apparatus and method
US6469779B2 (en) * 1997-02-07 2002-10-22 Arcturus Engineering, Inc. Laser capture microdissection method and apparatus
US5995867A (en) * 1997-03-19 1999-11-30 Lucid Inc Cellular surgery utilizing confocal microscopy
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6642018B1 (en) * 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
EP1073716B1 (en) * 1998-04-28 2004-04-28 Amersham Health AS Improvements in or relating to separation processes
DE19916749B4 (de) * 1999-04-14 2004-02-12 Carl Zeiss Jena Gmbh Verfahren zur Untersuchung von Proben
US6690470B1 (en) 1999-11-04 2004-02-10 Arcturus Engineering, Inc. Automated laser capture microdissection
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
WO2001040454A1 (en) * 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population
AU2001249548A1 (en) * 2000-03-27 2001-10-08 Thomas Jefferson University Compositions and methods for identifying and targeting cancer cells
US7193706B2 (en) * 2000-08-02 2007-03-20 Arizona Board Of Regents, Acting On Behalf Of Arizona State University Computer interfaced scanning fluorescence lifetime microscope applied to directed evolution
WO2002022774A1 (en) * 2000-09-12 2002-03-21 Oncosis Llc Chamber for laser-based processing
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
EP2363828A1 (en) 2000-10-24 2011-09-07 Cyntellect, Inc. Device for selectively targeting cells within a three-dimensional specimen
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
AU2002237689B2 (en) * 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US20050143791A1 (en) * 2001-07-09 2005-06-30 Stuart Hameroff Process of treating a cell
US8722357B2 (en) 2001-11-05 2014-05-13 Life Technologies Corporation Automated microdissection instrument
US10156501B2 (en) 2001-11-05 2018-12-18 Life Technologies Corporation Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area
WO2003089901A2 (en) * 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
WO2004009237A2 (en) * 2002-07-22 2004-01-29 Xy, Inc. Sperm cell process system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CN1674780A (zh) * 2002-08-01 2005-09-28 Xy公司 低压精子分离系统
US7855078B2 (en) * 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP2305173B1 (en) 2003-03-28 2016-05-11 Inguran, LLC Apparatus and methods for providing sorted particles
WO2004104178A2 (en) * 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
US7776584B2 (en) * 2003-08-01 2010-08-17 Genetix Limited Animal cell colony picking apparatus and method
JP4533382B2 (ja) 2003-08-28 2010-09-01 セルラ・インコーポレイテッド マイクロ流体分析およびソーティング用の一体化された構造物
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
JP2007537727A (ja) 2004-03-29 2007-12-27 モンサント テクノロジー エルエルシー 受精で用いられる精子分散液
JP2005333889A (ja) * 2004-05-27 2005-12-08 Cybox Co Ltd 細胞壊死方法及び細胞壊死装置
MX2007000888A (es) * 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
WO2006031574A2 (en) 2004-09-09 2006-03-23 Arcturus Bioscience, Inc. Laser microdissection apparatus and method
CN101208426A (zh) * 2005-02-18 2008-06-25 阿不赛斯株式会社 细胞分离的方法与设备
US20070178067A1 (en) * 2005-11-09 2007-08-02 John Maier System and method for cytological analysis by raman spectroscopic imaging
BRPI0914919A2 (pt) 2008-06-30 2015-08-25 Microbix Biosystems Inc Método para selecionar um primeiro grupo de células de uma população de células e aparelho. Sistema, método e processo para detectar e alterar seletivamente uma subpopulação de células desejada em uma população de células de espécime.
