BR9804947A - Modifica-Æo de cristal de um agente farmac-utico - Google Patents

Modifica-Æo de cristal de um agente farmac-utico

Info

Publication number
BR9804947A
BR9804947A BR9804947A BR9804947A BR9804947A BR 9804947 A BR9804947 A BR 9804947A BR 9804947 A BR9804947 A BR 9804947A BR 9804947 A BR9804947 A BR 9804947A BR 9804947 A BR9804947 A BR 9804947A
Authority
BR
Brazil
Prior art keywords
pharmaceutical agent
crystal modification
crystal
modification
pharmaceutical
Prior art date
Application number
BR9804947A
Other languages
English (en)
Portuguese (pt)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9804947(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR9804947A publication Critical patent/BR9804947A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR9804947A 1997-06-10 1998-06-08 Modifica-Æo de cristal de um agente farmac-utico BR9804947A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003427 WO1998056772A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
BR9804947A true BR9804947A (pt) 1999-08-24

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9804946A BR9804946A (pt) 1997-06-10 1998-06-08 Modifica-Æo de cristal de um agente farmac-utico
BR9804947A BR9804947A (pt) 1997-06-10 1998-06-08 Modifica-Æo de cristal de um agente farmac-utico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9804946A BR9804946A (pt) 1997-06-10 1998-06-08 Modifica-Æo de cristal de um agente farmac-utico

Country Status (36)

Country Link
US (6) US6740669B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP0994864B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JP3672574B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (2) KR100425656B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (3) CN1132820C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (4) AR012945A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) ATE232852T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU725528B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (2) BR9804946A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (3) CA2256015C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CO (2) CO4940448A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY2007014I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (2) CZ292260B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (3) DE122007000051I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK0994864T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES2197485T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR07C0037I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HU225153B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ID (2) ID21014A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (2) IL125733A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU91345I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (2) MY120156A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL300284I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO329315B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (2) NZ331370A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PE (2) PE80999A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (2) PL192114B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT994864E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (2) RU2194041C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SI (2) SI0994863T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (2) SK283685B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TR (2) TR199801630T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (2) TW526195B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UY (1) UY25844A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (2) WO1998056772A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (2) ZA984967B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
JP2005529933A (ja) * 2002-05-31 2005-10-06 シェーリング　コーポレイション キサンチンホスホジエステラーゼｖインヒビター多形体
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
CA2772075C (en) * 2009-09-04 2017-02-28 Rashida A. Karmali Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
EP2465853A1 (en) 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
EP2727914A1 (en) 2010-04-30 2014-05-07 Laboratorios Lesvi, S.L. Polymorph of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-carboxamide
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US5283244A (en) 1990-11-06 1994-02-01 Yamanouchi Pharmaceutical Co., Ltd. Fused pyrazine derivatives
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
ATE194607T1 (de) 1995-02-22 2000-07-15 Hoechst Japan Amorph piretanide, polymorphe davon, verfahren zur dessen herstellung und ihre verwendung
DK0918758T3 (da) * 1996-07-11 2002-08-19 Novartis Ag Fremgangsmåde til fremstilling af 1-substituerede 4-cyan-1,2,3-triazoler
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
EP0994864B1 (en) 2003-04-16
KR100409168B1 (ko) 2004-01-31
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
TR199801631T1 (xx) 1999-06-21
DE122007000051I2 (de) 2009-02-19
AU725528B2 (en) 2000-10-12
CO4940452A1 (es) 2000-07-24
CA2256013A1 (en) 1998-12-17
DK0994863T3 (da) 2003-05-26
CN1298708C (zh) 2007-02-07
US20060116520A1 (en) 2006-06-01
NO983667L (no) 1998-12-17
KR100425656B1 (ko) 2004-05-17
MY125854A (en) 2006-08-30
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
NO983666L (no) 1998-12-17
ID27660A (id) 2001-04-19
EP0994864A1 (en) 2000-04-26
NL300284I2 (nl) 2007-11-01
CA2256015C (en) 2008-06-03
JP3672575B2 (ja) 2005-07-20
ATE237599T1 (de) 2003-05-15
US20040167186A1 (en) 2004-08-26
TR199801630T1 (xx) 1999-06-21
JP2000516259A (ja) 2000-12-05
CA2614926A1 (en) 1998-12-17
US20100310655A1 (en) 2010-12-09
RU2198167C2 (ru) 2003-02-10
CZ253398A3 (cs) 1999-04-14
PL192114B1 (pl) 2006-08-31
HUP0000798A3 (en) 2000-10-30
CZ292481B6 (cs) 2003-09-17
US20030125568A1 (en) 2003-07-03
EP0994863B1 (en) 2003-02-19
ZA984966B (en) 1999-01-11
TW526195B (en) 2003-04-01
HK1028241A1 (en) 2001-02-09
US7750028B2 (en) 2010-07-06
PE80999A1 (es) 1999-09-06
AR012945A1 (es) 2000-11-22
DK0994864T3 (da) 2003-07-21
DE69813560D1 (de) 2003-05-22
HUP0000798A2 (hu) 2000-10-30
DE122007000051I1 (de) 2007-11-08
IL125732A (en) 2002-12-01
SI0994864T1 (en) 2003-10-31
KR19990087836A (ko) 1999-12-27
IL125733A0 (en) 1999-04-11
TW403740B (en) 2000-09-01
AR061004A2 (es) 2008-07-30
WO1998056772A1 (en) 1998-12-17
EP0994863A1 (en) 2000-04-26
NZ331371A (en) 2000-08-25
CA2614926C (en) 2010-02-09
ES2192779T3 (es) 2003-10-16
HU226107B1 (en) 2008-04-28
AR012946A1 (es) 2000-11-22
CZ253498A3 (cs) 1999-04-14
PL330798A1 (en) 1999-06-07
JP2000516258A (ja) 2000-12-05
IL125733A (en) 2002-12-01
NO329314B1 (no) 2010-09-27
ZA984967B (en) 1999-01-11
CN1217716A (zh) 1999-05-26
AU8437298A (en) 1998-12-30
DE69813560T2 (de) 2004-02-05
HUP0002113A3 (en) 2002-09-30
ID21014A (id) 1999-04-08
LU91345I2 (fr) 2007-09-04
UY25844A1 (es) 2001-08-27
MY120156A (en) 2005-09-30
US20010037029A1 (en) 2001-11-01
NO983666D0 (no) 1998-08-11
JP3672574B2 (ja) 2005-07-20
PE79799A1 (es) 1999-09-03
CO4940448A1 (es) 2000-07-24
RU2194041C2 (ru) 2002-12-10
KR19990087835A (ko) 1999-12-27
LU91345I9 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2018-12-31
HU225153B1 (en) 2006-07-28
HK1028031A1 (en) 2001-02-02
CZ292260B6 (cs) 2003-08-13
SK283685B6 (sk) 2003-12-02
BR9804946A (pt) 1999-08-24
CA2256015A1 (en) 1998-12-17
PL330764A1 (en) 1999-05-24
US8076362B2 (en) 2011-12-13
DE69811500D1 (de) 2003-03-27
HK1028242A1 (en) 2001-02-09
DE69811500T2 (de) 2004-04-01
CN1572789A (zh) 2005-02-02
PL191943B1 (pl) 2006-07-31
AR061005A2 (es) 2008-07-30
ES2197485T3 (es) 2004-01-01
AU725517B2 (en) 2000-10-12
IL125732A0 (en) 1999-04-11
FR07C0037I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2008-05-16
CY2007014I2 (el) 2009-11-04
NZ331370A (en) 2000-08-25
CA2256013C (en) 2007-10-16
US6740669B1 (en) 2004-05-25
FR07C0037I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2007-08-17
SK109398A3 (en) 1998-12-02
NO329315B1 (no) 2010-09-27
PT994864E (pt) 2003-07-31
CN1132820C (zh) 2003-12-31
ATE232852T1 (de) 2003-03-15
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
US6455556B2 (en) 2002-09-24
SK109498A3 (en) 1998-12-02
CN1159300C (zh) 2004-07-28
HUP0002113A2 (hu) 2001-02-28
CN1259127A (zh) 2000-07-05
SI0994863T1 (en) 2003-08-31

