ES2054747T3 - Nuevos antidepresivos. - Google Patents

Nuevos antidepresivos.

Info

Publication number
ES2054747T3
ES2054747T3 ES88112996T ES88112996T ES2054747T3 ES 2054747 T3 ES2054747 T3 ES 2054747T3 ES 88112996 T ES88112996 T ES 88112996T ES 88112996 T ES88112996 T ES 88112996T ES 2054747 T3 ES2054747 T3 ES 2054747T3
Authority
ES
Spain
Prior art keywords
present
uptake
serotonin
new antidepressants
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88112996T
Other languages
English (en)
Inventor
Jules Freedman
Mark W Dudley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2054747T3 publication Critical patent/ES2054747T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

EL PRESENTE INVENTO SUMINISTRA COMPUESTOS NUEVOS TALES COMO CIERTAS AMINAS HIBRANDENAS ACRILICAS, LAS CUALES SON UTILES COMO ANTIDEPRESIVOS Y COMO INHIBIDORES DE NOREPINEFRINAS SINAPTICAS Y TOMA SEROTONICA. EL PRESENTE INVENTO TAMBIEN PROPORCIONA UNA MEJORA EN EL TRATAMIENTO DE LA DEPRESION QUE COMPRENDE LA INHIBICION DE LA SEROTOMICA SINAPTICO Y LA TOMA EPINEFRINICA.
ES88112996T 1987-08-14 1988-08-10 Nuevos antidepresivos. Expired - Lifetime ES2054747T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8566587A 1987-08-14 1987-08-14

Publications (1)

Publication Number Publication Date
ES2054747T3 true ES2054747T3 (es) 1994-08-16

Family

ID=22193153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88112996T Expired - Lifetime ES2054747T3 (es) 1987-08-14 1988-08-10 Nuevos antidepresivos.

Country Status (19)

Country Link
US (2) US5880120A (es)
EP (1) EP0303961B1 (es)
JP (1) JP2650045B2 (es)
KR (1) KR0126137B1 (es)
CN (1) CN1021323C (es)
AT (1) ATE104269T1 (es)
AU (2) AU606444B2 (es)
CA (1) CA1327795C (es)
DE (1) DE3889032T2 (es)
DK (1) DK454688A (es)
ES (1) ES2054747T3 (es)
FI (1) FI91852C (es)
HU (1) HU204504B (es)
IE (1) IE63082B1 (es)
IL (1) IL87412A (es)
NO (1) NO167913C (es)
NZ (1) NZ225758A (es)
PT (1) PT88251B (es)
ZA (1) ZA885824B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103682A1 (es) * 1995-09-20 1997-09-16 Lilly Sa Composicion farmaceutica oral de fluoxetina, solida y con caracteristicas organolepticas mejoradas.

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GB9315600D0 (en) * 1993-07-28 1993-09-08 Smithkline Beecham Plc Compounds
CA2147356A1 (en) * 1993-08-30 1995-03-09 Yohji Sakurai Benzylamine derivatives
WO1996002494A1 (en) * 1994-07-14 1996-02-01 Smithkline Beecham Plc Benzocycloalkylamine derivatives as calcium channel antagonists
DK1246806T3 (da) * 1999-11-03 2008-06-16 Amr Technology Inc Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
EP1299393A2 (en) 2000-07-11 2003-04-09 Bristol-Myers Squibb Pharma Company 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
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JP2005501070A (ja) * 2001-08-08 2005-01-13 イーライ・リリー・アンド・カンパニー 神経障害を処置するための組み合わせ療法
US7345096B2 (en) 2002-10-15 2008-03-18 Wyeth Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
US20040152710A1 (en) * 2002-10-15 2004-08-05 Deecher Darlene Coleman Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
US7419980B2 (en) 2003-10-14 2008-09-02 Wyeth Fused-aryl and heteroaryl derivatives and methods of their use
US7524846B2 (en) 2003-10-14 2009-04-28 Wyeth Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use
US7402698B2 (en) 2003-10-14 2008-07-22 Wyeth Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use
US7531543B2 (en) 2003-10-14 2009-05-12 Wyeth Phenylpiperazine cycloalkanol derivatives and methods of their use
US7365076B2 (en) 2003-10-14 2008-04-29 Wyeth Substituted aryl cycloalkanol derivatives and methods of their use
US7550485B2 (en) 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
AU2004281750A1 (en) * 2003-10-14 2005-04-28 Wyeth Use of adrenergic alphaze antagonists for the treatment of vasomotor symptoms
US7491723B2 (en) 2003-10-14 2009-02-17 Wyeth Alkanol and cycloalkanol-amine derivatives and methods of their use
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
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JP5554319B2 (ja) 2008-04-01 2014-07-23 アボット ゲーエムベーハー ウント カンパニー カーゲー テトラヒドロイソキノリン類、それを含む医薬組成物および治療におけるそれの使用
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103682A1 (es) * 1995-09-20 1997-09-16 Lilly Sa Composicion farmaceutica oral de fluoxetina, solida y con caracteristicas organolepticas mejoradas.

Also Published As

Publication number Publication date
IL87412A0 (en) 1989-01-31
FI91852C (fi) 1994-08-25
DK454688A (da) 1989-02-15
CN1021323C (zh) 1993-06-23
ATE104269T1 (de) 1994-04-15
EP0303961A3 (en) 1989-05-17
ZA885824B (en) 1989-04-26
US6136803A (en) 2000-10-24
NO883595D0 (no) 1988-08-12
JP2650045B2 (ja) 1997-09-03
AU606444B2 (en) 1991-02-07
IL87412A (en) 1995-05-26
KR890003671A (ko) 1989-04-17
PT88251A (pt) 1989-06-30
EP0303961B1 (en) 1994-04-13
AU624278B2 (en) 1992-06-04
KR0126137B1 (ko) 1997-12-26
AU2057988A (en) 1989-02-16
HUT51593A (en) 1990-05-28
IE882484L (en) 1989-02-14
DE3889032T2 (de) 1994-08-11
HU204504B (en) 1992-01-28
PT88251B (pt) 1995-03-01
NO167913B (no) 1991-09-16
JPS6466151A (en) 1989-03-13
AU6598990A (en) 1991-01-24
DE3889032D1 (de) 1994-05-19
IE63082B1 (en) 1995-03-22
CN1033043A (zh) 1989-05-24
FI91852B (fi) 1994-05-13
FI883739A (fi) 1989-02-15
US5880120A (en) 1999-03-09
EP0303961A2 (en) 1989-02-22
NO167913C (no) 1991-12-27
FI883739A0 (fi) 1988-08-11
DK454688D0 (da) 1988-08-12
NO883595L (no) 1989-02-15
NZ225758A (en) 1990-10-26
CA1327795C (en) 1994-03-15

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