WO2010081052A1 (en) * 2009-01-09 2010-07-15 Cyntellect, Inc. Genetic analysis of cells
KR20110108390A (ko) 2009-01-12 2011-10-05 신텔렉트 인코포레이티드 레이저로 매개된 박막 절개 및 세포 군체의 이동
US8665439B2 (en) * 2009-06-30 2014-03-04 Microbix Biosystems, Inc. Method and apparatus for limiting effects of refraction in cytometry
US9877644B2 (en) 2009-11-10 2018-01-30 Illumigyn Ltd. Optical speculum
US8638995B2 (en) 2009-11-10 2014-01-28 Illumigyn Ltd. Optical speculum
US9271640B2 (en) 2009-11-10 2016-03-01 Illumigyn Ltd. Optical speculum
DE102009060490A1 (de) 2009-12-22 2011-06-30 Carl Zeiss Microlmaging GmbH, 07745 Hochauflösendes Mikroskop und Bildteileranordnung
US9134301B2 (en) * 2010-11-22 2015-09-15 Bio-Rad Laboratories, Inc. Sorting of adherent cells by selective transformation of labels
CA2991625A1 (en) 2011-02-15 2012-08-23 Microbix Biosystems Inc. Methods, systems, and apparatus for performing flow cytometry
JP5333538B2 (ja) 2011-07-27 2013-11-06 株式会社デンソー 弾性表面波センサ
US9279802B2 (en) 2011-09-27 2016-03-08 Shimadzu Corporation Cell sorter and cell sorting method
TWI588199B (zh) 2012-05-25 2017-06-21 羅門哈斯公司 光擴散聚合物組成物、製造該光擴散聚合物組成物的方法以及由之製得的物品
US8808644B2 (en) 2012-08-20 2014-08-19 Biochemical Diagnostics, Inc. Methods for dispensing fluids into microplates utilizing microwell covers
HK1221135A1 (zh) * 2013-09-18 2017-05-26 伊鲁米吉有限公司 光学窥器
US10074006B2 (en) * 2014-03-17 2018-09-11 Carnegie Mellon University Methods and systems for disease classification
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
AU2015266594A1 (en) 2014-05-30 2017-01-19 Todd Frank OVOKAITYS Method and system for generation and use of activated stem cells
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US11291931B2 (en) 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
US10324080B2 (en) * 2015-11-17 2019-06-18 Purdue Research Foundation Systems and methods for automated image-guided patch-clamp electrophysiology in vitro
JP6033980B1 (ja) * 2016-06-01 2016-11-30 株式会社片岡製作所 細胞処理システム
JP6541160B2 (ja) 2017-02-13 2019-07-10 株式会社片岡製作所 細胞処理装置および対象物の処理方法
JP6532063B2 (ja) * 2017-02-13 2019-06-19 株式会社片岡製作所 細胞処理装置
KR102034244B1 (ko) * 2017-09-01 2019-10-18 주식회사 코어파마 순환암세포를 선택적으로 사멸시키는 시스템
US11427804B2 (en) 2018-06-15 2022-08-30 Abs Global, Inc. Apparatus and method for cell kill confirmation
JP6574028B1 (ja) * 2018-06-29 2019-09-11 株式会社片岡製作所 細胞処理装置および細胞のレーザ処理方法
WO2020014273A1 (en) 2018-07-09 2020-01-16 Akadeum Life Sciences, Inc. System and method for buoyant particle processing
JP2021129555A (ja) * 2020-02-18 2021-09-09 株式会社島津製作所 細胞精製装置および細胞精製方法
WO2022126109A1 (en) 2020-12-08 2022-06-16 Ovokaitys Todd Frank Methods and systems for increased production of stem cells
WO2022269389A1 (en) * 2021-06-21 2022-12-29 Evolution Optiks Limited Electromagnetic energy directing system, and method using same
EP4392158A4 (en) 2021-08-26 2025-09-03 Akadeum Life Sciences Inc METHOD AND SYSTEM FOR FLOATING SEPARATION
US12196754B2 (en) 2022-04-01 2025-01-14 Akadeum Life Sciences, Inc. Method and system for buoyant-particle-assisted cell therapy
JP2026511329A (ja) 2023-02-14 2026-04-14 アカデューム ライフ サイエンセズ,インコーポレイテッド 部分的または完全に自動化された浮力補助分離方法およびシステム

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674926A (en) * 1968-10-15 1972-07-04 Reynolds Metals Co Feature counter with improved masking and grey level detection
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4803992A (en) * 1980-10-28 1989-02-14 Lemelson Jerome H Electro-optical instruments and methods for producing same
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
IL68507A (en) * 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4532402A (en) * 1983-09-02 1985-07-30 Xrl, Inc. Method and apparatus for positioning a focused beam on an integrated circuit