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIDO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO REQUISITO DE NOVIDADE (ART. 8O E 11 DA LPI) E ATIVIDADE INVENTIVA (ART. 8O E 13 DA LPI)

B12B Appeal against refusal [chapter 12.2 patent gazette]
B15W Others matters related to applications: legal action concerning application

Free format text: INPI-52400.007820/2015-16 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0011226-08.2015.4.02.5101 ACAO ORDINARIA PARA ANULACAO DE ATO ADMINISTRATIVO QUE MANTEVE O INDEFERIMENTO DO PEDIDO AUTOR: NOVARTIS AG REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI.

B15N Others concerning applications: notification of judicial decision

Free format text: INPI NO 52400.007820/2015-16 TRIBUNAL REGIONAL DA 2A REGIAO NUP: 00408.007202/2016-75 (REF. 0011226-08.2015.4.02.5101) INTERESSADOS: NOVARTIS AG E OUTRO ANTE O EXPOSTO, JULGO IMPROCEDENTE O PEDIDO D E NULIDADE DO ATO ADMINISTRATIVO DEINDEFERIMENTO, EM GRAU DE RECURSO, DO PEDIDO DE PATENTE DE INVENCAO PI9804947-0 PARA ?MODIFICACAODE CRISTAL DE UM AGENTE FARMACEUTICO?, NA FORMA DO ART.487, INCISO I, DO CODIGO DE PROCESSO CIVIL. TRANSITOU EM JULGADO EM 02 DE SETEMBRO DE 2020.