DE69837393D1 - Stimulierung von hämatopoietischen zellen im vitro - Google Patents
Stimulierung von hämatopoietischen zellen im vitroInfo
- Publication number
- DE69837393D1 DE69837393D1 DE69837393T DE69837393T DE69837393D1 DE 69837393 D1 DE69837393 D1 DE 69837393D1 DE 69837393 T DE69837393 T DE 69837393T DE 69837393 T DE69837393 T DE 69837393T DE 69837393 D1 DE69837393 D1 DE 69837393D1
- Authority
- DE
- Germany
- Prior art keywords
- hematopoietic cells
- vitro
- stimulation
- methods
- dpiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 title abstract 3
- 230000000638 stimulation Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 abstract 1
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6030697P | 1997-09-29 | 1997-09-29 | |
US60306P | 1997-09-29 | ||
PCT/US1998/020343 WO1999016864A1 (en) | 1997-09-29 | 1998-09-29 | Stimulation of hematopoietic cells in vitro |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69837393D1 true DE69837393D1 (de) | 2007-05-03 |
DE69837393T2 DE69837393T2 (de) | 2007-12-06 |
Family
ID=22028666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69837393T Expired - Fee Related DE69837393T2 (de) | 1997-09-29 | 1998-09-29 | Stimulierung von hämatopoietischen zellen im vitro |
Country Status (16)
Country | Link |
---|---|
US (3) | US6258597B1 (de) |
EP (1) | EP1019494B1 (de) |
JP (2) | JP2001518290A (de) |
KR (1) | KR100458403B1 (de) |
CN (1) | CN1163594C (de) |
AT (1) | ATE357509T1 (de) |
AU (1) | AU743996B2 (de) |
BR (1) | BR9813233A (de) |
CA (1) | CA2304206A1 (de) |
DE (1) | DE69837393T2 (de) |
ES (1) | ES2285785T3 (de) |
IL (1) | IL135068A (de) |
NO (1) | NO20001583L (de) |
NZ (1) | NZ503359A (de) |
TR (1) | TR200000815T2 (de) |
WO (1) | WO1999016864A1 (de) |
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US6573096B1 (en) * | 2000-04-01 | 2003-06-03 | The Research Foundation At State University Of New York | Compositions and methods for inhibition of cancer invasion and angiogenesis |
US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7727964B2 (en) | 2001-11-26 | 2010-06-01 | Trustees Of Tufts College | Peptidomimetic inhibitors of post-proline cleaving enzymes |
EP1487471A4 (de) * | 2001-11-26 | 2010-03-10 | Tufts College | Verfahren zur behandlung von autoimmunkrankheiten und damit zusammenhängende reagentien |
WO2003092605A2 (en) * | 2002-04-30 | 2003-11-13 | Trustees Of Tufts College | Protease inhibitors |
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KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
JP4865540B2 (ja) | 2003-04-08 | 2012-02-01 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 化学誘引物質に対する増大された感受性を有する幹細胞およびそれを産生および使用する方法 |
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US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
JP2007505121A (ja) | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
KR100918322B1 (ko) * | 2003-11-12 | 2009-09-22 | 페노믹스 코포레이션 | 헤테로시클릭 보론산 화합물 |
US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
US7576121B2 (en) * | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
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EP1729757A2 (de) * | 2004-02-23 | 2006-12-13 | Trustees Of Tufts College | Hemmer von dipeptidylpeptidase iv zur regulierung des glucosestoffwechsels |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN102134231B (zh) | 2004-03-15 | 2020-08-04 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
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-
1998
- 1998-09-29 CN CNB988096463A patent/CN1163594C/zh not_active Expired - Fee Related
- 1998-09-29 NZ NZ503359A patent/NZ503359A/en active IP Right Revival
- 1998-09-29 EP EP98949595A patent/EP1019494B1/de not_active Expired - Lifetime
- 1998-09-29 US US09/162,934 patent/US6258597B1/en not_active Expired - Fee Related
- 1998-09-29 BR BR9813233-4A patent/BR9813233A/pt not_active IP Right Cessation
- 1998-09-29 AT AT98949595T patent/ATE357509T1/de not_active IP Right Cessation
- 1998-09-29 WO PCT/US1998/020343 patent/WO1999016864A1/en active IP Right Grant
- 1998-09-29 KR KR10-2000-7003348A patent/KR100458403B1/ko not_active IP Right Cessation
- 1998-09-29 DE DE69837393T patent/DE69837393T2/de not_active Expired - Fee Related
- 1998-09-29 CA CA002304206A patent/CA2304206A1/en not_active Abandoned
- 1998-09-29 TR TR2000/00815T patent/TR200000815T2/xx unknown
- 1998-09-29 JP JP2000513935A patent/JP2001518290A/ja not_active Ceased
- 1998-09-29 AU AU95887/98A patent/AU743996B2/en not_active Ceased
- 1998-09-29 IL IL13506898A patent/IL135068A/en not_active IP Right Cessation
- 1998-09-29 ES ES98949595T patent/ES2285785T3/es not_active Expired - Lifetime
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2000
- 2000-03-27 NO NO20001583A patent/NO20001583L/no not_active Application Discontinuation
-
2001
- 2001-03-20 US US09/812,528 patent/US6703238B2/en not_active Expired - Fee Related
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2003
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Also Published As
Publication number | Publication date |
---|---|
CN1272136A (zh) | 2000-11-01 |
CN1163594C (zh) | 2004-08-25 |
AU9588798A (en) | 1999-04-23 |
IL135068A (en) | 2004-03-28 |
IL135068A0 (en) | 2001-05-20 |
ATE357509T1 (de) | 2007-04-15 |
US6703238B2 (en) | 2004-03-09 |
WO1999016864A1 (en) | 1999-04-08 |
TR200000815T2 (tr) | 2000-12-21 |
US20010018210A1 (en) | 2001-08-30 |
NZ503359A (en) | 2002-02-01 |
US6258597B1 (en) | 2001-07-10 |
DE69837393T2 (de) | 2007-12-06 |
BR9813233A (pt) | 2000-08-22 |
KR20010030775A (ko) | 2001-04-16 |
JP4102403B2 (ja) | 2008-06-18 |
US20040152192A1 (en) | 2004-08-05 |
US7276371B2 (en) | 2007-10-02 |
ES2285785T3 (es) | 2007-11-16 |
EP1019494B1 (de) | 2007-03-21 |
JP2001518290A (ja) | 2001-10-16 |
EP1019494A1 (de) | 2000-07-19 |
AU743996B2 (en) | 2002-02-14 |
NO20001583D0 (no) | 2000-03-27 |
CA2304206A1 (en) | 1999-04-08 |
JP2006081554A (ja) | 2006-03-30 |
KR100458403B1 (ko) | 2004-11-26 |
NO20001583L (no) | 2000-05-29 |
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