DE69837393D1 - Stimulierung von hämatopoietischen zellen im vitro - Google Patents
Stimulierung von hämatopoietischen zellen im vitroInfo
- Publication number
- DE69837393D1 DE69837393D1 DE69837393T DE69837393T DE69837393D1 DE 69837393 D1 DE69837393 D1 DE 69837393D1 DE 69837393 T DE69837393 T DE 69837393T DE 69837393 T DE69837393 T DE 69837393T DE 69837393 D1 DE69837393 D1 DE 69837393D1
- Authority
- DE
- Germany
- Prior art keywords
- hematopoietic cells
- vitro
- stimulation
- methods
- dpiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 title abstract 3
- 230000000638 stimulation Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 abstract 1
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6030697P | 1997-09-29 | 1997-09-29 | |
| US60306P | 1997-09-29 | ||
| PCT/US1998/020343 WO1999016864A1 (en) | 1997-09-29 | 1998-09-29 | Stimulation of hematopoietic cells in vitro |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69837393D1 true DE69837393D1 (de) | 2007-05-03 |
| DE69837393T2 DE69837393T2 (de) | 2007-12-06 |
Family
ID=22028666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69837393T Expired - Fee Related DE69837393T2 (de) | 1997-09-29 | 1998-09-29 | Stimulierung von hämatopoietischen zellen im vitro |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6258597B1 (de) |
| EP (1) | EP1019494B1 (de) |
| JP (2) | JP2001518290A (de) |
| KR (1) | KR100458403B1 (de) |
| CN (1) | CN1163594C (de) |
| AT (1) | ATE357509T1 (de) |
| AU (1) | AU743996B2 (de) |
| BR (1) | BR9813233A (de) |
| CA (1) | CA2304206A1 (de) |
| DE (1) | DE69837393T2 (de) |
| ES (1) | ES2285785T3 (de) |
| IL (1) | IL135068A (de) |
| NO (1) | NO20001583L (de) |
| NZ (1) | NZ503359A (de) |
| TR (1) | TR200000815T2 (de) |
| WO (1) | WO1999016864A1 (de) |
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| US5965532A (en) | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
| WO1999016864A1 (en) | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
| JP2002513762A (ja) | 1998-05-04 | 2002-05-14 | ポイント セラピューティクス, インコーポレイテッド | 造血刺激 |
| US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| JP2003512052A (ja) | 1999-10-15 | 2003-04-02 | アドバンスド セル テクノロジー、インコーポレイテッド | 分化前駆細胞及び系統欠失胚性幹細胞の産生方法 |
| US6573096B1 (en) * | 2000-04-01 | 2003-06-03 | The Research Foundation At State University Of New York | Compositions and methods for inhibition of cancer invasion and angiogenesis |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| JP4771661B2 (ja) * | 2001-11-26 | 2011-09-14 | トラスティーズ オブ タフツ カレッジ | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
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| JP2005531540A (ja) * | 2002-04-30 | 2005-10-20 | トラスティーズ・オブ・タフツ・カレッジ | セリンプロテアーゼ阻害剤のスマートプロドラッグ |
| JP2006507352A (ja) * | 2002-07-09 | 2006-03-02 | ポイント セラピューティクス, インコーポレイテッド | イソロイシンのボロプロリン化合物に関する方法および組成物 |
| US20040076620A1 (en) * | 2002-09-03 | 2004-04-22 | Donnie Rudd | Method of repairing primate mammalian tissue |
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| US20040077985A1 (en) * | 2002-09-03 | 2004-04-22 | Donnie Rudd | Method of replenishing cells damaged by treatment for cancer |
| US20040044300A1 (en) * | 2002-09-03 | 2004-03-04 | Donnie Rudd | Method of replenishing cells damaged by treatment for cancer |
| US20040043009A1 (en) * | 2002-09-03 | 2004-03-04 | Donnie Rudd | Method of repairing primate mammalian tissue |
| KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| EP1611233B1 (de) | 2003-04-08 | 2016-01-06 | Yeda Research And Development Co., Ltd. | Stammzellen mit erhöhter empfindlichkeit für sdf-1 sowie methoden zu deren herstellung und verwendung |