JPS6083584A (ja) * 1983-10-13 1985-05-11 Rikagaku Kenkyusho 生細胞内への物質移入法
US5103660A (en) * 1984-04-23 1992-04-14 Johnson Virgil T Removable steering wheel device, and methods of constructing and utilizing same
JP2522773B2 (ja) * 1986-09-08 1996-08-07 新技術事業団 細胞識別・定量方法
AU605129B2 (en) * 1986-11-13 1991-01-10 Purepulse Technologies, Inc. Preservation of foodstuffs by irradiation
DE3708511A1 (de) * 1987-03-16 1988-09-29 Kratzer Michael Einrichtung zur selektiven zerstoerung von zellen
US5188633A (en) * 1987-03-16 1993-02-23 Michael Kratzer Device for selective destruction of cells
JPH07122902B2 (ja) 1987-04-17 1995-12-25 株式会社日立製作所 細胞位置検出装置
HU204856B (en) * 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
JPH074222B2 (ja) * 1988-05-20 1995-01-25 農業生物資源研究所長 細胞破砕選別装置及び選択的遺伝子導入装置
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
JPH02168160A (ja) * 1988-12-22 1990-06-28 Omron Tateisi Electron Co 細胞選別装置
JP2700702B2 (ja) * 1989-11-20 1998-01-21 浜松ホトニクス株式会社 医療装置用レーザ発生装置
DE59004780D1 (de) * 1989-12-22 1994-04-07 Asea Brown Boveri Faseroptischer Sensor.
US5622853A (en) * 1990-05-01 1997-04-22 Becton Dickinson And Company T lymphocyte precursor
US5202230A (en) * 1990-09-07 1993-04-13 Kamentsky Louis A Methods of detecting cut cells in a tissue section
EP0501688A1 (en) * 1991-02-27 1992-09-02 Hitachi, Ltd. Apparatus and method for applying a laser beam through a microscope
US5298963A (en) * 1992-02-26 1994-03-29 Mitsui Mining & Smelting Co., Ltd. Apparatus for inspecting the surface of materials
US6007814A (en) * 1992-06-15 1999-12-28 Sloan-Kettering Institute For Cancer Research Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
RU2054486C1 (ru) 1992-09-01 1996-02-20 Валерий Георгиевич Петухов Способ идентификации микроорганизмов
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
US5422720A (en) * 1993-07-21 1995-06-06 Becton Dickinson And Company Blood culture sensor station utilizing two distinct light sources
US5381224A (en) * 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
US6251100B1 (en) * 1993-09-24 2001-06-26 Transmedica International, Inc. Laser assisted topical anesthetic permeation
EP0662512A3 (en) * 1993-12-20 1997-01-15 Becton Dickinson Co Human hematopoietic stem cells.
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5795755A (en) * 1994-07-05 1998-08-18 Lemelson; Jerome H. Method of implanting living cells by laser poration at selected sites
US5523543A (en) * 1994-09-09 1996-06-04 Litel Instruments Laser ablation control system and method
EP0746865B1 (en) * 1994-12-08 2003-03-26 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
JP3077539B2 (ja) * 1994-12-22 2000-08-14 松下電器産業株式会社 レーザ加工方法
US6148096A (en) * 1995-09-15 2000-11-14 Accumed International, Inc. Specimen preview and inspection system
US6040139A (en) 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
US5646411A (en) * 1996-02-01 1997-07-08 Molecular Dynamics, Inc. Fluorescence imaging system compatible with macro and micro scanning objectives
EP0912285B1 (en) * 1996-04-25 2003-05-14 The Gleason Works Cutting tool for toothed articles
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
WO1998052016A1 (en) 1997-05-09 1998-11-19 Morphometrix Technologies Inc. Multi-spectral imaging system and method for cytology
US6005256A (en) * 1998-02-12 1999-12-21 Raytheon Company Method and apparatus for performing cell analysis based on simultaneous multiple marker emissions from neoplasia (CASMMEN)
US6642018B1 (en) * 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
WO2000057951A1 (en) * 1999-03-26 2000-10-05 Flock Stephen T Delivery of pharmaceutical compounds and collection of biomolecules using electromagnetic energy and uses thereof
US6381224B1 (en) * 1999-03-31 2002-04-30 Motorola, Inc. Method and apparatus for controlling a full-duplex communication system
WO2001040454A1 (en) * 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population

Also Published As

Publication number Publication date
CA2281112A1 (en) 1998-10-01
JP2010029193A (ja) 2010-02-12
EP1011697B1 (en) 2006-12-27
JP2002511843A (ja) 2002-04-16
JP4512206B2 (ja) 2010-07-28
US20030138923A1 (en) 2003-07-24
ATE349220T1 (de) 2007-01-15
DE69836747T2 (de) 2007-10-04
KR20000075758A (ko) 2000-12-26
AU6782698A (en) 1998-10-20
DE69836747D1 (de) 2007-02-08
WO1998042356A1 (en) 1998-10-01
EP1011697A1 (en) 2000-06-28
US5874266A (en) 1999-02-23
US6143535A (en) 2000-11-07
CN1251528A (zh) 2000-04-26
EP1011697A4 (en) 2002-11-20
US7129070B2 (en) 2006-10-31
AU743239B2 (en) 2002-01-24

Similar Documents

Publication Publication Date Title
BR9808068A (pt) Processo in vitro para eliminar células tumorosas de uma população de células que inclui células não-tumorosas, para enriquecerr o número de células germinativas numa população de células hematopoéticas, para preparar células hematopoéticas isoladas para reintrodução num paciente, para a eliminação de uma primeira população de células de uma segunda população de células, e, processo de eliminação de células tumorosas de uma população de células que inclui células não-tumorosas
EA199900486A1 (ru) Применение сфингомиелиназы для повышения уровней церамидов в коже и слизистых оболочках, а также содержащие ее дерматологические и косметические композиции, которые удобны для местного применения
JPS57500830A (https=)
ES2185705T3 (es) Proteina bifuncional, preparacion y uso.
BRPI0412845A (pt) herpes-vìrus, uso de um vìrus, composição farmacêutica, e, método de tratamento de um tumor em um indivìduo em necessidade do mesmo
ES285023U (es) Sonda de dialisis,principalmente prevista para su insercion en tejidos biologicos
ES2059140T3 (es) Procedimiento mejorado y aparato para la introduccion de sustancias biologicas en celulas vivas.
BR0207775A (pt) Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização
DE69837393D1 (de) Stimulierung von hämatopoietischen zellen im vitro
PA8481501A1 (es) 4-carboxiamino-2-metil-1,2,3,4-tetrahidroquinolinas
ES2195664T3 (es) Uso de fumaratos de dialquilo.
IT8022740A0 (it) Procedimento per la produzione di etanolo in forte concentrazione impiegando microorganismi immobilizzati.
MX9301753A (es) Generacion in vitro de celulas dentriticas humanas y utilizacion de las mismas.
AR018234A1 (es) Metodo para producir una muestra para inseminacion de flujo de equinos y disposicion de citometria de flujo.
BR9609424A (pt) Novos peptìdeos, compostos, composição farmacêutica, processo para tratar um tumor em um mamìfero, e, processo para preparar os compostos
RU94042393A (ru) Галихондрины, родственные соединения и способ лечения опухоли у млекопитающих
BR9509269A (pt) Processo para tratar diabetes
DE69630955D1 (de) Immortalisierung bzw. desimmortalisierung von zellen
ES2122968T3 (es) Procedimiento de tratamiento de celulas de cancer de vejiga.
RU96102402A (ru) Композиция для фотодинамического повреждения клеток-мишеней и способ фотодинамического повреждения клеток-мишеней
BR8305979A (pt) Processo para a preparacao de uma cepa melhorada de c.acetobutylicum e sua cultura biologicamente pura
ES8402346A1 (es) Procedimiento para la obtencion de lineas de celulas animales y humanas cultivables permanentemente.
ATE377022T1 (de) Isolierte decapeptide, die an hla moleküle binden,sowie deren verwendung
National Research Council Formaldehyde-An Assessment of Its Health Effects
ES2187648T3 (es) Metodo para la administracion de farmacos para terapia genica.

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]