| FR2853551B1 (fr) | 2003-04-09 | 2006-08-04 | Lab Francais Du Fractionnement | Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee |
| EP1625122A1 (de) | 2003-05-14 | 2006-02-15 | Takeda San Diego, Inc. | Dipeptidylpeptidase-hemmer |
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| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
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| US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
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| DK1689757T3 (en) * | 2003-11-12 | 2014-12-08 | Sino Med Internat Alliance Inc | HETEROCYCLIC DRY ACID COMPOUNDS |
| IL158868A0 (en) | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
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| EP1828192B1 (de) * | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidylpeptidasehemmer |
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-
1998
- 1998-09-29 WO PCT/US1998/020343 patent/WO1999016864A1/en not_active Ceased
- 1998-09-29 JP JP2000513935A patent/JP2001518290A/ja not_active Ceased
- 1998-09-29 ES ES98949595T patent/ES2285785T3/es not_active Expired - Lifetime
- 1998-09-29 KR KR10-2000-7003348A patent/KR100458403B1/ko not_active Expired - Fee Related
- 1998-09-29 AT AT98949595T patent/ATE357509T1/de not_active IP Right Cessation
- 1998-09-29 TR TR2000/00815T patent/TR200000815T2/xx unknown
- 1998-09-29 IL IL13506898A patent/IL135068A/en not_active IP Right Cessation
- 1998-09-29 US US09/162,934 patent/US6258597B1/en not_active Expired - Fee Related
- 1998-09-29 CA CA002304206A patent/CA2304206A1/en not_active Abandoned
- 1998-09-29 BR BR9813233-4A patent/BR9813233A/pt not_active IP Right Cessation
- 1998-09-29 NZ NZ503359A patent/NZ503359A/en active IP Right Revival
- 1998-09-29 CN CNB988096463A patent/CN1163594C/zh not_active Expired - Fee Related
- 1998-09-29 EP EP98949595A patent/EP1019494B1/de not_active Expired - Lifetime
- 1998-09-29 AU AU95887/98A patent/AU743996B2/en not_active Ceased
- 1998-09-29 DE DE69837393T patent/DE69837393T2/de not_active Expired - Fee Related
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2000
- 2000-03-27 NO NO20001583A patent/NO20001583L/no not_active Application Discontinuation
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- 2001-03-20 US US09/812,528 patent/US6703238B2/en not_active Expired - Fee Related
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- 2003-12-01 US US10/725,952 patent/US7276371B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2304206A1 (en) | 1999-04-08 |
| AU743996B2 (en) | 2002-02-14 |
| ATE357509T1 (de) | 2007-04-15 |
| US20010018210A1 (en) | 2001-08-30 |
| EP1019494A1 (de) | 2000-07-19 |
| IL135068A (en) | 2004-03-28 |
| JP4102403B2 (ja) | 2008-06-18 |
| KR20010030775A (ko) | 2001-04-16 |
| US6703238B2 (en) | 2004-03-09 |
| TR200000815T2 (tr) | 2000-12-21 |
| IL135068A0 (en) | 2001-05-20 |
| NO20001583D0 (no) | 2000-03-27 |
| WO1999016864A1 (en) | 1999-04-08 |
| KR100458403B1 (ko) | 2004-11-26 |
| NO20001583L (no) | 2000-05-29 |
| JP2001518290A (ja) | 2001-10-16 |
| DE69837393T2 (de) | 2007-12-06 |
| BR9813233A (pt) | 2000-08-22 |
| CN1272136A (zh) | 2000-11-01 |
| EP1019494B1 (de) | 2007-03-21 |
| US7276371B2 (en) | 2007-10-02 |
| AU9588798A (en) | 1999-04-23 |
| ES2285785T3 (es) | 2007-11-16 |
| CN1163594C (zh) | 2004-08-25 |
| US20040152192A1 (en) | 2004-08-05 |
| JP2006081554A (ja) | 2006-03-30 |
| US6258597B1 (en) | 2001-07-10 |
| NZ503359A (en) | 2002-02-01 |
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